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Conserved domains on  [gi|1734334388|ref|NP_001360041|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-295 2.46e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.85  E-value: 2.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   1 MTIIMNCFMIYLIIKKSPKEIGRYRYLMLYISFFEIIYCIAGKVVRPFVHSYGSRAIIIVEAKDAWVNRTIMKVINSVVS 80
Cdd:pfam10326  11 LSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILLALYC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  81 GCYGCSSSILAIHFMYRYGSL-HVNHRNMFEGWKFVAWCFIPASYGAIWSLTIFFIFPDDDGFTELIRSDILETFDWKME 159
Cdd:pfam10326  91 GFYGVSISLLAVQFIYRYLALcRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDID 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 160 DIVYTGFYYFREDKNGLHGFEPLPIVGMCILWSMMTSSSFVVYFFGYRCYKLVSTMTKNSfSSLAQGLQHQLFKALVWQT 239
Cdd:pfam10326 171 EVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQT 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734334388 240 VIPIFMVYIPSSLILICPLFNINLGRISVVITVTMSIFTALDPLPNIFIIKNYKRA 295
Cdd:pfam10326 250 LIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-295 2.46e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.85  E-value: 2.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   1 MTIIMNCFMIYLIIKKSPKEIGRYRYLMLYISFFEIIYCIAGKVVRPFVHSYGSRAIIIVEAKDAWVNRTIMKVINSVVS 80
Cdd:pfam10326  11 LSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILLALYC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  81 GCYGCSSSILAIHFMYRYGSL-HVNHRNMFEGWKFVAWCFIPASYGAIWSLTIFFIFPDDDGFTELIRSDILETFDWKME 159
Cdd:pfam10326  91 GFYGVSISLLAVQFIYRYLALcRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDID 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 160 DIVYTGFYYFREDKNGLHGFEPLPIVGMCILWSMMTSSSFVVYFFGYRCYKLVSTMTKNSfSSLAQGLQHQLFKALVWQT 239
Cdd:pfam10326 171 EVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQT 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734334388 240 VIPIFMVYIPSSLILICPLFNINLGRISVVITVTMSIFTALDPLPNIFIIKNYKRA 295
Cdd:pfam10326 250 LIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-295 2.46e-86

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 260.85  E-value: 2.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   1 MTIIMNCFMIYLIIKKSPKEIGRYRYLMLYISFFEIIYCIAGKVVRPFVHSYGSRAIIIVEAKDAWVNRTIMKVINSVVS 80
Cdd:pfam10326  11 LSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILLALYC 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  81 GCYGCSSSILAIHFMYRYGSL-HVNHRNMFEGWKFVAWCFIPASYGAIWSLTIFFIFPDDDGFTELIRSDILETFDWKME 159
Cdd:pfam10326  91 GFYGVSISLLAVQFIYRYLALcRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLDID 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 160 DIVYTGFYYFREDKNGLHGFEPLPIVGMCILWSMMTSSSFVVYFFGYRCYKLVSTMTKNSfSSLAQGLQHQLFKALVWQT 239
Cdd:pfam10326 171 EVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQT 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734334388 240 VIPIFMVYIPSSLILICPLFNINLGRISVVITVTMSIFTALDPLPNIFIIKNYKRA 295
Cdd:pfam10326 250 LIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 2-294 1.57e-30

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 116.57  E-value: 1.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   2 TIIMNCFMIYLIIKKSPKEIGRYRYLMLYISFFEIIYCIAGKVVRPFVHSYGSRAIIIVeaKDAW------VNRTIMKVI 75
Cdd:pfam10319  18 SFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFV--SDGPffeyseLGQHALSAR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  76 NSVVSGCYGcsssILAIHFMYRYGSLHVNH--RNMFEGWKFVAWCFIPASYGAIWSLTIFFIFPDDDGFTELIRSDILET 153
Cdd:pfam10319  96 CSFISASYA----VLLIHFIYRYLVLFNPQltRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRET 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 154 FDWKMEDIVYTGFYYfredKNGLHGFEPLPIVGMcILWSMMTSSSFVVYF-FGYrcyKLVSTMTKNS--FSSLAQGLQHQ 230
Cdd:pfam10319 172 YGVDSMDINMLGALY----WEASDETVFRSWLGI-LLLTVISVYSIILYIvLGY---KIMRKLNKMSvtMSKKTKRLQKQ 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1734334388 231 LFKALVWQTVIPIFMVYIPSSLILICPLFNINLGR-ISVVITVTMSIFTALDPLPNIFIIKNYKR 294
Cdd:pfam10319 244 LLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRwNNYLEVIALSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 2-295 1.77e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 63.34  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   2 TIIMNCFMIYLIIKKSPKEIGRYRYLMLYISFFEIIYCIAGKVVRPFVHSYGSRAIIIVEAKDAWVNRTIMKVINSVVSG 81
Cdd:pfam10317  12 GLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQH 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  82 CYGCSSSILAIHFMYRYGSLHVNHRnMFEGWKFVAWCFIPASYgaiwSLTIFFIFPDDDgFTELIRSDILETFDWKMEDI 161
Cdd:pfam10317  92 FLLHSGWSLLLTFYYRYYILKHVDP-KRKKLILLIIIHYIPSL----SQLIVIFLSPTD-FLPVEALTKELHPNYNLTDY 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 162 VYTGFYYFRedknglhgfEPLPIVGMCIlwsmMTSSSFVVYFFGYRC-YKLVSTMTKNS--FSSLAQGLQHQLFKALVWQ 238
Cdd:pfam10317 166 TVTGFSDLQ---------SFPALINTLI----MTIPVFPIPIIILILrRKILKLLNSNSvnMSPTTKAQHRQLIKGLTIQ 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1734334388 239 TVIPIFMVYIPSSLILICPLFNINLGRISVVITVTMSIFTALDPLPNIFIIKNYKRA 295
Cdd:pfam10317 233 ALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRA 289
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 2-301 3.13e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 51.00  E-value: 3.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388   2 TIIMNCFMIYLIIKKSPKEIGRYRYLMLY----ISFFEIIYCIAGKvvrPFVH--SYGSRAIIIveAKDAWVNRTIMKVI 75
Cdd:pfam10318  17 SIPIHIFGFYCILFKTPKKMKSVKWSLLNlhfwSALLDLSLSFLTI---PYIFlpALAGYPLGL--LSYLGVPTPIQFYI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388  76 NSVVSGCYGCssSILAIhFMYRYGSLHVNHRNMFegWKFVAWCFIPASY--GAIWSLTIFFIFPDDdgftELIRSDILET 153
Cdd:pfam10318  92 GVTSLALVGV--SIILL-FENRYSILFTNKKRIT--WKKTRVLYLIFNYiiALLFLIPIYLNIPDQ----EAAKLKVLKK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734334388 154 FDWKMEDIVYT-GFYYFREDKNglhgfeplpIVGMCILWSMMTSSSFVVYFFGYRCYKLVSTMtKNSFSSLAQGLQHQLF 232
Cdd:pfam10318 163 LPCLPPEFFDNpPVFVLAIDST---------YFLICIVLLILILIIQILFFVFLTIYYLFKSV-KSSLSKKTRKLQKKFF 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734334388 233 KALVWQTVIPIFMVYIPSSLILICPLFNINLGRISVVITVTMSIFTALDPLPNIFIIKNYKRATYQLLC 301
Cdd:pfam10318 233 IALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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