titan9 [Arabidopsis thaliana]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RWD_DRWD_ELF-like super family | cl45901 | RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ... |
221-278 | 6.51e-04 | ||
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells. The actual alignment was detected with superfamily member cd23787: Pssm-ID: 480265 Cd Length: 102 Bit Score: 38.47 E-value: 6.51e-04
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| Name | Accession | Description | Interval | E-value | ||
| RWD_CSM1 | cd23787 | RWD domain of Saccharomyces cerevisiae chromosome segregation in meiosis protein 1 (CSM1) and ... |
221-278 | 6.51e-04 | ||
RWD domain of Saccharomyces cerevisiae chromosome segregation in meiosis protein 1 (CSM1) and related proteins; Saccharomyces cerevisiae CSM1 is a component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. It also plays a mitotic role in DNA replication. The family also includes Schizosaccharomyces pombe chromosome segregation protein 1 (PCS1), which is a component of a monopolin-like complex composed of PCS1 and MDE4. The PCS1/MDE4 complex associates with the kinetochore and is essential for accurate chromosome segregation during mitosis and meiosis II. PCS1 may clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S. cerevisiae ortholog CSM1, PCS1 is not required for mono-orientation during meiosis I. Pssm-ID: 467649 Cd Length: 102 Bit Score: 38.47 E-value: 6.51e-04
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| Name | Accession | Description | Interval | E-value | ||
| RWD_CSM1 | cd23787 | RWD domain of Saccharomyces cerevisiae chromosome segregation in meiosis protein 1 (CSM1) and ... |
221-278 | 6.51e-04 | ||
RWD domain of Saccharomyces cerevisiae chromosome segregation in meiosis protein 1 (CSM1) and related proteins; Saccharomyces cerevisiae CSM1 is a component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. It also plays a mitotic role in DNA replication. The family also includes Schizosaccharomyces pombe chromosome segregation protein 1 (PCS1), which is a component of a monopolin-like complex composed of PCS1 and MDE4. The PCS1/MDE4 complex associates with the kinetochore and is essential for accurate chromosome segregation during mitosis and meiosis II. PCS1 may clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S. cerevisiae ortholog CSM1, PCS1 is not required for mono-orientation during meiosis I. Pssm-ID: 467649 Cd Length: 102 Bit Score: 38.47 E-value: 6.51e-04
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