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Conserved domains on  [gi|2330590383|ref|NP_001365496|]
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uncharacterized protein LOC100041734 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017141)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.39e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.39e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2330590383   4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLIAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-624 4.09e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 213 KPYECNQCSKTFACHGQLRIHERTHSGEKPYECNQ--CSKTFAFHGQLRKHERIHTGEKPYKCDQCGKAFSHQGNLKMHK 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 291 ITTHTEEKPYKCDQCGKGFAYHGRFEVHKRAHTGEKPYECKQCGKAFAcqNYYQIHKRIHTGEKPYECKQCGKAFAYQhy 370
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV--NTPQSNSLHPPLPANSLSKDPSSNLSLL-- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 371 yqIHKRIHTGEK-PYECKQCGKAFAYQNQYQVHKRIH--TGEKPYECKQ-CSKSFASRRQLRIHERTHSGEKP--YECNQ 444
Cdd:COG5048   188 --ISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASesPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 445 CGKTFAFRGQLRKHERIHTG-EKPYKCDECGKAFSLQGNLKMHK-ITTHTEE--TPYKCD--QCGKAFAYHSMFQVHKRT 518
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 519 HTGEKPYDCK--QCSKSF------ASRGQLRKHERIHTGEKPYKCDQ-CGKAFAHHSNLKVHKITTHTEETP-YKCDQCG 588
Cdd:COG5048   346 HTSISPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLSFRPYnCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2330590383 589 KVFAYHSIFQVHKRTHTREKPYECKQCGKAFSCQNY 624
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 4.60e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 624 YYQVHKRTHTGEKPYECKQCSKSFAS 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 6.48e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 173 NLRMHKRMHTEHKPYECNQCTKSFAS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 7.59e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|....*
gi 2330590383 118 LQIHERTHSGEKPYECKQCSKSFAS 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.39e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.39e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2330590383   4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLIAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 7.20e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.02  E-value: 7.20e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2330590383    4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLIAVGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.37e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.66  E-value: 1.37e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2330590383   4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLI 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-624 4.09e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 213 KPYECNQCSKTFACHGQLRIHERTHSGEKPYECNQ--CSKTFAFHGQLRKHERIHTGEKPYKCDQCGKAFSHQGNLKMHK 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 291 ITTHTEEKPYKCDQCGKGFAYHGRFEVHKRAHTGEKPYECKQCGKAFAcqNYYQIHKRIHTGEKPYECKQCGKAFAYQhy 370
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV--NTPQSNSLHPPLPANSLSKDPSSNLSLL-- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 371 yqIHKRIHTGEK-PYECKQCGKAFAYQNQYQVHKRIH--TGEKPYECKQ-CSKSFASRRQLRIHERTHSGEKP--YECNQ 444
Cdd:COG5048   188 --ISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASesPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 445 CGKTFAFRGQLRKHERIHTG-EKPYKCDECGKAFSLQGNLKMHK-ITTHTEE--TPYKCD--QCGKAFAYHSMFQVHKRT 518
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 519 HTGEKPYDCK--QCSKSF------ASRGQLRKHERIHTGEKPYKCDQ-CGKAFAHHSNLKVHKITTHTEETP-YKCDQCG 588
Cdd:COG5048   346 HTSISPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLSFRPYnCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2330590383 589 KVFAYHSIFQVHKRTHTREKPYECKQCGKAFSCQNY 624
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-564 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*
gi 2330590383 540 LRKHERIHTGEKPYKCDQCGKAFAH 564
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 624 YYQVHKRTHTGEKPYECKQCSKSFAS 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 6.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 173 NLRMHKRMHTEHKPYECNQCTKSFAS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|....*
gi 2330590383 118 LQIHERTHSGEKPYECKQCSKSFAS 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.39e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.39e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2330590383   4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLIAVG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 7.20e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.02  E-value: 7.20e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2330590383    4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLIAVGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.37e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.66  E-value: 1.37e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2330590383   4 LTYDDVYVNFTQEEWALLNPSQKSLYKDVMLETYRNLI 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-624 4.09e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 213 KPYECNQCSKTFACHGQLRIHERTHSGEKPYECNQ--CSKTFAFHGQLRKHERIHTGEKPYKCDQCGKAFSHQGNLKMHK 290
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 291 ITTHTEEKPYKCDQCGKGFAYHGRFEVHKRAHTGEKPYECKQCGKAFAcqNYYQIHKRIHTGEKPYECKQCGKAFAYQhy 370
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV--NTPQSNSLHPPLPANSLSKDPSSNLSLL-- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 371 yqIHKRIHTGEK-PYECKQCGKAFAYQNQYQVHKRIH--TGEKPYECKQ-CSKSFASRRQLRIHERTHSGEKP--YECNQ 444
Cdd:COG5048   188 --ISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQlSPKSLLSQSPSSLSSSDSSSSASesPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 445 CGKTFAFRGQLRKHERIHTG-EKPYKCDECGKAFSLQGNLKMHK-ITTHTEE--TPYKCD--QCGKAFAYHSMFQVHKRT 518
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrSVNHSGEslKPFSCPysLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 519 HTGEKPYDCK--QCSKSF------ASRGQLRKHERIHTGEKPYKCDQ-CGKAFAHHSNLKVHKITTHTEETP-YKCDQCG 588
Cdd:COG5048   346 HTSISPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITHLSFRPYnCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 2330590383 589 KVFAYHSIFQVHKRTHTREKPYECKQCGKAFSCQNY 624
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-480 4.42e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 4.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 103 YKCSQCGKAYAGPHTLQIHERTHSGEKPYEC--KQCSKSFASHGQLRKHERIHTRGKSYKCNQ----------------C 164
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasssslssS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 165 SKAFVYPGNLRMHKRMHTEHKPYECNQCTKSFASHRQLRIHERIHTEEK-------PYECNQCSKTFACHGQLRIHERTH 237
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 238 SGEKPYECNQCSKTFAFHGQLRKHERIHTGEKPYKCDQCGKAF-----SHQGNLKMHKITTHTEEKPYKCDQCGKGFAYH 312
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 313 GRFEVHKRAHTG-EKPYECKQCGKAFACQNYYQIHKR--IHTGE--KPYEC--KQCGKAFAYQHYYQIHKRIHTGEKPYE 385
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 386 CKQC-------GKAFAYQNQYQVHKRIHTGEKPYEC--KQCSKSFASRRQLRIHERTHSGEKPYECN--QCGKTFAFRGQ 454
Cdd:COG5048   354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|....*.
gi 2330590383 455 LRKHERIHTGEKPYKCDECGKAFSLQ 480
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-592 1.54e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 185 KPYECNQCTKSFASHRQLRIHERIHTEEKPYECNQCSKTFACH--GQLRIHERTHSGEKPYECNQCSKTFAFhgQLRKHE 262
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNS--KASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 263 RIHTGEKPYKCDQCgkaFSHQGNLKMHKITTHTEEKPYK--CDQCGKGFAYHGRFEVHKRAHtGEKPYECKQCGKAFACQ 340
Cdd:COG5048   110 LSSSSSNSNDNNLL---SSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 341 NYYQiHKRIHTGEKPYECKQCGKAFAYQHYYQIHKRIH-TGEKPYECKQCGKAFAYQNQYQVHK----RIHTGEKPYECK 415
Cdd:COG5048   186 LLIS-SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLsssdSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 416 QCSKSFASRRQLRIHERTHSG-EKPYECNQCGKTFAFRGQLRKHER--IHTGE--KPYKCDE--CGKAFSLQGNLKMHKI 488
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 489 T-THTEETPYKCDQCGKAF------AYHSMFQVHKRTHTgEKPYDC--KQCSKSFASRGQLRKHERIHTGEKP--YKCDQ 557
Cdd:COG5048   345 LhTSISPAKEKLLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2330590383 558 CGKAFAHHSNLKVHKItTHTEETPYKCDQCGKVFA 592
Cdd:COG5048   424 CSKSFNRHYNLIPHKK-IHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-661 8.50e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 326 KPYECKQCGKAFACQNYYQIHKRIHTGEKPYECKQCGKAFAYQ--HYYQIHKRIHTGEKPYECKQ--------------- 388
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 389 -CGKAFAYQNQYQVHK-------------RIHTGEKPYECKQCSKSFASRRQ----------------------LRIHER 432
Cdd:COG5048   112 sSSSNSNDNNLLSSHSlppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 433 THSGEKPYECNQCGKTFAFRGQLRKHERIHTGEKPYKCDECGKAF-----SLQGNLKMHKITTHTEETPYKCDQCGKAFA 507
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 508 YHSMFQVHKRTHTG-EKPYDCKQCSKSFASRGQLRKHER--IHTGE--KPYKCD--QCGKAFAHHSNLKVHKIT-THTEE 579
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLhTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 580 TPYKCDQCGKVF-----AYHSIFQVHKRTHTREKPYEC--KQCGKAFSCQNYYQVHKRTHTGEKPYECK--QCSKSFASH 650
Cdd:COG5048   352 AKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410
                  ....*....|.
gi 2330590383 651 GQLRKHERIHT 661
Cdd:COG5048   432 YNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-312 6.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2330590383 267 GEKPYKCD--QCGKAFSHQGNLKMHKITTH------------------TEEKPYKCDQCGK------GFAYH 312
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHqnqklhenpspekmnifsAKDKPYRCEVCDKryknlnGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-564 6.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.02e-04
                          10        20
                  ....*....|....*....|....*
gi 2330590383 540 LRKHERIHTGEKPYKCDQCGKAFAH 564
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 6.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.45e-04
                          10        20
                  ....*....|....*....|....*
gi 2330590383 258 LRKHERIHTGEKPYKCDQCGKAFSH 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-370 7.14e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 7.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 120 IHERTHSGEKPYECKQCSKSFASHGQLRKHERIHTRGKSYKCNQCSkaFVYPGNLRMHKRMHTEHK--------PYECNQ 191
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdssssaseSPRSSL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 192 CTKSFASHRQLRIHERIHT-EEKPYECNQCSKTFACHGQLRIHERT--HSGE--KPYEC--NQCSKTFAFHGQLRKHERI 264
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 265 HTGEKPYKCDQCGKAFSHQGNLK------MHKITTHTEEKPYKCDqcgkgfaYHGRFEVHKRAHTGEKPYE--------- 329
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETL-------SNSCIRNFKRDSNLSLHIIthlsfrpyn 418

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2330590383 330 --CKQCGKAFACQNYYQIHKRIHTGEKPYECKQCGKAFAYQHY 370
Cdd:COG5048   419 ckNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-478 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....
gi 2330590383 455 LRKHERIHTGEKPYKCDECGKAFS 478
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 549-633 1.19e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 549 GEKPYKCD--QCGKAFAHHSNLKVHKITTHTEETPYKCDQCGKvfayHSIFQVhkrthtREKPYECKQCGKAFSCQNYYQ 626
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----MNIFSA------KDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2330590383 627 VHkRTHT 633
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
624-649 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 624 YYQVHKRTHTGEKPYECKQCSKSFAS 649
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 6.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 342 YYQIHKRIHTGEKPYECKQCGKAFAY 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 6.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 370 YYQIHKRIHTGEKPYECKQCGKAFAY 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 6.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 2330590383 173 NLRMHKRMHTEHKPYECNQCTKSFAS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-423 7.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.22e-03
                          10        20
                  ....*....|....*....|....*
gi 2330590383 399 YQVHKRIHTGEKPYECKQCSKSFAS 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|....*
gi 2330590383 118 LQIHERTHSGEKPYECKQCSKSFAS 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-665 7.94e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 382 KPYECKQCGKAFAYQNQYQVHKRIHTGEKPYEC--KQCSKSFASRRQLRIHERTHSGEKPYECNQCGKTFAFrgQLRKHE 459
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNS--KASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 460 RIHTGEKP-YKCDECGKAFSLQGNLKMHkITTHTEETPYKCDQCGKAFAYHSMFQVHKRTHTGEKPYDCKQCSKSFASRg 538
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQL-PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL- 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2330590383 539 qlrKHERIHTGEKPYKCDQCGkafaHHSNLKVHKITTHTEE---TPYKCDQCGKVFAYHSIFQVHKRTHTREKPYECKQC 615
Cdd:COG5048   188 ---ISSNVSTSIPSSSENSPL----SSSYSIPSSSSDQNLEnssSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2330590383 616 -----GKAFSCQ-NYYQVHKRTHTG-EKPYECKQCSKSFASHGQLRKHER--IHTGEKS 665
Cdd:COG5048   261 prsslPTASSQSsSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESL 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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