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Conserved domains on  [gi|1584352090|ref|NP_001355753|]
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protein unc-80 homolog isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1905-2992 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


:

Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1905 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1984
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1985 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2064
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2065 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2144
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2145 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2224
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2225 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2304
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2305 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2384
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2385 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2464
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2465 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2544
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2545 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2622
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2623 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2702
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2703 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2781
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2782 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2860
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2861 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2940
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1584352090 2941 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2992
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1173-1855 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


:

Pssm-ID: 466075  Cd Length: 704  Bit Score: 1215.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1173 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1252
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1253 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1332
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1333 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1393
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1394 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1465
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1466 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1545
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1546 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1624
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1625 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1702
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1703 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1782
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090 1783 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1855
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.71e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


:

Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.71e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1905-2992 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1905 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1984
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1985 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2064
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2065 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2144
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2145 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2224
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2225 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2304
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2305 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2384
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2385 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2464
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2465 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2544
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2545 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2622
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2623 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2702
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2703 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2781
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2782 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2860
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2861 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2940
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1584352090 2941 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2992
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1173-1855 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466075  Cd Length: 704  Bit Score: 1215.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1173 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1252
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1253 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1332
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1333 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1393
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1394 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1465
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1466 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1545
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1546 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1624
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1625 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1702
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1703 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1782
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090 1783 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1855
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.71e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.71e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1905-2992 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1905 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1984
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1985 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2064
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2065 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2144
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2145 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2224
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2225 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2304
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2305 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2384
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2385 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2464
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2465 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2544
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2545 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2622
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2623 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2702
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2703 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2781
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2782 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2860
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 2861 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2940
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1584352090 2941 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2992
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1173-1855 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466075  Cd Length: 704  Bit Score: 1215.79  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1173 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1252
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1253 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1332
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1333 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1393
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1394 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1465
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1466 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1545
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1546 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1624
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1625 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1702
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090 1703 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1782
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090 1783 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1855
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.71e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.71e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584352090   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584352090  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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