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Conserved domains on  [gi|1063722191|ref|NP_001329704|]
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Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 1-186 2.56e-105

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06437:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 232  Bit Score: 309.24  E-value: 2.56e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   1 MECTKWAsKDININYERRENRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRaIPFLIHNPEVALVQARWRF 80
Cdd:cd06437    52 IVEEYAA-QGVNIKHVRRADRTGYKAGALAEGMKVA---KGEYVAIFDADFVPPPDFLQK-TPPYFADPKLGFVQTRWGH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  81 VNANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVN 160
Cdd:cd06437   127 INANYSLLTRVQAMSLDYHFTIEQVARSSTGLFFNFNGTAGVWRKECIEDAGGWNHDTLTEDLDLSYRAQLKGWKFVYLD 206

                         170       180
                  ....*....|....*....|....*.
gi 1063722191 161 DLEVKSELPSQFKAFRFQQHRWSCGP 186
Cdd:cd06437   207 DVVVPAELPASMSAYRSQQHRWSKGP 232
 
Name Accession Description Interval E-value
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 1-186 2.56e-105

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 309.24  E-value: 2.56e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   1 MECTKWAsKDININYERRENRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRaIPFLIHNPEVALVQARWRF 80
Cdd:cd06437    52 IVEEYAA-QGVNIKHVRRADRTGYKAGALAEGMKVA---KGEYVAIFDADFVPPPDFLQK-TPPYFADPKLGFVQTRWGH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  81 VNANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVN 160
Cdd:cd06437   127 INANYSLLTRVQAMSLDYHFTIEQVARSSTGLFFNFNGTAGVWRKECIEDAGGWNHDTLTEDLDLSYRAQLKGWKFVYLD 206

                         170       180
                  ....*....|....*....|....*.
gi 1063722191 161 DLEVKSELPSQFKAFRFQQHRWSCGP 186
Cdd:cd06437   207 DVVVPAELPASMSAYRSQQHRWSKGP 232
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-309 3.52e-27

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 109.06  E-value: 3.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   3 CTKWASKDININYERRENRNGyKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLiHNPEValvqarwrfvn 82
Cdd:COG1215    78 ARELAAEYPRVRVIERPENGG-KAAALNAGLKAA---RGDIVVFLDADTVLDPDWLRRLVAAF-ADPGV----------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  83 antclmtrmqemslnyhfmaeqqsgstrhaffGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDL 162
Cdd:COG1215   142 --------------------------------GASGANLAFRREALEEVGGFDEDTLGEDLDLSLRLLRAGYRIVYVPDA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 163 EVKSELPSQFKAFRFQQHRWSCGpanlirkmTMEIIHNKRVKIWKKFYVIYSFFFLRKIVVHFFTYFFYCVILptsvflp 242
Cdd:COG1215   190 VVYEEAPETLRALFRQRRRWARG--------GLQLLLKHRPLLRPRRLLLFLLLLLLPLLLLLLLLALLALLL------- 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063722191 243 evnipnwstIYVPSVITLLSAIATPRSFYLVIFWVLFenvmamhrTKGTLIGLFEGGRVnEWVVTEK 309
Cdd:COG1215   255 ---------LLLPALLLALLLALRRRRLLLPLLHLLY--------GLLLLLAALRGKKV-VWKKTPR 303
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 43-237 1.63e-17

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 79.69  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  43 YLAIFDADFQPEPDYLQRAIPFLiHNPEVALVQArWRFVNANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGV 122
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEM-ASPEVAIIQG-PILPMNVGNYLEELAALFFADDHGKSIPVRMALGRVLPFVGSGAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 123 WRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDLEVKSELPSQFKAFRFQQHRWSCGpANLIRKMtmeiihnKR 202
Cdd:pfam13632  79 LRRSALQEVGGWDDGSVSEDFDFGLRLQRAGYRVRFAPYSAVYEKSPLTFRDFLRQRRRWAYG-CLLILLI-------RL 150

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063722191 203 VKIWKKFYVIYSFFFLRKIVVHFFTYFFYCVILPT 237
Cdd:pfam13632 151 LGYLGTLLWSGLPLALLLLLLFSISSLALVLLLLA 185
bcsA PRK11498
cellulose synthase catalytic subunit; Provisional
 9-155 2.10e-04

cellulose synthase catalytic subunit; Provisional


Pssm-ID: 236918 [Multi-domain]  Cd Length: 852  Bit Score: 43.47  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   9 KDININYERRENRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFVNA----- 83
Cdd:PRK11498  311 QEVGVKYIARPTHEHAKAGNINNALKYA---KGEFVAIFDCDHVPTRSFLQMTMGWFLKDKKLAMMQTPHHFFSPdpfer 387

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063722191  84 NTCLMTRM-QEMSLNYHFMaeQQSGSTRHAFFgFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWK 155
Cdd:PRK11498  388 NLGRFRKTpNEGTLFYGLV--QDGNDMWDATF-FCGSCAVIRRKPLDEIGGIAVETVTEDAHTSLRLHRRGYT 457
 
Name Accession Description Interval E-value
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 1-186 2.56e-105

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 309.24  E-value: 2.56e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   1 MECTKWAsKDININYERRENRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRaIPFLIHNPEVALVQARWRF 80
Cdd:cd06437    52 IVEEYAA-QGVNIKHVRRADRTGYKAGALAEGMKVA---KGEYVAIFDADFVPPPDFLQK-TPPYFADPKLGFVQTRWGH 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  81 VNANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVN 160
Cdd:cd06437   127 INANYSLLTRVQAMSLDYHFTIEQVARSSTGLFFNFNGTAGVWRKECIEDAGGWNHDTLTEDLDLSYRAQLKGWKFVYLD 206

                         170       180
                  ....*....|....*....|....*.
gi 1063722191 161 DLEVKSELPSQFKAFRFQQHRWSCGP 186
Cdd:cd06437   207 DVVVPAELPASMSAYRSQQHRWSKGP 232
CESA_NdvC_like cd06435
NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; ...
 23-192 2.63e-29

NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response.


Pssm-ID: 133057 [Multi-domain]  Cd Length: 236  Bit Score: 113.26  E-value: 2.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  23 GYKAGALKHGMRHSYVkQCQYLAIFDADFQPEPDYLQRAIPfLIHNPEVALVQARWRFVNANTCLMTRMQEMSLNYHFMA 102
Cdd:cd06435    68 GAKAGALNYALERTAP-DAEIIAVIDADYQVEPDWLKRLVP-IFDDPRVGFVQAPQDYRDGEESLFKRMCYAEYKGFFDI 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 103 EQQSGSTRHAFFgFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDLEVKSELPSQFKAFRFQQHRW 182
Cdd:cd06435   146 GMVSRNERNAII-QHGTMCLIRRSALDDVGGWDEWCITEDSELGLRMHEAGYIGVYVAQSYGHGLIPDTFEAFKKQRFRW 224

                         170
                  ....*....|
gi 1063722191 183 SCGPANLIRK 192
Cdd:cd06435   225 AYGAVQILKK 234
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 2-142 2.80e-27

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 106.16  E-value: 2.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   2 ECTKWASKDININYERRENRNGYKAGALKHGMRHSYVKqcqYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFV 81
Cdd:cd06423    43 ILEELAALYIRRVLVVRDKENGGKAGALNAGLRHAKGD---IVVVLDADTILEPDALKRLVVPFFADPKVGAVQGRVRVR 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063722191  82 NANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGVWRMVAMEEAGGWKDRTTVED 142
Cdd:cd06423   120 NGSENLLTRLQAIEYLSIFRLGRRAQSALGGVLVLSGAFGAFRREALREVGGWDEDTLTED 180
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-309 3.52e-27

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 109.06  E-value: 3.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   3 CTKWASKDININYERRENRNGyKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLiHNPEValvqarwrfvn 82
Cdd:COG1215    78 ARELAAEYPRVRVIERPENGG-KAAALNAGLKAA---RGDIVVFLDADTVLDPDWLRRLVAAF-ADPGV----------- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  83 antclmtrmqemslnyhfmaeqqsgstrhaffGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDL 162
Cdd:COG1215   142 --------------------------------GASGANLAFRREALEEVGGFDEDTLGEDLDLSLRLLRAGYRIVYVPDA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 163 EVKSELPSQFKAFRFQQHRWSCGpanlirkmTMEIIHNKRVKIWKKFYVIYSFFFLRKIVVHFFTYFFYCVILptsvflp 242
Cdd:COG1215   190 VVYEEAPETLRALFRQRRRWARG--------GLQLLLKHRPLLRPRRLLLFLLLLLLPLLLLLLLLALLALLL------- 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063722191 243 evnipnwstIYVPSVITLLSAIATPRSFYLVIFWVLFenvmamhrTKGTLIGLFEGGRVnEWVVTEK 309
Cdd:COG1215   255 ---------LLLPALLLALLLALRRRRLLLPLLHLLY--------GLLLLLAALRGKKV-VWKKTPR 303
CESA_CelA_like cd06421
CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of ...
 12-185 1.10e-26

CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end.


Pssm-ID: 133043 [Multi-domain]  Cd Length: 234  Bit Score: 106.12  E-value: 1.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  12 NINYERRENRNGYKAGALKHGMRHSYVKqcqYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFVNANTCLMTRM 91
Cdd:cd06421    59 GYRYLTRPDNRHAKAGNLNNALAHTTGD---FVAILDADHVPTPDFLRRTLGYFLDDPKVALVQTPQFFYNPDPFDWLAD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  92 QEMSLNYHFMAEQQSG--STRHAFFGfnGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDLEVKSELP 169
Cdd:cd06421   136 GAPNEQELFYGVIQPGrdRWGAAFCC--GSGAVVRREALDEIGGFPTDSVTEDLATSLRLHAKGWRSVYVPEPLAAGLAP 213

                         170
                  ....*....|....*.
gi 1063722191 170 SQFKAFRFQQHRWSCG 185
Cdd:cd06421   214 ETLAAYIKQRLRWARG 229
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 43-237 1.63e-17

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 79.69  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  43 YLAIFDADFQPEPDYLQRAIPFLiHNPEVALVQArWRFVNANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGV 122
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEM-ASPEVAIIQG-PILPMNVGNYLEELAALFFADDHGKSIPVRMALGRVLPFVGSGAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 123 WRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVNDLEVKSELPSQFKAFRFQQHRWSCGpANLIRKMtmeiihnKR 202
Cdd:pfam13632  79 LRRSALQEVGGWDDGSVSEDFDFGLRLQRAGYRVRFAPYSAVYEKSPLTFRDFLRQRRRWAYG-CLLILLI-------RL 150

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063722191 203 VKIWKKFYVIYSFFFLRKIVVHFFTYFFYCVILPT 237
Cdd:pfam13632 151 LGYLGTLLWSGLPLALLLLLLFSISSLALVLLLLA 185
CESA_like_2 cd06427
CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) ...
 25-182 1.55e-13

CESA_like_2 is a member of the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, Glucan Biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of glucan.


Pssm-ID: 133049 [Multi-domain]  Cd Length: 241  Bit Score: 69.59  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  25 KAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRA-IPFLIHNPEVALVQARWRFVNANTCLMTRMQEMSLNYHFMAE 103
Cdd:cd06427    72 KPKACNYALAFA---RGEYVVIYDAEDAPDPDQLKKAvAAFARLDDKLACVQAPLNYYNARENWLTRMFALEYAAWFDYL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191 104 QQSGSTRHAFFGFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWKFIFVND--LEvksELPSQFKAFRFQQHR 181
Cdd:cd06427   149 LPGLARLGLPIPLGGTSNHFRTDVLRELGGWDPFNVTEDADLGLRLARAGYRTGVLNSttLE---EANNALGNWIRQRSR 225


                  .
gi 1063722191 182 W 182
Cdd:cd06427   226 W 226
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-129 9.24e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 65.88  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   3 CTKWASKDININYERRENRNGyKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLIHNPeVALVQARWRFVN 82
Cdd:pfam00535  45 AEEYAKKDPRVRVIRLPENRG-KAGARNAGLRAA---TGDYIAFLDADDEVPPDWLEKLVEALEEDG-ADVVVGSRYVIF 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063722191  83 ANTCLMTRMQEMSLNYHFMAEQQSGSTRHAFFGFNGTAGVWRMVAME 129
Cdd:pfam00535 120 GETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIGGFALYRREALEE 166
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 9-185 2.79e-11

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 62.77  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   9 KDININYERRENRNGY--KAGALKHGMRHsyVKQcQYLAIFDADFQPEPDYLQRAIPFLIHnPEVALVQARwRFVNANTC 86
Cdd:pfam13641  57 PDVRLRVIRNARLLGPtgKSRGLNHGFRA--VKS-DLVVLHDDDSVLHPGTLKKYVQYFDS-PKVGAVGTP-VFSLNRST 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  87 LMTRMQEMSLNYHFMaeqQSGSTRHAFfGF---NGTAGVWRMVAMEEAGGW-KDRTTVEDMDLAVRVGLLGWKFIFVNDL 162
Cdd:pfam13641 132 MLSALGALEFALRHL---RMMSLRLAL-GVlplSGAGSAIRREVLKELGLFdPFFLLGDDKSLGRRLRRHGWRVAYAPDA 207

                         170       180
                  ....*....|....*....|...
gi 1063722191 163 EVKSELPSQFKAFRFQQHRWSCG 185
Cdd:pfam13641 208 AVRTVFPTYLAASIKQRARWVYG 230
Glyco_transf_21 pfam13506
Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2. ...
 23-183 1.09e-07

Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.


Pssm-ID: 433264 [Multi-domain]  Cd Length: 173  Bit Score: 51.13  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  23 GYKAGALKHGM---RHSYVKQCqylaifDADFQPEPDYLQR-AIPFLihNPEVALVQARWRFVNANTcLMTRMqEMSLNY 98
Cdd:pfam13506  16 NPKVNNLLQGLeaaKYDLLVIS------DSDIRVPPDYLRDlLAPLA--DPKVGLVTSPPVGSDPKG-LAAAL-EAAFFN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  99 HFMAEQQSGSTRhafFGF-NGTAGVWRMVAMEEAGG---WKDrTTVEDMDLAVRVGLLGWKFIFVND--LEVKSELPSQF 172
Cdd:pfam13506  86 TLAGVLQAALSG---IGFaVGMSMAFRRADLERIGGfeaLAD-YLAEDYALGKLLRAAGLKVVLSPRpiLQTSGPRRTSF 161

                         170
                  ....*....|.
gi 1063722191 173 KAFRFQQHRWS 183
Cdd:pfam13506 162 RAFMARQLRWA 172
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 3-160 2.16e-06

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 48.16  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   3 CTKWASKDININYERREnRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLIHNPeVALVQArWRFVN 82
Cdd:COG0463    49 LRELAAKDPRIRVIRLE-RNRGKGAARNAGLAAA---RGDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYG-SRLIR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  83 ANTCLMTRMQEMSLNYHfmaeqqsgstrHAFFGFNGTAGVWRMV---AMEEAGgwKDRTTVEDMDLaVRVGLLGWKFIFV 159
Cdd:COG0463   123 EGESDLRRLGSRLFNLV-----------RLLTNLPDSTSGFRLFrreVLEELG--FDEGFLEDTEL-LRALRHGFRIAEV 188


                  .
gi 1063722191 160 N 160
Cdd:COG0463   189 P 189
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-81 2.48e-06

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 47.12  E-value: 2.48e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063722191   5 KWASKDININYERREnRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFV 81
Cdd:cd00761    46 EYAKKDPRVIRVINE-ENQGLAAARNAGLKAA---RGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGPGNLL 118
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 45-142 3.50e-05

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 44.30  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  45 AIFDADFQPEPDYLQRAIPFLiHNPEVALVQARWRFVNANTCLMTRMQEM---SLNYHFmaeqQSGSTRHAFFGFNGTAG 121
Cdd:cd06436    94 AVIDADGRLDPNALEAVAPYF-SDPRVAGTQSRVRMYNRHKNLLTILQDLeffIIIAAT----QSLRALTGTVGLGGNGQ 168

                          90       100
                  ....*....|....*....|....
gi 1063722191 122 VWRMVAMEEAGG---WKDRTTvED 142
Cdd:cd06436   169 FMRLSALDGLIGeepWSDSLL-ED 191
bcsA PRK11498
cellulose synthase catalytic subunit; Provisional
 9-155 2.10e-04

cellulose synthase catalytic subunit; Provisional


Pssm-ID: 236918 [Multi-domain]  Cd Length: 852  Bit Score: 43.47  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191   9 KDININYERRENRNGYKAGALKHGMRHSyvkQCQYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFVNA----- 83
Cdd:PRK11498  311 QEVGVKYIARPTHEHAKAGNINNALKYA---KGEFVAIFDCDHVPTRSFLQMTMGWFLKDKKLAMMQTPHHFFSPdpfer 387

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063722191  84 NTCLMTRM-QEMSLNYHFMaeQQSGSTRHAFFgFNGTAGVWRMVAMEEAGGWKDRTTVEDMDLAVRVGLLGWK 155
Cdd:PRK11498  388 NLGRFRKTpNEGTLFYGLV--QDGNDMWDATF-FCGSCAVIRRKPLDEIGGIAVETVTEDAHTSLRLHRRGYT 457
Glucan_BSP_MdoH cd04191
Glucan_BSP_MdoH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Periplasmic ...
 12-101 1.01e-03

Glucan_BSP_MdoH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Periplasmic Glucan Biosynthesis protein MdoH is a glucosyltransferase that catalyzes the elongation of beta-1,2 polyglucose chains of glucan, requiring a beta-glucoside as a primer and UDP-glucose as a substrate. Glucans are composed of 5 to 10 units of glucose forming a highly branched structure, where beta-1,2-linked glucose constitutes a linear backbone to which branches are attached by beta-1,6 linkages. In Escherichia coli, glucans are located in the periplasmic space, functioning as regulator of osmolarity. It is synthesized at a maximum when cells are grown in a medium with low osmolarity. It has been shown to span the cytoplasmic membrane.


Pssm-ID: 133034 [Multi-domain]  Cd Length: 254  Bit Score: 40.34  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063722191  12 NINYERRENRNGYKAGALKHGMRhSYVKQCQYLAIFDADFQPEPDYLQRAIPFLIHNPEVALVQARWRFVNANTcLMTRM 91
Cdd:cd04191    68 RIYYRRRRENTGRKAGNIADFCR-RWGSRYDYMVVLDADSLMSGDTIVRLVRRMEANPRAGIIQTAPKLIGAET-LFARL 145

                          90
                  ....*....|
gi 1063722191  92 QEMSlNYHFM 101
Cdd:cd04191   146 QQFA-NRLYG 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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