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Conserved domains on  [gi|1972228022|ref|NP_001379848|]
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GCS light chain [Caenorhabditis elegans]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 78-210 1.40e-13

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19071:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 251  Bit Score: 68.66  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAV-TSLKEqLKTKDIEVLILSFPeldlidGESEEDENNRWFEKVkplYTYMEKLVETS 156
Cdd:cd19071    54 REELFITTKLWPTDHGYERVREALeESLKD-LGLDYLDLYLIHWP------VPGKEGGSKEARLET---WRALEELVDEG 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972228022 157 EIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:cd19071   124 LVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 78-210 1.40e-13

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 68.66  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAV-TSLKEqLKTKDIEVLILSFPeldlidGESEEDENNRWFEKVkplYTYMEKLVETS 156
Cdd:cd19071    54 REELFITTKLWPTDHGYERVREALeESLKD-LGLDYLDLYLIHWP------VPGKEGGSKEARLET---WRALEELVDEG 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972228022 157 EIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:cd19071   124 LVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 149-210 4.12e-06

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 46.97  E-value: 4.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:COG0656   113 LEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQ-QRELLAFCREHGIVV 173
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 77-213 2.01e-05

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 45.00  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKVF--LSAWDV----QQIDQAV-TSLKEqLKTKDIEVLILSFPELDLIDGEseedennrwfekvkpLYTYM 149
Cdd:pfam00248  60 KRDKVVIATKVPdgDGPWPSggskENIRKSLeESLKR-LGTDYIDLYYLHWPDPDTPIEE---------------TWDAL 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972228022 150 EKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQVPP-ELQALANDNDVQLLVH 213
Cdd:pfam00248 124 EELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAY 188
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
78-189 4.92e-03

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 37.74  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQQIDqAVTSLKEQLKTkdievLILSFPELDLIdgeseedennRWfeKVKPLYTYME------K 151
Cdd:PRK11565   68 REELFITTKL----WNDDHKR-PREALEESLKK-----LQLDYVDLYLM----------HW--PVPAIDHYVEawkgmiE 125

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972228022 152 LVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:PRK11565  126 LQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIEL 163
 
Name Accession Description Interval E-value
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 78-210 1.40e-13

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 68.66  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAV-TSLKEqLKTKDIEVLILSFPeldlidGESEEDENNRWFEKVkplYTYMEKLVETS 156
Cdd:cd19071    54 REELFITTKLWPTDHGYERVREALeESLKD-LGLDYLDLYLIHWP------VPGKEGGSKEARLET---WRALEELVDEG 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972228022 157 EIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:cd19071   124 LVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQ-QKELVEFCKEHGIVV 176
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 78-219 3.31e-10

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 59.17  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQidqavtSLKEQLKTkdievLILSFPELDLIdgeseedeNNRWFEKVKPL-----YTYMEKL 152
Cdd:cd19120    65 REDLFITTKVSPGIKDPRE------ALRKSLAK-----LGVDYVDLYLI--------HSPFFAKEGGPtlaeaWAELEAL 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972228022 153 VETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQVP-PELQALANDNDVQL--------LVHNDPTPF 219
Cdd:cd19120   126 KDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPYLYPQqPALLEYCREHGIVVsaysplspLTRDAGGPL 201
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 78-210 1.02e-07

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 51.81  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAV-TSLKeQLKTKDIEVLILSFPeldlidgeseedennrwFEKVKPLYTYMEKLVETS 156
Cdd:cd19133    63 REELFITTKLWIQDAGYEKAKKAFeRSLK-RLGLDYLDLYLIHQP-----------------FGDVYGAWRAMEELYKEG 124

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972228022 157 EIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:cd19133   125 KIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQ-QIEAVEFLKKYGVQI 177
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 78-187 1.50e-07

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 51.51  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaW-DVQQIDQAVTSLKEQLKTkdievLILSFPELDLI--------DGESEEDENNRWfEKVKPLYTY 148
Cdd:cd19116    69 REDLFITTKL----WnSYHEREQVEPALRESLKR-----LGLDYVDLYLIhwpvafkeNNDSESNGDGSL-SDIDYLETW 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972228022 149 --MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHV 187
Cdd:cd19116   139 rgMEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQI 179
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 77-189 2.84e-07

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 50.48  E-value: 2.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFPELDLidgeseedennrwFEKVKPLYTYMEKLVETS 156
Cdd:cd19127    61 DRSDIFVTTKLWISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVPND-------------FDRTIQAYKALEKLLAEG 127

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972228022 157 EIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19127   128 RVRAIGVSNFTPEHLERLIDATTVVPAVNQVEL 160
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 75-188 1.51e-06

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 48.04  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  75 NYERDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFPeldlidgeSEEDENNRWFEKvkplytyMEKLVE 154
Cdd:cd19073    51 GVPREDLFITTKVWRDHLRPEDLKKSVDRSLEKLGTDYVDLLLIHWP--------NPTVPLEETLGA-------LKELKE 115

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1972228022 155 TSEIASIGVSDFSARQLKTIIDHFDVKPSINHVR 188
Cdd:cd19073   116 AGKVKSIGVSNFTIELLEEALDISPLPIAVNQVE 149
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 149-210 4.12e-06

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 46.97  E-value: 4.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:COG0656   113 LEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQ-QRELLAFCREHGIVV 173
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 78-189 6.27e-06

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 46.21  E-value: 6.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAwdvQQIDQAVTSLKEQLKTKDIEVLilsfpELDLIdgeseedennRWFEKVKPLYT----YMEKLV 153
Cdd:cd19131    63 REELFITTKLWNSD---QGYDSTLRAFDESLRKLGLDYV-----DLYLI----------HWPVPAQDKYVetwkALIELK 124

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1972228022 154 ETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19131   125 KEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIEL 160
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 78-189 1.17e-05

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 45.57  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQ--QIDQAVTSLKEQLKTKDIEVLILSFP---------ELDLIDGESEEDENNRWFEKVKPLy 146
Cdd:cd19117    67 REEIFITTKL----WCTWhrRVEEALDQSLKKLGLDYVDLYLMHWPvpldpdgndFLFKKDDGTKDHEPDWDFIKTWEL- 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972228022 147 tyMEKLVETSEIASIGVSDFSARQLKTIIDHFDVK--PSINHVRL 189
Cdd:cd19117   142 --MQKLPATGKVKAIGVSNFSIKNLEKLLASPSAKivPAVNQIEL 184
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 77-213 2.01e-05

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 45.00  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKVF--LSAWDV----QQIDQAV-TSLKEqLKTKDIEVLILSFPELDLIDGEseedennrwfekvkpLYTYM 149
Cdd:pfam00248  60 KRDKVVIATKVPdgDGPWPSggskENIRKSLeESLKR-LGTDYIDLYYLHWPDPDTPIEE---------------TWDAL 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972228022 150 EKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQVPP-ELQALANDNDVQLLVH 213
Cdd:pfam00248 124 EELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLRRRQEeELLEYCKKNGIPLIAY 188
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 77-210 4.46e-05

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 43.77  E-value: 4.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKvfLSAWDvQQIDQAVTSLKEQLktkdiEVLILSFPELDLI-----DGESEEDENNR------WFEkvkpl 145
Cdd:cd19136    58 SREDIFITSK--LAPKD-QGYEKARAACLGSL-----ERLGTDYLDLYLIhwpgvQGLKPSDPRNAelrresWRA----- 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972228022 146 ytyMEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSIN----HVRLdgccqVPPELQALANDNDVQL 210
Cdd:cd19136   125 ---LEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNqvefHPHL-----VQKELLKFCKDHGIHL 185
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 78-189 5.70e-05

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 43.49  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFPeLDLIDGESEEDENNRWFEKVKPLYTYMEKLVETSE 157
Cdd:cd19125    68 REDLFITSKLWCTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWP-VRLKKGAHMPEPEEVLPPDIPSTWKAMEKLVDSGK 146

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1972228022 158 IASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19125   147 VRAIGVSNFSVKKLEDLLAVARVPPAVNQVEC 178
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 70-208 7.56e-05

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 43.26  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  70 NDHIDN--YERDEIKITMKV---FLSAWDVQQidQAVTSLkEQLKTKDIEVLILSFPELDLIDGESEEDENNRWfeKVKP 144
Cdd:cd19111    51 KWWLKNgkLKREEVFITTKLppvYLEFKDTEK--SLEKSL-ENLKLPYVDLYLIHHPCGFVNKKDKGERELASS--DVTS 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1972228022 145 LYTYMEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDV 208
Cdd:cd19111   126 VWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAKVKPSNLQLECHAYLQ-QRELRKFCNKKNI 188
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 149-210 1.21e-04

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 42.78  E-value: 1.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDVQL 210
Cdd:cd19123   143 MEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVELHPYLQ-QPELLAFCRDNGIHL 203
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 78-208 1.25e-04

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 42.78  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFP-ELDLIDGESEEDENNRWFEKVKPL---YTYMEKLV 153
Cdd:cd19154    69 REDLFITTKLWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPaAFKDDEGESGTMENGMSIHDAVDVedvWRGMEKVY 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1972228022 154 ETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRLDGCCQvPPELQALANDNDV 208
Cdd:cd19154   149 DEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYFP-QKELVEFCKKHNI 202
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 139-187 1.42e-04

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 42.37  E-value: 1.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972228022 139 FEKVKPLYTY--MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHV 187
Cdd:cd19106   128 YDSTHYKETWkaMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQV 178
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 78-245 1.90e-04

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 42.05  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFP--------ELDLIDGESEEDENNRWFEKVKPLYTY- 148
Cdd:cd19113    68 REELFLTSKLWNNFHDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpiEEKYPPGFYCGDGDNFVYEDVPILDTWk 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022 149 -MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSI----NHVRLdgccqVPPELQALANDNDVQLLVHNDPTPfptnn 223
Cdd:cd19113   148 aLEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVlqieHHPYL-----QQPKLIEYAQKAGITITAYSSFGP----- 217

                         170       180
                  ....*....|....*....|..
gi 1972228022 224 ifKTFCEIDSGSQKAvCSPLFE 245
Cdd:cd19113   218 --QSFVELNQGRALN-TPTLFE 236
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 78-189 2.20e-04

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 41.71  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDvqQIDQavtSLKEQLKTKDIE---VLILSFPeldlIDGESEEDENNRWFEKVKP---------- 144
Cdd:cd19119    71 REELFITTKVWPTFYD--EVER---SLDESLKALGLDyvdLLLVHWP----VCFEKDSDDSGKPFTPVNDdgktryaasg 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1972228022 145 ----LYTYMEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19119   142 dhitTYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVEL 190
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 149-187 3.90e-04

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 41.24  E-value: 3.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHV 187
Cdd:cd19118   145 MVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQI 183
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 73-187 8.49e-04

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 39.91  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  73 IDNYERDEIKITMKV---FLSAWDVqqIDQAVTSLKeQLKTKDIEVLILSFPElDLIDGEseedennrwfEKVKplytYM 149
Cdd:cd19072    62 IKGFDREDLFITTKVspdHLKYDDV--IKAAKESLK-RLGTDYIDLYLIHWPN-PSIPIE----------ETLR----AM 123

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1972228022 150 EKLVETSEIASIGVSDFSARQLKTIIDHF-DVKPSINHV 187
Cdd:cd19072   124 EELVEEGKIRYIGVSNFSLEELEEAQSYLkKGPIVANQV 162
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 78-189 1.05e-03

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 39.73  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQQIDQAVTSLKEqlktKDIEVLILSFPELDLIdgeseedennRW--FEKVKPLYTYMEKLVET 155
Cdd:cd19126    63 REELFVTTKL----WNDDQRARRTEDAFQ----ESLDRLGLDYVDLYLI----------HWpgKDKFIDTWKALEKLYAS 124

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1972228022 156 SEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19126   125 GKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEF 158
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 77-189 1.44e-03

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 39.53  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFPeldlIDGESEEDE------------NNRWFEKVKP 144
Cdd:cd19122    68 KREDLFICTKVWNHLHEPEDVKWSIDNSLKNLKLDYIDLFLVHWP----IAAEKNDQRspklgpdgkyviLKDLTENPEP 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972228022 145 LYTYMEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19122   144 TWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 78-189 1.49e-03

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 39.42  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQQ-IDQAVTSLKEQLKTkdievLILSFPELDLIdgeseedennRWFEKVKPLYTY--MEKLVE 154
Cdd:cd19156    63 REEVFVTTKL----WNSDQgYESTLAAFEESLEK-----LGLDYVDLYLI----------HWPVKGKFKDTWkaFEKLYK 123

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972228022 155 TSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19156   124 EKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIEL 158
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 77-190 1.60e-03

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 39.18  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  77 ERDEIKITMKVflsAWDVQQIDQAVTSLKEQLKTKDIEVLilsfpELDLIdgeseedennRWFEKVKPLYT-YMEKLVET 155
Cdd:cd19132    59 PREELFVTTKL---PGRHHGYEEALRTIEESLYRLGLDYV-----DLYLI----------HWPNPSRDLYVeAWQALIEA 120

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972228022 156 SE---IASIGVSDFSARQLKTIIDHFDVKPSINHVRLD 190
Cdd:cd19132   121 REeglVRSIGVSNFLPEHLDRLIDETGVTPAVNQIELH 158
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 106-189 2.31e-03

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 38.66  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022 106 EQLKTKDIEVLILSFPELDLID---GESEEDENNRWFEK-----------VKPLYTYMEKLVETSEIASIGVSDFSARQL 171
Cdd:cd19155    89 EKFLLKSLEKLQLDYVDLYLIHfpvGSLSKEDDSGKLDPtgehkqdyttdLLDIWKAMEAQVDQGLTRSIGLSNFNREQM 168

                          90
                  ....*....|....*...
gi 1972228022 172 KTIIDHFDVKPSINHVRL 189
Cdd:cd19155   169 ARILKNARIKPANLQVEL 186
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 74-257 3.91e-03

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 37.89  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  74 DNYERDEIKITMKVFLSAWDVQQI-DQAVTSLKEqLKTKDIEVLILSFP-ELDLIDGESEEDENNRWFEKVKPL---YTY 148
Cdd:cd19128    54 GGVKREDLFITSKLWPTMHQPENVkEQLLITLQD-LQLEYLDLFLIHWPlAFDMDTDGDPRDDNQIQSLSKKPLedtWRA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVrldgccQVPPELQalaNDNDVQLLVHND--PTPFPT----- 221
Cdd:cd19128   133 MEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQI------ECHPYFQ---NDKLIKFCIENNihVTAYRPlggsy 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1972228022 222 ---NNIFKTFCEIDSGSQKAVCSPL------FETTWLSRYSVWVR 257
Cdd:cd19128   204 gdgNLTFLNDSELKALATKYNTTPPqviiawHLQKWPKNYSVIPK 248
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 78-189 4.37e-03

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 37.76  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQQ-IDQAVTSLKEQLKTKDIEVLilsfpELDLIdgeseedennRW--FEKVKPLYTYMEKLVE 154
Cdd:cd19157    64 REELFITSKV----WNADQgYDSTLKAFEASLERLGLDYL-----DLYLI----------HWpvKGKYKETWKALEKLYK 124

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972228022 155 TSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:cd19157   125 DGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEF 159
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
78-189 4.92e-03

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 37.74  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVflsaWDVQQIDqAVTSLKEQLKTkdievLILSFPELDLIdgeseedennRWfeKVKPLYTYME------K 151
Cdd:PRK11565   68 REELFITTKL----WNDDHKR-PREALEESLKK-----LQLDYVDLYLM----------HW--PVPAIDHYVEawkgmiE 125

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972228022 152 LVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHVRL 189
Cdd:PRK11565  126 LQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIEL 163
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 78-187 6.53e-03

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 37.25  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSawDVQQiDQAVTSLKEQLKTkdievLILSFPELDLIDGESEEDENNRWF----EKVKPL-----YTY 148
Cdd:cd19124    65 RDELFVTSKLWCS--DAHP-DLVLPALKKSLRN-----LQLEYVDLYLIHWPVSLKPGKFSFpieeEDFLPFdikgvWEA 136

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1972228022 149 MEKLVETSEIASIGVSDFSARQLKTIIDHFDVKPSINHV 187
Cdd:cd19124   137 MEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQV 175
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 78-209 9.52e-03

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 36.92  E-value: 9.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972228022  78 RDEIKITMKVFLSAWDVQQIDQAVTSLKEQLKTKDIEVLILSFPELDLIDGESEEDENNRWFEkvkplytyMEKLVETSE 157
Cdd:cd19135    66 REDLFLTTKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVKETRAETWRA--------LEELYDEGL 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1972228022 158 IASIGVSDFSARQLKTIIDHFDVKPSINHVRLDgCCQVPPELQALANDNDVQ 209
Cdd:cd19135   138 CRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFH-PFQNPVELIEYCRDNNIV 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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