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Conserved domains on  [gi|1730154167|ref|NP_001359172|]
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dynein assembly factor with WD repeat domains 1 isoform b [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-428 2.11e-112

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.73  E-value: 2.11e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 100 VLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAET 179
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVW 259
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 260 DASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGT 339
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 340 ARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 419
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                  ....*....
gi 1730154167 420 KDNSCRIWR 428
Cdd:COG2319   392 ADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-428 2.11e-112

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.73  E-value: 2.11e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 100 VLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAET 179
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVW 259
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 260 DASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGT 339
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 340 ARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 419
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                  ....*....
gi 1730154167 420 KDNSCRIWR 428
Cdd:COG2319   392 ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-428 3.17e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.98  E-value: 3.17e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 139 ELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWD 218
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 219 IQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTC 298
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 299 MLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSS 378
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1730154167 379 DKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIWR 428
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 278-426 1.27e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 66.07  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 278 SSALfnWDCSLILT----------GSMDKTCMLWDATSGKYVAT---LTGHDDEILDSCFD-YTGKLIATASADGTARVY 343
Cdd:PTZ00421   26 STAL--WDCSNTIAcndrfiavpwQQLGSTAVLKHTDYGKLASNppiLLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGW 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 344 N----ATTRKC---VTKLEGHEGEISKISFNPQGNRLL-TGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIV 415
Cdd:PTZ00421  104 GipeeGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLL 183

                         170
                  ....*....|.
gi 1730154167 416 ITGSKDNSCRI 426
Cdd:PTZ00421  184 CTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 347-386 1.52e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.52e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  347 TRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWD 386
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-218 5.55e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 5.55e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
100-428 2.11e-112

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 335.73  E-value: 2.11e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 100 VLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAET 179
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVW 259
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 260 DASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGT 339
Cdd:COG2319   232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 340 ARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 419
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                  ....*....
gi 1730154167 420 KDNSCRIWR 428
Cdd:COG2319   392 ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
64-389 8.97e-102

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 308.38  E-value: 8.97e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167  64 AEPLITASRTKQVRLLvqRLQEKLRQHsdhnfylfkVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTL 143
Cdd:COG2319    90 GRLLASASADGTVRLW--DLATGLLLR---------TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 144 EGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGE 223
Cdd:COG2319   159 TGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 224 EVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDA 303
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 304 TSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTAR 383
Cdd:COG2319   318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                  ....*.
gi 1730154167 384 IWDVQT 389
Cdd:COG2319   398 LWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
100-428 1.46e-101

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 307.99  E-value: 1.46e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 100 VLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWSAET 179
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVW 259
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 260 DASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGT 339
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 340 ARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 419
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349


                  ....*....
gi 1730154167 420 KDNSCRIWR 428
Cdd:COG2319   350 DDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-428 3.17e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.98  E-value: 3.17e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 139 ELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWD 218
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 219 IQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTC 298
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 299 MLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSS 378
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1730154167 379 DKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIWR 428
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-386 4.58e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 274.60  E-value: 4.58e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167  97 LFKVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWS 176
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 177 AETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTV 256
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 257 VVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASA 336
Cdd:cd00200   160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1730154167 337 DGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWD 386
Cdd:cd00200   240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
122-427 6.10e-89

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 275.64  E-value: 6.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 122 TGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQ 201
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 202 STVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSAL 281
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 282 FNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEI 361
Cdd:COG2319   170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1730154167 362 SKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIW 427
Cdd:COG2319   250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-344 3.16e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 241.47  E-value: 3.16e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167  45 VFGVNFSTDVNTLVgeiqqaepliTASRTKQVRLLVQRLQEKLRQhsdhnfylfkvLRAHILPLTNVALNKAGSCFITGS 124
Cdd:cd00200    12 VTCVAFSPDGKLLA----------TGSGDGTIKVWDLETGELLRT-----------LKGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 125 YDRTCKVWDTASGEELHTLEGHKNVVYAIAFnNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTV 204
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 205 VATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNW 284
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 285 DCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYN 344
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
160-428 7.27e-72

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 231.72  E-value: 7.27e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 160 GDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLS 239
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 240 FDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEI 319
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 320 LDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGH 399
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                         250       260
                  ....*....|....*....|....*....
gi 1730154167 400 TDEIFSCAFNYKGNIVITGSKDNSCRIWR 428
Cdd:COG2319   246 SGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
197-427 5.21e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 5.21e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 197 SFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAE 276
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 277 ISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEG 356
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730154167 357 HEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIW 427
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
239-428 4.75e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 4.75e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 239 SFDTSGDRIITGSFDHTVVVWDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDE 318
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 319 ILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEG 398
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1730154167 399 HTDEIFSCAFNYKGNIVITGSKDNSCRIWR 428
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
PTZ00421 PTZ00421
coronin; Provisional
 278-426 1.27e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 66.07  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 278 SSALfnWDCSLILT----------GSMDKTCMLWDATSGKYVAT---LTGHDDEILDSCFD-YTGKLIATASADGTARVY 343
Cdd:PTZ00421   26 STAL--WDCSNTIAcndrfiavpwQQLGSTAVLKHTDYGKLASNppiLLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGW 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 344 N----ATTRKC---VTKLEGHEGEISKISFNPQGNRLL-TGSSDKTARIWDVQTGQCLQVLEGHTDEIFSCAFNYKGNIV 415
Cdd:PTZ00421  104 GipeeGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLL 183

                         170
                  ....*....|.
gi 1730154167 416 ITGSKDNSCRI 426
Cdd:PTZ00421  184 CTTSKDKKLNI 194
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 122-273 6.26e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 6.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 122 TGSYDRTCKVWDTASGEELHTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGhTAEIVCLSFNPQ 201
Cdd:PLN00181  550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSE 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 202 S-TVVATGSMDTTAKLWDIQNGE-EVVTLTGHLAEIISLSF-DTSgdRIITGSFDHTVVVWDASTG------RKVHTLIG 272
Cdd:PLN00181  629 SgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFvDSS--TLVSSSTDNTLKLWDLSMSisgineTPLHSFMG 706


                  .
gi 1730154167 273 H 273
Cdd:PLN00181  707 H 707
PTZ00421 PTZ00421
coronin; Provisional
 188-315 9.54e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 9.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 188 GHTAEIVCLSFNP-QSTVVATGSMDTTAKLWDI------QN-GEEVVTLTGHLAEIISLSFDTSGDRII-TGSFDHTVVV 258
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltQNiSDPIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNV 152

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1730154167 259 WDASTGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWDATSGKYVATLTGH 315
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 347-386 1.52e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.52e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  347 TRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWD 386
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 1.62e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 1.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  179 TGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 189-427 1.92e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 189 HTAEIVC-LSFNPQSTVVATGSMDTTAKLWD----IQNGEE----VVTLTGH--LAEIISLSFDTSgdRIITGSFDHTVV 257
Cdd:PLN00181  481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDihypVVELASRskLSGICWNSYIKS--QVASSNFEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 258 VWDASTGRKVHTLIGH-----CAEISSAlfnwDCSLILTGSMDKTCMLWDATSGKYVATLTGHDDEildSCFDY---TGK 329
Cdd:PLN00181  559 VWDVARSQLVTEMKEHekrvwSIDYSSA----DPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI---CCVQFpseSGR 631

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 330 LIATASADGTARVYNATTRKC-VTKLEGHEGEISKISFnPQGNRLLTGSSDKTARIWDVQTGQC------LQVLEGHTDE 402
Cdd:PLN00181  632 SLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNV 710

                         250       260
                  ....*....|....*....|....*
gi 1730154167 403 IFSCAFNYKGNIVITGSKDNSCRIW 427
Cdd:PLN00181  711 KNFVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
180-218 5.55e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 5.55e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 180 GKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 389-427 5.85e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 5.85e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1730154167  389 TGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIW 427
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
348-386 1.71e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.71e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 348 RKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWD 386
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
390-427 2.46e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 2.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1730154167 390 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNSCRIW 427
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-176 1.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1730154167  136 SGEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 176
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 186-271 4.62e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 51.87  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 186 FRGHTAEIVCLSFNP-QSTVVATGSMDTTAKLWDIQNGEEVVT--------LTGHLAEIISLSFDTSGDRIITGS-FDHT 255
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPMNYYIMCSSgFDSF 149

                          90
                  ....*....|....*.
gi 1730154167 256 VVVWDASTGRKVHTLI 271
Cdd:PTZ00420  150 VNIWDIENEKRAFQIN 165
WD40 pfam00400
WD domain, G-beta repeat;
137-176 4.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 4.73e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730154167 137 GEELHTLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWS 176
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 221-260 6.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  221 NGEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWD 260
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 305-344 7.84e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.84e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  305 SGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYN 344
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
222-260 1.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.39e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 222 GEEVVTLTGHLAEIISLSFDTSGDRIITGSFDHTVVVWD 260
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-302 1.47e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1730154167  263 TGRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWD 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
264-302 3.43e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.43e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 264 GRKVHTLIGHCAEISSALFNWDCSLILTGSMDKTCMLWD 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
306-344 6.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.82e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730154167 306 GKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYN 344
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 163-312 3.87e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.45  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 163 IATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIqngeevvtLTGHLAEIISLSFDT 242
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV--------LRGRSSEKRSRNTQT 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1730154167 243 SGDRIitgsfDHTVVvwdastGRKVHTLIGH-----CAEISSALfnwdcSLILTGSMDKTCMLWDATSGKYVATL 312
Cdd:pfam20426 169 EFPRK-----DHVIA------ETPFHILCGHddiitCLYVSVEL-----DIVISGSKDGTCIFHTLREGRYVRSI 227
PTZ00421 PTZ00421
coronin; Provisional
 107-293 4.10e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 107 PLTNVALNKAGSC-FITGSYDRTCKVWD-------TASGEELHTLEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWSAE 178
Cdd:PTZ00421   77 PIIDVAFNPFDPQkLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 179 TGKCYHTFRGHTAEIVCLSFNPQSTVVATGSMDTTAKLWDIQNGEEVVTLTGHLAE-------------IISLSFDTSGD 245
Cdd:PTZ00421  157 RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSKSQQ 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1730154167 246 RiitgsfdhTVVVWDAstgRK----VHTL-IGHCAEISSALFNWDCSLILTGS 293
Cdd:PTZ00421  237 R--------QIMLWDT---RKmaspYSTVdLDQSSALFIPFFDEDTNLLYIGS 278
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 330-406 4.94e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 4.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1730154167 330 LIATASADGTARVYNATTRKCVT-KLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGHTDEIfSC 406
Cdd:pfam12894   9 LIALATEDGELLLHRLNWQRVWTlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLI-TC 85
PTZ00421 PTZ00421
coronin; Provisional
 270-399 4.97e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 270 LIGHCAEISSALFN-WDCSLILTGSMDKTCMLWD-------ATSGKYVATLTGHDDEILDSCFDYTGK-LIATASADGTA 340
Cdd:PTZ00421   71 LLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1730154167 341 RVYNATTRKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARIWDVQTGQCLQVLEGH 399
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00420 PTZ00420
coronin; Provisional
 338-427 5.90e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 338 GTARVYNATTRKCVTKLEGHEGEISKISFNPQGNRLL-TGSSDKTARIW----------DVQTGQClqVLEGHTDEIFSC 406
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWeiphndesvkEIKDPQC--ILKGHKKKISII 131

                          90       100
                  ....*....|....*....|..
gi 1730154167 407 AFNYKGNIVITGSK-DNSCRIW 427
Cdd:PTZ00420  132 DWNPMNYYIMCSSGfDSFVNIW 153
PTZ00421 PTZ00421
coronin; Provisional
 228-363 1.02e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 228 LTGHLAEIISLSFDTSGD-RIITGSFDHTVVVWD-------ASTGRKVHTLIGHCAEISSALFNWDCSLIL-TGSMDKTC 298
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPFDPqKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1730154167 299 MLWDATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVYNATTRKCVTKLEGHEGEISK 363
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215
PTZ00420 PTZ00420
coronin; Provisional
 143-343 1.11e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 143 LEGHKNVVYAIAFNNPYGDKIATGSFDKTCKLWS--------AETGKCYHTFRGHTAEIVCLSFNPQST-VVATGSMDTT 213
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSF 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 214 AKLWDIQNGEEVVTLTgHLAEIISLSFDTSGDrIITGSfdhtvvvwdaSTGRKVHTLIGHCAEISSAL------------ 281
Cdd:PTZ00420  150 VNIWDIENEKRAFQIN-MPKKLSSLKWNIKGN-LLSGT----------CVGKHMHIIDPRKQEIASSFhihdggkntkni 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730154167 282 ----FNWDCSLILTGSMDKTCM----LWD---ATSGKYVATLTGHDDEILDSCFDYTGKLIATASADGTARVY 343
Cdd:PTZ00420  218 widgLGGDDNYILSTGFSKNNMremkLWDlknTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYY 290
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 99-133 2.20e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.20e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1730154167   99 KVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWD 133
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-133 4.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1730154167  99 KVLRAHILPLTNVALNKAGSCFITGSYDRTCKVWD 133
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 305-424 5.20e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 305 SGKYVATLTGHDDEILDSCFDYTGKLIATASADGtarvynattrKCVTKLEGHEGEISKISFNPQGNRLLTGSSDKTARI 384
Cdd:pfam20426  81 GAQCFATLQTPSENFLISCGNWENSFQVISLNDG----------RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1730154167 385 WDVQTGQCLQ-----------------------VLEGHTDEIFSCAFNYKGNIVITGSKDNSC 424
Cdd:pfam20426 151 WEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVELDIVISGSKDGTC 213
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 130-199 8.82e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 8.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730154167 130 KVWDTAsgeelhtLEGHKNVVYAIAFNnPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLSFN 199
Cdd:pfam12894  28 RVWTLS-------PDKEDLEVTSLAWR-PDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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