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Conserved domains on  [gi|1972287703|ref|NP_001379789|]
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Adenylosuccinate synthetase [Caenorhabditis elegans]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
10-430 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 681.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAE--DADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEF 167
Cdd:pfam00709  79 IEE---LEERGidVPDRLFISDRAHLILPYHKALDGLREEARG-KKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 168 SEKYRRLVEHYKKQFPSI---EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLK--PYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:pfam00709 232 YVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALR 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQ 404
Cdd:pfam00709 312 YAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARK 391

                         410       420
                  ....*....|....*....|....*.
gi 1972287703 405 YVKFIEDFIKVPIVYIGVGAERESLI 430
Cdd:pfam00709 392 YVEFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
10-430 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 681.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAE--DADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEF 167
Cdd:pfam00709  79 IEE---LEERGidVPDRLFISDRAHLILPYHKALDGLREEARG-KKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 168 SEKYRRLVEHYKKQFPSI---EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLK--PYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:pfam00709 232 YVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALR 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQ 404
Cdd:pfam00709 312 YAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARK 391

                         410       420
                  ....*....|....*....|....*.
gi 1972287703 405 YVKFIEDFIKVPIVYIGVGAERESLI 430
Cdd:pfam00709 392 YVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 8-431 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 635.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703    8 VSVLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAE--KADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   88 SELAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEdslaaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFE 165
Cdd:smart00788  79 KEIEE---LEAKGvdVKDRLFISDRAHLILPYHIALDKARE-----KARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  166 EFSEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFG 241
Cdd:smart00788 150 VLREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLR--PYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHG 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  242 TYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLF 321
Cdd:smart00788 228 TYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAV 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  322 LLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEK 401
Cdd:smart00788 308 LLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPEN 387

                          410       420       430
                   ....*....|....*....|....*....|
gi 1972287703  402 CRQYVKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:smart00788 388 AKKYIERIEELVGVPVSIISTGPDREQTIV 417
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 8-433 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 613.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIENHkiNVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERA--DVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  88 SELAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFE 165
Cdd:COG0104    79 EEIDG---LEARGvdVRSRLRISERAHLILPYHRALDKAREEARG-KKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 166 EFSEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFG 241
Cdd:COG0104   154 VLREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLK--PYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 242 TYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLF 321
Cdd:COG0104   232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 322 LLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEK 401
Cdd:COG0104   312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1972287703 402 CRQYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:COG0104   392 ARAYVERIEELLGVPISIVSVGPDREQTIVRR 423
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 10-433 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 592.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIENhkINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:PRK01117    5 VVVGTQWGDEGKGKIVDLLSER--ADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESGWE--KRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEF 167
Cdd:PRK01117   83 IDE---LEARGVDvrERLRISERAHLILPYHRALDKAREKARG-KKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPETF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 168 SEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLaeLKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTY 243
Cdd:PRK01117  158 AEKLEENLEYKNFLLTKYygaeAVDFEEILDEYLEYAERL--KPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 244 PYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLL 323
Cdd:PRK01117  236 PFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVAL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 324 RRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCR 403
Cdd:PRK01117  316 RYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENAR 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 1972287703 404 QYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:PRK01117  396 KYIKRIEELTGVPISIISTGPDRDQTIILR 425
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 10-431 3.25e-173

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 491.68  E-value: 3.25e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIENHKInvTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDI--VARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESGW--EKRIMISSEAHLVFGVHSQVDGRQEDSLAAKNkIGTTNRGIGPTYSSKCFRNGIRVADLMAD---F 164
Cdd:TIGR00184  79 MEY---LEKRGIsvRDRLFVSYRCHLILPYHKKLDKAREKSKLAKK-IGTTGKGIGPAYEDKVARSGLRVGDLLDDeafA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 165 EEFSEKYRRLVEHYKKQFPSIEVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:TIGR00184 155 EKAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELK--PFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQ 404
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*..
gi 1972287703 405 YVKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTID 419
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 8-431 8.03e-172

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 483.54  E-value: 8.03e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:cd03108     2 VTVVVGAQWGDEGKGKIVDYLAE--KADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  88 SELAhngILEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADlmadfe 165
Cdd:cd03108    80 EEIE---ELEKKGidVKGRLLISDRAHLVFPYHQELDGLEEKERG-GKKIGTTKRGIGPAYADKAARTGIRVGD------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 166 efsekyrrlvehykkqfpsievnvdeelakfkqhreklaelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYPY 245
Cdd:cd03108   150 -----------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPY 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 246 VTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLRR 325
Cdd:cd03108   189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 326 SAMINGYTAIALTKLDIldtfptikvavgyklngqvlssppaqanawgaieveykefegwneptvgvrkfedlpeKCRQY 405
Cdd:cd03108   269 AVRINGLTELALTKLDV----------------------------------------------------------NAQKY 290

                         410       420
                  ....*....|....*....|....*.
gi 1972287703 406 VKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:cd03108   291 IERIEELLGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
8-331 1.70e-27

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 110.92  E-value: 1.70e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIE--NHKINVTArcqGGNNAGHTVV-ANGRKYDFHILPSGIISPTCFNV-IGNGVVVNL 83
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAEraAPDVVVRA---AGPNAGHTYIdDEGRKFVHRMLPNGIVSPPLKQVlIGPGSEIDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  84 DAFFSE-LAHNGILEESGweKRIMISSEAHLVFGvHSQVDgrQEDSLAAknKIGTTNRGIGPTYSSKCFRNGIRVADLMA 162
Cdd:NF038379   78 EVLREEiEELEDAGHDVG--KRLLIHEQATVIEL-HKHVE--EEAGPMT--KIGSTKKGIGAARAAKIRRNPSTLGDAEG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 163 DFEEFSEKYRRLVEHykkqfpsiEVNVDEELAKFKQHReklaelklvgdtvgfiheqrnaGKQVLVEGANGALLDIDFGT 242
Cdd:NF038379  151 DFGEGAVRDQPWEIA--------ERVVDNALYDFALQA----------------------AERIQIEGTQGYSLGLHAGF 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 243 YPYVTSSNSTVGGACTGIGVPPTAV--GNVIGVVKAYQTRVGT-----GPFPTEL-FDSDG--EKLQTIGKEVgvttgrk 312
Cdd:NF038379  201 YPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGwsgnsYPDQGETtWEELGlpEELTTVTKKV------- 273

                         330
                  ....*....|....*....
gi 1972287703 313 RRCGWIDLFLLRRSAMING 331
Cdd:NF038379  274 RRVGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
10-430 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 681.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAE--DADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEF 167
Cdd:pfam00709  79 IEE---LEERGidVPDRLFISDRAHLILPYHKALDGLREEARG-KKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 168 SEKYRRLVEHYKKQFPSI---EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLK--PYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYP 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:pfam00709 232 YVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALR 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQ 404
Cdd:pfam00709 312 YAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARK 391

                         410       420
                  ....*....|....*....|....*.
gi 1972287703 405 YVKFIEDFIKVPIVYIGVGAERESLI 430
Cdd:pfam00709 392 YVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 8-431 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 635.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703    8 VSVLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAE--KADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   88 SELAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEdslaaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFE 165
Cdd:smart00788  79 KEIEE---LEAKGvdVKDRLFISDRAHLILPYHIALDKARE-----KARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  166 EFSEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFG 241
Cdd:smart00788 150 VLREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLR--PYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHG 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  242 TYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLF 321
Cdd:smart00788 228 TYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAV 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  322 LLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEK 401
Cdd:smart00788 308 LLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPEN 387

                          410       420       430
                   ....*....|....*....|....*....|
gi 1972287703  402 CRQYVKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:smart00788 388 AKKYIERIEELVGVPVSIISTGPDREQTIV 417
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 8-433 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 613.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIENHkiNVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:COG0104     1 NVVVVGAQWGDEGKGKIVDLLAERA--DVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  88 SELAHngiLEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFE 165
Cdd:COG0104    79 EEIDG---LEARGvdVRSRLRISERAHLILPYHRALDKAREEARG-KKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 166 EFSEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFG 241
Cdd:COG0104   154 VLREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLK--PYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 242 TYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLF 321
Cdd:COG0104   232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 322 LLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEK 401
Cdd:COG0104   312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1972287703 402 CRQYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:COG0104   392 ARAYVERIEELLGVPISIVSVGPDREQTIVRR 423
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 10-433 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 592.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIENhkINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:PRK01117    5 VVVGTQWGDEGKGKIVDLLSER--ADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESGWE--KRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEF 167
Cdd:PRK01117   83 IDE---LEARGVDvrERLRISERAHLILPYHRALDKAREKARG-KKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPETF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 168 SEKYRRLVEHYKKQFPSI----EVNVDEELAKFKQHREKLaeLKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTY 243
Cdd:PRK01117  158 AEKLEENLEYKNFLLTKYygaeAVDFEEILDEYLEYAERL--KPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 244 PYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLL 323
Cdd:PRK01117  236 PFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVAL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 324 RRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCR 403
Cdd:PRK01117  316 RYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENAR 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 1972287703 404 QYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:PRK01117  396 KYIKRIEELTGVPISIISTGPDRDQTIILR 425
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 8-433 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 572.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIENHkiNVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:PTZ00350   14 VVVILGAQWGDEGKGKLVDILSEKA--DIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  88 SELAhngILEESGWE--KRIMISSEAHLVFGVHSQVDGRQEDSLAAKNK-IGTTNRGIGPTYSSKCFRNGIRVADLMaDF 164
Cdd:PTZ00350   92 EEIE---QLTKKGINllGRLYISDRAHLVFDLHQAIDGIQESEKGKGGTqIGTTKRGIGPCYSTKASRTGLRVGDLL-NF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 165 EEFSEKYRRLVEHYKKQFPSIEVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:PTZ00350  168 ETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLK--DMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYP 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:PTZ00350  246 YVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALR 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLS--SPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKC 402
Cdd:PTZ00350  326 YVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGLEigRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENA 405

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1972287703 403 RQYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:PTZ00350  406 QKYVLFIEELLGVPIVWIGVGPNRENMIVKK 436
PLN02513 PLN02513
adenylosuccinate synthase
 8-433 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 524.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIENHKInvTARCQGGNNAGHTVV-ANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAF 86
Cdd:PLN02513    4 VSAVLGTQWGDEGKGKLVDILAQHFDI--VARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  87 FSELahnGILEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDF 164
Cdd:PLN02513   82 FEEI---DGLESNGvsCEGRLLVSDRAHLLFDFHQEVDGLREAELA-GSKIGTTKRGIGPAYSSKATRNGLRVGDLR-HM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 165 EEFSEKYRRLVEHYKKQFPSIE---VNVDEELAKFKQHREKLaeLKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFG 241
Cdd:PLN02513  157 DTFAEKLRELLADAAARFEGFEydaSMVEEEVEAYKKFAERL--EPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 242 TYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLF 321
Cdd:PLN02513  235 TYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIV 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 322 LLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKL-NGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPE 400
Cdd:PLN02513  315 ALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPA 394

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1972287703 401 KCRQYVKFIEDFIKVPIVYIGVGAERESLIVRQ 433
Cdd:PLN02513  395 AAQAYVERIEELVGVPVHYIGVGPGRDALIVKP 427
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 10-431 3.25e-173

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 491.68  E-value: 3.25e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIENHKInvTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDI--VARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESGW--EKRIMISSEAHLVFGVHSQVDGRQEDSLAAKNkIGTTNRGIGPTYSSKCFRNGIRVADLMAD---F 164
Cdd:TIGR00184  79 MEY---LEKRGIsvRDRLFVSYRCHLILPYHKKLDKAREKSKLAKK-IGTTGKGIGPAYEDKVARSGLRVGDLLDDeafA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 165 EEFSEKYRRLVEHYKKQFPSIEVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYP 244
Cdd:TIGR00184 155 EKAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELK--PFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 245 YVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLR 324
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 325 RSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFEDLPEKCRQ 404
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*..
gi 1972287703 405 YVKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTID 419
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 8-431 8.03e-172

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 483.54  E-value: 8.03e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFF 87
Cdd:cd03108     2 VTVVVGAQWGDEGKGKIVDYLAE--KADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  88 SELAhngILEESG--WEKRIMISSEAHLVFGVHSQVDGRQEDSLAaKNKIGTTNRGIGPTYSSKCFRNGIRVADlmadfe 165
Cdd:cd03108    80 EEIE---ELEKKGidVKGRLLISDRAHLVFPYHQELDGLEEKERG-GKKIGTTKRGIGPAYADKAARTGIRVGD------ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 166 efsekyrrlvehykkqfpsievnvdeelakfkqhreklaelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYPY 245
Cdd:cd03108   150 -----------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPY 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 246 VTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLRR 325
Cdd:cd03108   189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 326 SAMINGYTAIALTKLDIldtfptikvavgyklngqvlssppaqanawgaieveykefegwneptvgvrkfedlpeKCRQY 405
Cdd:cd03108   269 AVRINGLTELALTKLDV----------------------------------------------------------NAQKY 290

                         410       420
                  ....*....|....*....|....*.
gi 1972287703 406 VKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:cd03108   291 IERIEELLGVPITYISVGPDREQTII 316
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 9-431 8.10e-127

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 373.52  E-value: 8.10e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   9 SVLLGAQWGDEGKGKIIDYLIENHKINVtaRCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFS 88
Cdd:PRK13787    4 SLVVGTQWGDEGKAKVIDFLSKDTDIIV--RYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  89 ELAHngiLEESGW--EKRIMISSEAHLVFGVHSQVDGRQEDSLAAKNKIGTTNRGIGPTYSSKCFRNGIRVADLMADFEE 166
Cdd:PRK13787   82 ECDR---LQKEGFpvKDKLLLSDACHLLFPYHSQIDSARETTSSQEHKIGTTKKGIGICYADKMMRTGLRVGDLLDKSYK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 167 ------FSEKYRRLVEHYKKQfpsiEVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDF 240
Cdd:PRK13787  159 rrlkhlVDEKNRELDKLYGMP----PVSYNDINDGLKFFLSKVG--KNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 241 GTYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDL 320
Cdd:PRK13787  233 GTYPYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 321 FLLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQanAWGAIEVEYKEFEGWNEPTVGVRKFEDLPE 400
Cdd:PRK13787  313 EMLKHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPSQ--GLEKVEPLYEEFPGWKDDISGINEFQKLPE 390

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1972287703 401 KCRQYVKFIEDFIKVPIVYIGVGAERESLIV 431
Cdd:PRK13787  391 KCKNYISALEKWIGVKINLVSTGPDRKDTII 421
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 9-427 2.22e-120

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 357.19  E-value: 2.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   9 SVLLGAQWGDEGKGKIIDYLIENHkiNVTARCQGGNNAGHTVVANGRKYDFHILPSGIIsptcFN---VIGNGVVVNLDA 85
Cdd:PRK13786    3 TIITGAQFGDEGKGKIVDLLAKDY--DIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFL----LDarvLIGPGVVLNPEV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  86 FFSELAhngILEESGWE---KRIMISSEAHLVFGVHSQVDGRQEDSLaaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMa 162
Cdd:PRK13786   77 LAEEID---MLEKHGVKvdaEKLGIDAKTSIIMPYHIELDGLRESAR--TEKIGTTKRGIGFAYIDKIARDEVRMSDLV- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 163 DFEEFSEKYRRLVEHYKKQF------PSIeVNVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALL 236
Cdd:PRK13786  151 DKERLMRRLEELAPQKEKEIkelggdPSI-VRDEALIDKYLELGRQLA--PYITDVSYEINKALDEGKSVLAEGAQGTHL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 237 DIDFGTYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCG 316
Cdd:PRK13786  228 DVIHGTQKFVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCG 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 317 WIDLFLLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEYKEFEGWNEPTVGVRKFE 396
Cdd:PRK13786  308 WFDLPLLKKAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYE 387

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1972287703 397 DLPEKCRQYVKFIEDFIKVPIVYIGVGAERE 427
Cdd:PRK13786  388 DLPENARNYVERLEELMGVPIKYISVGPGRE 418
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 11-427 3.46e-119

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 353.34  E-value: 3.46e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  11 LLGAQWGDEGKGKIIDYLIENHKINVtaRCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSEL 90
Cdd:PRK13788    6 IIGAQWGDEGKGKVVDALAPEADFVV--RYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  91 AHngiLEESGWEKRIMISSEAHLVFGVHSQVDGRqedslaaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEEFSEK 170
Cdd:PRK13788   84 EN---LRAGGLNPKLLISERAHLVLPHHKYVDGR-------KNFVGTTGRGIGPAYSDRARRVGIRFGDLL-DEAVLRER 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 171 YRRLVEhyKKQFPSIEV---NVDEELAKFKQHREKLAelKLVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYPYVT 247
Cdd:PRK13788  153 VERLLE--AKPNSTREAgwdTVEKALADLAPMREILL--PFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 248 SSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIG----KEVGVTTGRKRRCGWIDLFLL 323
Cdd:PRK13788  229 SSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 324 RRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLssppaqanawgaieveYKEFEGWNEpTVGVRKFEDLPEKCR 403
Cdd:PRK13788  309 KYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDGQPV----------------YKELPGWGD-LDGVKSREALPKEAQ 371

                         410       420
                  ....*....|....*....|....
gi 1972287703 404 QYVKFIEDFIKVPIVYIGVGAERE 427
Cdd:PRK13788  372 AYLELIEETTGVPVVMFSTSPRRE 395
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 9-430 1.06e-117

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 349.40  E-value: 1.06e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   9 SVLLGAQWGDEGKGKIIDYLIENHKINVtaRCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFS 88
Cdd:PRK13783    3 RVIVGLQWGDEGKGKVVTYLSRYYDIVV--RYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  89 ELAhngILEES--GWEKRIMISSEAHLVFGVHSQVDGRQEDSLaaKNKIGTTNRGIGPTYSSKCFRNGIRVADLMaDFEE 166
Cdd:PRK13783   81 ELE---ELKEKfpDYSGRIFISELAHVVLPVHKELDEIIESVR--KNAIGTTKRGIGPAYADKVMRVGVRLADLF-DEEK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 167 FSEKYRRLVEHYKKQFpSIEVNVDEELAKFKQHREKLaeLKLVGDTVGFIHEQRNagKQVLVEGANGALLDIDFGTYPYV 246
Cdd:PRK13783  155 LREFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKI--KDLVVSPVEIKRILEE--KSVLFEGTQGVLLDLDVGTYPYV 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 247 TSSNSTVGGACTGIGVPpTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWIDLFLLRRS 326
Cdd:PRK13783  230 TSSNCSTTGVSAGMGFP-VKVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYA 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 327 AMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSpPAQANAWGAIEVEYKEFEGWNepTVGVRKFEDlpekcrqYV 406
Cdd:PRK13783  309 IEVSGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVRD-PSSLRDLEKAEPVYEEFDGWK--SLEDKNFLK-------FV 378

                         410       420
                  ....*....|....*....|....
gi 1972287703 407 KFIEDFIKVPIVYIGVGAERESLI 430
Cdd:PRK13783  379 DFIERETGRKIAYISTGPKIEEIV 402
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 7-434 5.33e-115

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 344.43  E-value: 5.33e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   7 TVSVLlGAQWGDEGKGKIIDylIENHKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTcFNVIGNGVVVNLDAF 86
Cdd:PRK13785    2 TVTIV-GSQLGDEGKGGVVD--LYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  87 FSELahnGILEESGWEKRIMISSEAHLVFGVHSQVDGRQEDSLAAKN-KIGTTNRGIGPTYSSKCFRNGIRVADLM---- 161
Cdd:PRK13785   78 FDEI---DALRERGLDPDVRVAERAHVILPYHRVLDGIEEEAKSDSDlEVGTTGRGIGPTYEDKAGRRGVRVGDLLdpdv 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 162 --ADFEEFSEKYRRLVEH-YKKQFPSI--EVNVDEELAKFKQHREKLAELKLVGDTVGFIHEQRNAGKQVLVEGANGALL 236
Cdd:PRK13785  155 lrDRLEYVVPQKRALAEDvYGLDASETpeAFDVDALFEEYREYGERLAEEDMTVNAGDFLAERIDDGDNVMLEGAQGTSI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 237 DIDFGTYPYVTSSNSTVGGACTGIGVPPTAVGN--VIGVVKAYQTRVGTGPFPTEL-----------FDSDGEKLQTI-- 301
Cdd:PRK13785  235 DIDHGNYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTELggvegdtpdegGRPDEEELATYir 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 302 --GKEVGVTTGRKRRCGWIDLFLLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWGAIEVEY 379
Cdd:PRK13785  315 eeGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNF 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1972287703 380 KEFEGWNE---PTVGVRKFEDLPEKCRQYVKFIEDFIKVPIVYIGVGAERESLIVRQQ 434
Cdd:PRK13785  395 RSFDGWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVLEN 452
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 10-430 4.00e-90

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 279.60  E-value: 4.00e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  10 VLLGAQWGDEGKGKIIDYLIEnhKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAFFSE 89
Cdd:PRK13784    5 VIVGAQWGDEGKGKIADTLAE--KADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  90 LAHngiLEESGWE---KRIMISSEAHLVFGVHSQVDGRQEDSlaAKNKIGTTNRGIGPTYSSKCFRNGIRVADLMAD--- 163
Cdd:PRK13784   83 ITR---LQAKGIAisaENLFVSESCTIITSYHKLLDAVRESN--TSEKIGTTGKGIGPAYEDKVSRKGIKFKHLFDKdll 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 164 ----FEEFSEKYRRLVEHYKKQFPSIEvnvdEELAKFKQHREKLAELKlvGDTVGFIHEQRNAGKQVLVEGANGALLDID 239
Cdd:PRK13784  158 rsrlAISLAEKETLFRDLYKVEYPTLE----QEFDKLFALGQKLKQYA--ADTFSIIDQAIAAGKNVVYEGAQGVLLDVD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 240 FGTYPYVTSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIGKEVGVTTGRKRRCGWID 319
Cdd:PRK13784  232 YGTYPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLD 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 320 LFLLRRSAMINGYTAIALTKLDILDTFPTIKVAVGYKLNGQVLSSPPAQANAWgAIEVEYKEFEGWNEPTVGVRkfEDLP 399
Cdd:PRK13784  312 LPLLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCAYPGIDLY-KVEPILVEMEPFSIDETVTK--DNMP 388

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1972287703 400 EKCRQYVKFIEDFIKVPIVYIGVGAERESLI 430
Cdd:PRK13784  389 AALKTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 7-430 8.98e-85

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 262.51  E-value: 8.98e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   7 TVSVLLGAQWGDEGKGKIIDYLIENHKINVTARCQGGNNAGHTVVANGRKYDFHILPSGIISPTCFNVIGNGVVVNLDAF 86
Cdd:PRK04293    2 TCTIVVGGFFGDEGKGKIIAYLALKDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  87 FSELAHNGILEESGWEKRIMISSEAHlvfgvhsqVDGRQEDSLAAKnKIGTTNRGIGPTYSSKCFRngirVADLMADFEE 166
Cdd:PRK04293   82 LKEVEELNVGGRVFVDYRCGIIEEKH--------VEEDRSDEHLSK-KIGSTGTGCGPANADRVLR----RLKLAKDVEE 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 167 fsekyrrlvehykkqfpsievnvdeeLAKFkqhreklaelklVGDTVGFIHEQRNAGKQVLVEGANGALLDIDFGTYPYV 246
Cdd:PRK04293  149 --------------------------LEKY------------LTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYV 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 247 TSSNSTVGGACTGIGVPPTAVGNVIGVVKAYQTRVGTGPFPTELFDSDGEKLQTIgkEVGVTTGRKRRCGWIDLFLLRRS 326
Cdd:PRK04293  191 TSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAEKLGLV--EYGTVTGRRRRVGPFDFELARRA 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 327 AMINGYTAIALTKLDILDtfptikvavgyklngqvlssPPAQanawgaieveykefegwneptvGVRKFEDLPEKCRQYV 406
Cdd:PRK04293  269 ARINGATQIAITKLDKLD--------------------KEAY----------------------GVTEYDKLPPEAKKFI 306

                         410       420
                  ....*....|....*....|....
gi 1972287703 407 KFIEDFIKVPIVYIGVGAERESLI 430
Cdd:PRK04293  307 EEIEEELGVPVTLISTGPELEDTI 330
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
8-331 1.70e-27

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 110.92  E-value: 1.70e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIE--NHKINVTArcqGGNNAGHTVV-ANGRKYDFHILPSGIISPTCFNV-IGNGVVVNL 83
Cdd:NF038379    1 VDVVVDGQFGSTGKGLIAGYLAEraAPDVVVRA---AGPNAGHTYIdDEGRKFVHRMLPNGIVSPPLKQVlIGPGSEIDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  84 DAFFSE-LAHNGILEESGweKRIMISSEAHLVFGvHSQVDgrQEDSLAAknKIGTTNRGIGPTYSSKCFRNGIRVADLMA 162
Cdd:NF038379   78 EVLREEiEELEDAGHDVG--KRLLIHEQATVIEL-HKHVE--EEAGPMT--KIGSTKKGIGAARAAKIRRNPSTLGDAEG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 163 DFEEFSEKYRRLVEHykkqfpsiEVNVDEELAKFKQHReklaelklvgdtvgfiheqrnaGKQVLVEGANGALLDIDFGT 242
Cdd:NF038379  151 DFGEGAVRDQPWEIA--------ERVVDNALYDFALQA----------------------AERIQIEGTQGYSLGLHAGF 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 243 YPYVTSSNSTVGGACTGIGVPPTAV--GNVIGVVKAYQTRVGT-----GPFPTEL-FDSDG--EKLQTIGKEVgvttgrk 312
Cdd:NF038379  201 YPYCTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGwsgnsYPDQGETtWEELGlpEELTTVTKKV------- 273

                         330
                  ....*....|....*....
gi 1972287703 313 RRCGWIDLFLLRRSAMING 331
Cdd:NF038379  274 RRVGTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 8-301 2.47e-14

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 75.09  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703   8 VSVLLGAQWGDEGKGKIIDYLIENHKINVTARCQGGNNAGHTVVAN-GRKYDFHILPSGIISPTCFNVIGNGVVVNLDAF 86
Cdd:PTZ00351  171 VIMVAGAFFGDEGKGKTVDAVAHHPLCTCIARVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSF 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703  87 FSELAHNGILEESGWEKRIMISSEAhLVFGVHSQVDgrqedsLAAKNKIGTTNRGIGPTYSSKCFRNGIRVADLMADFEE 166
Cdd:PTZ00351  251 MEKEIIQLIDAGIDYRDRLFIGNVC-IVTPYHKLLD------LLGSAANSSTLKGMAPVHGSKVMKRGIRLDHIFNDDET 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 167 FSEKYRRLVEHY------------------KKQFPSIEVNVDEELAKFKQHREKLAEL-KLVGDTV----------GFIH 217
Cdd:PTZ00351  324 LRKRLEKDMDTYlgllkvknlsdadvvrlcREENSDGVVRVPDYVIAFAQAKDKVEFLvKLYRDRVrhnpdfparcDVTY 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972287703 218 EQRNA---GKQVLVEGANGALL-DIDFGTYPYVTSSNSTVGGACTGIGVPPTAVGNVI-GVVKAY-QTRVGTGPFPTELF 291
Cdd:PTZ00351  404 ELHAAvlrGEKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNFQKFKSVVlNVHKAPgSSRVGIGACPSSFV 483

                         330
                  ....*....|
gi 1972287703 292 DSDGEKLQTI 301
Cdd:PTZ00351  484 PQDYFSAQNI 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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