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Conserved domains on  [gi|1114645733|ref|NP_001334680|]
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Rab3 GDP-GTP exchange factor, isoform K [Drosophila melanogaster]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 260-486 6.08e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.49  E-value: 6.08e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   260 TSLCIISHHPFFTTFRECLFILKKLIDACNESSSPkrvgasqkinrdnvwtvltghvsdatpsivlhdvreietWILRLL 339
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLPLE---------------------------------------LLISLL 43

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   340 STPVPVPGSTRVEVEVLSptvHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMS 419
Cdd:smart00799   44 LYPVPPPGGSLVLVSLGP---GDLIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAV 120

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1114645733   420 VMAFVTMLYPLEYMFPVIPLLPTCLscaEQLLLAPTPFVIGVPASFLVYKKNFRLpDDIWVVDLDST 486
Cdd:smart00799  121 IEALLALLYPFVWQHIYIPILPASL---LDVLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-111 2.95e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.48  E-value: 2.95e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733    10 CPRLVDYMAIVGAHTTPpmpkglqgLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVgprrTGSAIRDMTS 89
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT--------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFV----TQTSSKDPQF 68

                            90       100
                    ....*....|....*....|..
gi 1114645733    90 FVFALTDKDsGKTRYGICVNFY 111
Cdd:smart00800   69 FSFVLTDID-GSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 613-681 2.95e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.46  E-value: 2.95e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   613 DVATRVAMVRFFNaqNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQ-FLNQFARTQAVEFLAEW 681
Cdd:smart00801    1 NDEIREAFLRFFV--NLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERpFLSKFLETQMFSQFIEE 68
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 260-486 6.08e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.49  E-value: 6.08e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   260 TSLCIISHHPFFTTFRECLFILKKLIDACNESSSPkrvgasqkinrdnvwtvltghvsdatpsivlhdvreietWILRLL 339
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLPLE---------------------------------------LLISLL 43

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   340 STPVPVPGSTRVEVEVLSptvHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMS 419
Cdd:smart00799   44 LYPVPPPGGSLVLVSLGP---GDLIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAV 120

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1114645733   420 VMAFVTMLYPLEYMFPVIPLLPTCLscaEQLLLAPTPFVIGVPASFLVYKKNFRLpDDIWVVDLDST 486
Cdd:smart00799  121 IEALLALLYPFVWQHIYIPILPASL---LDVLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 260-484 1.74e-35

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 134.24  E-value: 1.74e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733  260 TSLCIISHHPFFTTFRECLFILKKlidacnessspkrvgasqkinrdnvwtvltgHVSDATPSIvlhdvrEIETWILRLL 339
Cdd:pfam02141    4 KAYCIISRLPFFNLFKKFLDELYR-------------------------------RRTISPLPN------PIERFIANLL 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733  340 -STPVPVPGSTRVEVevlSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSM 418
Cdd:pfam02141   47 yEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTL 123

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1114645733  419 SVMAFVTMLYPLEYMFPVIPLLPTCLScaeQLLLAPTPFVIGVPASFLvyKKNFRLPDDIWVVDLD 484
Cdd:pfam02141  124 VAEAVVALLYPFVWQHIYIPVLPASLL---DVLSAPTPFIIGVHSRYF--DLLEDPLDDVVLVDLD 184
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-111 2.95e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.48  E-value: 2.95e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733    10 CPRLVDYMAIVGAHTTPpmpkglqgLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVgprrTGSAIRDMTS 89
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT--------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFV----TQTSSKDPQF 68

                            90       100
                    ....*....|....*....|..
gi 1114645733    90 FVFALTDKDsGKTRYGICVNFY 111
Cdd:smart00800   69 FSFVLTDID-GSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 43-109 5.43e-16

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 73.80  E-value: 5.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1114645733   43 PDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTgsairdmTSFVFALTDKDsGKTRYGICVN 109
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSREP-------TFFSFVLTDED-GSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 613-681 2.95e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.46  E-value: 2.95e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   613 DVATRVAMVRFFNaqNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQ-FLNQFARTQAVEFLAEW 681
Cdd:smart00801    1 NDEIREAFLRFFV--NLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERpFLSKFLETQMFSQFIEE 68
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 260-486 6.08e-57

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 195.49  E-value: 6.08e-57
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   260 TSLCIISHHPFFTTFRECLFILKKLIDACNESSSPkrvgasqkinrdnvwtvltghvsdatpsivlhdvreietWILRLL 339
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLPLE---------------------------------------LLISLL 43

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   340 STPVPVPGSTRVEVEVLSptvHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMS 419
Cdd:smart00799   44 LYPVPPPGGSLVLVSLGP---GDLIELQRPLDSSLPLIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAV 120

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1114645733   420 VMAFVTMLYPLEYMFPVIPLLPTCLscaEQLLLAPTPFVIGVPASFLVYKKNFRLpDDIWVVDLDST 486
Cdd:smart00799  121 IEALLALLYPFVWQHIYIPILPASL---LDVLSAPTPFIIGVHSSYFEEVKELPD-EDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 260-484 1.74e-35

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 134.24  E-value: 1.74e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733  260 TSLCIISHHPFFTTFRECLFILKKlidacnessspkrvgasqkinrdnvwtvltgHVSDATPSIvlhdvrEIETWILRLL 339
Cdd:pfam02141    4 KAYCIISRLPFFNLFKKFLDELYR-------------------------------RRTISPLPN------PIERFIANLL 46

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733  340 -STPVPVPGSTRVEVevlSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSM 418
Cdd:pfam02141   47 yEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSELPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTL 123

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1114645733  419 SVMAFVTMLYPLEYMFPVIPLLPTCLScaeQLLLAPTPFVIGVPASFLvyKKNFRLPDDIWVVDLD 484
Cdd:pfam02141  124 VAEAVVALLYPFVWQHIYIPVLPASLL---DVLSAPTPFIIGVHSRYF--DLLEDPLDDVVLVDLD 184
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 10-111 2.95e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 95.48  E-value: 2.95e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733    10 CPRLVDYMAIVGAHTTPpmpkglqgLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVgprrTGSAIRDMTS 89
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT--------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFV----TQTSSKDPQF 68

                            90       100
                    ....*....|....*....|..
gi 1114645733    90 FVFALTDKDsGKTRYGICVNFY 111
Cdd:smart00800   69 FSFVLTDID-GSRRYGFCLRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 43-109 5.43e-16

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 73.80  E-value: 5.43e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1114645733   43 PDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTgsairdmTSFVFALTDKDsGKTRYGICVN 109
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSREP-------TFFSFVLTDED-GSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 613-681 2.95e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 63.46  E-value: 2.95e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1114645733   613 DVATRVAMVRFFNaqNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQ-FLNQFARTQAVEFLAEW 681
Cdd:smart00801    1 NDEIREAFLRFFV--NLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERpFLSKFLETQMFSQFIEE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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