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Conserved domains on  [gi|1063709773|ref|NP_001327692|]
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NOD26-like intrinsic protein 7;1 [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 41-194 1.04e-82

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member PLN00183:

Pssm-ID: 444743  Cd Length: 274  Bit Score: 246.31  E-value: 1.04e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPhQNLGNLTGFVIGTVI 120
Cdd:PLN00183  122 KVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQP-QSLGHLSGFVIGIAI 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709773 121 SLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLKTRPCPSPVSPSVSSLLR 194
Cdd:PLN00183  201 GLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRLRTQPCSPNSSPNTSLLLH 274
 
Name Accession Description Interval E-value
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 41-194 1.04e-82

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 246.31  E-value: 1.04e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPhQNLGNLTGFVIGTVI 120
Cdd:PLN00183  122 KVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQP-QSLGHLSGFVIGIAI 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709773 121 SLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLKTRPCPSPVSPSVSSLLR 194
Cdd:PLN00183  201 GLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRLRTQPCSPNSSPNTSLLLH 274
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 34-171 7.33e-30

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 109.33  E-value: 7.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  34 LECCVTCQVPL-----YITAQTLGATAATLV--GVSVYGVNADIMAT--KPALSCVSAFFVELIATSIVVFLASALHCGP 104
Cdd:pfam00230  76 LALLVGRRFSLlraifYIVAQLLGAIAGAALlyGVTVGLQRAGLFANtlAPGVNAGQAFVVEIILTFQLVYCVFATTDDR 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709773 105 HQ-NLGNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTY 171
Cdd:pfam00230 156 RNgSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 41-174 1.14e-28

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 106.36  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNAD----------IMATKPA--LSCVSAFFVELIATSIVVFLASALHCGPHqNL 108
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDatedggaklgVFATSPAigYSLGAAFLTEIIGTFVLVFVILGITDKRA-AP 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709773 109 GNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVA------WDFEDLWIYMTAPVIGAIIGVLTYRSI 174
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 41-172 5.41e-26

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 99.64  E-value: 5.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYG-----------VNADIMATKPA--LSCVSAFFVELIATSIVVFLASAL----HCG 103
Cdd:cd00333    78 RVIPYIIAQLLGAILGAALLYGLYYglyleflgannIVAGIFGTYPSpgVSNGNAFFVEFIGTFILVLVVFATtddpNGP 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709773 104 PhqnLGNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVAWD---FEDLWIYMTAPVIGAIIGVLTYR 172
Cdd:cd00333   158 P---PGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYD 226
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 41-171 3.63e-24

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 94.29  E-value: 3.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAAT----LVGVSVYGVNADIMAT-KPALSCVSAFFVELIATSIVVFLASALHCGPHQN-LGNLTGF 114
Cdd:TIGR00861  78 RVPVYIVAQLIGAILGAallyGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPL 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063709773 115 VIGTVISLGVLITGPISGGSMNPARSLGPAVVAWD--FEDLWIYMTAPVIGAIIGVLTY 171
Cdd:TIGR00861 158 AIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
 
Name Accession Description Interval E-value
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 41-194 1.04e-82

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 246.31  E-value: 1.04e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPhQNLGNLTGFVIGTVI 120
Cdd:PLN00183  122 KVPLYITAQTVGSVLATYVGVSVYGVKADLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQP-QSLGHLSGFVIGIAI 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709773 121 SLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLKTRPCPSPVSPSVSSLLR 194
Cdd:PLN00183  201 GLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLLRLRTQPCSPNSSPNTSLLLH 274
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 34-171 7.33e-30

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 109.33  E-value: 7.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  34 LECCVTCQVPL-----YITAQTLGATAATLV--GVSVYGVNADIMAT--KPALSCVSAFFVELIATSIVVFLASALHCGP 104
Cdd:pfam00230  76 LALLVGRRFSLlraifYIVAQLLGAIAGAALlyGVTVGLQRAGLFANtlAPGVNAGQAFVVEIILTFQLVYCVFATTDDR 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709773 105 HQ-NLGNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTY 171
Cdd:pfam00230 156 RNgSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 41-174 1.14e-28

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 106.36  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNAD----------IMATKPA--LSCVSAFFVELIATSIVVFLASALHCGPHqNL 108
Cdd:COG0580    80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDatedggaklgVFATSPAigYSLGAAFLTEIIGTFVLVFVILGITDKRA-AP 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709773 109 GNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVA------WDFEDLWIYMTAPVIGAIIGVLTYRSI 174
Cdd:COG0580   159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRAL 230
PLN00026 PLN00026
aquaporin NIP; Provisional
 41-177 7.47e-27

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 103.40  E-value: 7.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPhQNLGNLTGFVIGTVI 120
Cdd:PLN00026  148 HVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSVSTGQAFALEFIITFNLLFVVTAVATDT-RAVGELAGIAVGATV 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063709773 121 SLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLK 177
Cdd:PLN00026  227 MLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLR 283
PLN00184 PLN00184
aquaporin NIP1; Provisional
 41-180 2.63e-26

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 102.02  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADI--------MATKPALSCVSAFFVELIATSIVVFLASALhCGPHQNLGNLT 112
Cdd:PLN00184  131 QVPAYVISQVIGSTLAAATLRLLFGLDHDVcsgkhdvfIGSSPVGSDLQAFVMEFIVTFYLMFIISGV-ATDNRAIGELA 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709773 113 GFVIGTVISLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLKTRP 180
Cdd:PLN00184  210 GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKP 277
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 41-172 5.41e-26

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 99.64  E-value: 5.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYG-----------VNADIMATKPA--LSCVSAFFVELIATSIVVFLASAL----HCG 103
Cdd:cd00333    78 RVIPYIIAQLLGAILGAALLYGLYYglyleflgannIVAGIFGTYPSpgVSNGNAFFVEFIGTFILVLVVFATtddpNGP 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709773 104 PhqnLGNLTGFVIGTVISLGVLITGPISGGSMNPARSLGPAVVAWD---FEDLWIYMTAPVIGAIIGVLTYR 172
Cdd:cd00333   158 P---PGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYD 226
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 41-171 3.63e-24

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 94.29  E-value: 3.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAAT----LVGVSVYGVNADIMAT-KPALSCVSAFFVELIATSIVVFLASALHCGPHQN-LGNLTGF 114
Cdd:TIGR00861  78 RVPVYIVAQLIGAILGAallyGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPL 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063709773 115 VIGTVISLGVLITGPISGGSMNPARSLGPAVVAWD--FEDLWIYMTAPVIGAIIGVLTY 171
Cdd:TIGR00861 158 AIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGALVY 216
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 41-180 5.05e-24

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 95.75  E-value: 5.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNAD-IMATKPALSCVSAFFVELIATSIVVFLASALHCGpHQNLGNLTGFVIGTV 119
Cdd:PLN00182  119 QVPLYIGAQLTGSLLASLTLRLMFNVTPEaFFGTTPTDSSGQALVAEIIISFLLMFVISGVATD-SRAVGELAGIAVGMT 197

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063709773 120 ISLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSISLKTRP 180
Cdd:PLN00182  198 IILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDKP 258
PLN00166 PLN00166
aquaporin TIP2; Provisional
 44-174 6.95e-19

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 81.14  E-value: 6.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  44 LYITAQTLGATAATLVgvSVYGVNADIMAT---KPALSCVSAFFVELIATSIVVFLASALHCGPHQ-NLGNLTGFVIGTV 119
Cdd:PLN00166  103 FYWIAQCLGSIVACLL--LVFVTNGESVPThgvAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKgSLGTIAPIAIGFI 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063709773 120 ISLGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSI 174
Cdd:PLN00166  181 VGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDV 235
PLN00027 PLN00027
aquaporin TIP; Provisional
 44-174 3.03e-15

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 71.36  E-value: 3.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  44 LYITAQTLGATAAT-LVGVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPHQ-NLGNLTGFVIGTVIS 121
Cdd:PLN00027  105 LYWIAQLLGSVVAClLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKgDLGIIAPIAIGFIVG 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063709773 122 LGVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSI 174
Cdd:PLN00027  185 ANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PRK05420 PRK05420
aquaporin Z; Provisional
 41-175 4.35e-11

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 59.60  E-value: 4.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATLVGVSVYGVNADIMATKPAL-------------SCVSAFFVELIATS--IVVFLASALHCGPh 105
Cdd:PRK05420   80 ELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFasngygehspggySLLAALVCEVVLTAffLLVILGATDKRAP- 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063709773 106 qnlgnlTGFV---IGTVISLGVLITGPISGGSMNPARSLGPAVVA--WDFEDLWIYMTAPVIGAIIGVLTYRSIS 175
Cdd:PRK05420  159 ------AGFApiaIGLALTLIHLISIPVTNTSVNPARSTGVALFVggWALEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 44-174 8.98e-11

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 59.15  E-value: 8.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  44 LYITAQTLGATAATLV-GVSVYGVNADIMATKPALSCVSAFFVELIATSIVVFLASALHCGPHQNLGNLTGFVIGTVISL 122
Cdd:PLN00167  107 FYWISQMLASVMACLFlKVTTVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLAIGLVAGA 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063709773 123 GVLITGPISGGSMNPARSLGPAVVAWDFEDLWIYMTAPVIGAIIGVLTYRSI 174
Cdd:PLN00167  187 NVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNV 238
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 41-172 2.85e-08

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 52.44  E-value: 2.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  41 QVPLYITAQTLGATAATlvgVSVYGV---------------------NADIMATKPALSCVSAFFVELIATSIVVFLASA 99
Cdd:PTZ00016  127 KLPGYFVAQLLGAFVGA---ACVYGLyygffkdhgipelpwetmangFAGVFATYPREGNFYAIFSELILTAILLLVILA 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773 100 L---HCGPHQNLGNLTgfvIGTVISLGVLITGPISGGSMNPARSLGPAV---VAWDFED-------LWIYMTAPVIGAII 166
Cdd:PTZ00016  204 ItdpNNCPAFNYLPVA---VGLLVFVIGISFGGNTGYALNPARDLGPRLfsaILWGSEVftkdnyyFWVPLVAPFVGAVL 280


                  ....*.
gi 1063709773 167 GVLTYR 172
Cdd:PTZ00016  281 GMFLYD 286
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 81-169 7.72e-05

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  81 SAFFVELIATSIVVFL----ASALHcGPHQNLGNLT-GFVIGTVISLGVLITGPISGGSMNPARSLGPAVVA-WDFEDLW 154
Cdd:COG0580     4 KRLLAEFLGTFILVLLgcgvVAVLA-GTKGGIGWLGiALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGrFPWKDVL 82

                          90
                  ....*....|....*
gi 1063709773 155 IYMTAPVIGAIIGVL 169
Cdd:COG0580    83 PYIIAQLLGAFLGAA 97
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 82-169 3.81e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 39.93  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  82 AFFVELIATSIVVFLASALHCGPHQNLGNLTGFVI-----GTVISLGVLITGPISGGSMNPARSLGPAVVA-WDFEDLWI 155
Cdd:cd00333     2 KYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGialawGFAIFVLVYAVGHISGGHINPAVTLALAVGGrFPLIRVIP 81

                          90
                  ....*....|....
gi 1063709773 156 YMTAPVIGAIIGVL 169
Cdd:cd00333    82 YIIAQLLGAILGAA 95
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 82-174 9.23e-03

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 35.76  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  82 AFFVELIATSIVVFLASALHCGPHQNLGNLTGFVI-------GTVISLGVLITGPISGGSMNPARSLGPAVVA-WDFEDL 153
Cdd:pfam00230  10 AVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLlavalafGLALATLVYCAGHISGAHLNPAVTLALLVGRrFSLLRA 89

                          90       100
                  ....*....|....*....|.
gi 1063709773 154 WIYMTAPVIGAIIGVLTYRSI 174
Cdd:pfam00230  90 IFYIVAQLLGAIAGAALLYGV 110
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 83-167 9.36e-03

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 35.87  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709773  83 FFVELIATSIVVFL-----ASALHCGPHQNLGNLTgFVIGTVISLGVLITGPISGGSMNPARSLGPAVV-AWDFEDLWIY 156
Cdd:PTZ00016   53 YVAEFLGTFVLLFFgegvvATTHTVGNNGDYLAIT-IGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFgKFPWKKLPGY 131

                          90
                  ....*....|.
gi 1063709773 157 MTAPVIGAIIG 167
Cdd:PTZ00016  132 FVAQLLGAFVG 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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