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Conserved domains on  [gi|1063730528|ref|NP_001331192|]
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glycine/proline-rich protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
564-1222 7.28e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 7.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  564 WEIP-PPGklPPDASPLG---IGSFGVGPPG----------ASPFIASPSGEGPLSEGLLGIRSFGISPLSIRPlgISPL 629
Cdd:PHA03247  2412 WEQPdPPG--PPDVRFVGseeIEELPFVSPGgdvlaglaadGDPFFARTILGAPFSLSLLLGELFPGAPVYRRP--AEAR 2487
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  630 GISPPNIEPSKADASDADPSNAGPLGISPLSI--DPPVAG----------------ASDE--GPLGKLPPDLSPPGKGSS 689
Cdd:PHA03247  2488 FPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAIlpDEPVGEpvhprmltwirgleelASDDagDPPPPLPPAAPPAAPDRS 2567
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  690 gegplvESPPSEGPLGVDPlGAGSLGISPlGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAeGSPDVGIF 769
Cdd:PHA03247  2568 ------VPPPRPAPRPSEP-AVTSRARRP-DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-PSPAANEP 2638
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  770 GISPPIIDPPVEGASDGDPPEKLSLD--ISPLGKGPSGVSLLG-----AGPPGVGPVIAS----PPGEGPRDAGPLGAGS 838
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPrrARRLGRAAQASSPPQrprrrAARPTVGSLTSLadppPPPPTPEPAPHALVSA 2718
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  839 LGISPLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPpdVGPFGISPPIiDPPGEDASDGDPPGKFPLDISp 918
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT--AGPPAPAPPA-APAAGPPRRLTRPAVASLSES- 2794
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  919 LGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAGPLGAGSLGISPlnirrlgisPFGISPPNIDLPVAGTSI-GGPLDEG 997
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP---------PPPPGPPPPSLPLGGSVApGGDVRRR 2865
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  998 ASDGGPPDV--GPFGI------SPSIIDPPGEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAGPPGDGPVIASPPGESPL 1069
Cdd:PHA03247  2866 PPSRSPAAKpaAPARPpvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1070 DAGPLGAGS-LGISPF----GISPPNIDWPVAGTSFGGPPGEGASNGGPlvvGPFDMPVVGASDGDAleKLPLDIslpgk 1144
Cdd:PHA03247  2946 TTDPAGAGEpSGAVPQpwlgALVPGRVAVPRFRVPQPAPSREAPASSTP---PLTGHSLSRVSSWAS--SLALHE----- 3015
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063730528 1145 gpsDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPP 1222
Cdd:PHA03247  3016 ---ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPP 3090
CytochromB561_N super family cl46356
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
1230-1346 2.37e-03

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


The actual alignment was detected with superfamily member pfam09786:

Pssm-ID: 480696  Cd Length: 579  Bit Score: 42.12  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1230 DPLCASP-----LGIDPPIVDASDGDPFG-------AGSPDEDPSNENASGEGASGESPPCSDvscKGPSSAGASIGcSL 1297
Cdd:pfam09786  100 TPSRLTNqqlglLGLKPNDSSFVTTHRKKppkskssPQSPSPVLVPLHQSVSPSSSESRKGGD---KSPAGSGKKLR-SF 175
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730528 1298 DNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAALVTLPSGKDPFDISP 1346
Cdd:pfam09786  176 STSSKSPASPSVYLRGSPVPLNSSPLPSDRNYENSVQSSPEIDSAVSTP 224
COG4625 super family cl34793
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
59-373 9.71e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


The actual alignment was detected with superfamily member COG4625:

Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 40.53  E-value: 9.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528   59 DTGFDVRFAAGFAADLTIGFTIGFDSGFATFLDVGLDDGFATGLDISFAGGFVTGFATDFDVGFDTGFTIGFDTGFDVGL 138
Cdd:COG4625    213 GAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGG 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  139 PAVFSIGFDTGFAVGFAISFTVGFDAGFPTGFFVSLDVGFVADFVIGFATGIGVGFEVDFATDFDTCFATGFAVSFDVGF 218
Cdd:COG4625    293 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGG 372
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  219 AGGFSIGFAADFANGFTVGFDGGFDASFFVGLDVGFVVGFVTSFAAGLDVGFAIDFATGFDTGFAFGLAFGFDVGFAAGF 298
Cdd:COG4625    373 GGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGG 452
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063730528  299 AVGFATGFTVVFDVGFASDFFVGLDVGFLTGFATDFDIGFVVDFDIGFATGFVVGFDDGSIVGLVVGLPASLDDG 373
Cdd:COG4625    453 GGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNYTQSAGSTLAVEVDAANSDRLVVTGTATLNGG 527
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
564-1222 7.28e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 7.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  564 WEIP-PPGklPPDASPLG---IGSFGVGPPG----------ASPFIASPSGEGPLSEGLLGIRSFGISPLSIRPlgISPL 629
Cdd:PHA03247  2412 WEQPdPPG--PPDVRFVGseeIEELPFVSPGgdvlaglaadGDPFFARTILGAPFSLSLLLGELFPGAPVYRRP--AEAR 2487
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  630 GISPPNIEPSKADASDADPSNAGPLGISPLSI--DPPVAG----------------ASDE--GPLGKLPPDLSPPGKGSS 689
Cdd:PHA03247  2488 FPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAIlpDEPVGEpvhprmltwirgleelASDDagDPPPPLPPAAPPAAPDRS 2567
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  690 gegplvESPPSEGPLGVDPlGAGSLGISPlGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAeGSPDVGIF 769
Cdd:PHA03247  2568 ------VPPPRPAPRPSEP-AVTSRARRP-DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-PSPAANEP 2638
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  770 GISPPIIDPPVEGASDGDPPEKLSLD--ISPLGKGPSGVSLLG-----AGPPGVGPVIAS----PPGEGPRDAGPLGAGS 838
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPrrARRLGRAAQASSPPQrprrrAARPTVGSLTSLadppPPPPTPEPAPHALVSA 2718
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  839 LGISPLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPpdVGPFGISPPIiDPPGEDASDGDPPGKFPLDISp 918
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT--AGPPAPAPPA-APAAGPPRRLTRPAVASLSES- 2794
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  919 LGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAGPLGAGSLGISPlnirrlgisPFGISPPNIDLPVAGTSI-GGPLDEG 997
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP---------PPPPGPPPPSLPLGGSVApGGDVRRR 2865
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  998 ASDGGPPDV--GPFGI------SPSIIDPPGEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAGPPGDGPVIASPPGESPL 1069
Cdd:PHA03247  2866 PPSRSPAAKpaAPARPpvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1070 DAGPLGAGS-LGISPF----GISPPNIDWPVAGTSFGGPPGEGASNGGPlvvGPFDMPVVGASDGDAleKLPLDIslpgk 1144
Cdd:PHA03247  2946 TTDPAGAGEpSGAVPQpwlgALVPGRVAVPRFRVPQPAPSREAPASSTP---PLTGHSLSRVSSWAS--SLALHE----- 3015
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063730528 1145 gpsDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPP 1222
Cdd:PHA03247  3016 ---ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPP 3090
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
738-1169 6.42e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 6.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  738 PSNIDPS--SALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLlgagPPG 815
Cdd:pfam03154  134 PKDIDQDnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV----PPQ 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  816 VGPVIASPPGEGPRDAGPLGAGSLGISpLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPPDVGPFGISPPI 895
Cdd:pfam03154  210 GSPATSQPPNQTQSTAAPHTLIQQTPT-LHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  896 IDPPGedasdgdPPGKFPLDiSPLGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAG-PLGAGSLGISPLNIRRlgISPf 974
Cdd:pfam03154  289 MQHPV-------PPQPFPLT-PQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQqPPREQPLPPAPLSMPH--IKP- 357
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  975 gisPPNIDLPvagtsiggPLDEGASDGGPPDV---GPFGISPSIidPPgegafdgdPPGKLPLDISPVGKGPSgvsppga 1051
Cdd:pfam03154  358 ---PPTTPIP--------QLPNPQSHKHPPHLsgpSPFQMNSNL--PP--------PPALKPLSSLSTHHPPS------- 409
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1052 gppgdgpviASPP------GESPLDAGPLGAGSLGISPfGISPPNIDWPVAGTSFGGP-----PGEGASNGGPLVVGPFD 1120
Cdd:pfam03154  410 ---------AHPPplqlmpQSQQLPPPPAQPPVLTQSQ-SLPPPAASHPPTSGLHQVPsqspfPQHPFVPGGPPPITPPS 479
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730528 1121 MPVVGASDgdaleklpldiSLPGKGPSDVGPPGAGLPGAAPPGVDLSNV 1169
Cdd:pfam03154  480 GPPTSTSS-----------AMPGIQPPSSASVSSSGPVPAAVSCPLPPV 517
CytochromB561_N pfam09786
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
1230-1346 2.37e-03

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


Pssm-ID: 462899  Cd Length: 579  Bit Score: 42.12  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1230 DPLCASP-----LGIDPPIVDASDGDPFG-------AGSPDEDPSNENASGEGASGESPPCSDvscKGPSSAGASIGcSL 1297
Cdd:pfam09786  100 TPSRLTNqqlglLGLKPNDSSFVTTHRKKppkskssPQSPSPVLVPLHQSVSPSSSESRKGGD---KSPAGSGKKLR-SF 175
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730528 1298 DNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAALVTLPSGKDPFDISP 1346
Cdd:pfam09786  176 STSSKSPASPSVYLRGSPVPLNSSPLPSDRNYENSVQSSPEIDSAVSTP 224
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
59-373 9.71e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 40.53  E-value: 9.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528   59 DTGFDVRFAAGFAADLTIGFTIGFDSGFATFLDVGLDDGFATGLDISFAGGFVTGFATDFDVGFDTGFTIGFDTGFDVGL 138
Cdd:COG4625    213 GAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGG 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  139 PAVFSIGFDTGFAVGFAISFTVGFDAGFPTGFFVSLDVGFVADFVIGFATGIGVGFEVDFATDFDTCFATGFAVSFDVGF 218
Cdd:COG4625    293 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGG 372
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  219 AGGFSIGFAADFANGFTVGFDGGFDASFFVGLDVGFVVGFVTSFAAGLDVGFAIDFATGFDTGFAFGLAFGFDVGFAAGF 298
Cdd:COG4625    373 GGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGG 452
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063730528  299 AVGFATGFTVVFDVGFASDFFVGLDVGFLTGFATDFDIGFVVDFDIGFATGFVVGFDDGSIVGLVVGLPASLDDG 373
Cdd:COG4625    453 GGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNYTQSAGSTLAVEVDAANSDRLVVTGTATLNGG 527
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
564-1222 7.28e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 7.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  564 WEIP-PPGklPPDASPLG---IGSFGVGPPG----------ASPFIASPSGEGPLSEGLLGIRSFGISPLSIRPlgISPL 629
Cdd:PHA03247  2412 WEQPdPPG--PPDVRFVGseeIEELPFVSPGgdvlaglaadGDPFFARTILGAPFSLSLLLGELFPGAPVYRRP--AEAR 2487
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  630 GISPPNIEPSKADASDADPSNAGPLGISPLSI--DPPVAG----------------ASDE--GPLGKLPPDLSPPGKGSS 689
Cdd:PHA03247  2488 FPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAIlpDEPVGEpvhprmltwirgleelASDDagDPPPPLPPAAPPAAPDRS 2567
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  690 gegplvESPPSEGPLGVDPlGAGSLGISPlGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAeGSPDVGIF 769
Cdd:PHA03247  2568 ------VPPPRPAPRPSEP-AVTSRARRP-DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-PSPAANEP 2638
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  770 GISPPIIDPPVEGASDGDPPEKLSLD--ISPLGKGPSGVSLLG-----AGPPGVGPVIAS----PPGEGPRDAGPLGAGS 838
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPrrARRLGRAAQASSPPQrprrrAARPTVGSLTSLadppPPPPTPEPAPHALVSA 2718
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  839 LGISPLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPpdVGPFGISPPIiDPPGEDASDGDPPGKFPLDISp 918
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT--AGPPAPAPPA-APAAGPPRRLTRPAVASLSES- 2794
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  919 LGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAGPLGAGSLGISPlnirrlgisPFGISPPNIDLPVAGTSI-GGPLDEG 997
Cdd:PHA03247  2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP---------PPPPGPPPPSLPLGGSVApGGDVRRR 2865
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  998 ASDGGPPDV--GPFGI------SPSIIDPPGEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAGPPGDGPVIASPPGESPL 1069
Cdd:PHA03247  2866 PPSRSPAAKpaAPARPpvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1070 DAGPLGAGS-LGISPF----GISPPNIDWPVAGTSFGGPPGEGASNGGPlvvGPFDMPVVGASDGDAleKLPLDIslpgk 1144
Cdd:PHA03247  2946 TTDPAGAGEpSGAVPQpwlgALVPGRVAVPRFRVPQPAPSREAPASSTP---PLTGHSLSRVSSWAS--SLALHE----- 3015
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063730528 1145 gpsDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPP 1222
Cdd:PHA03247  3016 ---ETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPP 3090
PHA03377 PHA03377
EBNA-3C; Provisional
632-763 3.27e-07

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 55.06  E-value: 3.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  632 SPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDPlga 711
Cdd:PHA03377   551 TPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAP--- 627
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1063730528  712 gslgisPLGKSPLRIRPLGiSPFGKIPSNIDPSSALASDGGPPDEPASAEGS 763
Cdd:PHA03377   628 ------SVVRMFLRERLLE-QSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQP 672
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
629-1008 4.37e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.79  E-value: 4.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  629 LGISPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDP 708
Cdd:PHA03307    44 VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP 123
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  709 LGAGSLGISPLGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPV----EGAS 784
Cdd:PHA03307   124 ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPstppAAAS 203
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  785 DGDPPEKLSLDISPLGKGPSG----VSLLGAGPPGVGPVIASPPGEGPRDAGPLGAGSLGISPLNIRRLGISPSGISPPN 860
Cdd:PHA03307   204 PRPPRRSSPISASASSPAPAPgrsaADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  861 IDLPVAGTSI-GGPPDEGASDGGPPDVGPFGISPPIIDPPGEDAS---DGDPPGKFPLDISPLGkCPSGVSPLGVGPPGV 936
Cdd:PHA03307   284 PASSSSSPRErSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSStssSSESSRGAAVSPGPSP-SRSPSPSRPPPPADP 362
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  937 GPVIASPPGEGPLDAGPLGAGSLGI-------SPLNIRRLGISPFGIS-PPNIDLPVAGTSIGGPLDE--GASDGGP-PD 1005
Cdd:PHA03307   363 SSPRKRPRPSRAPSSPAASAGRPTRrraraavAGRARRRDATGRFPAGrPRPSPLDAGAASGAFYARYplLTPSGEPwPG 442

                   ...
gi 1063730528 1006 VGP 1008
Cdd:PHA03307   443 SPP 445
PHA03377 PHA03377
EBNA-3C; Provisional
733-833 1.17e-06

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 53.13  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  733 PFGKIPSNIDPSSALASDGGPPDEPASAEGSPDVGifgisPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLLGAG 812
Cdd:PHA03377   532 PHRKVQDGFQRSGRRQKRATPPKVSPSDRGPPKAS-----PPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDG 606
                           90       100
                   ....*....|....*....|.
gi 1063730528  813 PPGVGPVIASPPGEGPRDAGP 833
Cdd:PHA03377   607 PPASGPHEKQPPSSAPRDMAP 627
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
738-1169 6.42e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 6.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  738 PSNIDPS--SALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLlgagPPG 815
Cdd:pfam03154  134 PKDIDQDnrSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV----PPQ 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  816 VGPVIASPPGEGPRDAGPLGAGSLGISpLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPPDVGPFGISPPI 895
Cdd:pfam03154  210 GSPATSQPPNQTQSTAAPHTLIQQTPT-LHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH 288
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  896 IDPPGedasdgdPPGKFPLDiSPLGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAG-PLGAGSLGISPLNIRRlgISPf 974
Cdd:pfam03154  289 MQHPV-------PPQPFPLT-PQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQqPPREQPLPPAPLSMPH--IKP- 357
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  975 gisPPNIDLPvagtsiggPLDEGASDGGPPDV---GPFGISPSIidPPgegafdgdPPGKLPLDISPVGKGPSgvsppga 1051
Cdd:pfam03154  358 ---PPTTPIP--------QLPNPQSHKHPPHLsgpSPFQMNSNL--PP--------PPALKPLSSLSTHHPPS------- 409
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1052 gppgdgpviASPP------GESPLDAGPLGAGSLGISPfGISPPNIDWPVAGTSFGGP-----PGEGASNGGPLVVGPFD 1120
Cdd:pfam03154  410 ---------AHPPplqlmpQSQQLPPPPAQPPVLTQSQ-SLPPPAASHPPTSGLHQVPsqspfPQHPFVPGGPPPITPPS 479
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730528 1121 MPVVGASDgdaleklpldiSLPGKGPSDVGPPGAGLPGAAPPGVDLSNV 1169
Cdd:pfam03154  480 GPPTSTSS-----------AMPGIQPPSSASVSSSGPVPAAVSCPLPPV 517
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
568-911 8.99e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 8.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  568 PPGKLPPDASPLGIGSFGVGPPGASPFIASPSGEGPLSEGLLGIRSFG----ISPLSIRPLGiSPLGISPPNIEPSKADA 643
Cdd:PHA03307   126 PPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAlplsSPEETARAPS-SPPAEPPPSTPPAAASP 204
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  644 SDADPsnaGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDP--LGAGSLGISPLGK 721
Cdd:PHA03307   205 RPPRR---SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPtrIWEASGWNGPSSR 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  722 SPLRIRPLGISPFGKIPSNIDPSS--------ALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPVEGASDGDPPEklS 793
Cdd:PHA03307   282 PGPASSSSSPRERSPSPSPSSPGSgpapssprASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP--P 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  794 LDISPLGKGPSGVSLLGAGPpgvgpviASPPGEGPRDAGPLGAGSlgisplNIRRLGISPSGISPPNIDLPVAGTSIGGP 873
Cdd:PHA03307   360 ADPSSPRKRPRPSRAPSSPA-------ASAGRPTRRRARAAVAGR------ARRRDATGRFPAGRPRPSPLDAGAASGAF 426
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1063730528  874 PDEGasdggpPDVGPFGISPPIIDPPgedasdgdPPGK 911
Cdd:PHA03307   427 YARY------PLLTPSGEPWPGSPPP--------PPGR 450
PHA03247 PHA03247
large tegument protein UL36; Provisional
558-819 1.04e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  558 VGTGLSWEIPPPGKLPPDASPLGIGSFGVGPPGASPF-----------IASPSGEGPLSEGllGIRSFGISPLSIRPLGI 626
Cdd:PHA03247  2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAArqaspalpaapAPPAVPAGPATPG--GPARPARPPTTAGPPAP 2769
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  627 SPLGI---SPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGP 703
Cdd:PHA03247  2770 APPAApaaGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS 2849
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  704 L----GVDPLG-------AGSLGISPLGKSPLRIRPLGISPfgkiPSNIDPSSALASDGGPPDEPASAEGSPDVGIFGIS 772
Cdd:PHA03247  2850 LplggSVAPGGdvrrrppSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063730528  773 PPIIDPPVEGASDGDPPEKLSLDISPLGkGPSGVSL---LGAGPPGVGPV 819
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAG-EPSGAVPqpwLGALVPGRVAV 2974
PHA03377 PHA03377
EBNA-3C; Provisional
796-896 2.31e-05

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 48.90  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  796 ISPLGKGPSGVSLLGAGPPGVGPVIASPPGEGPRDAGPLGAGSLGISPLNirrlgispsgisppnidlpvagtsiGGPPD 875
Cdd:PHA03377   555 VSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCK-------------------------DGPPA 609
                           90       100
                   ....*....|....*....|.
gi 1063730528  876 EGASDGGPPDVGPFGISPPII 896
Cdd:PHA03377   610 SGPHEKQPPSSAPRDMAPSVV 630
PHA03377 PHA03377
EBNA-3C; Provisional
1140-1241 7.64e-05

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 47.35  E-value: 7.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1140 SLPGKGPSDVGPPGAglpgaAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNG 1219
Cdd:PHA03377   551 TPPKVSPSDRGPPKA-----SPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDM 625
                           90       100
                   ....*....|....*....|..
gi 1063730528 1220 GPPDTDSFGGDPLCASPLGIDP 1241
Cdd:PHA03377   626 APSVVRMFLRERLLEQSTGPKP 647
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
689-1107 9.48e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  689 SGEGPLVESPPSEGplgVDPLGAGSLGISPLGKSPLRIRPlgiSPFGKIPSNIDPSSALASDGGPPDEPASAEGSPDVGi 768
Cdd:PHA03307    37 SGSQGQLVSDSAEL---AAVTVVAGAAACDRFEPPTGPPP---GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP- 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  769 fgiSPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLLGAGPPGVGPVIASPPGEGPrdAGPLGAGSLGISPLNIRR 848
Cdd:PHA03307   110 ---GPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDA--ASSRQAALPLSSPEETAR 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  849 LGISPSGISPPNIDlPVAGTSIGGPPDEGASDGGPPDVGPFGISPPiiDPPGEDASDGDPPGKFPLDISPLGKCPSGVSP 928
Cdd:PHA03307   185 APSSPPAEPPPSTP-PAAASPRPPRRSSPISASASSPAPAPGRSAA--DDAGASSSDSSSSESSGCGWGPENECPLPRPA 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  929 LGVGPPGVGPviASPPGEGPLDAGPlGAGSLGISPLNIRRLGISPFGISPPNidLPVAGTSIGGPLDEGASDGGPPDVGP 1008
Cdd:PHA03307   262 PITLPTRIWE--ASGWNGPSSRPGP-ASSSSSPRERSPSPSPSSPGSGPAPS--SPRASSSSSSSRESSSSSTSSSSESS 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1009 FGISPSIIDPPGEGAFDGDPPGklPLDISPVGKGPSGVSPPGAGppgdgpviASPPGESPL-----DAGPLGAGSLGISP 1083
Cdd:PHA03307   337 RGAAVSPGPSPSRSPSPSRPPP--PADPSSPRKRPRPSRAPSSP--------AASAGRPTRrraraAVAGRARRRDATGR 406
                          410       420
                   ....*....|....*....|....
gi 1063730528 1084 FGISPPNIDWPVAGTSFGGPPGEG 1107
Cdd:PHA03307   407 FPAGRPRPSPLDAGAASGAFYARY 430
PHA03377 PHA03377
EBNA-3C; Provisional
804-918 1.23e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 46.58  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  804 SGVSLLGAGPPGVGPVIASPPGEGPRDAGPlgagslgisplnirrlgispsgisppnidlPVAGTSIGGPPDEGASDGGP 883
Cdd:PHA03377   543 SGRRQKRATPPKVSPSDRGPPKASPPVMAP------------------------------PSTGPRVMATPSTGPRDMAP 592
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1063730528  884 PDVGPFGISPPIIDPPGEDASDGDPPGKFPLDISP 918
Cdd:PHA03377   593 PSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAP 627
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
996-1307 1.40e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  996 EGASDGGPPDVGPFGISPSIIDPP-----GEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAgppgdgpviASPPGESPLD 1070
Cdd:PHA03307    59 AAACDRFEPPTGPPPGPGTEAPANesrstPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP---------TPPPASPPPS 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1071 AGPLGAGSLGISPFGISPPNIDWPVAGTSFGGPPGEGASNGGPLVV-----------GPFDMPVVGASDGDALEKLPLDI 1139
Cdd:PHA03307   130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPlsspeetarapSSPPAEPPPSTPPAAASPRPPRR 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1140 SLPGKGPSDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNG 1219
Cdd:PHA03307   210 SSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS 289
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1220 GPPDTDsfgGDPLCASPLGidPPIVDASDGDPFGAGSPDEDPSNENASGEGASGESPPCSDVSCKGPSSAGASigcsldn 1299
Cdd:PHA03307   290 SPRERS---PSPSPSSPGS--GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPP------- 357

                   ....*...
gi 1063730528 1300 GASTPSSP 1307
Cdd:PHA03307   358 PPADPSSP 365
PHA03377 PHA03377
EBNA-3C; Provisional
873-1003 4.33e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  873 PPDEGASDGGPPDVGPFGISPPIIDPPGedasdGDPPGKFPLDISPLGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAG 952
Cdd:PHA03377   552 PPKVSPSDRGPPKASPPVMAPPSTGPRV-----MATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMA 626
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1063730528  953 PlgagsLGISPLNIRRLGISPFGISPPNIDLPVAGTSIGGPLDEGASDGGP 1003
Cdd:PHA03377   627 P-----SVVRMFLRERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQP 672
PHA03377 PHA03377
EBNA-3C; Provisional
851-928 4.48e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 4.48e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063730528  851 ISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPPDVGPFGISPPIIDPpgedASDGdPPGKFPLDISPLGKCPSGVSP 928
Cdd:PHA03377   555 VSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAK----CKDG-PPASGPHEKQPPSSAPRDMAP 627
PHA03377 PHA03377
EBNA-3C; Provisional
941-1038 5.77e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 44.66  E-value: 5.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  941 ASPPGEGPLDAGPLGAGslgisplnirrlgispfgisPPNIDLPVAGTSIGGPLDEGASDGGPPDVGPFGISPSIIDPPG 1020
Cdd:PHA03377   550 ATPPKVSPSDRGPPKAS--------------------PPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPA 609
                           90
                   ....*....|....*...
gi 1063730528 1021 EGAFDGDPPGKLPLDISP 1038
Cdd:PHA03377   610 SGPHEKQPPSSAPRDMAP 627
PHA03247 PHA03247
large tegument protein UL36; Provisional
978-1356 8.42e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 8.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  978 PPNIDLPVAGTSIGGPLDEGASDGGPPDVgPFGISPSII--DPPGEG---------------AFD--GDPPGKLPLDISP 1038
Cdd:PHA03247  2483 PAEARFPFAAGAAPDPGGGGPPDPDAPPA-PSRLAPAILpdEPVGEPvhprmltwirgleelASDdaGDPPPPLPPAAPP 2561
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1039 VGKGPSgvsppgagppgdgpviASPPGESPLDAGPlGAGSLGISPfgISPPNIDWPVA-GTSFGGPPGEGASNGGPLVVG 1117
Cdd:PHA03247  2562 AAPDRS----------------VPPPRPAPRPSEP-AVTSRARRP--DAPPQSARPRApVDDRGDPRGPAPPSPLPPDTH 2622
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1118 PFDMPVVGASdgdaleklPLDISLPGKGPSDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGAS------DGCPPDVGP 1191
Cdd:PHA03247  2623 APDPPPPSPS--------PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqrprrRAARPTVGS 2694
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1192 FDIcllSIDPPVVGASDGGPPDEGASNGGPPDTDSFGGDPLCASPLGIDPPIVdasdgdPFGAGSPdedpsnenasgega 1271
Cdd:PHA03247  2695 LTS---LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV------PAGPATP-------------- 2751
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1272 SGESPPCSDVSCKGPSSAGASIGCSLDNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAAL---VTLPSGKDPFDISPPI 1348
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLapaAALPPAASPAGPLPPP 2831

                   ....*...
gi 1063730528 1349 VALLDVSP 1356
Cdd:PHA03247  2832 TSAQPTAP 2839
PHA03377 PHA03377
EBNA-3C; Provisional
640-824 1.81e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.73  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  640 KADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKgssgegPLVESPPSEG-PLG---------VDPL 709
Cdd:PHA03377   442 EAEQAQSTPERPGPSDQPSVPVEPAHLTPVEHTTVILHQPPQSPPTV------AIKPAPPPSRrRRGacvvydddiIEVI 515
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  710 GAGSLGISPLGKSPLRIRPLGISPF---GKIPSNIDPSSALASDGGPPDEPASAEGSPDVGifgisPPIIDPPVEGASDG 786
Cdd:PHA03377   516 DVETTEEEESVTQPAKPHRKVQDGFqrsGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTG-----PRVMATPSTGPRDM 590
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1063730528  787 DPPEKLSLDISPLGKGPSGVSLLGAGPPGVGPVIASPP 824
Cdd:PHA03377   591 APPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPS 628
PHA03377 PHA03377
EBNA-3C; Provisional
631-733 2.35e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  631 ISPPNiEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDPLG 710
Cdd:PHA03377   526 VTQPA-KPHRKVQDGFQRSGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCK 604
                           90       100
                   ....*....|....*....|...
gi 1063730528  711 AGSLGISPLGKSPLRIRPLGISP 733
Cdd:PHA03377   605 DGPPASGPHEKQPPSSAPRDMAP 627
CytochromB561_N pfam09786
Cytochrome B561, N terminal; Members of this family are found in the N terminal region of ...
1230-1346 2.37e-03

Cytochrome B561, N terminal; Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterized proteins.


Pssm-ID: 462899  Cd Length: 579  Bit Score: 42.12  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1230 DPLCASP-----LGIDPPIVDASDGDPFG-------AGSPDEDPSNENASGEGASGESPPCSDvscKGPSSAGASIGcSL 1297
Cdd:pfam09786  100 TPSRLTNqqlglLGLKPNDSSFVTTHRKKppkskssPQSPSPVLVPLHQSVSPSSSESRKGGD---KSPAGSGKKLR-SF 175
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730528 1298 DNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAALVTLPSGKDPFDISP 1346
Cdd:pfam09786  176 STSSKSPASPSVYLRGSPVPLNSSPLPSDRNYENSVQSSPEIDSAVSTP 224
PHA03377 PHA03377
EBNA-3C; Provisional
618-684 2.93e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 2.93e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063730528  618 PLSIRPLGISPLGISPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPP 684
Cdd:PHA03377   562 PPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPS 628
PHA03377 PHA03377
EBNA-3C; Provisional
1177-1262 2.98e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528 1177 SGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPPDTDSFGGDPLCASPLGIDPPIVDASDGDPFGAGS 1256
Cdd:PHA03377   543 SGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAP 622

                   ....*.
gi 1063730528 1257 PDEDPS 1262
Cdd:PHA03377   623 RDMAPS 628
PHA03377 PHA03377
EBNA-3C; Provisional
971-1043 8.73e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 40.81  E-value: 8.73e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063730528  971 ISPFGISPPNIDLPVAGTSIGGPLDEGASDGGPPDVGPFGISPSIIDPPGEGafdgdPPGKLPLDISPVGKGP 1043
Cdd:PHA03377   555 VSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDG-----PPASGPHEKQPPSSAP 622
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
59-373 9.71e-03

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 40.53  E-value: 9.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528   59 DTGFDVRFAAGFAADLTIGFTIGFDSGFATFLDVGLDDGFATGLDISFAGGFVTGFATDFDVGFDTGFTIGFDTGFDVGL 138
Cdd:COG4625    213 GAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGGGGGNGGGGGAGGGGGGGGGGSGGGGGGGGGGGSGGGGG 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  139 PAVFSIGFDTGFAVGFAISFTVGFDAGFPTGFFVSLDVGFVADFVIGFATGIGVGFEVDFATDFDTCFATGFAVSFDVGF 218
Cdd:COG4625    293 GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGAGGGGGSGGAGAGGGGAGGGGAGGGGGGGTGGGGGGGGG 372
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730528  219 AGGFSIGFAADFANGFTVGFDGGFDASFFVGLDVGFVVGFVTSFAAGLDVGFAIDFATGFDTGFAFGLAFGFDVGFAAGF 298
Cdd:COG4625    373 GGGGSGGGGAGGGGGSGGGGGGGAGGGGGGGGAGGTGGGGAGGGGGAAGGGGGGTGAGGGGGGGGTGAGGGGATGGGGGG 452
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063730528  299 AVGFATGFTVVFDVGFASDFFVGLDVGFLTGFATDFDIGFVVDFDIGFATGFVVGFDDGSIVGLVVGLPASLDDG 373
Cdd:COG4625    453 GGGAGGSGGGAGAGGGSGSGAGTLTLTGNNTYTGTTTVNGGGNYTQSAGSTLAVEVDAANSDRLVVTGTATLNGG 527
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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