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Conserved domains on  [gi|1063741556|ref|NP_001331830|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-427 2.32e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 332 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 411
Cdd:COG2319   217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                         170
                  ....*....|....*.
gi 1063741556 412 FSPDTESLFIGVWDRT 427
Cdd:COG2319   296 FSPDGKLLASGSDDGT 311
PRK14157 super family cl32961
heat shock protein GrpE; Provisional
 1-65 8.28e-04

heat shock protein GrpE; Provisional


The actual alignment was detected with superfamily member PRK14157:

Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 40.71  E-value: 8.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556   1 MSDYNgddlEDEYMADEYDMDDLEDDMNAAFDGRDIDASDSEVEDFDQLNKAADTS----AAQARNGKD 65
Cdd:PRK14157    1 MSDFN----KDDYLNDLPDADDLEAQGQAAQASSGADASAESGEQQDSAAQADANAgadaAPAAAEGEA 65
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-427 2.32e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 332 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 411
Cdd:COG2319   217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                         170
                  ....*....|....*.
gi 1063741556 412 FSPDTESLFIGVWDRT 427
Cdd:COG2319   296 FSPDGKLLASGSDDGT 311
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-427 1.12e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 279 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 358
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTL 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556 359 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-347 2.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.16e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063741556  308 NGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 347
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
309-347 2.43e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063741556 309 GQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 347
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 1-65 8.28e-04

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 40.71  E-value: 8.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556   1 MSDYNgddlEDEYMADEYDMDDLEDDMNAAFDGRDIDASDSEVEDFDQLNKAADTS----AAQARNGKD 65
Cdd:PRK14157    1 MSDFN----KDDYLNDLPDADDLEAQGQAAQASSGADASAESGEQQDSAAQADANAgadaAPAAAEGEA 65
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-427 2.32e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 332 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 411
Cdd:COG2319   217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                         170
                  ....*....|....*.
gi 1063741556 412 FSPDTESLFIGVWDRT 427
Cdd:COG2319   296 FSPDGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
257-427 8.95e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 8.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 257 DCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFA 335
Cdd:COG2319   183 DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 336 TGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPD 415
Cdd:COG2319   263 SGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                         170
                  ....*....|..
gi 1063741556 416 TESLFIGVWDRT 427
Cdd:COG2319   342 GKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
253-427 5.17e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 5.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:COG2319   221 SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 332 VTFATGNQDKTCRIWDTrKLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 411
Cdd:COG2319   301 KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                         170
                  ....*....|....*.
gi 1063741556 412 FSPDTESLFIGVWDRT 427
Cdd:COG2319   380 FSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-427 1.12e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 1.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 279 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 358
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTL 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556 359 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 COG2319
WD40 repeat [General function prediction only];
278-427 2.69e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 2.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 278 WPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAV 357
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRT 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063741556 358 LKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGykkeQEIDFF----GEISGISFSPDTESLFIGVWDRT 427
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-427 5.30e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 5.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFRY-LWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:cd00200   110 SSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 332 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQeidFFG---EIS 408
Cdd:cd00200   190 EKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGhtnSVT 265

                         170
                  ....*....|....*....
gi 1063741556 409 GISFSPDTESLFIGVWDRT 427
Cdd:cd00200   266 SLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
253-393 2.05e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 2.05e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 342

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063741556 332 VTFATGNQDKTCRIWDTRKLSEsVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKS 393
Cdd:COG2319   343 KTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-390 7.87e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 7.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 253 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 331
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556 332 VTFATGNQDKTCRIWDTRKLSEsVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYD 390
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-427 3.46e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 3.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 279 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 358
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTL 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556 359 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
WD40 COG2319
WD40 repeat [General function prediction only];
277-427 1.16e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 277 LWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVA 356
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLR 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063741556 357 VLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGyKKEQEI-DFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGT 185
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-427 4.97e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 4.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 312 IGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTrKLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDT 391
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063741556 392 KSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 COG2319
WD40 repeat [General function prediction only];
284-427 2.79e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 2.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 284 SLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKLSEsVAVLKGNLG 363
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL-LATLLGHTA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063741556 364 AVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-347 2.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.16e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063741556  308 NGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 347
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
287-421 1.72e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556 287 PDGKLVAVVGDDPDGLLV-DTSNGQTIGTLKgHLDYSFASAWHPNGVT-FATGNQDKTCRIWD--TRKLSESVAVLKGnl 362
Cdd:COG3391    77 ADGRRLYVANSGSGRVSViDLATGKVVATIP-VGGGPRGLAVDPDGGRlYVADSGNGRVSVIDtaTGKVVATIPVGAG-- 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063741556 363 gaVRSIRFTSDGR--YVAMAEPAD---FVHIYDTKSGyKKEQEIDFFGEISGISFSPDTESLFI 421
Cdd:COG3391   154 --PHGIAVDPDGKrlYVANSGSNTvsvIVSVIDTATG-KVVATIPVGGGPVGVAVSPDGRRLYV 214
WD40 pfam00400
WD domain, G-beta repeat;
309-347 2.43e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063741556 309 GQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 347
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 280-415 1.33e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.64  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741556  280 VNHSSLSPDGKLVAVV--GDdpdGLLVDTSNGQTIG-TLKGHLDYSFAsAWHPNG-----VTFATGNQDktcrIW--DTR 349
Cdd:COG4946    304 LTSFALSPDGKRVAFEarGE---VFTVPAEKGPTRNlTNTPGVRERLP-AWSPDGksiayFSDASGEYE----LYiaPAD 375

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556  350 KLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGykKEQEID---FFGEISGISFSPD 415
Cdd:COG4946    376 GSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASG--KVRKVDtdgYGDGISDLAWSPD 442
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-427 7.95e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 7.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063741556 354 SVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 427
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 1-65 8.28e-04

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 40.71  E-value: 8.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063741556   1 MSDYNgddlEDEYMADEYDMDDLEDDMNAAFDGRDIDASDSEVEDFDQLNKAADTS----AAQARNGKD 65
Cdd:PRK14157    1 MSDFN----KDDYLNDLPDADDLEAQGQAAQASSGADASAESGEQQDSAAQADANAgadaAPAAAEGEA 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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