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Conserved domains on  [gi|1063713158|ref|NP_001327426|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 17779305)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-377 2.19e-52

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 254394  Cd Length: 159  Bit Score: 171.64  E-value: 2.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 204 GVSVKGNMYWIAHWNNRPE-IFIQSFDFSTETFKIVCNLPFECNVLDTAALSSLRGDRLSLLHQSGETMKIEVWITNKLS 282
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEeDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 283 DEVVSWTKYVDVTSPDLPTLHTdqHLTHPSYFIDKNDNIMVWCEQETEEEtdddvCVSVCMISKDGIVKKQIDAGRCdlc 362
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFF--HFFAGSFFIDEEKKVAVVCDKDKEKK-----TNTIYIIGEDGYFKEVDSSYCS--- 150

                         170
                  ....*....|....*
gi 1063713158 363 sdnrPFVCGyaYVPS 377
Cdd:pfam07734 151 ----PLVCS--YVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 7-45 1.66e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 61.32  E-value: 1.66e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063713158   7 SLLPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRF 45
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-377 2.19e-52

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 171.64  E-value: 2.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 204 GVSVKGNMYWIAHWNNRPE-IFIQSFDFSTETFKIVCNLPFECNVLDTAALSSLRGDRLSLLHQSGETMKIEVWITNKLS 282
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEeDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 283 DEVVSWTKYVDVTSPDLPTLHTdqHLTHPSYFIDKNDNIMVWCEQETEEEtdddvCVSVCMISKDGIVKKQIDAGRCdlc 362
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFF--HFFAGSFFIDEEKKVAVVCDKDKEKK-----TNTIYIIGEDGYFKEVDSSYCS--- 150

                         170
                  ....*....|....*
gi 1063713158 363 sdnrPFVCGyaYVPS 377
Cdd:pfam07734 151 ----PLVCS--YVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 94-323 2.20e-45

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 155.98  E-value: 2.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158  94 MVHCDGLLLCRCKNersrsyKLAVWNPFLSRVKWIEPMDFYSSN---DFYGFGYDNvCRDEYKLLRIFDgeiedesEIAG 170
Cdd:TIGR01640   1 VVPCDGLICFSYGK------RLVVWNPSTGQSRWLPTPKSRRSNkesDTYFLGYDP-IEKQYKVLCFSD-------RSGN 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 171 SYEPKIQIYDFKSDSWRIVDdTRLDWSIDPPCkGVSVKGNMYWIAHWNN-RPEIFIQSFDFSTETFKIVCNLPFE-CNVL 248
Cdd:TIGR01640  67 RNQSEHQVYTLGSNSWRTIE-CSPPHHPLKSR-GVCINGVLYYLAYTLKtNPDYFIVSFDVSSERFKEFIPLPCGnSDSV 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063713158 249 DTAALSSLRGdRLSLLHQSGETMKIEVWITNKLsdEVVSWTKYVDVTSPDLPTLHTDqhlTHPSYFIDKNDNIMV 323
Cdd:TIGR01640 145 DYLSLINYKG-KLAVLKQKKDTNNFDLWVLNDA--GKQEWSKLFTVPIPPLPDLVDD---NFLSGFTDKGEIVLC 213
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 7-45 1.66e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 61.32  E-value: 1.66e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063713158   7 SLLPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRF 45
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-49 1.58e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.57  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1063713158    9 LPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRFIYKY 49
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 7-48 5.57e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063713158   7 SLLPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRFIYK 48
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 204-377 2.19e-52

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 171.64  E-value: 2.19e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 204 GVSVKGNMYWIAHWNNRPE-IFIQSFDFSTETFKIVCNLPFECNVLDTAALSSLRGDRLSLLHQSGETMKIEVWITNKLS 282
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEeDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 283 DEVVSWTKYVDVTSPDLPTLHTdqHLTHPSYFIDKNDNIMVWCEQETEEEtdddvCVSVCMISKDGIVKKQIDAGRCdlc 362
Cdd:pfam07734  81 PNAVSWSKFLTVDMPPLPGLFF--HFFAGSFFIDEEKKVAVVCDKDKEKK-----TNTIYIIGEDGYFKEVDSSYCS--- 150

                         170
                  ....*....|....*
gi 1063713158 363 sdnrPFVCGyaYVPS 377
Cdd:pfam07734 151 ----PLVCS--YVPS 159
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 94-323 2.20e-45

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 155.98  E-value: 2.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158  94 MVHCDGLLLCRCKNersrsyKLAVWNPFLSRVKWIEPMDFYSSN---DFYGFGYDNvCRDEYKLLRIFDgeiedesEIAG 170
Cdd:TIGR01640   1 VVPCDGLICFSYGK------RLVVWNPSTGQSRWLPTPKSRRSNkesDTYFLGYDP-IEKQYKVLCFSD-------RSGN 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063713158 171 SYEPKIQIYDFKSDSWRIVDdTRLDWSIDPPCkGVSVKGNMYWIAHWNN-RPEIFIQSFDFSTETFKIVCNLPFE-CNVL 248
Cdd:TIGR01640  67 RNQSEHQVYTLGSNSWRTIE-CSPPHHPLKSR-GVCINGVLYYLAYTLKtNPDYFIVSFDVSSERFKEFIPLPCGnSDSV 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063713158 249 DTAALSSLRGdRLSLLHQSGETMKIEVWITNKLsdEVVSWTKYVDVTSPDLPTLHTDqhlTHPSYFIDKNDNIMV 323
Cdd:TIGR01640 145 DYLSLINYKG-KLAVLKQKKDTNNFDLWVLNDA--GKQEWSKLFTVPIPPLPDLVDD---NFLSGFTDKGEIVLC 213
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 7-45 1.66e-12

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 61.32  E-value: 1.66e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063713158   7 SLLPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRF 45
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-49 1.58e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 38.57  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1063713158    9 LPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRFIYKY 49
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 7-48 5.57e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063713158   7 SLLPIDIIEEICCRIPVEYLTQFKLTCKQWFALLKDKRFIYK 48
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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