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Conserved domains on  [gi|1109303185|ref|NP_001334437|]
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interferon regulatory factor 4 isoform b [Mus musculus]

Protein Classification

interferon regulatory factor( domain architecture ID 10457095)

interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 5.10e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.05  E-value: 5.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 248 DCRLHICLYYRDILVKELTTTSPEGCRISHGHT------YDVSNLDQVLFPYPD---DNGQRKNIEKLLSHLERGLVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 319 APDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 1109303185 398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 7.71e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 7.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  23 KLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1109303185 103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 5.10e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.05  E-value: 5.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 248 DCRLHICLYYRDILVKELTTTSPEGCRISHGHT------YDVSNLDQVLFPYPD---DNGQRKNIEKLLSHLERGLVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 319 APDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 1109303185 398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 7.71e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 7.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  23 KLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1109303185 103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 23-130 1.93e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 174.06  E-value: 1.93e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185   23 KLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 1109303185  103 KSNDFEELVERSQlDISDPYKVYRIVPE 130
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-129 9.42e-46

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 153.99  E-value: 9.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  24 LRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDyNREEDAALFKAWALFKGKFREGiDKPDPPTWKTRLRCALNK 103
Cdd:cd00103     4 LRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCALRS 81

                          90       100
                  ....*....|....*....|....*.
gi 1109303185 104 SNDFEELVERSQLDISDPYKVYRIVP 129
Cdd:cd00103    82 SRGFEEVKDKSKDTPGDPHRVYRLLP 107
DWB smart00524
Domain B in dwarfin family proteins;
267-379 5.06e-03

Domain B in dwarfin family proteins;


Pssm-ID: 197770  Cd Length: 171  Bit Score: 37.67  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  267 TTSPEGCRISHGHtydvsnldqvlFPYPDDNGQRKNIEKllsHLERGLVLWMAPDGLYAKRLCQSRI-----YWDGPLAL 341
Cdd:smart00524  31 TDPSDGNRFCLGQ-----------LSNVNRNEATELIRK---HIGKGVQLSYENGDVWLYNRSDSPIfvqspYLDEPGGR 96

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1109303185  342 CSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPR 379
Cdd:smart00524  97 TLDTVHKLPPGYSIKVFDMEKFAQLLARELAKGFEGVY 134
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 248-417 5.10e-88

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 266.05  E-value: 5.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 248 DCRLHICLYYRDILVKELTTTSPEGCRISHGHT------YDVSNLDQVLFPYPD---DNGQRKNIEKLLSHLERGLVLWM 318
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSYGPPdpqvalYGPVALQQVRFPDPDgipDERQREYTRRLLNVLERGLLLWV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185 319 APDGLYAKRLCQSRIYWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFPD-PQRQR 397
Cdd:pfam10401  81 AGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDdKPREK 160

                         170       180
                  ....*....|....*....|
gi 1109303185 398 KLITAHVEPLLARQLYYFAQ 417
Cdd:pfam10401 161 KLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 23-128 7.71e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 211.27  E-value: 7.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  23 KLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1109303185 103 KSNDFEELVERSQLDISDPYKVYRIV 128
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 23-130 1.93e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 174.06  E-value: 1.93e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185   23 KLRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN 102
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 1109303185  103 KSNDFEELVERSQlDISDPYKVYRIVPE 130
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 24-129 9.42e-46

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 153.99  E-value: 9.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  24 LRQWLIDQIDSGKYPGLVWENEEKSVFRIPWKHAGKQDyNREEDAALFKAWALFKGKFREGiDKPDPPTWKTRLRCALNK 103
Cdd:cd00103     4 LRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPG-GTPDPAEWKARLLCALRS 81

                          90       100
                  ....*....|....*....|....*.
gi 1109303185 104 SNDFEELVERSQLDISDPYKVYRIVP 129
Cdd:cd00103    82 SRGFEEVKDKSKDTPGDPHRVYRLLP 107
DWB smart00524
Domain B in dwarfin family proteins;
267-379 5.06e-03

Domain B in dwarfin family proteins;


Pssm-ID: 197770  Cd Length: 171  Bit Score: 37.67  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109303185  267 TTSPEGCRISHGHtydvsnldqvlFPYPDDNGQRKNIEKllsHLERGLVLWMAPDGLYAKRLCQSRI-----YWDGPLAL 341
Cdd:smart00524  31 TDPSDGNRFCLGQ-----------LSNVNRNEATELIRK---HIGKGVQLSYENGDVWLYNRSDSPIfvqspYLDEPGGR 96

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1109303185  342 CSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPR 379
Cdd:smart00524  97 TLDTVHKLPPGYSIKVFDMEKFAQLLARELAKGFEGVY 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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