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Conserved domains on  [gi|1799133364|ref|NP_001364594|]
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DUF4704 domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 1903342)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0006511
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 398-441 6.53e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22100:

Pssm-ID: 459239  Cd Length: 45  Bit Score: 40.61  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1799133364 398 NIPVMVLQLVLTkCLNYEHLGRLREVHPHWDEIAGQLLNSGYYK 441
Cdd:cd22100     3 ELPDEIIEKILS-YLSYDEISKLRLVCRRFNEVCQRILNQGFKK 45
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
544-634 7.04e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.12  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133364 544 ERVMEERMG-ENLRLKAAQRIIRLESFVVDA--QVAKLEKESNKAKEDVRWEIDQLHQKNSQLRKDNREMKANQMRLEAR 620
Cdd:COG4372     6 EKVGKARLSlFGLRPKTGILIAALSEQLRKAlfELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85

                          90
                  ....*....|....
gi 1799133364 621 VEALEQKFKTLARL 634
Cdd:COG4372    86 NEQLQAAQAELAQA 99
 
Name Accession Description Interval E-value
F-box_FBXO28 cd22100
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ...
 398-441 6.53e-05

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438872  Cd Length: 45  Bit Score: 40.61  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1799133364 398 NIPVMVLQLVLTkCLNYEHLGRLREVHPHWDEIAGQLLNSGYYK 441
Cdd:cd22100     3 ELPDEIIEKILS-YLSYDEISKLRLVCRRFNEVCQRILNQGFKK 45
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
544-634 7.04e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.12  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133364 544 ERVMEERMG-ENLRLKAAQRIIRLESFVVDA--QVAKLEKESNKAKEDVRWEIDQLHQKNSQLRKDNREMKANQMRLEAR 620
Cdd:COG4372     6 EKVGKARLSlFGLRPKTGILIAALSEQLRKAlfELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85

                          90
                  ....*....|....
gi 1799133364 621 VEALEQKFKTLARL 634
Cdd:COG4372    86 NEQLQAAQAELAQA 99
 
Name Accession Description Interval E-value
F-box_FBXO28 cd22100
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ...
 398-441 6.53e-05

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438872  Cd Length: 45  Bit Score: 40.61  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1799133364 398 NIPVMVLQLVLTkCLNYEHLGRLREVHPHWDEIAGQLLNSGYYK 441
Cdd:cd22100     3 ELPDEIIEKILS-YLSYDEISKLRLVCRRFNEVCQRILNQGFKK 45
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
544-634 7.04e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.12  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133364 544 ERVMEERMG-ENLRLKAAQRIIRLESFVVDA--QVAKLEKESNKAKEDVRWEIDQLHQKNSQLRKDNREMKANQMRLEAR 620
Cdd:COG4372     6 EKVGKARLSlFGLRPKTGILIAALSEQLRKAlfELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85

                          90
                  ....*....|....
gi 1799133364 621 VEALEQKFKTLARL 634
Cdd:COG4372    86 NEQLQAAQAELAQA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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