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Conserved domains on  [gi|1622996247|ref|NP_001356810|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
SCOP:  4003349

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
1-194 1.09e-78

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 237.91  E-value: 1.09e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   1 MLLEWWSCTECTLFTDqatVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIV 80
Cdd:cd07990     2 FLFEWLSGVKVVVYGD---EPKLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  81 FCKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTV 160
Cdd:cd07990    79 FLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622996247 161 AAVYDVTLNFRGNKNPSLL-GILYGKKYEADMCVR 194
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
180-252 7.87e-30

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 108.04  E-value: 7.87e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622996247 180 GILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKG-MFPGEQFKPARRPWTLLNFLSW 252
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGtFFPGKEHIIPRRLKSLLVFIFW 74
NhaC super family cl47294
Na+/H+ antiporter NhaC/MleN [Energy production and conversion];
235-302 6.03e-03

Na+/H+ antiporter NhaC/MleN [Energy production and conversion];


The actual alignment was detected with superfamily member COG1757:

Pssm-ID: 441363 [Multi-domain]  Cd Length: 418  Bit Score: 38.01  E-value: 6.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622996247 235 EQFKPARRPwtllNFLSWATILLSPLFSFVLGVFAS-----GSPLLILTFLGFVGAASFGVRRLIGVTEIEKG 302
Cdd:COG1757    11 DKLKSREKP----NFYAIVWEALLPILVLIVVLVVGvllytGLALHIGLLIGLIVAALLGLRKGLSWKEIEEG 79
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
1-194 1.09e-78

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 237.91  E-value: 1.09e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   1 MLLEWWSCTECTLFTDqatVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIV 80
Cdd:cd07990     2 FLFEWLSGVKVVVYGD---EPKLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  81 FCKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTV 160
Cdd:cd07990    79 FLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622996247 161 AAVYDVTLNFRGNKNPSLL-GILYGKKYEADMCVR 194
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
2-263 4.30e-76

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 237.72  E-value: 4.30e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   2 LLEWWSCTECTLFTDQATVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIVF 81
Cdd:PLN02380   60 LVDWWAGVKVQLYADEETFELMGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVF 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  82 CKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTVA 161
Cdd:PLN02380  140 LERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRSFVP 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247 162 AVYDVTLNF-RGNKNPSLLGILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKGMFPGEQFKPA 240
Cdd:PLN02380  220 AIYDVTVAVpKGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFGDQEYQDI 299
                         250       260
                  ....*....|....*....|....
gi 1622996247 241 RRPW-TLLNFLSWATILLSPLFSF 263
Cdd:PLN02380  300 GRPKkSLIVVISWACLLILGAIKF 323
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
180-252 7.87e-30

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 108.04  E-value: 7.87e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622996247 180 GILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKG-MFPGEQFKPARRPWTLLNFLSW 252
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGtFFPGKEHIIPRRLKSLLVFIFW 74
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
28-150 7.18e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 91.26  E-value: 7.18e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   28 AVIILNHNFEIDFLCGWTMCERFGvlGSSKVLAKKELLYVPLIGWTWYFLEIVFCKRKWE-EDRDTVVEGLRRLSDypeY 106
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKL--GRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE---G 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1622996247  107 MWFLLYCEGTRFTETKHRvSMEVAAAKGLPVLKYHLLPRTKGFT 150
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLL-PFKKGAARLALEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
28-138 5.73e-11

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 59.21  E-value: 5.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  28 AVIILNHNFEIDFLCGWTMCERFGVLGssKVLAKKELLYVPLIGWTWYFLEIVFCKRKWEEDRDTVVEGLRRLSDYPEYM 107
Cdd:pfam01553  16 AIVVANHQSYLDVLLLSLALYKRGRPL--VFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLREGKLV 93
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622996247 108 WflLYCEGTRFTETKHRV----SMEVAAAKGLPVL 138
Cdd:pfam01553  94 V--IFPEGTRSREGELLPfkkgAFRLAIEAGVPIV 126
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
2-117 6.60e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 43.46  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   2 LLEWWSCTECTLFTDQATVErfGKEH------AVIILNHNFEIDFLCGWTMCERfgvlgSSKVLAKKELLYVPLIGWTWY 75
Cdd:COG0204    15 LVRLWARLLLRLLGVRVRVE--GLENlpadgpVLIVANHQSWLDILLLLAALPR-----PVRFVAKKELFKIPLLGWLLR 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1622996247  76 FLEIVFCKR-KWEEDRDTVVEGLRRLSdypEYMWFLLYCEGTR 117
Cdd:COG0204    88 ALGAIPVDRsKRRAALRALRQAVEALK---AGESLVIFPEGTR 127
NhaC COG1757
Na+/H+ antiporter NhaC/MleN [Energy production and conversion];
235-302 6.03e-03

Na+/H+ antiporter NhaC/MleN [Energy production and conversion];


Pssm-ID: 441363 [Multi-domain]  Cd Length: 418  Bit Score: 38.01  E-value: 6.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622996247 235 EQFKPARRPwtllNFLSWATILLSPLFSFVLGVFAS-----GSPLLILTFLGFVGAASFGVRRLIGVTEIEKG 302
Cdd:COG1757    11 DKLKSREKP----NFYAIVWEALLPILVLIVVLVVGvllytGLALHIGLLIGLIVAALLGLRKGLSWKEIEEG 79
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
1-194 1.09e-78

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 237.91  E-value: 1.09e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   1 MLLEWWSCTECTLFTDqatVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIV 80
Cdd:cd07990     2 FLFEWLSGVKVVVYGD---EPKLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  81 FCKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTV 160
Cdd:cd07990    79 FLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV 158
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622996247 161 AAVYDVTLNFRGNKNPSLL-GILYGKKYEADMCVR 194
Cdd:cd07990   159 DAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
2-263 4.30e-76

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 237.72  E-value: 4.30e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   2 LLEWWSCTECTLFTDQATVERFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIVF 81
Cdd:PLN02380   60 LVDWWAGVKVQLYADEETFELMGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVF 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  82 CKRKWEEDRDTVVEGLRRLSDYPEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTVA 161
Cdd:PLN02380  140 LERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRSFVP 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247 162 AVYDVTLNF-RGNKNPSLLGILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKGMFPGEQFKPA 240
Cdd:PLN02380  220 AIYDVTVAVpKGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFGDQEYQDI 299
                         250       260
                  ....*....|....*....|....
gi 1622996247 241 RRPW-TLLNFLSWATILLSPLFSF 263
Cdd:PLN02380  300 GRPKkSLIVVISWACLLILGAIKF 323
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
24-235 2.03e-48

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 166.03  E-value: 2.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  24 GKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKKELLYVPLIGWTWYFLEIVFCKRKWEEDRDTVVEGLRRLSDY 103
Cdd:PLN02510   90 PEERVLLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDP 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247 104 PEYMWFLLYCEGTRFTETKHRVSMEVAAAKGLPVLKYHLLPRTKGFTTAVKCLRGTVAAVYDVTLNFRgNKNPSLLGILY 183
Cdd:PLN02510  170 RDPLWLALFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGYK-HRCPSFLDNVF 248
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622996247 184 G-KKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKGMFPGE 235
Cdd:PLN02510  249 GiDPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNE 301
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
180-252 7.87e-30

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 108.04  E-value: 7.87e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622996247 180 GILYGKKYEADMCVRRFPLEDIPLDEKEAAQWLHKLYQEKDALQEIYNQKG-MFPGEQFKPARRPWTLLNFLSW 252
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGtFFPGKEHIIPRRLKSLLVFIFW 74
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
28-150 7.18e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 91.26  E-value: 7.18e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   28 AVIILNHNFEIDFLCGWTMCERFGvlGSSKVLAKKELLYVPLIGWTWYFLEIVFCKRKWE-EDRDTVVEGLRRLSDypeY 106
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKL--GRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE---G 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1622996247  107 MWFLLYCEGTRFTETKHRvSMEVAAAKGLPVLKYHLLPRTKGFT 150
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLL-PFKKGAARLALEAGVPIVPVAIRGT 118
PRK14014 PRK14014
putative acyltransferase; Provisional
57-222 4.28e-12

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 65.64  E-value: 4.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  57 KVLAKKELLYVPLIGWTWYFLEIVFCKR-----------KWEEDRDTVVEGLRRLSDYPeyMWFLLYCEGTRFTETKHRv 125
Cdd:PRK14014  116 KFFLKQELIWVPFLGLAWWALDFPFMKRyskaylaknpeLKGKDLETTRRACEKFKRMP--TTIVNFVEGTRFTPEKHQ- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247 126 smevaaAKGLPvlkY-HLL-PRTKGFTTAVKCLRGTVAAVYDVTLNFRGnKNPSLLGILYGKKYEADMCVRRFPLEDIPL 203
Cdd:PRK14014  193 ------QQQSP---YqHLLkPKAGGIAFALNAMGEQFDGLLDVTIVYPD-GRPSFWDLLSGRVKKIVVHVRLLPIPEELI 262
                         170       180
                  ....*....|....*....|....*..
gi 1622996247 204 D--EKEAA------QWLHKLYQEKDAL 222
Cdd:PRK14014  263 GdyFNDKEfrrrfqQWLNQLWQEKDQL 289
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
28-138 5.73e-11

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 59.21  E-value: 5.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  28 AVIILNHNFEIDFLCGWTMCERFGVLGssKVLAKKELLYVPLIGWTWYFLEIVFCKRKWEEDRDTVVEGLRRLSDYPEYM 107
Cdd:pfam01553  16 AIVVANHQSYLDVLLLSLALYKRGRPL--VFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLREGKLV 93
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622996247 108 WflLYCEGTRFTETKHRV----SMEVAAAKGLPVL 138
Cdd:pfam01553  94 V--IFPEGTRSREGELLPfkkgAFRLAIEAGVPIV 126
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
2-117 6.60e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 43.46  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247   2 LLEWWSCTECTLFTDQATVErfGKEH------AVIILNHNFEIDFLCGWTMCERfgvlgSSKVLAKKELLYVPLIGWTWY 75
Cdd:COG0204    15 LVRLWARLLLRLLGVRVRVE--GLENlpadgpVLIVANHQSWLDILLLLAALPR-----PVRFVAKKELFKIPLLGWLLR 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1622996247  76 FLEIVFCKR-KWEEDRDTVVEGLRRLSdypEYMWFLLYCEGTR 117
Cdd:COG0204    88 ALGAIPVDRsKRRAALRALRQAVEALK---AGESLVIFPEGTR 127
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
20-117 5.27e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 40.33  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622996247  20 VERFGKEH------AVIILNHNFEID-FLCGWTMCERFgvlgssKVLAKKELLYVPLIGWTWYFLEIVFCKR-KWEEDRD 91
Cdd:cd07989    12 VRVEGLENlppkgpVIIVANHQSYLDpLVLGAALPRPI------RFVAKKELFKIPFLGWLLRLLGAIPIDRgNGRSARE 85
                          90       100
                  ....*....|....*....|....*.
gi 1622996247  92 TVVEGLRRLSdypEYMWFLLYCEGTR 117
Cdd:cd07989    86 ALREAIEALK---EGESVVIFPEGTR 108
NhaC COG1757
Na+/H+ antiporter NhaC/MleN [Energy production and conversion];
235-302 6.03e-03

Na+/H+ antiporter NhaC/MleN [Energy production and conversion];


Pssm-ID: 441363 [Multi-domain]  Cd Length: 418  Bit Score: 38.01  E-value: 6.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622996247 235 EQFKPARRPwtllNFLSWATILLSPLFSFVLGVFAS-----GSPLLILTFLGFVGAASFGVRRLIGVTEIEKG 302
Cdd:COG1757    11 DKLKSREKP----NFYAIVWEALLPILVLIVVLVVGvllytGLALHIGLLIGLIVAALLGLRKGLSWKEIEEG 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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