Suppressor of hairless protein homolog [Caenorhabditis elegans]
Protein Classification
LAG1-DNAbind and BTD domain-containing protein( domain architecture ID 10558086)
protein containing domains LAG1-DNAbind, BTD, and IPT
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| BTD | pfam09270 | Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ... |
365-490 | 4.46e-77 | ||||
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR). : Pssm-ID: 462734 Cd Length: 123 Bit Score: 240.69 E-value: 4.46e-77
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| LAG1-DNAbind | pfam09271 | LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ... |
171-334 | 1.02e-64 | ||||
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins. : Pssm-ID: 462735 Cd Length: 148 Bit Score: 209.48 E-value: 1.02e-64
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| IPT super family | cl15674 | Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
512-614 | 7.99e-55 | ||||
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers. The actual alignment was detected with superfamily member cd01176: Pssm-ID: 472823 Cd Length: 97 Bit Score: 181.50 E-value: 7.99e-55
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| Name | Accession | Description | Interval | E-value | ||||
| BTD | pfam09270 | Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ... |
365-490 | 4.46e-77 | ||||
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR). Pssm-ID: 462734 Cd Length: 123 Bit Score: 240.69 E-value: 4.46e-77
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| LAG1-DNAbind | pfam09271 | LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ... |
171-334 | 1.02e-64 | ||||
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins. Pssm-ID: 462735 Cd Length: 148 Bit Score: 209.48 E-value: 1.02e-64
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| IPT_RBP-Jkappa | cd01176 | IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was ... |
512-614 | 7.99e-55 | ||||
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes. Pssm-ID: 238581 Cd Length: 97 Bit Score: 181.50 E-value: 7.99e-55
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| TIG_SUH | pfam20144 | TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless ... |
517-612 | 5.30e-35 | ||||
TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless protein. Pssm-ID: 466305 Cd Length: 92 Bit Score: 127.33 E-value: 5.30e-35
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| Name | Accession | Description | Interval | E-value | ||||
| BTD | pfam09270 | Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a ... |
365-490 | 4.46e-77 | ||||
Beta-trefoil DNA-binding domain; Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR). Pssm-ID: 462734 Cd Length: 123 Bit Score: 240.69 E-value: 4.46e-77
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| LAG1-DNAbind | pfam09271 | LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical ... |
171-334 | 1.02e-64 | ||||
LAG1, DNA binding; Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins. Pssm-ID: 462735 Cd Length: 148 Bit Score: 209.48 E-value: 1.02e-64
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| IPT_RBP-Jkappa | cd01176 | IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was ... |
512-614 | 7.99e-55 | ||||
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes. Pssm-ID: 238581 Cd Length: 97 Bit Score: 181.50 E-value: 7.99e-55
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| TIG_SUH | pfam20144 | TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless ... |
517-612 | 5.30e-35 | ||||
TIG domain; This entry represents a TIG-like domain found in the suppressor of hairless protein. Pssm-ID: 466305 Cd Length: 92 Bit Score: 127.33 E-value: 5.30e-35
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| IPT_TF | cd00602 | IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ... |
515-613 | 7.09e-21 | ||||
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region. Pssm-ID: 238336 Cd Length: 101 Bit Score: 87.72 E-value: 7.09e-21
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| IPT | cd00102 | Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ... |
513-614 | 1.03e-06 | ||||
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers. Pssm-ID: 238050 [Multi-domain] Cd Length: 89 Bit Score: 47.07 E-value: 1.03e-06
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