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Conserved domains on  [gi|1063743825|ref|NP_001331659|]
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CYCLIN D3;2 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 95-193 8.72e-53

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 170.96  E-value: 8.72e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  95 CRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPWMSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARYL 174
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 1063743825 175 FEAKTIQRMELLILSTLQW 193
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 198-288 6.99e-28

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 105.47  E-value: 6.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 198 VTPISFFDHIIRRFGSKWHQqLDFCRKCERLLISVIADTRFMRYFPSVLATAIMILVFEELKPCDEVEYQSQITTLLKVN 277
Cdd:cd20544     1 VTPFSFLDYFISKIGLSDSR-EELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                          90
                  ....*....|.
gi 1063743825 278 QEKVNECYELL 288
Cdd:cd20544    80 KEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 95-193 8.72e-53

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 170.96  E-value: 8.72e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  95 CRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPWMSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARYL 174
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 1063743825 175 FEAKTIQRMELLILSTLQW 193
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 198-288 6.99e-28

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 105.47  E-value: 6.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 198 VTPISFFDHIIRRFGSKWHQqLDFCRKCERLLISVIADTRFMRYFPSVLATAIMILVFEELKPCDEVEYQSQITTLLKVN 277
Cdd:cd20544     1 VTPFSFLDYFISKIGLSDSR-EELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                          90
                  ....*....|.
gi 1063743825 278 QEKVNECYELL 288
Cdd:cd20544    80 KEKVKKCYELM 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 67-195 5.05e-26

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 101.44  E-value: 5.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  67 DEILSLISKENETNP---CFGEQilDGFLVSCRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPwmsQL 143
Cdd:pfam00134   1 DIFQYLRELELKYLPkpdYMDQQ--PDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKL---QL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063743825 144 VAVASLSLAAKVEEIQVPLLLDLQVEEARyLFEAKTIQRMELLILSTLQWRM 195
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 101-189 8.96e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.38  E-value: 8.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPwmsQLVAVASLSLAAKVEEIQVPLLLDLQVeeARYlFEAKTI 180
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHY--TGY-FTEEEI 74


                   ....*....
gi 1063743825  181 QRMELLILS 189
Cdd:smart00385  75 LRMERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 198-291 1.56e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 58.02  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 198 VTPISFfdhiIRRFG--SKWHQQLDFCRKCERLLISVIADTRFMRYFPSVLATAIMILVFEELkpcDEVEYQSQITTLLK 275
Cdd:pfam02984   1 PTPLSF----LRRFSkaADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL---NSPEWTETLEHYTG 73

                          90
                  ....*....|....*.
gi 1063743825 276 VNQEKVNECYELLLEH 291
Cdd:pfam02984  74 YSEEDLKPCVKLLLEL 89
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
101-297 1.68e-10

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 62.49  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARyLFEAKTI 180
Cdd:COG5024   218 DWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 181 QRMELLILSTLQWRMHPVTPISFfdhiIRRFgSKWHQQLDFCRKCERLLISV-IADTRFMRYFPSVLATAIMILVFEEL- 258
Cdd:COG5024   294 IRAERYMLEVLDFNISWPSPMSF----LRRI-SKASDYDIFSRTPAKFSSEIsPVDYKFIQISPSWCAAAAMYLSRKILs 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1063743825 259 -KPCDE--VEYQSQITtllkvNQEKVNECYELLLEHNPSKKR 297
Cdd:COG5024   369 qNQWDRtlIHYSGNYT-----NPDLKPLNESNKENLQNPSVH 405
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 95-193 8.72e-53

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 170.96  E-value: 8.72e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  95 CRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPWMSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARYL 174
Cdd:cd20543     1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 1063743825 175 FEAKTIQRMELLILSTLQW 193
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 198-288 6.99e-28

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 105.47  E-value: 6.99e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 198 VTPISFFDHIIRRFGSKWHQqLDFCRKCERLLISVIADTRFMRYFPSVLATAIMILVFEELKPCDEVEYQSQITTLLKVN 277
Cdd:cd20544     1 VTPFSFLDYFISKIGLSDSR-EELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLSPN 79

                          90
                  ....*....|.
gi 1063743825 278 QEKVNECYELL 288
Cdd:cd20544    80 KEKVKKCYELM 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 67-195 5.05e-26

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 101.44  E-value: 5.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  67 DEILSLISKENETNP---CFGEQilDGFLVSCRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPwmsQL 143
Cdd:pfam00134   1 DIFQYLRELELKYLPkpdYMDQQ--PDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKL---QL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063743825 144 VAVASLSLAAKVEEIQVPLLLDLQVEEARyLFEAKTIQRMELLILSTLQWRM 195
Cdd:pfam00134  76 VGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 101-189 8.96e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.38  E-value: 8.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPwmsQLVAVASLSLAAKVEEIQVPLLLDLQVeeARYlFEAKTI 180
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSP---SLIAAAALYLASKTEETPPWTKELVHY--TGY-FTEEEI 74


                   ....*....
gi 1063743825  181 QRMELLILS 189
Cdd:smart00385  75 LRMERLLLE 83
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 94-193 3.17e-11

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 60.46  E-value: 3.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  94 SCRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPllldlQVEEARY 173
Cdd:cd20561    35 SMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK---LQLVGTAAMLLASKFEEIYPP-----EVAEFVY 106

                          90       100
                  ....*....|....*....|....
gi 1063743825 174 L----FEAKTIQRMELLILSTLQW 193
Cdd:cd20561   107 ItddtYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 100-193 4.68e-11

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 60.02  E-value: 4.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSiklQTDKP-WMSQLVAVASLSLAAKVEEIQVPllldlQVEEARYL---- 174
Cdd:cd20519    41 LDWLMEVCEVYRLHRETFYLAVDFVDRYLST---QTNVPkTQLQLIGITCLFIAAKLEEIYPP-----KLSEFAYVtdga 112

                          90
                  ....*....|....*....
gi 1063743825 175 FEAKTIQRMELLILSTLQW 193
Cdd:cd20519   113 CTEDEILTMELIILKALNW 131
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 96-193 5.12e-11

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 59.15  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  96 RKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQ--VPLLLDLQVEEARY 173
Cdd:cd20528     7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELDdnIPKISDLNRYLCNS 83

                          90       100
                  ....*....|....*....|
gi 1063743825 174 LFEAKTIQRMELLILSTLQW 193
Cdd:cd20528    84 VYSKQEYLQMELLILEFFQW 103
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 198-291 1.56e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 58.02  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 198 VTPISFfdhiIRRFG--SKWHQQLDFCRKCERLLISVIADTRFMRYFPSVLATAIMILVFEELkpcDEVEYQSQITTLLK 275
Cdd:pfam02984   1 PTPLSF----LRRFSkaADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTL---NSPEWTETLEHYTG 73

                          90
                  ....*....|....*.
gi 1063743825 276 VNQEKVNECYELLLEH 291
Cdd:pfam02984  74 YSEEDLKPCVKLLLEL 89
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
101-297 1.68e-10

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 62.49  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARyLFEAKTI 180
Cdd:COG5024   218 DWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AFTRDDI 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 181 QRMELLILSTLQWRMHPVTPISFfdhiIRRFgSKWHQQLDFCRKCERLLISV-IADTRFMRYFPSVLATAIMILVFEEL- 258
Cdd:COG5024   294 IRAERYMLEVLDFNISWPSPMSF----LRRI-SKASDYDIFSRTPAKFSSEIsPVDYKFIQISPSWCAAAAMYLSRKILs 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1063743825 259 -KPCDE--VEYQSQITtllkvNQEKVNECYELLLEHNPSKKR 297
Cdd:COG5024   369 qNQWDRtlIHYSGNYT-----NPDLKPLNESNKENLQNPSVH 405
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 100-191 1.78e-10

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 58.41  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPllldlQVEEARYL----F 175
Cdd:cd20504    39 VDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSK---LQLVGTACMFIAAKYEEIYPP-----EVEEFVYItddtY 110

                          90
                  ....*....|....*.
gi 1063743825 176 EAKTIQRMELLILSTL 191
Cdd:cd20504   111 TKKQVLRMEHLVLKVL 126
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 95-193 1.48e-09

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 54.63  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  95 CRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQtdkPWMSQLVAVASLSLAAKV--EEIQVPLLLDLqVEEAR 172
Cdd:cd20526     1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKAR---PKYLRCIAISCLFLAAKTneEDEVIPSTKDL-VRVSK 76

                          90       100
                  ....*....|....*....|.
gi 1063743825 173 YLFEAKTIQRMELLILSTLQW 193
Cdd:cd20526    77 CGCSVAEVLRMERIILDKLHW 97
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 100-192 5.71e-09

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 54.07  E-value: 5.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPLLLDLqVEEARYLFEAKT 179
Cdd:cd20507    41 VDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKK---LQLVGVTALLIASKYEEIYPPEIKDF-VYITDNAYTREE 116

                          90
                  ....*....|...
gi 1063743825 180 IQRMELLILSTLQ 192
Cdd:cd20507   117 ILQMERDILKTLD 129
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 100-193 9.43e-09

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 53.70  E-value: 9.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKlQTDKPwMSQLVAVASLSLAAKVEEIQVPllldlQVEEARYLFEA-- 177
Cdd:cd20580    47 LDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQK-NINKS-MLQLIGITSLFIASKLEEIYPP-----KLHEFAYVTDGac 119

                          90
                  ....*....|....*...
gi 1063743825 178 --KTIQRMELLILSTLQW 193
Cdd:cd20580   120 seDDILDMELIILKALKW 137
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 101-193 1.30e-08

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 53.07  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPLLLDLqVEEARYLFEAKTI 180
Cdd:cd20568    46 DWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK---LQLVGISALFIASKYEEVNSPSIKNF-AYMTDGAYTVEDI 121

                          90
                  ....*....|...
gi 1063743825 181 QRMELLILSTLQW 193
Cdd:cd20568   122 LRAERYMLNTLEF 134
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 101-195 2.70e-08

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 51.17  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 101 DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPllldlQVEEARYL----FE 176
Cdd:cd20542     6 DWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSL---LQLLGITCLFIACKFEERFPP-----EVATLCYLtddsYS 77

                          90
                  ....*....|....*....
gi 1063743825 177 AKTIQRMELLILSTLQWRM 195
Cdd:cd20542    78 KKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 100-191 4.09e-08

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 52.54  E-value: 4.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPllldlQVEEARYL----F 175
Cdd:cd20560    73 VDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK---LQLVGTAAILLASKYEEIYPP-----EVDEFVYItddtY 144

                          90
                  ....*....|....*.
gi 1063743825 176 EAKTIQRMELLILSTL 191
Cdd:cd20560   145 TKKQLLRMEHLLLKVL 160
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 100-193 8.12e-08

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 51.19  E-value: 8.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMtSIKLQTDKPWmsQLVAVASLSLAAKVEEIQVPLLLDLqVEEARYLFEAKT 179
Cdd:cd20567    58 IDWLIEVHLKFELMPETLYLTVNLIDRFL-SVKQVPRKEL--QLVGVTAMLIASKYEEIWAPEVNDF-VYISDNAYTRKQ 133

                          90
                  ....*....|....
gi 1063743825 180 IQRMELLILSTLQW 193
Cdd:cd20567   134 ILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 81-194 2.26e-07

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 49.72  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  81 PCFGEQILDGFLVSCRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQV 160
Cdd:cd20562    27 PDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQR---LQLLGVSCMLIASKYEEICA 103

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1063743825 161 PllldlQVEEARYL----FEAKTIQRMELLILSTLQWR 194
Cdd:cd20562   104 P-----QVEEFCYItdntYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 100-191 7.12e-07

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 46.94  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEIQVPLLLDLQVEEARyLFEAKT 179
Cdd:cd20536     6 ISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC---FQLLGVTSLLIACKQEEIYPPEVKDLLALCCG-AYTREQ 81

                          90
                  ....*....|..
gi 1063743825 180 IQRMELLILSTL 191
Cdd:cd20536    82 ICNLECIILTKL 93
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 98-162 9.92e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 46.25  E-value: 9.92e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063743825  98 EALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKPwmsQLVAVASLSLAAKVEEIQVPL 162
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSP---ELIAAACLYLACKLEELPRTL 62
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 100-193 1.47e-06

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 47.18  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 100 LDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIK--LQTdkpwMSQLVAVASLSLAAKVEEIQVPllldlQVEEARYLFEA 177
Cdd:cd20579    47 LDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnvVKT----RLQLIGISSLFIAAKLEEIYPP-----KLHQFAYVTDG 117

                          90       100
                  ....*....|....*....|
gi 1063743825 178 ----KTIQRMELLILSTLQW 193
Cdd:cd20579   118 acteDEILSMELIIMKALKW 137
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 103-194 2.44e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 45.58  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 103 VLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQtdkPWMSQLVAVASLSLAAKV--EEIQVPLLLDLqVEEARYLFEAKTI 180
Cdd:cd20583     9 LLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQ---PKHLGCVGLSCFYLAVKAieEERNVPLATDL-IRISQYRFTVSDM 84

                          90
                  ....*....|....
gi 1063743825 181 QRMELLILSTLQWR 194
Cdd:cd20583    85 MRMEKIILEKLCWK 98
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 80-193 8.24e-06

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 45.24  E-value: 8.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  80 NPCFgeqiLDGFLVSCRKEAL--DWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEE 157
Cdd:cd20566    26 RPHY----LDGKEINERMRAIlvDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK---LQLVGVTALLLASKYEE 98

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063743825 158 IQVPLLLDLqVEEARYLFEAKTIQRMELLILSTLQW 193
Cdd:cd20566    99 MYSPEIGDF-VYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 119-193 1.15e-05

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 44.98  E-value: 1.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063743825 119 LAVNYFDRFMTSIKLQTDKpwmSQLVAVASLSLAAKVEEiQVPLLLDLQVEEARYLFEAKTIQRMELLILSTLQW 193
Cdd:cd20515    79 LAVNYLDRFLSLVPIRKSQ---LQLLGAVCLFLASKLKE-TIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 199-290 7.91e-05

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 41.44  E-value: 7.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 199 TPISFFDHIIRRFGSKWhQQLDFCRKCERLLISVIA-DTRFMRYFPSVLATAIMILVFEELKPCDEVEYQ---SQITTLL 274
Cdd:cd20516     1 TPLDFLEHILHRLPLDS-EDVDKVRKHAETFIALCAtDYKFSSYPPSMIAAASILAALRGLLLHSGNSKEdllEKLQQLT 79

                          90
                  ....*....|....*.
gi 1063743825 275 KVNQEKVNECYELLLE 290
Cdd:cd20516    80 RIDEDLLRACQEQIED 95
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 110-191 1.83e-04

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 40.22  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825 110 YGFTSLTAILAVNYFDRFMTSIKLqtdKPWMSQLVAVASLSLAAKV--EEIQVPLLLDLqVEEARYLFEAKTIQRMELLI 187
Cdd:cd20584    16 FGFSTETFVLAVNILDRFLALMKV---KPKHLSCIGICCFHLAARVveEECNIPSSHDL-IRISQCKCTVSDLKRMEKII 91


                  ....
gi 1063743825 188 LSTL 191
Cdd:cd20584    92 SEKL 95
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 96-191 2.08e-04

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 40.03  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  96 RKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMTSIKLqtdKPWMSQLVAVASLSLAAKV--EEIQVPLLLDLqVEEARY 173
Cdd:cd20523     1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKV---KPKHLACITVSCFHIAIKSveEDQNIPSAEDL-IRISQC 76

                          90
                  ....*....|....*...
gi 1063743825 174 LFEAKTIQRMELLILSTL 191
Cdd:cd20523    77 GCTAADLMRMEGIILEKL 94
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 66-193 1.24e-03

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 39.19  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743825  66 DDEILSLISKENETNP-------CFGEQILDgflvSCRKEALDWVLRVKSHYGFTSLTAILAVNYFDRFMtSIKLqTDKP 138
Cdd:cd20573    22 NDRVLQTMLKAEETCLpsvsyfkCVQKEILP----SMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFL-SVEP-TKKS 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063743825 139 WMsQLVAVASLSLAAKVEEiQVPLLLDLQVEEARYLFEAKTIQRMELLILSTLQW 193
Cdd:cd20573    96 RL-QLLGATCMFLASKMKE-TIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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