Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938197   3 TTPLAENQDEDPLEvtsqyvaqadlklpdlsnslvsasqsvgvtDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDT 82
Cdd:pfam17654  46 TTQEAEQQDEDPLE------------------------------DPNLELDVEELNKEFMERSEELYDALMNCHWQPLDS 95

                  ....*.
gi 1237938197  83 VHSEIP 88
Cdd:pfam17654  96 VTSEIP 101

Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938197   3 TTPLAENQDEDPLEvtsqyvaqadlklpdlsnslvsasqsvgvtDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDT 82
Cdd:pfam17654  46 TTQEAEQQDEDPLE------------------------------DPNLELDVEELNKEFMERSEELYDALMNCHWQPLDS 95

                  ....*.
gi 1237938197  83 VHSEIP 88
Cdd:pfam17654  96 VTSEIP 101

Selenocysteine tRNA 1 associated proteins; This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) pfam00076 and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938197   3 TTPLAENQDEDPLEvtsqyvaqadlklpdlsnslvsasqsvgvtDPHLHLNIEESNQEFMVKSEELYDSLMNCHWQPLDT 82
Cdd:pfam17654  46 TTQEAEQQDEDPLE------------------------------DPNLELDVEELNKEFMERSEELYDALMNCHWQPLDS 95

                  ....*.
gi 1237938197  83 VHSEIP 88
Cdd:pfam17654  96 VTSEIP 101