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Conserved domains on  [gi|1063730214|ref|NP_001332193|]
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Cyclin family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 162-307 4.94e-96

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410270  Cd Length: 147  Bit Score: 281.15  E-value: 4.94e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 162 KPKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQPKMYMH-IQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVN 240
Cdd:cd20567     1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMsQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063730214 241 IIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20567    81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 312-330 1.08e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20511:

Pssm-ID: 477360  Cd Length: 117  Bit Score: 43.83  E-value: 1.08e-05
                          10
                  ....*....|....*....
gi 1063730214 312 PTQYVFLVRFIKASMSDPE 330
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKK 19
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 162-307 4.94e-96

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 281.15  E-value: 4.94e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 162 KPKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQPKMYMH-IQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVN 240
Cdd:cd20567     1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMsQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063730214 241 IIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20567    81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 185-310 2.06e-63

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 197.35  E-value: 2.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 185 DMYSFYKEVEKESQPK-MYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISA 263
Cdd:pfam00134   1 DIFQYLRELELKYLPKpDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063730214 264 LLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEWYLT 310
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
4-333 3.41e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 164.95  E-value: 3.41e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214   4 RANVPEQVRGAPLVDGLKIQNKNGAVKSRRALGDIGNLVS-VPGVQGGKAQPPINRPITRSFRAQLLANAQLERKPINGD 82
Cdd:COG5024    14 RNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLStVTRLSNGINFHSSKSTKLVVGTCLWLAKKTWGIISSGES 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214  83 NKVpalgpkrqplaARNPEAQRAVQKKNLVvkQQTKPVEVIETKKEVTKKEVAMSPKNKKVTYSSVLSARSKAACGIVNK 162
Cdd:COG5024    94 NER-----------ARIPRLSECNLDSILF--IQMTLNEDSYEPMIDYILKKDENSLSPYELDENQLALDEKQAESKRES 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 163 PKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQP-KMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNI 241
Cdd:COG5024   161 QSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPnPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 242 IDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEWYLTVPTQYVFLVRF 321
Cdd:COG5024   241 IDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRI 320

                         330
                  ....*....|..
gi 1063730214 322 IKASMSDPEVST 333
Cdd:COG5024   321 SKASDYDIFSRT 332
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 219-302 2.59e-22

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 89.19  E-value: 2.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214  219 DWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDnaYSSRQILVME 298
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 1063730214  299 KAIL 302
Cdd:smart00385  79 RLLL 82
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 312-330 1.08e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 43.83  E-value: 1.08e-05
                          10
                  ....*....|....*....
gi 1063730214 312 PTQYVFLVRFIKASMSDPE 330
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKK 19
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 162-307 4.94e-96

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 281.15  E-value: 4.94e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 162 KPKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQPKMYMH-IQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVN 240
Cdd:cd20567     1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMsQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063730214 241 IIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20567    81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 181-306 6.29e-69

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 211.23  E-value: 6.29e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 181 EYVDDMYSFYKEVEKESQPKM-YMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLV 259
Cdd:cd20507     3 EYVKDIYKYLRQLEKKYAIDPdYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063730214 260 GISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLE 306
Cdd:cd20507    83 GVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 185-310 2.06e-63

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 197.35  E-value: 2.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 185 DMYSFYKEVEKESQPK-MYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISA 263
Cdd:pfam00134   1 DIFQYLRELELKYLPKpDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063730214 264 LLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEWYLT 310
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 181-306 5.83e-54

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 173.20  E-value: 5.83e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 181 EYVDDMYSFYKEVEKESQPKM-YMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLV 259
Cdd:cd20504     1 EYADDIYEYLRESELKHRPKPdYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063730214 260 GISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLE 306
Cdd:cd20504    81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 167-306 3.77e-53

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 171.28  E-value: 3.77e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 167 DIDESDKDNHLAAVEYVDDMYSFYKEVEKESQPKMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFL 246
Cdd:cd20508     1 DIDEENSDDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 247 SVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLE 306
Cdd:cd20508    81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 177-307 1.05e-50

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 164.78  E-value: 1.05e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 177 LAAVEYVDDMYSFYKEVEKESQP-KMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRE 255
Cdd:cd20568     3 LMVAEYVPEIFEYLRELELKTLPnPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063730214 256 LQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20568    83 LQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
4-333 3.41e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 164.95  E-value: 3.41e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214   4 RANVPEQVRGAPLVDGLKIQNKNGAVKSRRALGDIGNLVS-VPGVQGGKAQPPINRPITRSFRAQLLANAQLERKPINGD 82
Cdd:COG5024    14 RNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLStVTRLSNGINFHSSKSTKLVVGTCLWLAKKTWGIISSGES 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214  83 NKVpalgpkrqplaARNPEAQRAVQKKNLVvkQQTKPVEVIETKKEVTKKEVAMSPKNKKVTYSSVLSARSKAACGIVNK 162
Cdd:COG5024    94 NER-----------ARIPRLSECNLDSILF--IQMTLNEDSYEPMIDYILKKDENSLSPYELDENQLALDEKQAESKRES 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 163 PKIIDIDESDKDNHLAAVEYVDDMYSFYKEVEKESQP-KMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNI 241
Cdd:COG5024   161 QSWQDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPnPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 242 IDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEWYLTVPTQYVFLVRF 321
Cdd:COG5024   241 IDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRI 320

                         330
                  ....*....|..
gi 1063730214 322 IKASMSDPEVST 333
Cdd:COG5024   321 SKASDYDIFSRT 332
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 182-307 1.60e-43

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 146.40  E-value: 1.60e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 182 YVDDMYSFYKEVEKESQPKM-YMH-IQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLV 259
Cdd:cd20562     8 YATDIYLNLRVAELKRRPLPdYMEkIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063730214 260 GISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20562    88 GVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 181-307 2.21e-43

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 146.16  E-value: 2.21e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 181 EYVDDMYSFYK--EVEKESQPKmYMHIQtEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQL 258
Cdd:cd20566     7 DYVKDIYQYLRqlEVQQSIRPH-YLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1063730214 259 VGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20566    85 VGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 181-307 8.30e-43

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 144.25  E-value: 8.30e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 181 EYVDDMYSFYKEVEKES--QPKmYMHIQtEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQL 258
Cdd:cd20565     3 EYVKDIYAYLRQLEEEQavRPK-YLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1063730214 259 VGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20565    81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 169-302 8.78e-43

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 145.37  E-value: 8.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 169 DESDKDNHLAAVEYVDDMYSFYKEVEKESQPKM-YMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLS 247
Cdd:cd20560    23 DSAADVDVLAVPEYAEDIHQYLREAELKHRPKPgYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLS 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063730214 248 VKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAIL 302
Cdd:cd20560   103 CMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLL 157
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 181-302 4.10e-42

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 142.89  E-value: 4.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 181 EYVDDMYSFYKEVEKESQPKM-YMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLV 259
Cdd:cd20561     3 DYHEDIHTYLREMEVKCKPKVgYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1063730214 260 GISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAIL 302
Cdd:cd20561    83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVL 125
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 193-307 1.25e-40

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 138.99  E-value: 1.25e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 193 VEKESQPKMYMHIQT---EMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSV-KAVPKRELQLVGISALLIAS 268
Cdd:cd20519    13 LKKEELYKRDRDFLNrhpSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLIGITCLFIAA 92

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063730214 269 KYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20519    93 KLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 213-305 8.36e-35

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 122.44  E-value: 8.36e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 213 MRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSR 292
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                          90
                  ....*....|...
gi 1063730214 293 QILVMEKAILGNL 305
Cdd:cd20536    81 QICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 214-309 8.52e-33

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 117.42  E-value: 8.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 214 RAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQ 293
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                          90
                  ....*....|....*.
gi 1063730214 294 ILVMEKAILGNLEWYL 309
Cdd:cd20542    81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 200-307 1.43e-28

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 107.66  E-value: 1.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 200 KMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSV-KAVPKRELQLVGISALLIASKYEEIWPPQV 278
Cdd:cd20579    29 KNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVKTRLQLIGISSLFIAAKLEEIYPPKL 108

                          90       100
                  ....*....|....*....|....*....
gi 1063730214 279 NDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20579   109 HQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 191-307 2.25e-28

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 106.85  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 191 KEVEKESQ---PKMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRF-LSVKAVPKRELQLVGISALLI 266
Cdd:cd20580    17 NMLKKESKyvhDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFI 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063730214 267 ASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20580    97 ASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 171-307 8.59e-24

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 95.06  E-value: 8.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 171 SDKDNHLaaveyVDDMYSFYK--EVEKESQP--KMYMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFL 246
Cdd:cd20515    14 RDRSPAL-----LLDDRVLQNllSLEERYLPsaSYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFL 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063730214 247 SVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20515    89 SLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 219-302 2.59e-22

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 89.19  E-value: 2.59e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214  219 DWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDnaYSSRQILVME 298
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....
gi 1063730214  299 KAIL 302
Cdd:smart00385  79 RLLL 82
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 217-307 1.27e-20

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 85.13  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 217 LIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWP--PQVNDLVYVTDNAYSSRQI 294
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                          90
                  ....*....|...
gi 1063730214 295 LVMEKAILGNLEW 307
Cdd:cd20559    82 IQMEMHILNTLNW 94
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 211-297 2.34e-20

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 84.29  E-value: 2.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 211 EKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYS 290
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80


                  ....*..
gi 1063730214 291 SRQILVM 297
Cdd:cd20521    81 YEDVVRM 87
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 205-307 1.30e-17

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 78.49  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 205 IQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYV 284
Cdd:cd20575    47 VQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIY 126

                          90       100
                  ....*....|....*....|...
gi 1063730214 285 TDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20575   127 TDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 194-307 1.57e-16

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 75.40  E-value: 1.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 194 EKESQPKM--YMHIQTEMNEKMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYE 271
Cdd:cd20573    33 EETCLPSVsyFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMK 112

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063730214 272 EIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20573   113 ETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 218-309 6.40e-16

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 72.34  E-value: 6.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 218 IDWLLEVHIKFELNLETLYLTVNIIDRFL-SVKAVPKReLQLVGISALLIASKYEE----IwpPQVNDLVYVTDNAYSSR 292
Cdd:cd20526     6 VRWLAELNSQFKFYPETFALAVSILDRFLaSVKARPKY-LRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVA 82

                          90
                  ....*....|....*..
gi 1063730214 293 QILVMEKAILGNLEWYL 309
Cdd:cd20526    83 EVLRMERIILDKLHWDL 99
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 188-307 1.14e-15

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 73.10  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 188 SFYKEVEKESQPKMymhiqtemnekmRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIA 267
Cdd:cd20574    42 SYFKCVQKDIQPFM------------RRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLA 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1063730214 268 SKYEEIWPPQVNDLVYVTDNAYSSRQILVMEKAILGNLEW 307
Cdd:cd20574   110 SKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 214-307 1.74e-14

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 68.50  E-value: 1.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 214 RAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPK---RELQLVGISALLIASKYEEIWPPQVNDL-VYVTDNAY 289
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKdkpWMLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVF 81

                          90
                  ....*....|....*...
gi 1063730214 290 SSRQILVMEKAILGNLEW 307
Cdd:cd20543    82 EAKTIQRMELLVLSTLEW 99
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 212-307 1.46e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 65.70  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 212 KMRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWP--PQVNDLVYVTDNAY 289
Cdd:cd20528     5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCNSV 84

                          90
                  ....*....|....*....
gi 1063730214 290 SSRQILV-MEKAILGNLEW 307
Cdd:cd20528    85 YSKQEYLqMELLILEFFQW 103
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 217-299 2.32e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 64.74  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 217 LIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIwPPQVNDLVYVTDnaYSSRQILV 296
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELRK 78


                  ...
gi 1063730214 297 MEK 299
Cdd:cd00043    79 AEK 81
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 213-307 3.83e-13

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 64.50  E-value: 3.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 213 MRAILIDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKYEEIWPPQVNDLVYVTDNAYSSR 292
Cdd:cd20517     5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTNL 84

                          90
                  ....*....|....*
gi 1063730214 293 QILVMEKAILGNLEW 307
Cdd:cd20517    85 ELINQEKDILEALKW 99
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 221-307 1.57e-09

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 54.44  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 221 LLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKY--EEIWPPQVNDLVYVTDNAYSSRQILVME 298
Cdd:cd20583     9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRME 88


                  ....*....
gi 1063730214 299 KAILGNLEW 307
Cdd:cd20583    89 KIILEKLCW 97
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 218-305 2.19e-09

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 53.90  E-value: 2.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730214 218 IDWLLEVHIKFELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKY--EEIWPPQVNDLVYVTDNAYSSRQIL 295
Cdd:cd20523     5 VDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLM 84

                          90
                  ....*....|
gi 1063730214 296 VMEKAILGNL 305
Cdd:cd20523    85 RMEGIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 228-301 1.40e-06

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 45.99  E-value: 1.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063730214 228 FELNLETLYLTVNIIDRFLSVKAVPKRELQLVGISALLIASKY--EEIWPPQVNDLVYVTDNAYSSRQILVMEKAI 301
Cdd:cd20584    16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKII 91
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 312-330 1.08e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 43.83  E-value: 1.08e-05
                          10
                  ....*....|....*....
gi 1063730214 312 PTQYVFLVRFIKASMSDPE 330
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKK 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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