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Conserved domains on  [gi|1063741438|ref|NP_001331727|]
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uncharacterized protein AT5G55570 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HypA super family cl46630
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ...
 56-135 1.22e-03

Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.


The actual alignment was detected with superfamily member pfam01155:

Pssm-ID: 460085  Cd Length: 111  Bit Score: 36.35  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741438  56 TTSALSELADTVAETGKSEITW-QIIVGTIAGIIP-------------FVVAGVEFS-KRIIAQKRCEECGGTglVSRDK 120
Cdd:pfam01155   6 AQSIVEIVEEEAKEHGATRVTKvTLEVGELSGVEPealrfafevaakgTLAEGAELEiEEVPARARCRDCGKE--FELEE 83

                          90
                  ....*....|....*
gi 1063741438 121 KYFRCPECGNFDFSL 135
Cdd:pfam01155  84 RDLVCPRCGSPDVEI 98
 
Name Accession Description Interval E-value
HypA pfam01155
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ...
 56-135 1.22e-03

Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.


Pssm-ID: 460085  Cd Length: 111  Bit Score: 36.35  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741438  56 TTSALSELADTVAETGKSEITW-QIIVGTIAGIIP-------------FVVAGVEFS-KRIIAQKRCEECGGTglVSRDK 120
Cdd:pfam01155   6 AQSIVEIVEEEAKEHGATRVTKvTLEVGELSGVEPealrfafevaakgTLAEGAELEiEEVPARARCRDCGKE--FELEE 83

                          90
                  ....*....|....*
gi 1063741438 121 KYFRCPECGNFDFSL 135
Cdd:pfam01155  84 RDLVCPRCGSPDVEI 98
PRK09263 PRK09263
anaerobic ribonucleoside triphosphate reductase; Provisional
 106-132 4.00e-03

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 236436 [Multi-domain]  Cd Length: 711  Bit Score: 36.01  E-value: 4.00e-03
                          10        20
                  ....*....|....*....|....*..
gi 1063741438 106 RCEECGGTGLVSRDKKYFRCPECGNFD 132
Cdd:PRK09263  643 ECYECGFTGEFECTEKGFTCPKCGNHD 669
HybF COG0375
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion ...
 82-135 7.93e-03

Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440144  Cd Length: 113  Bit Score: 33.99  E-value: 7.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063741438  82 GTIAgiipfvvAGVEFS-KRIIAQKRCEECGGTglVSRDKKYFRCPECGNFDFSL 135
Cdd:COG0375    54 GTIA-------EGAELEiEEVPARARCRDCGKE--FELEELFLRCPKCGSPDLEI 99
 
Name Accession Description Interval E-value
HypA pfam01155
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ...
 56-135 1.22e-03

Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.


Pssm-ID: 460085  Cd Length: 111  Bit Score: 36.35  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063741438  56 TTSALSELADTVAETGKSEITW-QIIVGTIAGIIP-------------FVVAGVEFS-KRIIAQKRCEECGGTglVSRDK 120
Cdd:pfam01155   6 AQSIVEIVEEEAKEHGATRVTKvTLEVGELSGVEPealrfafevaakgTLAEGAELEiEEVPARARCRDCGKE--FELEE 83

                          90
                  ....*....|....*
gi 1063741438 121 KYFRCPECGNFDFSL 135
Cdd:pfam01155  84 RDLVCPRCGSPDVEI 98
PRK09263 PRK09263
anaerobic ribonucleoside triphosphate reductase; Provisional
 106-132 4.00e-03

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 236436 [Multi-domain]  Cd Length: 711  Bit Score: 36.01  E-value: 4.00e-03
                          10        20
                  ....*....|....*....|....*..
gi 1063741438 106 RCEECGGTGLVSRDKKYFRCPECGNFD 132
Cdd:PRK09263  643 ECYECGFTGEFECTEKGFTCPKCGNHD 669
HybF COG0375
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion ...
 82-135 7.93e-03

Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440144  Cd Length: 113  Bit Score: 33.99  E-value: 7.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063741438  82 GTIAgiipfvvAGVEFS-KRIIAQKRCEECGGTglVSRDKKYFRCPECGNFDFSL 135
Cdd:COG0375    54 GTIA-------EGAELEiEEVPARARCRDCGKE--FELEELFLRCPKCGSPDLEI 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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