DNA cross-link repair 1A protein isoform 3 [Mus musculus]
DNA cross-link repair protein( domain architecture ID 11039898)
DNA cross-link repair protein similar to Mus musculus DNA cross-link repair 1A protein that may be required for DNA interstrand cross-link repair, and also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons
List of domain hits
Name | Accession | Description | Interval | E-value | |||
metallo-hydrolase-like_MBL-fold super family | cl23716 | mainly hydrolytic enzymes and related proteins which carry out various biological functions; ... |
160-315 | 2.84e-102 | |||
mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain; Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site. The actual alignment was detected with superfamily member cd16298: Pssm-ID: 451500 [Multi-domain] Cd Length: 157 Bit Score: 303.67 E-value: 2.84e-102
|
|||||||
DRMBL | pfam07522 | DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence ... |
385-491 | 2.36e-50 | |||
DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair. : Pssm-ID: 429512 Cd Length: 108 Bit Score: 167.45 E-value: 2.36e-50
|
|||||||
Name | Accession | Description | Interval | E-value | ||||
SNM1A-like_MBL-fold | cd16298 | 5'-exonucleases human SNM1A and related proteins; MBL-fold metallo-hydrolase domain; Includes ... |
160-315 | 2.84e-102 | ||||
5'-exonucleases human SNM1A and related proteins; MBL-fold metallo-hydrolase domain; Includes human SNM1A (SNM1 homolog A, also known as DNA cross-link repair 1A protein) which is a 5'-exonuclease and functions in interstrand cross-links (ICL) repair. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293856 [Multi-domain] Cd Length: 157 Bit Score: 303.67 E-value: 2.84e-102
|
||||||||
DRMBL | pfam07522 | DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence ... |
385-491 | 2.36e-50 | ||||
DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair. Pssm-ID: 429512 Cd Length: 108 Bit Score: 167.45 E-value: 2.36e-50
|
||||||||
YSH1 | COG1236 | RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure ... |
157-354 | 7.80e-13 | ||||
RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440849 [Multi-domain] Cd Length: 404 Bit Score: 70.22 E-value: 7.80e-13
|
||||||||
Lactamase_B | smart00849 | Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins ... |
200-300 | 9.82e-07 | ||||
Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor. Pssm-ID: 214854 [Multi-domain] Cd Length: 177 Bit Score: 49.09 E-value: 9.82e-07
|
||||||||
Lactamase_B_2 | pfam12706 | Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and ... |
200-317 | 2.92e-03 | ||||
Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and is related to pfam00753. Pssm-ID: 432732 [Multi-domain] Cd Length: 196 Bit Score: 38.83 E-value: 2.92e-03
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
SNM1A-like_MBL-fold | cd16298 | 5'-exonucleases human SNM1A and related proteins; MBL-fold metallo-hydrolase domain; Includes ... |
160-315 | 2.84e-102 | ||||
5'-exonucleases human SNM1A and related proteins; MBL-fold metallo-hydrolase domain; Includes human SNM1A (SNM1 homolog A, also known as DNA cross-link repair 1A protein) which is a 5'-exonuclease and functions in interstrand cross-links (ICL) repair. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293856 [Multi-domain] Cd Length: 157 Bit Score: 303.67 E-value: 2.84e-102
|
||||||||
SNM1A-1C-like_MBL-fold | cd16273 | SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain; ... |
169-315 | 1.11e-87 | ||||
SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain; Includes human SNM1A (SNM1 homolog A, also known as DNA cross-link repair 1A protein) and Saccharomyces cerevisiae Pso2 protein (PSOralen derivative sensitive 2, also known as SNM1, sensitive to nitrogen mustard 1), both proteins are 5'-exonucleases and function in interstrand cross-links (ICL) repair. Also includes the nuclease artemis (also known as SNM1C, SNM1 homolog C, SNM1-like protein, and DNA cross-link repair 1C protein) which plays a role in V(D)J recombination/DNA repair. Purified artemis protein possesses single-strand-specific 5' to 3' exonuclease activity. Upon complex formation with, and phosphorylation by, DNA-dependent protein kinase, artemis gains endonucleolytic activity on hairpins and 5' and 3' overhangs. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293831 Cd Length: 160 Bit Score: 266.33 E-value: 1.11e-87
|
||||||||
DRMBL | pfam07522 | DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence ... |
385-491 | 2.36e-50 | ||||
DNA repair metallo-beta-lactamase; The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in pfam00753 and are common to all metallo-beta-lactamases. The fifth motif appears to be specific to function. This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair. Pssm-ID: 429512 Cd Length: 108 Bit Score: 167.45 E-value: 2.36e-50
|
||||||||
artemis-SNM1C-like_MBL-fold | cd16297 | artemis-SNM1C and related proteins; MBL-fold metallo-hydrolase domain; Includes the nuclease ... |
184-315 | 5.03e-20 | ||||
artemis-SNM1C and related proteins; MBL-fold metallo-hydrolase domain; Includes the nuclease artemis (also known as SNM1C, SNM1 homolog C, SNM1-like protein and DNA cross-link repair 1C protein) which plays a role in V(D)J recombination/DNA repair. Purified artemis protein possesses single-strand-specific 5' to 3' exonuclease activity. Upon complex formation with, and phosphorylation by, DNA-dependent protein kinase, artemis gains endonucleolytic activity on hairpins and 5' and 3' overhangs. Inactivation of Artemis causes severe combined immunodeficiency (SCID). Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293855 Cd Length: 171 Bit Score: 87.18 E-value: 5.03e-20
|
||||||||
YSH1 | COG1236 | RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure ... |
157-354 | 7.80e-13 | ||||
RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440849 [Multi-domain] Cd Length: 404 Bit Score: 70.22 E-value: 7.80e-13
|
||||||||
RNaseJ_MBL-fold | cd07714 | RNAaseJ, MBL-fold metallo-hydrolase domain; RNase J, also called Ribonuclease J, is a ... |
200-360 | 6.10e-12 | ||||
RNAaseJ, MBL-fold metallo-hydrolase domain; RNase J, also called Ribonuclease J, is a prokaryotic ribonuclease which plays a key part in RNA processing and in RNA degradation. It can act as an endonuclease which is specific for single-stranded regions of RNA irrespective of their sequence or location, and as a processive 5' exonuclease which only acts on substrates having a single phosphate or a hydroxyl at the 5' end. Many bacterial species have only one RNase J, but some, such as Bacillus subtilis, have two. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293800 [Multi-domain] Cd Length: 248 Bit Score: 65.51 E-value: 6.10e-12
|
||||||||
RnjA | COG0595 | mRNA degradation ribonuclease J1/J2 [Translation, ribosomal structure and biogenesis]; |
198-335 | 6.99e-12 | ||||
mRNA degradation ribonuclease J1/J2 [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440360 [Multi-domain] Cd Length: 553 Bit Score: 67.78 E-value: 6.99e-12
|
||||||||
metallo-hydrolase-like_MBL-fold | cd07732 | uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo ... |
178-289 | 8.49e-10 | ||||
uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain; Includes functionally uncharacterized Enterococcus faecalis EF2904. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. Pssm-ID: 293818 [Multi-domain] Cd Length: 202 Bit Score: 58.39 E-value: 8.49e-10
|
||||||||
PhnP | COG1235 | Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [Inorganic ion transport and metabolism]; ... |
200-329 | 1.45e-09 | ||||
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [Inorganic ion transport and metabolism]; Pssm-ID: 440848 [Multi-domain] Cd Length: 259 Bit Score: 58.75 E-value: 1.45e-09
|
||||||||
Lactamase_B | smart00849 | Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins ... |
200-300 | 9.82e-07 | ||||
Metallo-beta-lactamase superfamily; Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor. Pssm-ID: 214854 [Multi-domain] Cd Length: 177 Bit Score: 49.09 E-value: 9.82e-07
|
||||||||
metallo-hydrolase-like_MBL-fold | cd06262 | mainly hydrolytic enzymes and related proteins which carry out various biological functions; ... |
179-311 | 7.59e-06 | ||||
mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain; Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site. Pssm-ID: 293792 [Multi-domain] Cd Length: 188 Bit Score: 46.51 E-value: 7.59e-06
|
||||||||
ElaC | COG1234 | Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]; |
197-312 | 1.98e-04 | ||||
Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440847 [Multi-domain] Cd Length: 250 Bit Score: 42.87 E-value: 1.98e-04
|
||||||||
GloB | COG0491 | Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General ... |
200-286 | 5.14e-04 | ||||
Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]; Pssm-ID: 440257 [Multi-domain] Cd Length: 215 Bit Score: 41.60 E-value: 5.14e-04
|
||||||||
UlaG | COG2220 | L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and ... |
179-286 | 1.02e-03 | ||||
L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and metabolism]; Pssm-ID: 441822 [Multi-domain] Cd Length: 224 Bit Score: 40.67 E-value: 1.02e-03
|
||||||||
Lactamase_B_2 | pfam12706 | Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and ... |
200-317 | 2.92e-03 | ||||
Beta-lactamase superfamily domain; This family is part of the beta-lactamase superfamily and is related to pfam00753. Pssm-ID: 432732 [Multi-domain] Cd Length: 196 Bit Score: 38.83 E-value: 2.92e-03
|
||||||||
metallo-hydrolase-like_MBL-fold | cd16279 | uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo; ... |
200-270 | 3.60e-03 | ||||
uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo; Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry. Some members of this subgroup are named as octanoyltransferase (also known as lipoate-protein ligase B). Pssm-ID: 293837 [Multi-domain] Cd Length: 193 Bit Score: 38.61 E-value: 3.60e-03
|
||||||||
class_II_PDE_MBL-fold | cd07735 | class II cyclic nucleotide phosphodiesterases Saccharomyces cerevisiae PDE1, Dictyostelium ... |
198-314 | 4.41e-03 | ||||
class II cyclic nucleotide phosphodiesterases Saccharomyces cerevisiae PDE1, Dictyostelium discoideum PDE1 and PDE7, and related proteins; MBL-fold metallo-hydrolase domain; Cyclic nucleotide phosphodiesterases (PDEs) decompose the second messengers cyclic adenosine and guanosine 3',5'-monophosphate (cAMP and cGMP, respectively). Saccharomyces cerevisiae PDE1 and Dictyostelium discoideum PDE1 and PDE7, have dual cAMP/cGMP specificity. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. Pssm-ID: 293821 Cd Length: 259 Bit Score: 39.12 E-value: 4.41e-03
|
||||||||
arylsulfatase_AtsA-like_MBL-fold | cd07719 | Pseudoalteromonas carrageenovora arylsulfatase AtsA and related proteins; MBL-fold ... |
200-212 | 5.11e-03 | ||||
Pseudoalteromonas carrageenovora arylsulfatase AtsA and related proteins; MBL-fold metallo-hydrolase domain; Arylsulfatase (also known as aryl-sulfate sulfohydrolase, EC 3.1.6.1). Pseudoalteromonas carrageenovora arylsulfatase AtsA may function as a glycosulfohydrolase involved with desulfation of sulfated polysaccharides, which catalyzes hydrolysis of the arylsulfate ester bond, producing the aryl compounds and inorganic sulfate. CD also includes some sequences annotated as ribonucleases. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily. Pssm-ID: 293805 [Multi-domain] Cd Length: 193 Bit Score: 38.27 E-value: 5.11e-03
|
||||||||
Lactamase_B | pfam00753 | Metallo-beta-lactamase superfamily; |
200-307 | 5.44e-03 | ||||
Metallo-beta-lactamase superfamily; Pssm-ID: 425851 [Multi-domain] Cd Length: 196 Bit Score: 38.12 E-value: 5.44e-03
|
||||||||
Blast search parameters | ||||
|