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Conserved domains on  [gi|1388153567|ref|NP_001350096|]
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vacuolar protein sorting-associated protein 37A isoform 3 [Homo sapiens]

Protein Classification

vacuolar protein sorting family 37 protein( domain architecture ID 12073684)

vacuolar protein sorting family 37 protein similar to vacuolar protein sorting-associated protein 37 (Vps37), which is a component of the ESCRT-I complex, a regulator of vesicular trafficking process

CATH:  1.10.287.660
Gene Ontology:  GO:0000813|GO:0043162|GO:0006623|GO:0006612|GO:0048306
SCOP:  4001064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 235-374 5.71e-43

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


:

Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 147.00  E-value: 5.71e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388153567 235 SELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTV------LDKMKSTFEKK 308
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLqelleeLKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1388153567 309 MQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDDFLSSFMEKRTICHCRRAKE 374
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREKL 146
UEV_TSG101-like cd11685
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ...
 70-131 1.53e-03

ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity.


:

Pssm-ID: 467408  Cd Length: 126  Bit Score: 38.44  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388153567  70 PPQFPQEKPVISVYPPI------RHHLMDKQGVyVTSPLVNNFTMH-SDLGKIIQSLLDEFWKNPPVLA 131
Cdd:cd11685    59 PETYPYSPPIVYVVPTPsmmiikPHPHVDPNGR-VYLPYLSEWNPPsSNLVDLVQELSAVFSEEPPVYS 126
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 235-374 5.71e-43

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 147.00  E-value: 5.71e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388153567 235 SELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTV------LDKMKSTFEKK 308
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLqelleeLKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1388153567 309 MQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDDFLSSFMEKRTICHCRRAKE 374
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREKL 146
UEV_TSG101-like cd11685
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ...
 70-131 1.53e-03

ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity.


Pssm-ID: 467408  Cd Length: 126  Bit Score: 38.44  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388153567  70 PPQFPQEKPVISVYPPI------RHHLMDKQGVyVTSPLVNNFTMH-SDLGKIIQSLLDEFWKNPPVLA 131
Cdd:cd11685    59 PETYPYSPPIVYVVPTPsmmiikPHPHVDPNGR-VYLPYLSEWNPPsSNLVDLVQELSAVFSEEPPVYS 126
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 235-374 5.71e-43

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 147.00  E-value: 5.71e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388153567 235 SELSVSQLTDMNEQEEVLLEQFLTLPQLKQIITDKDDLVKSIEELARKNLLLEPSLEAKRQTV------LDKMKSTFEKK 308
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLqelleeLKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1388153567 309 MQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKMEIDDFLSSFMEKRTICHCRRAKE 374
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREKL 146
UEV_TSG101-like cd11685
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ...
 70-131 1.53e-03

ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity.


Pssm-ID: 467408  Cd Length: 126  Bit Score: 38.44  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388153567  70 PPQFPQEKPVISVYPPI------RHHLMDKQGVyVTSPLVNNFTMH-SDLGKIIQSLLDEFWKNPPVLA 131
Cdd:cd11685    59 PETYPYSPPIVYVVPTPsmmiikPHPHVDPNGR-VYLPYLSEWNPPsSNLVDLVQELSAVFSEEPPVYS 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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