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Conserved domains on  [gi|1972306950|ref|NP_001379783|]
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Apple domain-containing protein [Caenorhabditis elegans]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641280)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

CATH:  2.20.100.10
SCOP:  4003415

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 548-594 1.91e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.91e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   548 WEEWGEWADCSTTCGQGTQKRLRKCDS------GNECSGPGEEMRFCQIASCP 594
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-494 1.75e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.75e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   448 WSNWGQWEKCSKECGAGHTYRNRECID------GVSCEGASEEKILCNQQPCP 494
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 351-398 1.67e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.04  E-value: 1.67e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1972306950   351 WTLWSPWSLCTATCGVGEIQRNRVCQT------GRNCDGPSVEVEACKaLLPCP 398
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACN-EQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 400-446 4.37e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 4.37e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   400 WSSWMSWTGCGNSCGKSIERRSRICQN------GLLCPGPATEERTCDKRPCP 446
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-621 1.49e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.49e-04
                            10        20
                    ....*....|....*....|....*.
gi 1972306950   596 WGDWTPWSGCSVSCGQGVCERTRKCI 621
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 309-348 2.14e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 2.14e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1972306950   309 EWTEWSECSASC--GISLRTRQCL------GGITCIGPS--TIPCQVPEC 348
Cdd:smart00209    3 EWSEWSPCSVTCggGVQTRTRSCCspppqnGGGPCTGEDveTRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 548-594 1.91e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.91e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   548 WEEWGEWADCSTTCGQGTQKRLRKCDS------GNECSGPGEEMRFCQIASCP 594
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-494 1.75e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.75e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   448 WSNWGQWEKCSKECGAGHTYRNRECID------GVSCEGASEEKILCNQQPCP 494
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
550-593 1.25e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1972306950  550 EWGEWADCSTTCGQGTQKRLRKCDS----GNECSGPGEEMRFCQIASC 593
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 351-398 1.67e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.04  E-value: 1.67e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1972306950   351 WTLWSPWSLCTATCGVGEIQRNRVCQT------GRNCDGPSVEVEACKaLLPCP 398
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACN-EQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 400-446 4.37e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 4.37e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   400 WSSWMSWTGCGNSCGKSIERRSRICQN------GLLCPGPATEERTCDKRPCP 446
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
352-393 1.01e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.01e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1972306950  352 TLWSPWSLCTATCGVGEIQRNRVC----QTGRNCDGPSVEVEACKA 393
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKM 46
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-621 1.49e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.49e-04
                            10        20
                    ....*....|....*....|....*.
gi 1972306950   596 WGDWTPWSGCSVSCGQGVCERTRKCI 621
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
TSP_1 pfam00090
Thrombospondin type 1 domain;
449-493 3.74e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.32  E-value: 3.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1972306950  449 SNWGQWEKCSKECGAGHTYRNREC----IDGVSCEGASEEKILCNQQPC 493
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 548-594 1.32e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 42.24  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1972306950  548 WEEWGEWADCSTTCGQ--GTQKRLRKC--DSGNECSGPGEEMRFCQIASCP 594
Cdd:PTZ00087   233 YTEWGEWSNCSMECDHpdNVQIRERKCahPSGDCFKGDLKETRPCQVPLPP 283
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 597-622 1.38e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 1.38e-03
                           10        20
                   ....*....|....*....|....*.
gi 1972306950  597 GDWTPWSGCSVSCGQGVCERTRKCIT 622
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIV 29
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 309-348 2.14e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 2.14e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1972306950   309 EWTEWSECSASC--GISLRTRQCL------GGITCIGPS--TIPCQVPEC 348
Cdd:smart00209    3 EWSEWSPCSVTCggGVQTRTRSCCspppqnGGGPCTGEDveTRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 307-328 3.95e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 3.95e-03
                           10        20
                   ....*....|....*....|..
gi 1972306950  307 VVEWTEWSECSASCGISLRTRQ 328
Cdd:pfam19028    3 VSEWSEWSECSVTCGGGVQTRT 24
TSP_1 pfam00090
Thrombospondin type 1 domain;
401-445 6.71e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1972306950  401 SSWMSWTGCGNSCGKSIERRSRICQN----GLLCPGPATEERTCDKRPC 445
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 548-594 1.91e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.91e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   548 WEEWGEWADCSTTCGQGTQKRLRKCDS------GNECSGPGEEMRFCQIASCP 594
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-494 1.75e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.75e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   448 WSNWGQWEKCSKECGAGHTYRNRECID------GVSCEGASEEKILCNQQPCP 494
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
550-593 1.25e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1972306950  550 EWGEWADCSTTCGQGTQKRLRKCDS----GNECSGPGEEMRFCQIASC 593
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 351-398 1.67e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.04  E-value: 1.67e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1972306950   351 WTLWSPWSLCTATCGVGEIQRNRVCQT------GRNCDGPSVEVEACKaLLPCP 398
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACN-EQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 400-446 4.37e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 4.37e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1972306950   400 WSSWMSWTGCGNSCGKSIERRSRICQN------GLLCPGPATEERTCDKRPCP 446
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
352-393 1.01e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.01e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1972306950  352 TLWSPWSLCTATCGVGEIQRNRVC----QTGRNCDGPSVEVEACKA 393
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKM 46
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 596-621 1.49e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.49e-04
                            10        20
                    ....*....|....*....|....*.
gi 1972306950   596 WGDWTPWSGCSVSCGQGVCERTRKCI 621
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 552-593 1.54e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 40.51  E-value: 1.54e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1972306950  552 GEWADCSTTCGQGTQKRLRKC--------DSGNECSGPG--EEMRFCQIASC 593
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCvqkgggsiVPDSECSAQKkpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
449-493 3.74e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.32  E-value: 3.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1972306950  449 SNWGQWEKCSKECGAGHTYRNREC----IDGVSCEGASEEKILCNQQPC 493
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 548-594 1.32e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 42.24  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1972306950  548 WEEWGEWADCSTTCGQ--GTQKRLRKC--DSGNECSGPGEEMRFCQIASCP 594
Cdd:PTZ00087   233 YTEWGEWSNCSMECDHpdNVQIRERKCahPSGDCFKGDLKETRPCQVPLPP 283
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 597-622 1.38e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 1.38e-03
                           10        20
                   ....*....|....*....|....*.
gi 1972306950  597 GDWTPWSGCSVSCGQGVCERTRKCIT 622
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIV 29
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 309-348 2.14e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 2.14e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1972306950   309 EWTEWSECSASC--GISLRTRQCL------GGITCIGPS--TIPCQVPEC 348
Cdd:smart00209    3 EWSEWSPCSVTCggGVQTRTRSCCspppqnGGGPCTGEDveTRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
597-620 2.96e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 2.96e-03
                           10        20
                   ....*....|....*....|....
gi 1972306950  597 GDWTPWSGCSVSCGQGVCERTRKC 620
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTC 24
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 307-328 3.95e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 3.95e-03
                           10        20
                   ....*....|....*....|..
gi 1972306950  307 VVEWTEWSECSASCGISLRTRQ 328
Cdd:pfam19028    3 VSEWSEWSECSVTCGGGVQTRT 24
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 589-644 3.96e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.10  E-value: 3.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972306950  589 QIASCpywGDWTPWSGCSVSCGQGVCERTR-----KCITDeflqlpTLEELERDDSLEKHE 644
Cdd:PTZ00441   236 RTASC---GPWDEWTPCSVTCGKGTHSRSRpilheGCTTH------MVEECEEEECPVEPE 287
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 550-571 5.16e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.10  E-value: 5.16e-03
                           10        20
                   ....*....|....*....|..
gi 1972306950  550 EWGEWADCSTTCGQGTQKRLRK 571
Cdd:pfam19028    5 EWSEWSECSVTCGGGVQTRTRT 26
TSP_1 pfam00090
Thrombospondin type 1 domain;
401-445 6.71e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1972306950  401 SSWMSWTGCGNSCGKSIERRSRICQN----GLLCPGPATEERTCDKRPC 445
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSpfpgGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 354-397 9.33e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 9.33e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1972306950  354 WSPWSLCTATCGVGEIQRNRVCQT-----GRNCdGPSVEVEACKaLLPC 397
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRTVIVepqngGRPC-PELLERRPCN-LPPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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