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Conserved domains on  [gi|1063730230|ref|NP_001331517|]
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TRICHOME BIREFRINGENCE-LIKE 9 [Arabidopsis thaliana]

Protein Classification

trichome birefringence-like family protein( domain architecture ID 10627628)

trichome birefringence-like (TBL) family protein belongs to the SGNH/GDSL hydrolase superfamily of hydrolytic enzymes

CATH:  3.40.50.1110
PubMed:  20657172|35871440|15522763
SCOP:  3001315

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 120-308 7.11e-82

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


:

Pssm-ID: 463996  Cd Length: 281  Bit Score: 249.03  E-value: 7.11e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 120 LPRFNASDLLERSRNGRIVFVGDSIGRNQWESLMCMLSQAIPNKSEIYevngnPITKHKGFLSMRFPRENLTVEYHRSPF 199
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 200 LVVIGRPPDKSPKeIKTTVRVDEFNW-QSKRWVGSDVLVFNSGHWWNEDK-TVLTGCYFEEGRKVNKTMGVMEAFGKSLK 277
Cdd:pfam13839  76 LVDSVEDPNGPGK-GKRVLHLDSIDErWASQWKGADVLVFNTGHWWLRPKiYYEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063730230 278 TWKSWVLEKLDPDKSYVFFRSYSPVHYRLGQ 308
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFEGGE 185
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 61-119 8.09e-22

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


:

Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 86.39  E-value: 8.09e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063730230  61 ECDYSKGKWVRRASSSSssvngLFYGEECRFLDSGFRCHKHGRKDSGYLDWRWQPHGCD 119
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYP-----LYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 120-308 7.11e-82

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 249.03  E-value: 7.11e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 120 LPRFNASDLLERSRNGRIVFVGDSIGRNQWESLMCMLSQAIPNKSEIYevngnPITKHKGFLSMRFPRENLTVEYHRSPF 199
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 200 LVVIGRPPDKSPKeIKTTVRVDEFNW-QSKRWVGSDVLVFNSGHWWNEDK-TVLTGCYFEEGRKVNKTMGVMEAFGKSLK 277
Cdd:pfam13839  76 LVDSVEDPNGPGK-GKRVLHLDSIDErWASQWKGADVLVFNTGHWWLRPKiYYEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063730230 278 TWKSWVLEKLDPDKSYVFFRSYSPVHYRLGQ 308
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFEGGE 185
PLN02629 PLN02629
powdery mildew resistance 5
 62-304 3.10e-52

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 176.25  E-value: 3.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230  62 CDYSKGKWVRRASSSsssvngLFYGEEC-RFLDSGFRCHKHGRKDSGYLDWRWQPHGCDLPRFNASDLLERSRNGRIVFV 140
Cdd:PLN02629   53 CALFVGTWVRDDSYP------LYQSSDCpGVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGKTVMFV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 141 GDSIGRNQWESLMCMLSQAIPNKSeiyevngNPITKHKGFLSMRFPRENLTVEYHRSPFLVvigrppDKSPKEIKTTVRV 220
Cdd:PLN02629  127 GDSLGRNQWESLICLISSSVPSTR-------TQMSRGDPLSTFKFLDYGVSISFYKAPYLV------DIDAVQGKRVLKL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 221 DEFNWQSKRWVGSDVLVFNSGHWWNEDKTVLTGCYFEEGRKVNKTMGVMEAFGKSLKTWKSWVLEKLDPDKSYVFFRSYS 300
Cdd:PLN02629  194 EEISGNANAWRDADVLIFNTGHWWSHQGSLQGWDYIESGGTYYQDMDRLVALEKALRTWAYWVDTNVDRSRTRVFFQSIS 273


                  ....
gi 1063730230 301 PVHY 304
Cdd:PLN02629  274 PTHY 277
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 61-119 8.09e-22

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 86.39  E-value: 8.09e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063730230  61 ECDYSKGKWVRRASSSSssvngLFYGEECRFLDSGFRCHKHGRKDSGYLDWRWQPHGCD 119
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYP-----LYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
beta-trefoil_FSCN2_rpt1 cd23345
first fascin-like domain, beta-trefoil fold, found in fascin-2 and similar proteins; Fascin-2, ...
 245-299 7.77e-03

first fascin-like domain, beta-trefoil fold, found in fascin-2 and similar proteins; Fascin-2, also called retinal fascin, is a photoreceptor-specific paralog of the actin-bundling protein fascin. It may play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Fascin-2 is composed of four fascin beta-trefoil domains, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The model corresponds to the first fascin-like beta-trefoil domain.


Pssm-ID: 467453 [Multi-domain]  Cd Length: 130  Bit Score: 35.95  E-value: 7.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063730230 245 NEDKTVLTGCYFeeGRKVNktmgvmeAFGKSLKTWKSWVLEKLDPDKSYVFFRSY 299
Cdd:cd23345    12 NCENRYLTAEAF--GFKVN-------ASAPSLKKKQIWTLEQDEGDSSVVFLKSH 57
 
Name Accession Description Interval E-value
PC-Esterase pfam13839
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is ...
 120-308 7.11e-82

GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p; The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.


Pssm-ID: 463996  Cd Length: 281  Bit Score: 249.03  E-value: 7.11e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 120 LPRFNASDLLERSRNGRIVFVGDSIGRNQWESLMCMLSQAIPNKSEIYevngnPITKHKGFLSMRFPRENLTVEYHRSPF 199
Cdd:pfam13839   1 LPRFDAAEFLERLRGKRIAFVGDSLARNQWESLLCLLSSAVEDPKSVY-----KITKDRGFRRFRFPDYNFTVEFYWSPF 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 200 LVVIGRPPDKSPKeIKTTVRVDEFNW-QSKRWVGSDVLVFNSGHWWNEDK-TVLTGCYFEEGRKVNKTMGVMEAFGKSLK 277
Cdd:pfam13839  76 LVDSVEDPNGPGK-GKRVLHLDSIDErWASQWKGADVLVFNTGHWWLRPKiYYEGGDYFGCGGKNYTDMDRLDAYRKALR 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063730230 278 TWKSWVLEKLDPDKSYVFFRSYSPVHYRLGQ 308
Cdd:pfam13839 155 TWARWVDSNLDPSKTRVFFRTFSPSHFEGGE 185
PLN02629 PLN02629
powdery mildew resistance 5
 62-304 3.10e-52

powdery mildew resistance 5


Pssm-ID: 215338 [Multi-domain]  Cd Length: 387  Bit Score: 176.25  E-value: 3.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230  62 CDYSKGKWVRRASSSsssvngLFYGEEC-RFLDSGFRCHKHGRKDSGYLDWRWQPHGCDLPRFNASDLLERSRNGRIVFV 140
Cdd:PLN02629   53 CALFVGTWVRDDSYP------LYQSSDCpGVIDPEFNCQMYGRPDSDYLKYRWQPLNCELPRFNGLEFLLKMKGKTVMFV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 141 GDSIGRNQWESLMCMLSQAIPNKSeiyevngNPITKHKGFLSMRFPRENLTVEYHRSPFLVvigrppDKSPKEIKTTVRV 220
Cdd:PLN02629  127 GDSLGRNQWESLICLISSSVPSTR-------TQMSRGDPLSTFKFLDYGVSISFYKAPYLV------DIDAVQGKRVLKL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730230 221 DEFNWQSKRWVGSDVLVFNSGHWWNEDKTVLTGCYFEEGRKVNKTMGVMEAFGKSLKTWKSWVLEKLDPDKSYVFFRSYS 300
Cdd:PLN02629  194 EEISGNANAWRDADVLIFNTGHWWSHQGSLQGWDYIESGGTYYQDMDRLVALEKALRTWAYWVDTNVDRSRTRVFFQSIS 273


                  ....
gi 1063730230 301 PVHY 304
Cdd:PLN02629  274 PTHY 277
PMR5N pfam14416
PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich ...
 61-119 8.09e-22

PMR5 N terminal Domain; The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain.


Pssm-ID: 464168 [Multi-domain]  Cd Length: 54  Bit Score: 86.39  E-value: 8.09e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063730230  61 ECDYSKGKWVRRASSSSssvngLFYGEECRFLDSGFRCHKHGRKDSGYLDWRWQPHGCD 119
Cdd:pfam14416   1 ECDLFDGRWVYDEDSYP-----LYTNSSCPFIDDQFNCQKNGRPDSDYLKWRWQPDGCD 54
beta-trefoil_FSCN2_rpt1 cd23345
first fascin-like domain, beta-trefoil fold, found in fascin-2 and similar proteins; Fascin-2, ...
 245-299 7.77e-03

first fascin-like domain, beta-trefoil fold, found in fascin-2 and similar proteins; Fascin-2, also called retinal fascin, is a photoreceptor-specific paralog of the actin-bundling protein fascin. It may play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Fascin-2 is composed of four fascin beta-trefoil domains, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The model corresponds to the first fascin-like beta-trefoil domain.


Pssm-ID: 467453 [Multi-domain]  Cd Length: 130  Bit Score: 35.95  E-value: 7.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063730230 245 NEDKTVLTGCYFeeGRKVNktmgvmeAFGKSLKTWKSWVLEKLDPDKSYVFFRSY 299
Cdd:cd23345    12 NCENRYLTAEAF--GFKVN-------ASAPSLKKKQIWTLEQDEGDSSVVFLKSH 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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