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Conserved domains on  [gi|1783658103|ref|NP_001364054|]
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FAST kinase domain-containing protein 5, mitochondrial [Mus musculus]

Protein Classification

FAST kinase domain-containing protein( domain architecture ID 10535844)

FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RESC6-like super family cl46254
RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, ...
 163-441 8.57e-32

RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins; RESC6 (GRBC6, MRB3010) is a component of the RNA-editing substrate-binding complex (RESC), that is composed of about 20 components and is involved in kinetoplast RNA processing. The mitochondrial DNA of Trypanosomatids, known as the kinetoplast DNA (kDNA or mtDNA), consists of a network of dozens of maxicircles and thousands of minicircles concatenated together. Maxicircles are equivalent to other eukaryotic mitochondrial DNAs, while minicircles encode guide RNAs (gRNAs) involved in U-insertion/deletion editing processes exclusive of Trypanosomatids that produce the maturation of the maxicircle-encoded transcripts. Although most gRNAs are encoded by minicircles, varying numbers of maxicircle-encoded gRNAs have been identified in kinetoplastids species. Trypanosoma brucei maxicircles encode 9S and 12S rRNAs, two gRNAs, two ribosomal proteins and 16 subunits of respiratory complexes. 12 of the 18 maxicircle genes are present as cryptogenes whose transcripts require U-insertion/deletion editing, mediated by gRNAs, to restore a protein-coding capacity. RESC interacts with two other complexes, the RNA-editing helicase 2 complex (REH2C) and RNA-editing catalytic complex (RECC) to form an assembly (editosome/holoenzyme) that carries out U-insertion/deletion mRNA editing. RESC6 is predicted (by AlphaFold) to adopt an all-helical structure with a disordered region at the N-terminus. The helical structure that is predicted with high confidence resembles Armadillo (ARM)/beta-catenin-like repeats. ARM repeats have been implicated in mediating protein-protein interactions.


The actual alignment was detected with superfamily member cd23739:

Pssm-ID: 480594 [Multi-domain]  Cd Length: 249  Bit Score: 124.30  E-value: 8.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 163 TNYFYKLSSLPAEQ---NSVLLSSNSFALLCQLSVKNIQLFNTSDLISILKAFVDLRIPPSLSMLDVYETRFCHQVWEMT 239
Cdd:cd23739     6 ALAVQRLSRLVVEGraeKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLRRLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 240 LDQLLLVADLWRNLGRRVP--RFFKIFFSYLNLHWRELSLSQLIhLIYIIGENRQVPqDLMQRLESLILKYVDSVNLEEV 317
Cdd:cd23739    86 FRHLASLAESLATLQRAQEqkELLSELLKLLERRWTEIEDPRDL-VTLMRIVGHLSP-LLMNRLEDKALELLEQFTLEEL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 318 GTICLGFFKSSSSlSEFVMRKIGDlacanmqHLsshtlvhilkmfrfthvdhihfmkqfgeiaPQRIPSLGVQGVMHLTL 397
Cdd:cd23739   164 RRVLLTLAAQKRR-SVPLLRALSY-------HL------------------------------LQRSDQLSPKQLSDVLY 205

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1783658103 398 ACSALRILDERVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNY 441
Cdd:cd23739   206 ACGKLNFHDTQLLEKIAADLLSKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 511-601 8.00e-26

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 101.49  E-value: 8.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 511 KELFTLDGTVAIECPDYKGNRLNSHLQQETSANLWNLASKDmrsKPEFLETLYLLETMLGGPQYIKHHMILPHTRSSDLE 590
Cdd:pfam08368   2 LKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKKK---SPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 1783658103 591 VQLDANMKPMP 601
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 429-498 2.15e-17

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 77.14  E-value: 2.15e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 429 VAKILWSFGTLNYKPPNTEEFYSSLINEIHRKMPEFNqyPEHLLTCLIGLAFSEYFPVEFINVALSPGFV 498
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFS--PELLLDLVWSLCVLGRFPEALLNKVLSPDFL 68
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 697-756 2.63e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 2.63e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103  697 IQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLPLlkRTRLEKLAYLHEK 756
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 163-441 8.57e-32

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 124.30  E-value: 8.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 163 TNYFYKLSSLPAEQ---NSVLLSSNSFALLCQLSVKNIQLFNTSDLISILKAFVDLRIPPSLSMLDVYETRFCHQVWEMT 239
Cdd:cd23739     6 ALAVQRLSRLVVEGraeKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLRRLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 240 LDQLLLVADLWRNLGRRVP--RFFKIFFSYLNLHWRELSLSQLIhLIYIIGENRQVPqDLMQRLESLILKYVDSVNLEEV 317
Cdd:cd23739    86 FRHLASLAESLATLQRAQEqkELLSELLKLLERRWTEIEDPRDL-VTLMRIVGHLSP-LLMNRLEDKALELLEQFTLEEL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 318 GTICLGFFKSSSSlSEFVMRKIGDlacanmqHLsshtlvhilkmfrfthvdhihfmkqfgeiaPQRIPSLGVQGVMHLTL 397
Cdd:cd23739   164 RRVLLTLAAQKRR-SVPLLRALSY-------HL------------------------------LQRSDQLSPKQLSDVLY 205

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1783658103 398 ACSALRILDERVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNY 441
Cdd:cd23739   206 ACGKLNFHDTQLLEKIAADLLSKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 511-601 8.00e-26

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 101.49  E-value: 8.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 511 KELFTLDGTVAIECPDYKGNRLNSHLQQETSANLWNLASKDmrsKPEFLETLYLLETMLGGPQYIKHHMILPHTRSSDLE 590
Cdd:pfam08368   2 LKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKKK---SPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 1783658103 591 VQLDANMKPMP 601
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 429-498 2.15e-17

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 77.14  E-value: 2.15e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 429 VAKILWSFGTLNYKPPNTEEFYSSLINEIHRKMPEFNqyPEHLLTCLIGLAFSEYFPVEFINVALSPGFV 498
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFS--PELLLDLVWSLCVLGRFPEALLNKVLSPDFL 68
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 697-756 2.63e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 2.63e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103  697 IQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLPLlkRTRLEKLAYLHEK 756
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 697-756 1.01e-11

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 60.29  E-value: 1.01e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 697 IQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLPLlkRTRLEKLAYLHEK 756
Cdd:pfam08373   1 IEVDGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQL--KTKEEKVEYLKKK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 163-441 8.57e-32

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 124.30  E-value: 8.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 163 TNYFYKLSSLPAEQ---NSVLLSSNSFALLCQLSVKNIQLFNTSDLISILKAFVDLRIPPSLSMLDVYETRFCHQVWEMT 239
Cdd:cd23739     6 ALAVQRLSRLVVEGraeKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWRLRRLS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 240 LDQLLLVADLWRNLGRRVP--RFFKIFFSYLNLHWRELSLSQLIhLIYIIGENRQVPqDLMQRLESLILKYVDSVNLEEV 317
Cdd:cd23739    86 FRHLASLAESLATLQRAQEqkELLSELLKLLERRWTEIEDPRDL-VTLMRIVGHLSP-LLMNRLEDKALELLEQFTLEEL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 318 GTICLGFFKSSSSlSEFVMRKIGDlacanmqHLsshtlvhilkmfrfthvdhihfmkqfgeiaPQRIPSLGVQGVMHLTL 397
Cdd:cd23739   164 RRVLLTLAAQKRR-SVPLLRALSY-------HL------------------------------LQRSDQLSPKQLSDVLY 205

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1783658103 398 ACSALRILDERVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNY 441
Cdd:cd23739   206 ACGKLNFHDTQLLEKIAADLLSKVPEMKPVLVASLLKSFGQLRW 249
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 511-601 8.00e-26

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 101.49  E-value: 8.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 511 KELFTLDGTVAIECPDYKGNRLNSHLQQETSANLWNLASKDmrsKPEFLETLYLLETMLGGPQYIKHHMILPHTRSSDLE 590
Cdd:pfam08368   2 LKLLQLNATVCLECPEYKGPWLPPKYCVKSFKVPLSSSKKK---SPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFE 78

                          90
                  ....*....|.
gi 1783658103 591 VQLDANMKPMP 601
Cdd:pfam08368  79 CKLDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 429-498 2.15e-17

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 77.14  E-value: 2.15e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 429 VAKILWSFGTLNYKPPNTEEFYSSLINEIHRKMPEFNqyPEHLLTCLIGLAFSEYFPVEFINVALSPGFV 498
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFS--PELLLDLVWSLCVLGRFPEALLNKVLSPDFL 68
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 697-756 2.63e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 2.63e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103  697 IQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLPLlkRTRLEKLAYLHEK 756
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKL--KSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 697-756 1.01e-11

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 60.29  E-value: 1.01e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1783658103 697 IQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLPLlkRTRLEKLAYLHEK 756
Cdd:pfam08373   1 IEVDGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQL--KTKEEKVEYLKKK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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