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Conserved domains on  [gi|1540583198|ref|NP_001354789|]
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sialidase-3 isoform a [Homo sapiens]

Protein Classification

sialidase family protein( domain architecture ID 10202570)

sialidase (glycoside hydrolase 33) family protein such as non-viral exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides

CATH:  2.120.10.10
CAZY:  GH33
EC:  3.2.1.-
PubMed:  7934919|8994884
SCOP:  3001607

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
44-436 3.52e-69

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


:

Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 223.49  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSElkhWATFAVGPGHGI 200
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPSG---WKFFFTGPGRGI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 201 QLQSGRLVIPAYTYYIPSwffcfqlpckTRPHSLMIYSDDLGVTWHHGRLIRPMV--TVECEVAEVT-GRaghpvLYCSA 277
Cdd:cd15482   152 QLSDGRLVFPAYARNGGG----------GGDGAVVIYSDDGGKTWTRGGGVPSSGagGDEPSIVELSdGR-----LLMNA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 278 RTPN--RCRAEALSTDHGEGFQRLALSRQLcePPHGCQGSVVSFRPleiphrcqdssskdaptiqqsspgsslrleeeag 355
Cdd:cd15482   217 RNSGggGGRAVAESTDGGETWSEPVPTPSL--PDPGCQGSLIRLPD---------------------------------- 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 356 tPSESWLLYSHPTSR-KQRVDLGIYLnqTPLEAACWSRPWILHCGP-CGYSDLAALeEEGLFGCLFECGTKQECEQIAFR 433
Cdd:cd15482   261 -GGRKVLLFSNPASPgKGRTNLTLRL--SDDGGKTWPDVRVLEDGPgSGYSSLTQL-PDGTIGLLYEEGRGGGYEGIKFA 336

                  ...
gi 1540583198 434 LFT 436
Cdd:cd15482   337 RLT 339
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
44-436 3.52e-69

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 223.49  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSElkhWATFAVGPGHGI 200
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPSG---WKFFFTGPGRGI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 201 QLQSGRLVIPAYTYYIPSwffcfqlpckTRPHSLMIYSDDLGVTWHHGRLIRPMV--TVECEVAEVT-GRaghpvLYCSA 277
Cdd:cd15482   152 QLSDGRLVFPAYARNGGG----------GGDGAVVIYSDDGGKTWTRGGGVPSSGagGDEPSIVELSdGR-----LLMNA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 278 RTPN--RCRAEALSTDHGEGFQRLALSRQLcePPHGCQGSVVSFRPleiphrcqdssskdaptiqqsspgsslrleeeag 355
Cdd:cd15482   217 RNSGggGGRAVAESTDGGETWSEPVPTPSL--PDPGCQGSLIRLPD---------------------------------- 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 356 tPSESWLLYSHPTSR-KQRVDLGIYLnqTPLEAACWSRPWILHCGP-CGYSDLAALeEEGLFGCLFECGTKQECEQIAFR 433
Cdd:cd15482   261 -GGRKVLLFSNPASPgKGRTNLTLRL--SDDGGKTWPDVRVLEDGPgSGYSSLTQL-PDGTIGLLYEEGRGGGYEGIKFA 336

                  ...
gi 1540583198 434 LFT 436
Cdd:cd15482   337 RLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
46-443 9.41e-54

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 184.37  E-value: 9.41e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  46 LFRQEDDRGITYRIPALLYIPPThTFLAFAEKR-STRRD--EDaLHLVLRRGLRIGQlvQWGPLKPLM---EATLPGHRT 119
Cdd:COG4409    26 VFTSGDDGYASYRIPALVTTPKG-TLLAFADARyNGSGDlpGD-IDIVMRRSTDGGK--TWSPPQVILdygEGGGLSAGV 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 120 MNPCPVWEQKSGCVFLFFicVRGH------VTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVigsELKHWATFA 193
Cdd:COG4409   102 GDPAPVVDRKTGRIFLLA--DWMPgndgegWSGSEPGTDPKGTRQLWVTYSDDDGKTWSEPRNITPQV---KDPDWRFLA 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 194 VGPGHGIQLQS----GRLVIPAYtyYIPSwffcfqlpckTRPHSLMIYSDDLGVTWHHGRLIRPMVTV-ECEVAEVT-GR 267
Cdd:COG4409   177 TGPGHGIQLKNgehkGRLVFPAY--YSDG----------GKPSAAVIYSDDHGKTWKLGESANDKANTnEAQVVELSdGR 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 268 aghpvLYCSAR--TPNRCRAEALSTDHGEGFQRLALSRQLCEPphGCQGSVVSFrpleiphrcQDSSSKDaptiqqsspg 345
Cdd:COG4409   245 -----LMLNMRnqSGGGKRAVATSKDGGETWSEVTFDPALPEP--VCQASIIRY---------DKGDGKD---------- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 346 sslrleeeagtpsesWLLYSHPTSRKQRVDLGIYLNQTplEAACWSRPWILHCGPCGYSDLAALEEEGlFGCLFECGTKq 425
Cdd:COG4409   299 ---------------VLLFSNPASPKGRKNGTVRLSYD--DGKTWPYSKVIEPGGSAYSCLTVLDDGT-IGLLYERGDA- 359
                         410
                  ....*....|....*...
gi 1540583198 426 ecEQIAFRLFTHREILSH 443
Cdd:COG4409   360 --GNIVFARFPLDWLTQK 375
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
70-417 8.94e-26

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 106.25  E-value: 8.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  70 TFLAFAEkrSTRRDEDALHLVLRRGLRIGQLvQWGPLKPLMEAT---LPGHRTMNPCPVwEQKSGCVFLFFICvrghvte 146
Cdd:pfam13088   2 TLLAAWF--GGSREGAPDVSIWRSVFDPGSN-KWSAPQVVADGEqlgRYIRKLGNPVLF-RDPGGTLVLFYKV------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 147 rqqIVSGRN--AARLCFIYSQDAGCSWSEVRDLTEevigselkHWATFAVGPGHG--IQLQSGRLVIPAYTYYIPSWffc 222
Cdd:pfam13088  71 ---GVSPGGwaGSKIYRITSSDNGRTWSAPRRLPP--------GPFLNISGPVKNkpVQLADGRLLLPSYHELAGKW--- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 223 fqlpcktrpHSLMIYSDDLGVTWHHGRLIrPMVTVECEVAEVTGRAGHpvLYCSARTPNRCRAEALSTDHGEGFQrlals 302
Cdd:pfam13088 137 ---------AAHLELSDDGGVTWRKGRPD-NAISGELQPSVLVLADGR--LVMLFRSQEGAILASESTDGGLTWS----- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 303 rqlcePPHgcqgsvvsfrPLEIPHrcqDSSSKDAPTIQqsspgsslrleeeagtPSESWLLYSHPTSRKQRVDLGIYLnq 382
Cdd:pfam13088 200 -----PPE----------PTNLPN---PNSGIDAVNLP----------------DGRLLLVYNPPNAGKPRGPLALAL-- 243
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1540583198 383 TPLEAACWSRPWILHCGP---CGYSDLAAlEEEGLFGC 417
Cdd:pfam13088 244 SEDGGKSWEEVLTLEDGPgdeYSYPSLIQ-ARDGYLHI 280
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
44-436 3.52e-69

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 223.49  E-value: 3.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSElkhWATFAVGPGHGI 200
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPSG---WKFFFTGPGRGI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 201 QLQSGRLVIPAYTYYIPSwffcfqlpckTRPHSLMIYSDDLGVTWHHGRLIRPMV--TVECEVAEVT-GRaghpvLYCSA 277
Cdd:cd15482   152 QLSDGRLVFPAYARNGGG----------GGDGAVVIYSDDGGKTWTRGGGVPSSGagGDEPSIVELSdGR-----LLMNA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 278 RTPN--RCRAEALSTDHGEGFQRLALSRQLcePPHGCQGSVVSFRPleiphrcqdssskdaptiqqsspgsslrleeeag 355
Cdd:cd15482   217 RNSGggGGRAVAESTDGGETWSEPVPTPSL--PDPGCQGSLIRLPD---------------------------------- 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 356 tPSESWLLYSHPTSR-KQRVDLGIYLnqTPLEAACWSRPWILHCGP-CGYSDLAALeEEGLFGCLFECGTKQECEQIAFR 433
Cdd:cd15482   261 -GGRKVLLFSNPASPgKGRTNLTLRL--SDDGGKTWPDVRVLEDGPgSGYSSLTQL-PDGTIGLLYEEGRGGGYEGIKFA 336

                  ...
gi 1540583198 434 LFT 436
Cdd:cd15482   337 RLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
46-443 9.41e-54

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 184.37  E-value: 9.41e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  46 LFRQEDDRGITYRIPALLYIPPThTFLAFAEKR-STRRD--EDaLHLVLRRGLRIGQlvQWGPLKPLM---EATLPGHRT 119
Cdd:COG4409    26 VFTSGDDGYASYRIPALVTTPKG-TLLAFADARyNGSGDlpGD-IDIVMRRSTDGGK--TWSPPQVILdygEGGGLSAGV 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 120 MNPCPVWEQKSGCVFLFFicVRGH------VTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVigsELKHWATFA 193
Cdd:COG4409   102 GDPAPVVDRKTGRIFLLA--DWMPgndgegWSGSEPGTDPKGTRQLWVTYSDDDGKTWSEPRNITPQV---KDPDWRFLA 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 194 VGPGHGIQLQS----GRLVIPAYtyYIPSwffcfqlpckTRPHSLMIYSDDLGVTWHHGRLIRPMVTV-ECEVAEVT-GR 267
Cdd:COG4409   177 TGPGHGIQLKNgehkGRLVFPAY--YSDG----------GKPSAAVIYSDDHGKTWKLGESANDKANTnEAQVVELSdGR 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 268 aghpvLYCSAR--TPNRCRAEALSTDHGEGFQRLALSRQLCEPphGCQGSVVSFrpleiphrcQDSSSKDaptiqqsspg 345
Cdd:COG4409   245 -----LMLNMRnqSGGGKRAVATSKDGGETWSEVTFDPALPEP--VCQASIIRY---------DKGDGKD---------- 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 346 sslrleeeagtpsesWLLYSHPTSRKQRVDLGIYLNQTplEAACWSRPWILHCGPCGYSDLAALEEEGlFGCLFECGTKq 425
Cdd:COG4409   299 ---------------VLLFSNPASPKGRKNGTVRLSYD--DGKTWPYSKVIEPGGSAYSCLTVLDDGT-IGLLYERGDA- 359
                         410
                  ....*....|....*...
gi 1540583198 426 ecEQIAFRLFTHREILSH 443
Cdd:COG4409   360 --GNIVFARFPLDWLTQK 375
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
70-417 8.94e-26

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 106.25  E-value: 8.94e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198  70 TFLAFAEkrSTRRDEDALHLVLRRGLRIGQLvQWGPLKPLMEAT---LPGHRTMNPCPVwEQKSGCVFLFFICvrghvte 146
Cdd:pfam13088   2 TLLAAWF--GGSREGAPDVSIWRSVFDPGSN-KWSAPQVVADGEqlgRYIRKLGNPVLF-RDPGGTLVLFYKV------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 147 rqqIVSGRN--AARLCFIYSQDAGCSWSEVRDLTEevigselkHWATFAVGPGHG--IQLQSGRLVIPAYTYYIPSWffc 222
Cdd:pfam13088  71 ---GVSPGGwaGSKIYRITSSDNGRTWSAPRRLPP--------GPFLNISGPVKNkpVQLADGRLLLPSYHELAGKW--- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 223 fqlpcktrpHSLMIYSDDLGVTWHHGRLIrPMVTVECEVAEVTGRAGHpvLYCSARTPNRCRAEALSTDHGEGFQrlals 302
Cdd:pfam13088 137 ---------AAHLELSDDGGVTWRKGRPD-NAISGELQPSVLVLADGR--LVMLFRSQEGAILASESTDGGLTWS----- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 303 rqlcePPHgcqgsvvsfrPLEIPHrcqDSSSKDAPTIQqsspgsslrleeeagtPSESWLLYSHPTSRKQRVDLGIYLnq 382
Cdd:pfam13088 200 -----PPE----------PTNLPN---PNSGIDAVNLP----------------DGRLLLVYNPPNAGKPRGPLALAL-- 243
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1540583198 383 TPLEAACWSRPWILHCGP---CGYSDLAAlEEEGLFGC 417
Cdd:pfam13088 244 SEDGGKSWEEVLTLEDGPgdeYSYPSLIQ-ARDGYLHI 280
COG4692 COG4692
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane ...
102-294 2.70e-08

Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443727 [Multi-domain]  Cd Length: 353  Bit Score: 55.32  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 102 QWGPLKPLMEATL--PGHRTMNPCPvWEQKSGCVFLFFIcvrghvterqqIVSGRN--AARLCFIYSQDAGCSWSEVRDL 177
Cdd:COG4692    83 KWSAPVRVATGEQddPRRPLWNPVL-FLAPDGRLWLFYK-----------VPSPGGwwGSLIRVRTSTDGGKTWSPPERL 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1540583198 178 TEEVIgselkhwatFAVGP--GHGIQLQSGRLVIPAYTYYIPSWFfcfqlpcktrphSLMIYSDDLGVTWHHGRL----- 250
Cdd:COG4692   151 PEGPF---------LIGGPvrNKPVVLSDGRILLPSYTESGGKWR------------SHVEISDDGGKTWTKSPIpkgfg 209
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1540583198 251 -IRPMVtvecevaeVTGRAGHPVLYCSARTPNR-CRAEalSTDHGE 294
Cdd:COG4692   210 aIQPSI--------LELKDGRLQALMRSRGAGRiYRSE--STDGGK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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