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Conserved domains on  [gi|1063712451|ref|NP_001327752|]
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autophagy 2 [Arabidopsis thaliana]

Protein Classification

Chorein_N and ATG_C domain-containing protein( domain architecture ID 10576697)

protein containing domains Chorein_N, MRS6, and ATG_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1784-1879 2.32e-25

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 101.81  E-value: 2.32e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451 1784 TNVRHNQPRNAKQGMLKACESIGDGIGKTASALVRTPLKKYQRGdGAGSAFATVVQGVPTAAIAPASACARAVHSALVGI 1863
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESK-GAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGV 79

                           90
                   ....*....|....*.
gi 1063712451 1864 RNSLDPEHKKESMEKY 1879
Cdd:pfam09333   80 RNQLDPENRRESEDKY 95
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 39-119 1.52e-14

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 71.44  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451   39 DIDLDQLDIQLRDGTIQLSDLAINVDYLnDKFDAPLVIKEGSIGSLLVKMPW---KTNGCQVEVDELELVLAPRLESNKS 115
Cdd:pfam12624   19 NLDPDQLKVGLWSGDVVLENLKLKKEAL-DKLDLPIEVKSGHIGKLTLKIPWtnlKSEPVVIEIEDVYLLAVPKDESEEY 97


                   ....
gi 1063712451  116 SSNE 119
Cdd:pfam12624   98 DEEE 101
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1784-1879 2.32e-25

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 101.81  E-value: 2.32e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451 1784 TNVRHNQPRNAKQGMLKACESIGDGIGKTASALVRTPLKKYQRGdGAGSAFATVVQGVPTAAIAPASACARAVHSALVGI 1863
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESK-GAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGV 79

                           90
                   ....*....|....*.
gi 1063712451 1864 RNSLDPEHKKESMEKY 1879
Cdd:pfam09333   80 RNQLDPENRRESEDKY 95
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 39-119 1.52e-14

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 71.44  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451   39 DIDLDQLDIQLRDGTIQLSDLAINVDYLnDKFDAPLVIKEGSIGSLLVKMPW---KTNGCQVEVDELELVLAPRLESNKS 115
Cdd:pfam12624   19 NLDPDQLKVGLWSGDVVLENLKLKKEAL-DKLDLPIEVKSGHIGKLTLKIPWtnlKSEPVVIEIEDVYLLAVPKDESEEY 97


                   ....
gi 1063712451  116 SSNE 119
Cdd:pfam12624   98 DEEE 101
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1784-1879 2.32e-25

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 101.81  E-value: 2.32e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451 1784 TNVRHNQPRNAKQGMLKACESIGDGIGKTASALVRTPLKKYQRGdGAGSAFATVVQGVPTAAIAPASACARAVHSALVGI 1863
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESK-GAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGV 79

                           90
                   ....*....|....*.
gi 1063712451 1864 RNSLDPEHKKESMEKY 1879
Cdd:pfam09333   80 RNQLDPENRRESEDKY 95
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 39-119 1.52e-14

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 71.44  E-value: 1.52e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063712451   39 DIDLDQLDIQLRDGTIQLSDLAINVDYLnDKFDAPLVIKEGSIGSLLVKMPW---KTNGCQVEVDELELVLAPRLESNKS 115
Cdd:pfam12624   19 NLDPDQLKVGLWSGDVVLENLKLKKEAL-DKLDLPIEVKSGHIGKLTLKIPWtnlKSEPVVIEIEDVYLLAVPKDESEEY 97


                   ....
gi 1063712451  116 SSNE 119
Cdd:pfam12624   98 DEEE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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