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Conserved domains on  [gi|1845980223|ref|NP_001369978|]
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Cysteine synthase 1 [Caenorhabditis elegans]

Protein Classification

PLP-dependent cysteine synthase family protein( domain architecture ID 10000483)

cysteine synthase family protein is a pyridoxal 5'-phosphate (PLP)-dependent enzyme similar to Helicobacter pylori cysteine synthase

CATH:  3.40.50.1100
Gene Ontology:  GO:0030170
SCOP:  4000798

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 7-305 7.44e-153

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


:

Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 431.01  E-value: 7.44e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   7 IGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAF 86
Cdd:COG0031     3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  87 VAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPE 166
Cdd:COG0031    82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 167 IWRQTKGTVDAVVfgvgtggtitgvgRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVI 246
Cdd:COG0031   162 IWEQTDGKVDAFVagvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 247 RIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARpEMAGKLIVTCLPSCGERYM 305
Cdd:COG0031   242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYL 299
 
Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 7-305 7.44e-153

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 431.01  E-value: 7.44e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   7 IGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAF 86
Cdd:COG0031     3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  87 VAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPE 166
Cdd:COG0031    82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 167 IWRQTKGTVDAVVfgvgtggtitgvgRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVI 246
Cdd:COG0031   162 IWEQTDGKVDAFVagvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 247 RIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARpEMAGKLIVTCLPSCGERYM 305
Cdd:COG0031   242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYL 299
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 16-306 2.12e-142

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 404.20  E-value: 2.12e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGYRC 95
Cdd:cd01561     1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  96 IVTMPASMSGERRTLLKAYGSEVVLTDPAK--GMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKG 173
Cdd:cd01561    80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEA 253
Cdd:cd01561   160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1845980223 254 IVMAQRLSYEEGLLGGISSGANVAAALQLAARPEmAGKLIVTCLPSCGERYMT 306
Cdd:cd01561   240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 14-310 2.27e-142

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 404.74  E-value: 2.27e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:TIGR01136   4 LIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPG-DTIIEATSGNTGIALAMVAAARGY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKG 173
Cdd:TIGR01136  83 KLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRDTDG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEA 253
Cdd:TIGR01136 163 RIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSDEDA 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1845980223 254 IVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLY 310
Cdd:TIGR01136 243 IETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
PLN02565 PLN02565
cysteine synthase
 3-323 3.86e-136

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 389.67  E-value: 3.86e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   3 DRNSIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGI 82
Cdd:PLN02565    1 EKSSIAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  83 ALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQT 162
Cdd:PLN02565   81 GLAFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYET 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 163 TGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIY 242
Cdd:PLN02565  161 TGPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 243 EDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLYTDIRESAMALAV 322
Cdd:PLN02565  241 DEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENMVF 320


                  .
gi 1845980223 323 E 323
Cdd:PLN02565  321 E 321
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 14-297 2.81e-65

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 207.93  E-value: 2.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGtvipGVTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:pfam00291   4 GIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPakGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVhYQTTGPEIWRQTKG 173
Cdd:pfam00291  80 KVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQLGG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSG---------RPAGPHKIQGIGAGFAPAVLDTKIYED 244
Cdd:pfam00291 157 DPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARslaagrpvpVPVADTIADGLGVGDEPGALALDLLDE 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1845980223 245 ----VIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALqLAARPEMAGKLIVTCL 297
Cdd:pfam00291 237 yvgeVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALK-LALAGELKGGDRVVVV 292
 
Name Accession Description Interval E-value
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 7-305 7.44e-153

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 431.01  E-value: 7.44e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   7 IGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAF 86
Cdd:COG0031     3 IYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPG-GTIVEATSGNTGIGLAM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  87 VAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPE 166
Cdd:COG0031    82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETPGAFWPNQFENPANPEAHYETTGPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 167 IWRQTKGTVDAVVfgvgtggtitgvgRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVI 246
Cdd:COG0031   162 IWEQTDGKVDAFVagvgtggtitgvgRYLKERNPDIKIVAVEPEGSPLLSGGEPGPHKIEGIGAGFVPKILDPSLIDEVI 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 247 RIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARpEMAGKLIVTCLPSCGERYM 305
Cdd:COG0031   242 TVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKR-LGPGKTIVTILPDSGERYL 299
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 16-306 2.12e-142

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 404.20  E-value: 2.12e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGYRC 95
Cdd:cd01561     1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPG-TTIIEPTSGNTGIGLAMVAAAKGYRF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  96 IVTMPASMSGERRTLLKAYGSEVVLTDPAK--GMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKG 173
Cdd:cd01561    80 IIVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEA 253
Cdd:cd01561   160 KVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFSGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEEA 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1845980223 254 IVMAQRLSYEEGLLGGISSGANVAAALQLAARPEmAGKLIVTCLPSCGERYMT 306
Cdd:cd01561   240 FAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 14-310 2.27e-142

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 404.74  E-value: 2.27e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:TIGR01136   4 LIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPG-DTIIEATSGNTGIALAMVAAARGY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKG 173
Cdd:TIGR01136  83 KLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEIWRDTDG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEA 253
Cdd:TIGR01136 163 RIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEPAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVITVSDEDA 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1845980223 254 IVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLY 310
Cdd:TIGR01136 243 IETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 14-310 3.61e-142

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 404.06  E-value: 3.61e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTkGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:TIGR01139   4 LIGNTPLVRLNRIE-GCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPG-KTIVEPTSGNTGIALAMVAAARGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGS-IILAQFDNPNNPLVHYQTTGPEIWRQTK 172
Cdd:TIGR01139  82 KLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSyFMLQQFENPANPEIHRKTTGPEIWRDTD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 173 GTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDE 252
Cdd:TIGR01139 162 GKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESPVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEVITVSDEE 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1845980223 253 AIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEmAGKLIVTCLPSCGERYMTSPLY 310
Cdd:TIGR01139 242 AIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
PLN02565 PLN02565
cysteine synthase
 3-323 3.86e-136

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 389.67  E-value: 3.86e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   3 DRNSIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGI 82
Cdd:PLN02565    1 EKSSIAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  83 ALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQT 162
Cdd:PLN02565   81 GLAFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPNSYILQQFENPANPKIHYET 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 163 TGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIY 242
Cdd:PLN02565  161 TGPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLSGGKPGPHKIQGIGAGFIPGVLDVDLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 243 EDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLYTDIRESAMALAV 322
Cdd:PLN02565  241 DEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAENMVF 320


                  .
gi 1845980223 323 E 323
Cdd:PLN02565  321 E 321
PLN00011 PLN00011
cysteine synthase
 1-323 2.19e-120

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 349.69  E-value: 2.19e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   1 MADRNSIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNT 80
Cdd:PLN00011    1 MEDRCLIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGKSTLIEATAGNT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  81 GIALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHY 160
Cdd:PLN00011   81 GIGLACIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPGGYIPQQFENPANPEIHY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 161 QTTGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTK 240
Cdd:PLN00011  161 RTTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESAVLSGGQPGPHLIQGIGSGIIPFNLDLT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 241 IYEDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLYTDIRESAMAL 320
Cdd:PLN00011  241 IVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAENL 320


                  ...
gi 1845980223 321 AVE 323
Cdd:PLN00011  321 PIE 323
PLN03013 PLN03013
cysteine synthase
 3-323 8.64e-120

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 352.16  E-value: 8.64e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   3 DRNSIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGI 82
Cdd:PLN03013  109 DGLNIADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGI 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  83 ALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQT 162
Cdd:PLN03013  189 GLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDAYMLQQFDNPANPKIHYET 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 163 TGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIY 242
Cdd:PLN03013  269 TGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIM 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 243 EDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGeRYMTSPLYTDIRESAMALAV 322
Cdd:PLN03013  349 DEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRWRKCS 427


                  .
gi 1845980223 323 E 323
Cdd:PLN03013  428 L 428
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 7-320 8.65e-119

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 347.33  E-value: 8.65e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   7 IGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGIALAF 86
Cdd:PLN02556   49 IKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTTLIEPTSGNMGISLAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  87 VAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTTGPE 166
Cdd:PLN02556  129 MAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDAFMLQQFSNPANTQVHFETTGPE 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 167 IWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGRPAGPHKIQGIGAGFAPAVLDTKIYEDVI 246
Cdd:PLN02556  209 IWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEPAESNVLNGGKPGPHHITGNGVGFKPDILDMDVMEKVL 288

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1845980223 247 RIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMTSPLYTDIRESAMAL 320
Cdd:PLN02556  289 EVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKEAENM 362
PRK10717 PRK10717
cysteine synthase A; Provisional
 6-310 1.72e-104

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 309.48  E-value: 1.72e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   6 SIGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVTtLIEPTSGNTGIALA 85
Cdd:PRK10717    2 KIFEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGT-IVEGTAGNTGIGLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  86 FVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLT------DPAKGMKGAIDMANQLKENIP-GSIILAQFDNPNNPLV 158
Cdd:PRK10717   81 LVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVpaapyaNPNNYVKGAGRLAEELVASEPnGAIWANQFDNPANREA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 159 HYQTTGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAI----LSG--RPAGPHKIQGIGAGF 232
Cdd:PRK10717  161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALysyyKTGelKAEGSSITEGIGQGR 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1845980223 233 APAVLDTKIYEDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARpEMAGKLIVTCLPSCGERYMtSPLY 310
Cdd:PRK10717  241 ITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARE-LGPGHTIVTILCDSGERYQ-SKLF 316
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
 7-306 1.05e-97

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 296.71  E-value: 1.05e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   7 IGENAAALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAF 86
Cdd:TIGR01137   1 ILDNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPG-DTIIEPTSGNTGIGLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  87 VAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGM---KGAIDMANQLKENIPGSIILAQFDNPNNPLVHYQTT 163
Cdd:TIGR01137  80 VAAIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPGAHILDQYRNPSNPLAHYDTT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 164 GPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESaILSGRPA------GPHKIQGIGAGFAPAVL 237
Cdd:TIGR01137 160 GPEILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPEGS-ILAQPEElnqtgrTPYKVEGIGYDFIPTVL 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 238 DTKIYEDVIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERYMT 306
Cdd:TIGR01137 239 DRKVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYMT 307
cysM PRK11761
cysteine synthase CysM;
14-310 4.42e-90

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 271.75  E-value: 4.42e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:PRK11761    9 TIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPG-DTLIEATSGNTGIALAMIAAIKGY 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGsIILAQFDNPNNPLVHYQTTGPEIWRQTKG 173
Cdd:PRK11761   88 RMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAEGEG-KVLDQFANPDNPLAHYETTGPEIWRQTEG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAilsgrpagphKIQGI---GAGFAPAVLDTKIYEDVIRIHS 250
Cdd:PRK11761  167 RITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPEEGS----------SIPGIrrwPEEYLPKIFDASRVDRVLDVSQ 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 251 DEAIVMAQRLSYEEGLLGGISSGANVAAALQLAARPEMAgkLIVTCLPSCGERYMTSPLY 310
Cdd:PRK11761  237 QEAENTMRRLAREEGIFCGVSSGGAVAAALRIARENPNA--VIVAIICDRGDRYLSTGVF 294
cysM TIGR01138
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ...
 12-310 2.99e-83

cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]


Pssm-ID: 130208 [Multi-domain]  Cd Length: 290  Bit Score: 254.07  E-value: 2.99e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  12 AALIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAK 91
Cdd:TIGR01138   3 EQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPG-DVLIEATSGNTGIALAMIAALK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  92 GYRCIVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSiILAQFDNPNNPLVHYQTTGPEIWRQT 171
Cdd:TIGR01138  82 GYRMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGK-LLDQFNNPDNPYAHYTSTGPEIWQQT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 172 KGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSGrpagphkIQGIGAGFAPAVLDTKIYEDVIRIHSD 251
Cdd:TIGR01138 161 GGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQPEEGSSIPG-------IRRWPTEYLPGIFDASLVDRVLDIHQR 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 252 EAIVMAQRLSYEEGLLGGISSGANVAAALQLAArpEMAGKLIVTCLPSCGERYMTSPLY 310
Cdd:TIGR01138 234 DAENTMRELAVREGIFCGVSSGGAVAAALRLAR--ELPDAVVVAIICDRGDRYLSTGVF 290
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 14-297 2.81e-65

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 207.93  E-value: 2.81e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  14 LIGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGtvipGVTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:pfam00291   4 GIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLKEGE----GGKTVVEASSGNHGRALAAAAARLGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPakGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVhYQTTGPEIWRQTKG 173
Cdd:pfam00291  80 KVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAARELAAEGPGAYYINQYDNPLNIEG-YGTIGLEILEQLGG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESAILSG---------RPAGPHKIQGIGAGFAPAVLDTKIYED 244
Cdd:pfam00291 157 DPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARslaagrpvpVPVADTIADGLGVGDEPGALALDLLDE 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1845980223 245 ----VIRIHSDEAIVMAQRLSYEEGLLGGISSGANVAAALqLAARPEMAGKLIVTCL 297
Cdd:pfam00291 237 yvgeVVTVSDEEALEAMRLLARREGIVVEPSSAAALAALK-LALAGELKGGDRVVVV 292
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 18-298 2.14e-64

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 203.90  E-value: 2.14e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVipGVTTLIEPTSGNTGIALAFVAAAKGYRCIV 97
Cdd:cd00640     1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKL--PKGVIIESTGGNTGIALAAAAARLGLKCTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  98 TMPASMSGERRTLLKAYGSEVVLTDPakGMKGAIDMANQLKENIPGSIILAQFDNPNNPLVHYqTTGPEIWRQTKG-TVD 176
Cdd:cd00640    79 VMPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQLGGqKPD 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 177 AVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEesailsgrpagphkiqgigagfapavldtkiyedVIRIHSDEAIVM 256
Cdd:cd00640   156 AVVVPVGGGGNIAGIARALKELLPNVKVIGVEPE----------------------------------VVTVSDEEALEA 201

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1845980223 257 AQRLSYEEGLLGGISSGANVAAALQLAARPeMAGKLIVTCLP 298
Cdd:cd00640   202 IRLLAREEGILVEPSSAAALAAALKLAKKL-GKGKTVVVILT 242
PLN02356 PLN02356
phosphateglycerate kinase
 15-306 2.36e-33

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 127.80  E-value: 2.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  15 IGNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGvTTLIEPTSGNTGIALAFVAAAKGYR 94
Cdd:PLN02356   51 IGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPG-GVVTEGSAGSTAISLATVAPAYGCK 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  95 CIVTMPASMSGERRTLLKAYGSEVVLTDPA-------------------------KGMKGAIDMANQLKEN--------- 140
Cdd:PLN02356  130 CHVVIPDDVAIEKSQILEALGATVERVRPVsithkdhyvniarrraleanelaskRRKGSETDGIHLEKTNgciseeeke 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 141 -------IPGSIILAQFDNPNNPLVHYQTTGPEIWRQTKGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESA 213
Cdd:PLN02356  210 nslfsssCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDPPGSG 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 214 ILSG---------------RPAGPHK--IQGIG-----AGFAPAVLDtkiyeDVIRIHSDEAIVMAQRLSYEEGLLGGIS 271
Cdd:PLN02356  290 LFNKvtrgvmytreeaegrRLKNPFDtiTEGIGinrltQNFLMAKLD-----GAFRGTDKEAVEMSRYLLKNDGLFVGSS 364

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1845980223 272 SGANVAAALQLaARPEMAGKLIVTCLPSCGERYMT 306
Cdd:PLN02356  365 SAMNCVGAVRV-AQSLGPGHTIVTILCDSGMRHLS 398
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 6-301 2.33e-15

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 75.71  E-value: 2.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   6 SIGEnaaaliGNTPMVYINKLTKGLPG-TVAVKIEYMNPAGSVKDRiGAAMLAAAEKDGtvipGVTTLIEPTSGNTGIAL 84
Cdd:cd01563    17 SLGE------GNTPLVRAPRLGERLGGkNLYVKDEGLNPTGSFKDR-GMTVAVSKAKEL----GVKAVACASTGNTSASL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  85 AFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTDpaKGMKGAIDMANQLKENIPGSIIlaqfdNPNNPLVH--YQT 162
Cdd:cd01563    86 AAYAARAGIKCVVFLPAGKALGKLAQALAYGATVLAVE--GNFDDALRLVRELAEENWIYLS-----NSLNPYRLegQKT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 163 TGPEIWRQTKGTV-DAVVFGVGTGGTITGVGRYLQE-QNPGV-----RVFAVEPEES-----AILSGRPAG-----PHKI 225
Cdd:cd01563   159 IAFEIAEQLGWEVpDYVVVPVGNGGNITAIWKGFKElKELGLidrlpRMVGVQAEGAapivrAFKEGKDDIepvenPETI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 226 -QGIGAGF---APAVLDTkIYEDVIRIH--SDEAIVMAQR-LSYEEGLLGGISSGANVAAALQLAARPEMAGKLIVTClP 298
Cdd:cd01563   239 aTAIRIGNpasGPKALRA-VRESGGTAVavSDEEILEAQKlLARTEGIFVEPASAASLAGLKKLREEGIIDKGERVVV-V 316


                  ...
gi 1845980223 299 SCG 301
Cdd:cd01563   317 LTG 319
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 16-122 1.92e-14

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 73.70  E-value: 1.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGAAML--AAAEKdgtvipGVTTLIEPTSGNTGIALAFVAAAKGY 93
Cdd:COG0498    65 GGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDR-AMQVAvsLALER------GAKTIVCASSGNGSAALAAYAARAGI 137

                          90       100       110
                  ....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPAS-MSGERRTLLKAYGSEVVLTD 122
Cdd:COG0498   138 EVFVFVPEGkVSPGQLAQMLTYGAHVIAVD 167
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 18-294 3.06e-11

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 63.52  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGA--AMLAAAEKDGTVipGVTTliePTSGNTGIALAFVAAAKGYRC 95
Cdd:COG1171    25 TPLLRSPTLSERLGAEVYLKLENLQPTGSFKLR-GAynALASLSEEERAR--GVVA---ASAGNHAQGVAYAARLLGIPA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  96 IVTMPASMSGERRTLLKAYGSEVVLTDPAkgMKGAIDMANQL-KENipGSIILAQFDNPNnpLVHYQTT-GPEIWRQTkG 173
Cdd:COG1171    99 TIVMPETAPAVKVAATRAYGAEVVLHGDT--YDDAEAAAAELaEEE--GATFVHPFDDPD--VIAGQGTiALEILEQL-P 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 174 TVDAVVfgvgtggtitgvgrYLQEQNPGVRVFAVEPEESA-----ILSGRPAGPHKIQGIGAGFAPAVLDTKIYE----- 243
Cdd:COG1171   172 DLDAVFvpvggggliagvaaALKALSPDIRVIGVEPEGAAamyrsLAAGEPVTLPGVDTIADGLAVGRPGELTFEilrdl 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1845980223 244 --DVIRIhSDEAIVMAQRLSYE-EGLLGGISSGANVAAALQLaaRPEMAGKLIV 294
Cdd:COG1171   252 vdDIVTV-SEDEIAAAMRLLLErTKIVVEPAGAAALAALLAG--KERLKGKRVV 302
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 17-153 4.56e-10

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 60.01  E-value: 4.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  17 NTPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDR-IGAAMLAAAEKDGTVIPGVttlIEPTSGNTGIALAFVAAAKGYRC 95
Cdd:cd06448     1 KTPLIESTALSKTAGCNVFLKLENLQPSGSFKIRgIGHLCQKSAKQGLNECVHV---VCSSGGNAGLAAAYAARKLGVPC 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1845980223  96 IVTMPASMSGERRTLLKAYGSEVVLTDPAKGmKGAIDMANQLKENIPGSIILAQFDNP 153
Cdd:cd06448    78 TIVVPESTKPRVVEKLRDEGATVVVHGKVWW-EADNYLREELAENDPGPVYVHPFDDP 134
PRK06450 PRK06450
threonine synthase; Validated
 6-119 6.17e-10

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 59.75  E-value: 6.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   6 SIGEnaaaliGNTPMVYINKltkglpgtVAVKIEYMNPAGSVKDRiGAAMLAAAEKDgtviPGVTTLIEPTSGNTGIALA 85
Cdd:PRK06450   53 SLGE------GRTPLIKKGN--------IWFKLDFLNPTGSYKDR-GSVTLISYLAE----KGIKQISEDSSGNAGASIA 113

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1845980223  86 FVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVV 119
Cdd:PRK06450  114 AYGAAAGIEVKIFVPETASGGKLKQIESYGAEVV 147
PRK08197 PRK08197
threonine synthase; Validated
 6-122 1.68e-09

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 58.47  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   6 SIGEnaaaliGNTPMVYINKLTK--GLPgTVAVKIEYMNPAGSVKDRiGAAMLAAAEKDgtviPGVTTLIEPTSGNTGIA 83
Cdd:PRK08197   74 SLGE------GMTPLLPLPRLGKalGIG-RLWVKDEGLNPTGSFKAR-GLAVGVSRAKE----LGVKHLAMPTNGNAGAA 141

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1845980223  84 LAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTD 122
Cdd:PRK08197  142 WAAYAARAGIRATIFMPADAPEITRLECALAGAELYLVD 180
PRK06381 PRK06381
threonine synthase; Validated
 16-178 1.87e-09

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 58.18  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYINKLTKGLP-GTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGtvIPGVTTliePTSGNTGIALAFVAAAKGYR 94
Cdd:PRK06381   14 GGTPLLRARKLEEELGlRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLG--YSGITV---GTCGNYGASIAYFARLYGLK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  95 CIVTMPASMSGERRTLLKAYGSEVVLTD----PAKGMKGAIDMANQLKENIPGSiilaqfDNPNNPLVHYQTTGPEIWRQ 170
Cdd:PRK06381   89 AVIFIPRSYSNSRVKEMEKYGAEIIYVDgkyeEAVERSRKFAKENGIYDANPGS------VNSVVDIEAYSAIAYEIYEA 162


                  ....*...
gi 1845980223 171 TKGTVDAV 178
Cdd:PRK06381  163 LGDVPDAV 170
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 16-141 8.14e-09

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 56.24  E-value: 8.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYINKLTKGLPGT-VAVKIEYMNPAGSVKDRIGAAMLAAAEKDGtvipgVTTLIEPTSGNTGIALAFVAAAKGYR 94
Cdd:TIGR00260  21 GVTPLFRAPALAANVGIKnLYVKELGHNPTLSFKDRGMAVALTKALELG-----NDTVLCASTGNTGAAAAAYAGKAGLK 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1845980223  95 CIVTMPA-SMSGERRTLLKAYGSEVVltdpakGMKGAIDMANQLKENI 141
Cdd:TIGR00260  96 VVVLYPAgKISLGKLAQALGYNAEVV------AIDGNFDDAQRLVKQL 137
PRK06815 PRK06815
threonine/serine dehydratase;
18-303 1.21e-08

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 55.47  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGAA----MLAAAEKDGTVIPGvttliepTSGNTGIALAFVAAAKGY 93
Cdd:PRK06815   21 TPLEHSPLLSQHTGCEVYLKCEHLQHTGSFKFR-GASnklrLLNEAQRQQGVITA-------SSGNHGQGVALAAKLAGI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTdPAKGMKGAIDMANQLKENipGSIILAQFdnpNNPLV--HYQTTGPEIWRQT 171
Cdd:PRK06815   93 PVTVYAPEQASAIKLDAIRALGAEVRLY-GGDALNAELAARRAAEQQ--GKVYISPY---NDPQViaGQGTIGMELVEQQ 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 172 kGTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESA-----ILSGR----PAGPHKIQGIGAGFAP-------- 234
Cdd:PRK06815  167 -PDLDAVFVAVGGGGLISGIATYLKTLSPKTEIIGCWPANSPslytsLEAGEivevAEQPTLSDGTAGGVEPgaitfplc 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1845980223 235 -AVLDTKIyedvirIHSDEAIVMAQRL--SYEEGLLGGiSSGANVAAALQLAarPEMAGKLIVTCLpsCGER 303
Cdd:PRK06815  246 qQLIDQKV------LVSEEEIKEAMRLiaETDRWLIEG-AAGVALAAALKLA--PRYQGKKVAVVL--CGKN 306
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 18-294 1.23e-08

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 55.57  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGA-AMLAAAEKDGTvIPGVTTLiepTSGNTGIALAFVAAAKGYRCI 96
Cdd:cd01562    18 TPLLTSPTLSELLGAEVYLKCENLQKTGSFKIR-GAyNKLLSLSEEER-AKGVVAA---SAGNHAQGVAYAAKLLGIPAT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  97 VTMPASMSGERRTLLKAYGSEVVLTDPakGMKGAIDMANQL-KENipGSIILAQFDNPNnpLVHYQ-TTGPEIWRQTkGT 174
Cdd:cd01562    93 IVMPETAPAAKVDATRAYGAEVVLYGE--DFDEAEAKARELaEEE--GLTFIHPFDDPD--VIAGQgTIGLEILEQV-PD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 175 VDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEESA-----ILSGRPAgPHKIQGIGA-GFAPAVLDTKIYE----- 243
Cdd:cd01562   166 LDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGAPamaqsLAAGKPV-TLPEVDTIAdGLAVKRPGELTFEiirkl 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1845980223 244 --DVIRIhSDEAIVMAQRLSYE------EGllggiSSGANVAAALQLAARPEmaGKLIV 294
Cdd:cd01562   245 vdDVVTV-SEDEIAAAMLLLFEreklvaEP-----AGALALAALLSGKLDLK--GKKVV 295
PRK08246 PRK08246
serine/threonine dehydratase;
31-281 2.39e-07

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 51.49  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  31 PGTVAVKIEYMNPAGSVKDRiGA--AMLAAAE-KDGTVIPgvttliepTSGNTGIALAFVAAAKGYRCIVTMPASMSGER 107
Cdd:PRK08246   36 PAPVWLKLEHLQHTGSFKAR-GAfnRLLAAPVpAAGVVAA--------SGGNAGLAVAYAAAALGVPATVFVPETAPPAK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 108 RTLLKAYGSEVVLTDP--AKGMKGAIDMANQlkeniPGSIILAQFDNPNNpLVHYQTTGPEIWRQTKGtVDAVVFGVGTG 185
Cdd:PRK08246  107 VARLRALGAEVVVVGAeyADALEAAQAFAAE-----TGALLCHAYDQPEV-LAGAGTLGLEIEEQAPG-VDTVLVAVGGG 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 186 GTITGVGRYLQeqnPGVRVFAVEPE-----ESAILSGRPA------------GPHKIQGIGAGFAPAVLDTKIyedvirI 248
Cdd:PRK08246  180 GLIAGIAAWFE---GRARVVAVEPEgaptlHAALAAGEPVdvpvsgiaadslGARRVGEIAFALARAHVVTSV------L 250

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1845980223 249 HSDEAIVMAQRLSYEEGLLGGISSGANVAAALQ 281
Cdd:PRK08246  251 VSDEAIIAARRALWEELRLAVEPGAATALAALL 283
PRK12483 PRK12483
threonine dehydratase; Reviewed
 18-294 8.70e-07

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 50.57  E-value: 8.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGA----AMLAAAEKDGTVIPGvttliepTSGNTGIALAFVAAAKGY 93
Cdd:PRK12483   38 TPLQRAPNLSARLGNQVLLKREDLQPVFSFKIR-GAynkmARLPAEQLARGVITA-------SAGNHAQGVALAAARLGV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLTDPAkgMKGAIDMANQLKENiPGSIILAQFDNPNnpLVHYQ-TTGPEIWRQTK 172
Cdd:PRK12483  110 KAVIVMPRTTPQLKVDGVRAHGGEVVLHGES--FPDALAHALKLAEE-EGLTFVPPFDDPD--VIAGQgTVAMEILRQHP 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 173 GTVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEES-----AILSGRPAGPHKIQGIGAGFAPAVLDTKIYE---- 243
Cdd:PRK12483  185 GPLDAIFVPVGGGGLIAGIAAYVKYVRPEIKVIGVEPDDSnclqaALAAGERVVLGQVGLFADGVAVAQIGEHTFElcrh 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1845980223 244 ---DVIRIHSDEaIVMAQRLSYEEGLLGGISSGA-NVAAALQLAARPEMAGKLIV 294
Cdd:PRK12483  265 yvdEVVTVSTDE-LCAAIKDIYDDTRSITEPAGAlAVAGIKKYAEREGIEGQTLV 318
PRK08329 PRK08329
threonine synthase; Validated
 30-142 2.95e-06

threonine synthase; Validated


Pssm-ID: 236244 [Multi-domain]  Cd Length: 347  Bit Score: 48.28  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  30 LPGTVAVKIEYMNPAGSVKDRiGAAMLAAAEKDgtviPGVTTLIEPTSGNTGIALAFVAAAKGYRCIVTMPASMSGERRT 109
Cdd:PRK08329   70 RSIKVYFKLDYLQPTGSFKDR-GTYVTVAKLKE----EGINEVVIDSSGNAALSLALYSLSEGIKVHVFVSYNASKEKIS 144

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1845980223 110 LLKAYGSEV--VLTDPAKGMKGAIDMANqlKENIP 142
Cdd:PRK08329  145 LLSRLGAELhfVEGDRMEVHEEAVKFSK--RNNIP 177
PRK06608 PRK06608
serine/threonine dehydratase;
18-122 4.80e-05

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 44.76  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIpgvTTLIEPTSGNTGIALAFVAAAKGYRCIV 97
Cdd:PRK06608   24 TPIVHSESLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKLP---DKIVAYSTGNHGQAVAYASKLFGIKTRI 100

                          90       100
                  ....*....|....*....|....*
gi 1845980223  98 TMPASMSGERRTLLKAYGSEVVLTD 122
Cdd:PRK06608  101 YLPLNTSKVKQQAALYYGGEVILTN 125
Trp-synth_B cd06446
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ...
 18-297 1.99e-04

Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.


Pssm-ID: 107207  Cd Length: 365  Bit Score: 42.91  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGT-VAVKIEYMNPAGSVK--DRIGAAMLAAAEkdgtvipGVTTLIEPT-SGNTGIALAFVAAAKGY 93
Cdd:cd06446    35 TPLYRAKRLSEYLGGAkIYLKREDLNHTGAHKinNALGQALLAKRM-------GKKRVIAETgAGQHGVATATACALFGL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  94 RCIVTMPASmSGER----RTLLKAYGSEVV-LTDPAKGMKGAIDMA-----NQLKEN--IPGSIIlAQFDNPNNPLVHYQ 161
Cdd:cd06446   108 ECEIYMGAV-DVERqplnVFRMELLGAEVVpVPSGSGTLKDAISEAirdwvTNVEDThyLLGSVV-GPHPYPNMVRDFQS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 162 TTGPEIWRQTK----GTVDAVV---------------FGvgtggtitgvgrylqeQNPGVRVFAVEPEESAILSGRPAG- 221
Cdd:cd06446   186 VIGEEAKKQILekegELPDVVIacvgggsnaaglfypFI----------------NDKDVKLIGVEAGGCGLETGGHAAy 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223 222 --------------------------PHKIQGiG---AGFAP--AVL-DTKIYEdVIRIHSDEAIVMAQRLSYEEGLLGG 269
Cdd:cd06446   250 lfggtagvlhglkmytlqdedgqivpPHSISA-GldyPGVGPehAYLkDSGRVE-YVAVTDEEALEAFKLLARTEGIIPA 327

                         330       340
                  ....*....|....*....|....*....
gi 1845980223 270 ISSGANVAAALQLAarPEMA-GKLIVTCL 297
Cdd:cd06446   328 LESSHAIAYAIKLA--KKLGkEKVIVVNL 354
PRK06110 PRK06110
threonine dehydratase;
1-119 2.77e-04

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 42.29  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223   1 MADRNSIgENAAALIGN----TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTVIPGVttlIEPT 76
Cdd:PRK06110    2 MFTLAEL-EAAAAVVYAamppTPQYRWPLLAERLGCEVWVKHENHTPTGAFKVRGGLVYFDRLARRGPRVRGV---ISAT 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1845980223  77 SGNTGIALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVV 119
Cdd:PRK06110   78 RGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAELI 120
PRK05638 PRK05638
threonine synthase; Validated
 16-119 4.36e-04

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 41.72  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  16 GNTPMVYiNKLTKGLPGTVAVKIEYMNPAGSVKDRIGAAMLAAAEKDGTvipgvTTLIEPTSGNTGIALAFVAAAKGYRC 95
Cdd:PRK05638   65 GGTPLIR-ARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAA-----NGFIVASDGNAAASVAAYSARAGKEA 138

                          90       100
                  ....*....|....*....|....
gi 1845980223  96 IVTMPASMSGERRTLLKAYGSEVV 119
Cdd:PRK05638  139 FVVVPRKVDKGKLIQMIAFGAKII 162
PRK08206 PRK08206
diaminopropionate ammonia-lyase; Provisional
 71-122 5.44e-04

diaminopropionate ammonia-lyase; Provisional


Pssm-ID: 236186  Cd Length: 399  Bit Score: 41.40  E-value: 5.44e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1845980223  71 TLIEPTSGNTGIALAFVAAAKGYRCIVTMPASMSGERRTLLKAYGSEVVLTD 122
Cdd:PRK08206  118 TFATATDGNHGRGVAWAAQQLGQKAVIYMPKGSSEERVDAIRALGAECIITD 169
eutB PRK07476
threonine dehydratase; Provisional
 18-121 7.20e-04

threonine dehydratase; Provisional


Pssm-ID: 236025 [Multi-domain]  Cd Length: 322  Bit Score: 40.72  E-value: 7.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGA----AMLAAAEKDGTVIPGVTtlieptsGNTGIALAFVAAAKGY 93
Cdd:PRK07476   20 TPLVASASLSARAGVPVWLKLETLQPTGSFKLR-GAtnalLSLSAQERARGVVTAST-------GNHGRALAYAARALGI 91

                          90       100
                  ....*....|....*....|....*...
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVLT 121
Cdd:PRK07476   92 RATICMSRLVPANKVDAIRALGAEVRIV 119
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
18-120 1.59e-03

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 39.72  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845980223  18 TPMVYINKLTKGLPGTVAVKIEYMNPAGSVKDRiGAA----MLAAAEKDGTVIPGvttliepTSGNTGIALAFVAAAKGY 93
Cdd:PRK08638   28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIR-GAFnklsSLTDAEKRKGVVAC-------SAGNHAQGVALSCALLGI 99

                          90       100
                  ....*....|....*....|....*..
gi 1845980223  94 RCIVTMPASMSGERRTLLKAYGSEVVL 120
Cdd:PRK08638  100 DGKVVMPKGAPKSKVAATCGYGAEVVL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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