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Conserved domains on  [gi|1063715379|ref|NP_001326350|]
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phosphate transporter 4;3 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-342 4.31e-108

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17380:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 320.27  E-value: 4.31e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17380    67 LLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGP 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskMPTW 160
Cdd:cd17380   147 LLLEYYGWPSVFYFFGLLGLLWALVWLIYL----------------------------------------------PPVW 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYhVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSITLTRKIMQSIGFI 240
Cdd:cd17380   181 AIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSF 320
Cdd:cd17380   260 GPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSW 339

                         330       340
                  ....*....|....*....|..
gi 1063715379 321 QGFILLTAILYLLSALFYNIYA 342
Cdd:cd17380   340 SLVFVLAAVVNLVGAVVFLLFG 361
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-342 4.31e-108

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 320.27  E-value: 4.31e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17380    67 LLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGP 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskMPTW 160
Cdd:cd17380   147 LLLEYYGWPSVFYFFGLLGLLWALVWLIYL----------------------------------------------PPVW 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYhVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSITLTRKIMQSIGFI 240
Cdd:cd17380   181 AIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSF 320
Cdd:cd17380   260 GPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSW 339

                         330       340
                  ....*....|....*....|..
gi 1063715379 321 QGFILLTAILYLLSALFYNIYA 342
Cdd:cd17380   340 SLVFVLAAVVNLVGAVVFLLFG 361
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 4-350 1.59e-46

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 164.15  E-value: 1.59e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   4 GVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILM 83
Cdd:TIGR00894 112 GMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLC 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  84 -SQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSELEYIKqkkqiSTMENKRISTSGIPPFGRLLSKMPTWAV 162
Cdd:TIGR00894 192 eSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN-----SSLQGQKGSTRQSLPIKAIPKSLPVWAI 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 163 IVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGT-SITLTRKIMQSIGFIG 241
Cdd:TIGR00894 267 WFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLG 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 242 PGIALIGLTTAKQPLV-ASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL--LG 318
Cdd:TIGR00894 347 PGIFAYALPYLSAAFYlTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKN 426

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1063715379 319 SFQGFILLTAILYLLSALFYNIYATGERVDFD 350
Cdd:TIGR00894 427 VWLIVFLIMAFVNILCVIFYLIFGSAERQDWA 458
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-338 6.74e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.97  E-value: 6.74e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG2271    78 LAIGLLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVwlsatssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskmPTW 160
Cdd:COG2271   156 WLLAAFGWRAAFLILGLPGLLLALL----------------------------------------------------RFW 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRgtsitltRKIMQSIGFI 240
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGs 319
Cdd:COG2271   257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG- 335

                         330
                  ....*....|....*....
gi 1063715379 320 FQGFILLTAILYLLSALFY 338
Cdd:COG2271   336 YQAAFLLLAALALLAALLA 354
MFS_1 pfam07690
Major Facilitator Superfamily;
1-307 7.32e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.46  E-value: 7.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:pfam07690  65 LLIGLLLFALGLLLLLFA--SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQitkseleyikqkkqistmENKRISTSGIPPFGRLLSKMPTW 160
Cdd:pfam07690 143 LLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK------------------PAEEARLSLIVAWKALLRDPVLW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVAnSMHSWGFFVILSWMPIYfNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRgtsitlTRKIMQSIGFI 240
Cdd:pfam07690 205 LLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLI 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGT 307
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-105 1.10e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   5 VALWSLATFLTPWAADssLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGnvvGLMLSPILMS 84
Cdd:PRK11551   87 VALFGLFSLATAQAWD--FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG---GALASVIGVL 161

                          90       100
                  ....*....|....*....|.
gi 1063715379  85 QGGIYGPFVIFGLSGFLWLLV 105
Cdd:PRK11551  162 AAGDAAWRHIFYVGGVGPLLL 182
MFS_SpdSyn NF037959
fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major ...
 293-346 4.96e-03

fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major Facilitator Superfamily) transporter domain and a C-terminal spermidine synthase (SpdSyn)-like domain. The encoding genes usually near the genes encoding S-adenosylmethionine decarboxylase (AdoMetDC) on many bacterial genomes. It has been shown in Shewanella oneidensis that the fused protein aminopropylates a substrate other than putrescine, and has a role outside of polyamine biosynthesis.


Pssm-ID: 468290 [Multi-domain]  Cd Length: 480  Bit Score: 38.67  E-value: 4.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379 293 GMCLTAGTLAAIVGTVGAGF-FVELLGSfQGFILLTAILYLLSALFYNIYATGER 346
Cdd:NF037959  133 GAMFAAGAIGAIAGTLLAGFlFISWLGS-AGTLLVVAAVYALLALLFLWLAGGRR 186
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 1-342 4.31e-108

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 320.27  E-value: 4.31e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17380    67 LLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGP 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskMPTW 160
Cdd:cd17380   147 LLLEYYGWPSVFYFFGLLGLLWALVWLIYL----------------------------------------------PPVW 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYhVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSITLTRKIMQSIGFI 240
Cdd:cd17380   181 AIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSF 320
Cdd:cd17380   260 GPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSW 339

                         330       340
                  ....*....|....*....|..
gi 1063715379 321 QGFILLTAILYLLSALFYNIYA 342
Cdd:cd17380   340 SLVFVLAAVVNLVGAVVFLLFG 361
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 1-342 3.04e-70

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 224.42  E-value: 3.04e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17318    89 LGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSG 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLsatssapdrhpqitkseleyikqkkqistmenkristsgippfgrLLSkMPTW 160
Cdd:cd17318   169 FLCESLGWPSIFYIFGGLGLLWCLLWF---------------------------------------------FLV-LPVW 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGT-SITLTRKIMQSIGF 239
Cdd:cd17318   203 AIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTTVRKLFTSIGF 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 240 IGPGIALIGLT-TAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFV---E 315
Cdd:cd17318   283 LGPGVFLIALGyLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQ 362

                         330       340
                  ....*....|....*....|....*..
gi 1063715379 316 LLGSFQGFILLTAILYLLSALFYNIYA 342
Cdd:cd17318   363 TIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 4-350 1.59e-46

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 164.15  E-value: 1.59e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   4 GVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILM 83
Cdd:TIGR00894 112 GMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLC 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  84 -SQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSELEYIKqkkqiSTMENKRISTSGIPPFGRLLSKMPTWAV 162
Cdd:TIGR00894 192 eSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN-----SSLQGQKGSTRQSLPIKAIPKSLPVWAI 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 163 IVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGT-SITLTRKIMQSIGFIG 241
Cdd:TIGR00894 267 WFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLG 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 242 PGIALIGLTTAKQPLV-ASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL--LG 318
Cdd:TIGR00894 347 PGIFAYALPYLSAAFYlTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQdsKN 426

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1063715379 319 SFQGFILLTAILYLLSALFYNIYATGERVDFD 350
Cdd:TIGR00894 427 VWLIVFLIMAFVNILCVIFYLIFGSAERQDWA 458
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 1-342 1.85e-39

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 143.77  E-value: 1.85e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17381    98 LGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskMPTW 160
Cdd:cd17381   178 LICYYLDWTYVFYIFGAVGLLWFFLWIWLV----------------------------------------------MPLW 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVP----WSMMAFTGYIAGFwsdLLIRRGTSITLTRKIMQS 236
Cdd:cd17381   212 AIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPylgcWLFMILSGQIADN---LREKQNFSTVCVRKIFTL 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 237 IGFIGPGIALI--GLTTAKQPLvASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFV 314
Cdd:cd17381   289 IGMIGPAVFLLaaGFTGCNYSL-AVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLT 367

                         330       340       350
                  ....*....|....*....|....*....|
gi 1063715379 315 E--LLGSFQGFILLTAILYLLSALFYNIYA 342
Cdd:cd17381   368 HnnTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 4-342 4.09e-37

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 137.09  E-value: 4.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   4 GVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILM 83
Cdd:cd17382    85 AIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILV 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  84 SQGGIYGPFVIFGLSGFLWLLVWLsatssapdrhpqitkseleyikqkkqistmenkristsgippfgrlLSKMPTWAVI 163
Cdd:cd17382   165 QYVGWSSPFYVYGVFGIIWYMFWM----------------------------------------------LVSMPVYAII 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 164 VANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGT-SITLTRKIMQSIGFIGP 242
Cdd:cd17382   199 VANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGME 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 243 GIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVG--TVGAGFFVELLGSF 320
Cdd:cd17382   279 ATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCpvIVGALTKHKTREEW 358

                         330       340
                  ....*....|....*....|..
gi 1063715379 321 QGFILLTAILYLLSALFYNIYA 342
Cdd:cd17382   359 QYVFLIASLVHFFGVIFYAIFA 380
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-338 2.23e-34

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 129.23  E-value: 2.23e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17319    71 LAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLsatssapdrhpqitkseleyikqkkqistmenkristsgippfgRLLSKMptW 160
Cdd:cd17319   149 WLLLLFGWRWAFIIEGLLGLLLAVLWW--------------------------------------------FYLRQV--W 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRrgtsitLTRKIMQSIGFI 240
Cdd:cd17319   183 GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR------GARRLVIIIGLL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGS 319
Cdd:cd17319   257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGS 336

                         330
                  ....*....|....*....
gi 1063715379 320 FQGFILLTAILYLLSALFY 338
Cdd:cd17319   337 YTAAFLFLAAVALLAALLV 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-338 6.74e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.97  E-value: 6.74e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG2271    78 LAIGLLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVwlsatssapdrhpqitkseleyikqkkqistmenkristsgippfgrllskmPTW 160
Cdd:COG2271   156 WLLAAFGWRAAFLILGLPGLLLALL----------------------------------------------------RFW 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRgtsitltRKIMQSIGFI 240
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLL 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGs 319
Cdd:COG2271   257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATG- 335

                         330
                  ....*....|....*....
gi 1063715379 320 FQGFILLTAILYLLSALFY 338
Cdd:COG2271   336 YQAAFLLLAALALLAALLA 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-337 7.45e-25

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 103.81  E-value: 7.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG2223    73 LLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSELeyikqKKQISTMENKRistsgippfgrllskmpTW 160
Cdd:COG2223   151 LLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----RDQLEALRDPR-----------------FW 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSItltrkimqsIGFI 240
Cdd:COG2223   209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL---------IVFA 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLksFSHLGFLINLQEIA----PEYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL 316
Cdd:COG2223   280 LMALGLLLLALALGSLWLFLVLFLLLGL--ALGGGNGAVFALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                         330       340
                  ....*....|....*....|.
gi 1063715379 317 LGSFQGFILLTAILYLLSALF 337
Cdd:COG2223   358 TGSYTAAFLVFAVLALVALVL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-303 3.02e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.86  E-value: 3.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG2814    78 LLLGLLLFALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFL-WLLVWLSATSSAPDRHPQITKSELEYIKQKkqistmenkristsgippfgrllskmPT 159
Cdd:COG2814   156 LLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARARLRGSLRELLRRP--------------------------RL 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 160 WAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSItltrkimqsIGF 239
Cdd:COG2814   210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL---------IGL 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379 240 IGPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAA 303
Cdd:COG2814   281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
1-307 7.32e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.46  E-value: 7.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:pfam07690  65 LLIGLLLFALGLLLLLFA--SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQitkseleyikqkkqistmENKRISTSGIPPFGRLLSKMPTW 160
Cdd:pfam07690 143 LLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK------------------PAEEARLSLIVAWKALLRDPVLW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVAnSMHSWGFFVILSWMPIYfNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRgtsitlTRKIMQSIGFI 240
Cdd:pfam07690 205 LLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLI 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGT 307
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-338 1.34e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.08  E-value: 1.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAAdsSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd06174    64 LLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGI--YGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSELEYIKQKkqistmenkristsgipPFGRLLSKMP 158
Cdd:cd06174   142 ILASSLGFgwRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLK-----------------LLKRVLKNPG 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 159 TWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRrgtsitltRKIMQSIG 238
Cdd:cd06174   205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIG 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 239 FIGPGIALIGLTTAKQPLVASAWLSL-AVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELL 317
Cdd:cd06174   277 LLLMALGLALLLLAPSLLLLLLLLLLlGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356

                         330       340
                  ....*....|....*....|.
gi 1063715379 318 GSFQGFILLTAILYLLSALFY 338
Cdd:cd06174   357 FGLTGAFLVLAVLLLLAAILL 377
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-337 8.53e-15

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 74.91  E-value: 8.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPpTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG2807    86 LLLALLLLAAGLLLRSLA--PSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTV 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPqitkseleyikqkkqistmenkriSTSGIPPFGRLLSKMPTW 160
Cdd:COG2807   163 PLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA------------------------AAPAAASLRSLWRSPLAW 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMHSWGFFVILSWMPIYFNSvYHVNLKQAAWFSAVpwsmMAFTGYIAGFWSDLLIRRGTSITLTRKIMQSIGFI 240
Cdd:COG2807   219 LLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSL----FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAkqPLVASAWLSLAVGLkSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSF 320
Cdd:COG2807   294 GLLGLLLAPGSL--PWLWAVLLGLGQGG-LFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSW 370

                         330
                  ....*....|....*..
gi 1063715379 321 QGFILLTAILYLLSALF 337
Cdd:COG2807   371 TAALLLLAALAVLMLVA 387
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-338 1.13e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.45  E-value: 1.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17325    64 LLLGLLLLAVSTLLFAFA--TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFV---IFGLSGFLWLLVWLSATSSAPDRhpqitkseleyikqkkqistmeNKRISTSGIPPFGRLLSKM 157
Cdd:cd17325   142 LLADALGYRAPFLvcaALALLALVLALLLLPEPRPPPNK----------------------RAVSAARLRSGLRLLLRDR 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 158 PTWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTsitltrkIMQSI 237
Cdd:cd17325   200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL-------ILIGL 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 238 GFIGPGIALIGLTTAKQPLVASAWL-SLAVGLKSFSHLGFLINLqeIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL 316
Cdd:cd17325   273 LLSAVALLLLPLATSFWLLLLLLALlGLGLGLVFPATLALLADI--VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350

                         330       340
                  ....*....|....*....|..
gi 1063715379 317 LGSFQGFILLTAILYLLSALFY 338
Cdd:cd17325   351 FGFATPFLAAAALLLLAAVLFL 372
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 4-337 1.64e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 61.87  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   4 GVALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILM 83
Cdd:cd17475    65 AVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  84 SQGGIYGPFVIFGLSGFLW-LLVWLS-ATSSAPDRHPQITKSELEYIKqkkqistmenkristsgippfgRLLSKMPTWA 161
Cdd:cd17475   145 LHYGWRAAFVVAGLVSILAaVLFWLFyREPPAASAATESASTLLRSLK----------------------EVLRNRDVWL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 162 VIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAW-FSAVPWSMMAftGYIA-GFWSDLLIRRgtsitLTRKIMQSIGF 239
Cdd:cd17475   203 IAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGAlLAVAQLGGAL--GRIGlGRVSDRVFGG-----RRRPVLVITAA 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 240 IGPG-IALIGLTTAKQPLVASAWLSLAVGLKSFSHLG-FLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL 316
Cdd:cd17475   276 IAAAaLLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGlYLTLVAESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355

                         330       340
                  ....*....|....*....|..
gi 1063715379 317 LGSFQ-GFILLTAILYLLSALF 337
Cdd:cd17475   356 THSYApAWLALALLLVLAALLL 377
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-337 1.58e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 58.71  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17324    67 LLVLLLLFILGNLLAALA--PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSG---FLWLLVWLSATSSAPDRHPQITKSELeyikqkkqistmenkristsgippfgRLLSKM 157
Cdd:cd17324   145 LLGQLLGWRAAFLAIAVLAllaALLLWRLLPSLPPKKPGSLGLLSSLL--------------------------LLLRNP 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 158 PTWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTsitltrkimqSI 237
Cdd:cd17324   199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL----------LI 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 238 GFIGPGIALIGLTTAKQPLVASAWLSLAVGLKSFS-HLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVEL 316
Cdd:cd17324   269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAaHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH 348

                         330       340
                  ....*....|....*....|.
gi 1063715379 317 LGsFQGFILLTAILYLLSALF 337
Cdd:cd17324   349 GG-WAGVGWVGAALLLLALLL 368
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 1-223 8.30e-09

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 56.62  E-value: 8.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFqlgNVVGLMLSP 80
Cdd:TIGR00881  63 LPIGLILCAIVNLFFGFS--TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSH---NVGGGLLPP 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGP----FVIFGLSGFLWLLVWLSATSSAPdRHPQITKSELEYIKQKKQISTMENKRISTSGIPPFGRLLSK 156
Cdd:TIGR00881 138 LVLFGIAELYSwhwvFIVPGIIAIIVSLICFLLLRDSP-QSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNK 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063715379 157 MpTWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPwSMMAFTGYIAGFW-SDLLIRR 223
Cdd:TIGR00881 217 V-LWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLY-ELGGLVGTLLAGWlSDKLFNG 282
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 21-252 1.81e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.27  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  21 SSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILmSQGGIYGPFVIFGLSGF 100
Cdd:cd17473    86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALP 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 101 LWLLVWLSATSSAPDRHPQItkseleyIKQKKQISTMENKRIstsgippfgrllskmptWAVIVANSMHSWGFFVILSWM 180
Cdd:cd17473   165 VLILVLLFLPEPARKSKSAA-------SPGAATAAALPWKRV-----------------LPIYFLAFLAMLLFYVIPIQL 220

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063715379 181 PIYFNSVYHVNLKQAAWFSAVpwsmMAFTGYIAGFWSDLLIRRgtsitLTRKIMQSIGFIGPGIALIGLTTA 252
Cdd:cd17473   221 PFLLQERGGGSAALIGLALAI----ASLAGAIGALLFGRLKRR-----LGKRRLLAIGFALMALGFLLLALA 283
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-223 2.50e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 55.06  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADssLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:TIGR00895  85 LLWSILLFSVFTLLCALATN--VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAG 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGL-SGFLWLLVWLSATSSA-------PDRHPQITKSELEYIKQKKQISTMENKRISTSGIPPFGR 152
Cdd:TIGR00895 163 WLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIdflvskrPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKA 242

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063715379 153 LLSK---MPTWAVIVANSMHSWGFFVILSWMPiYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRR 223
Cdd:TIGR00895 243 LFQGktaRITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR 315
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-97 7.21e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 53.36  E-value: 7.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17365    67 LLVSVALFGLFTLLTAFA--QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAA 144

                          90
                  ....*....|....*..
gi 1063715379  81 ILMSQGGIYGPFVIFGL 97
Cdd:cd17365   145 ALIPAFGWRSVFLLGGV 161
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 3-337 1.15e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.07  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   3 WGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPIL 82
Cdd:cd17371    69 ITILLFAVFTLLCGFA--QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  83 MS-QGGIYGPFVIFGLSGFLWLLVWLSAtssapdRHPQitksELEYIKQKKQISTMENKRISTSGIppFGRLLSKMPTWA 161
Cdd:cd17371   147 FPlLPPEIAWRVLFLLGALPALLVLFIR------RFVK----EPPQWQAARAARRHFADRPSLREL--FSPPLLRTTLLA 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 162 VIVANSMHSwGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMaFTGYIA-GFWSDLLIRRGTSItltrkimqsIGFI 240
Cdd:cd17371   215 SLLATGALG-GYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGG-FLGYLAgGFLADRIGRRNNFA---------LFAL 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLIN-LQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVeLLG 318
Cdd:cd17371   284 GSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAyLTELFPtAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSG 362

                         330
                  ....*....|....*....
gi 1063715379 319 SFQGFILLTAILYLLSALF 337
Cdd:cd17371   363 SLGTAIAVFAAVYYIAGLV 381
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-338 2.11e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAAdsSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17489    64 LLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFL-WLLVWLsatssAPDRHPQITKSELEYIKQKKQIstmenkrISTSGIPPfgrllskmpt 159
Cdd:cd17489   142 FLYQHLGFAVLFIVAAVLALLaLLLVFL-----VKDPPPVAAEEAEAGTRAFRRL-------VEKKVLPP---------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 160 wAVIVANSmhSWGFFVILSWMPIYFNsvyHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDlliRRGTSITltrkIMQSIGF 239
Cdd:cd17489   200 -ALILFLA--SIAYGAISTFLPLYAA---ERGISNAGLFFTVYAIALLLSRPFSGKLSD---RKGPKTV----IIPGLLL 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 240 IGPGIALIGLTTAKQPLVASAWLsLAVGLKSFSHLGFLINLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGs 319
Cdd:cd17489   267 LALGLLLLSFAGSPWMLLLAAVL-YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG- 344

                         330
                  ....*....|....*....
gi 1063715379 320 FQGFILLTAILYLLSALFY 338
Cdd:cd17489   345 YRAMFLLAAVVVLLALVLY 363
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 5-267 2.52e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 51.87  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   5 VALWSLATFLTpwAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVV-GLMLSPILM 83
Cdd:cd17327    78 IVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFgGLLAYGVFK 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  84 SQG--GIYG---PFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSELEYIKQKKQIST--MENKRISTSGIppfgrlLSK 156
Cdd:cd17327   156 ILGvgGLAGwrwLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQtgKGDQKFKWKQI------KEA 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 157 MPTWAVIVansmhsWGFFVILSWMPIYFNSVYHV--------NLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSIT 228
Cdd:cd17327   230 FKDPRTWL------LFLFFFCSQITNNGISNFLPlilkslgfYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAI 303

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1063715379 229 ltrkIMQSIGFIGpGIALIGLTTAKQPLVASAWLSLAVG 267
Cdd:cd17327   304 ----FACVLALVG-SIILLAAPNPPGAYFAAYILGGGSY 337
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 1-336 2.69e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.83  E-value: 2.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17316    69 LILTLLLFGLATLLIGLL--PTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGI-YGPFVIFGLSGFLWLLVWLSatssapdrhpqitkseleyikqkkqistmenkristsgippfgrllsKMPT 159
Cdd:cd17316   147 LLIPLLSGdWGWRILFLIGALPALLALLL-----------------------------------------------RRRT 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 160 WAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDllirrgtsiTLTRKIMQSIGF 239
Cdd:cd17316   180 LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD---------RIGRKKTLVIGL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 240 IGPGIALIGLTTAkqpLVASAWLSLAVG-LKSFSHLGFLINLQEIAPE-----YSGVLHGMCLTAGTLAAIVGTVGAGFF 313
Cdd:cd17316   251 ILSGILALPLFYL---LSGSPTLLLLLLfILSFFVGGVWGALYAYLAElfpteVRATGVGLSYNLGRLGGGGAPPLIALL 327

                         330       340
                  ....*....|....*....|...
gi 1063715379 314 VELLGSFQGFILLTAILYLLSAL 336
Cdd:cd17316   328 LASTGGTGVPALILALLAIVALI 350
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 17-337 9.00e-07

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 50.33  E-value: 9.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  17 WAADSSLWALLAARAMVGVAEGVALPCMNNMvARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILMSQGGIYGPFVIFG 96
Cdd:cd17341    82 ALAVSSYWGLLVLGFLLGFAGANFASGQPWA-SFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  97 LSGFLW---LLVWLSATSSAPDRHPQITKSELEYIKQKKQISTmeNKRistsgippfgrllskmpTWAVIVANSMhSWGF 173
Cdd:cd17341   161 NAFFVPgilLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLK--NYR-----------------TWILSLLYGV-TFGS 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 174 FVILS-WMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLirRGTSITLTRKIMQSIGFIgpgIALIGLTTA 252
Cdd:cd17341   221 FVGFSnVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF--GGRRRLWWLFIVMTIGAA---LLSLSLPTS 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 253 KQPLVASAWLSLAVGLksFSHLGFLINLQ---EIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSFQGFILLTAI 329
Cdd:cd17341   296 GTNLVLFLALFVALGL--GAGAGNGSVFRmvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGV 373


                  ....*...
gi 1063715379 330 LYLLSALF 337
Cdd:cd17341   374 LAVACTLL 381
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 9-338 2.28e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   9 SLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILMSQGGI 88
Cdd:cd06173    78 AAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  89 YGPFVIfglSGFLWLLVWLSATSSAPDRHPQITKSELEYIKQKKQIstmenkristsgippFGRLLSKMPTWAVIVANSM 168
Cdd:cd06173   158 GGAFAI---NALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG---------------LRYLRRSPLLRLLLLALAL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 169 HSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSItltrkimqsIGFIGPGIALIG 248
Cdd:cd06173   220 FALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL---------IGALLLGLALLV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 249 LTTAKQPLVASAWLSLAVGLKSFSHLGFLINLQEIAP-EYSGVLHGMCLTAGTLAAIVGTVGAGFFVELLGSFQGFILLT 327
Cdd:cd06173   291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPdELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370

                         330
                  ....*....|.
gi 1063715379 328 AILYLLSALFY 338
Cdd:cd06173   371 ALLLLAALLLL 381
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 1-328 3.53e-06

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 48.39  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFL---TPWAAdSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGI-----AMAGFQLGN 72
Cdd:cd17345    71 LAIGLILSAIINILigfVPSAT-SSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIwnishNVGGGLVGP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  73 VVGLMLSpiLMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRH--PQITKSELEYIKQKkqISTMENKRISTSGIppF 150
Cdd:cd17345   150 LAGLGLA--IFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEA--DGEEEEQELSAWEI--F 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 151 GRLLSKMP-TWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAW-FSAVPWSMMAFTgYIAGFWSDLLIRRgtsit 228
Cdd:cd17345   224 VKYVLKNKlLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWaFSLFEWAAIPGT-LLAGWLSDKLFKG----- 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 229 lTRKIMQSIGFIGPGIALIGLTTAKQPLvasaWLSLAVGLKSFSHLG--FLINLQ--EIAPEYS-GVLHGMC-LTAGTLA 302
Cdd:cd17345   298 -RRAPTGIIFMILVIVALIVYWLAPNVL----VDLIALIALGFLIYGpvMLIGLQalELVPKKAaGTAAGLTgLFGYLGG 372

                         330       340
                  ....*....|....*....|....*.
gi 1063715379 303 AIVGTVGAGFFVELLGSFQGFILLTA 328
Cdd:cd17345   373 SVLATALIGIIVDHFGWNGGFIVLLA 398
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-109 6.25e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 6.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd06173   277 LLIGALLLGLALLVLGLS--PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354

                          90       100
                  ....*....|....*....|....*....
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSA 109
Cdd:cd06173   355 LLADALGLSAVFLLAGALLLLAALLLLLL 383
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-105 6.64e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.11  E-value: 6.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:COG0477    82 LLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159

                          90       100
                  ....*....|....*....|....*
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLV 105
Cdd:COG0477   160 LLVAALGWRWIFLINAPLGLLALVL 184
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 4-107 1.61e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   4 GVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILM 83
Cdd:cd17474   271 GLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348

                          90       100
                  ....*....|....*....|....
gi 1063715379  84 SQGGIYGPFVIFGLSGFLWLLVWL 107
Cdd:cd17474   349 EIFGLSAPFLVGAAIALAAAVLLA 372
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-337 3.97e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAAdsSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRavgiaMAGFQLGNVVGLMLSP 80
Cdd:COG0738    76 LLLGLLLMALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-----LNLLHAFFSLGALLGP 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMS-----QGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITKSeleyikqkkqistmenkrisTSGIPPFGRLLS 155
Cdd:COG0738   149 LLGGllillGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEA--------------------AGSAASLKSLLK 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 156 KMPTWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFtGYIAGfwsDLLIRRgtsITLTRKIMQ 235
Cdd:COG0738   209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTI-GRFLG---GFLLKR---FGPVRLLRL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 236 SIGFIGPGIALIGLTTAkqpLVASAWLSLAVGLksFSHLGFLINL---QEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGF 312
Cdd:COG0738   282 SALLAAVGLLLALLAPG---PWLALIGLALVGL--GLSLMFPTIFslaLDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF 356

                         330       340
                  ....*....|....*....|....*
gi 1063715379 313 FVELLGSFQGFILLtAILYLLSALF 337
Cdd:COG0738   357 LADAFGLRAAFLVP-LVCYLLILLL 380
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 3-113 4.82e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.86  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   3 WGVALWSLATFLTpwAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPIL 82
Cdd:cd17321    66 IGLALFGLASLLC--ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL 143

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063715379  83 MSQGG---IYGPFVIFGLSGFLWLLVWLSATSSA 113
Cdd:cd17321   144 LELFGwrwIFLINVPIGLVALLLARTFSGAVLAA 177
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-107 5.07e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVG-LMLS 79
Cdd:cd17473   266 LAIGFALMALGFLLLALA--SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSpLVLG 343

                          90       100
                  ....*....|....*....|....*...
gi 1063715379  80 PILMSQGGIYGPFVIFGLSGFLWLLVWL 107
Cdd:cd17473   344 PLVNLTGGLSGAFLILGVLALVLAIVLL 371
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 1-337 9.86e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.75  E-value: 9.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPwAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPtERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17353    71 ILIGGILFGLGFILSA-FAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD-KRGLATGIVIAGFGLGSLIFSPLIA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLsGFLWLLVWLSATSSAPdrhPQITKSELEYIKQKKQISTMENKRISTSGIPPFGRLLskmptW 160
Cdd:cd17353   149 YLINTVGVPTTFLILGI-IFLIIIVIGAFLIRDP---PKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLL-----W 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVANSMhsWGFFVILSWMPIYFNsVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDllirrgtsiTLTRKIMQSIGFI 240
Cdd:cd17353   220 LMFFLNAT--AGLMLIGQAKPIGQE-FAGLDAGIAALAVSILSIFNGGGRPFWGWLSD---------KIGRKNTLSIAFL 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 241 GPGIALIGLTTAKQPLVasaWLSLAVGLKSFSHLGFL-----INLQEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVE 315
Cdd:cd17353   288 IQGVAMFLLPFIGSVAV---LFVLGVALIGFCYGGGFalfpaLTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY 364

                         330       340
                  ....*....|....*....|..
gi 1063715379 316 LLGSFQGFIlLTAILYLLSALF 337
Cdd:cd17353   365 TGGYNAAFI-IAAALSLVALAL 385
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 1-75 1.91e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 42.99  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVG 75
Cdd:cd17328    67 LAVGILIWSAATLLSSFA--PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG 139
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-105 1.96e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.95  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17330   244 LRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAG 321

                          90       100
                  ....*....|....*....|....*
gi 1063715379  81 ILMSqggIYGPFVIFGLSGFLWLLV 105
Cdd:cd17330   322 PLYS---FLGPGVPFLLAAGLLLIA 343
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 18-82 5.24e-04

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 41.46  E-value: 5.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379  18 AADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPIL 82
Cdd:cd17398    90 SSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLL 154
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 5-105 1.10e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 40.72  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   5 VALWSLATFLTPWAADssLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGnvvGLMLSPILMS 84
Cdd:PRK11551   87 VALFGLFSLATAQAWD--FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG---GALASVIGVL 161

                          90       100
                  ....*....|....*....|.
gi 1063715379  85 QGGIYGPFVIFGLSGFLWLLV 105
Cdd:PRK11551  162 AAGDAAWRHIFYVGGVGPLLL 182
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 5-94 1.28e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   5 VALWSLATFLTPWAADSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSPILMS 84
Cdd:cd17391   275 GALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAA 354

                          90
                  ....*....|
gi 1063715379  85 QGGIYGPFVI 94
Cdd:cd17391   355 HFGYRAVFVV 364
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 1-336 1.54e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.95  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARA-MVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLS 79
Cdd:cd17355    71 MLLGLLLLAAGLVLLALA--TSLWQLYLLWGlLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLG 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  80 PILMSQGGIYGPFVIFG-LSGFLWLLVWLSATSSAPDRHPQITKSELEyikqkkqistmenkrisTSGIPPFGRLLSKMP 158
Cdd:cd17355   149 AALIEAFGWRTALLVLAlLALLVLVPVLLLLRRRPADLALRAYDDASP-----------------ASPGSTLKEALRSAS 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 159 TWAVIVansmhswGFFVILSWMpiYFNSVYHVNLKQAAWFS----AVPWSMMAFTGYIAGFWSDLLIRRgtsitLTRKIM 234
Cdd:cd17355   212 FWLLAL-------AFFLCGFAV--VGLIVHLVPYLADRGISpaaaAVALALIGLFNIVGRLLSGWLGDR-----YSPRRL 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 235 QSIGFIGPGIALIGLTTAKQPLVASAWLSLAVGLKSFSHLGFLINL--QEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGF 312
Cdd:cd17355   278 LAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALaaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGL 357

                         330       340
                  ....*....|....*....|....
gi 1063715379 313 FVELLGSFQGFILLTAILYLLSAL 336
Cdd:cd17355   358 LYDRTGSYTAAWALAVALGLIAAL 381
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 1-101 1.77e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17490   264 IIIGFLLLGAYCFLIPFA--PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVG 341

                          90       100
                  ....*....|....*....|.
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFL 101
Cdd:cd17490   342 IISEAFGLQTGFFVIGVIALL 362
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-341 1.89e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAADSS----LWALLAARAMVGVAEGVALPCMNNMVARWFP-PTERSRAVGIAMAGFQLGNVVG 75
Cdd:COG2211    84 ILIGAIPLALSFVLLFTAPDLSptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLA 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  76 LMLSPILMSQGG---IYGPFVIFGLSGFLWLLVWLSATSSAPDRhpqitkseleYIKQKKQISTMENkristsgippFGR 152
Cdd:COG2211   164 SVLPPPLVAAFGgdaALGYRLTALIFAVLGLLAFLLTFFGTKER----------PVPEEEKVSLKES----------LKA 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 153 LLSKMPTWAVIVANSMHSWGFFVILSWMPIYFNSVYHVNLKQAAWFSAVPWSMMAFTGYIAGFWSDLLIRRGTSItltrk 232
Cdd:COG2211   224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI----- 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 233 imqsIGFIGPGIALIGLTTAkqPLVASAWLSLAVGLKSFSHLGFLINLQ----EIAPE--------YSGVLHGMCLTAGT 300
Cdd:COG2211   299 ----IGLLLAALGLLLLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDYdewktgrrREGLYFGIFTFAIK 372

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379 301 LAAIVGTVGAGFFVELLGSFQG--------------FILLTAILYLLSALFYNIY 341
Cdd:COG2211   373 LGQALAGALAGLLLALFGYVAGaaqspsaltgirllFFLLPAVLLLLAALLLLFY 427
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-330 2.70e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARwFPPTERSRAVGIAMAGFQLGNVVGLMLSP 80
Cdd:cd17478    64 LPLGPLLTGLGLSLLGFA--PNYWLLLLLVALAGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  81 ILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRhpqitkseleyikQKKQISTMENKRISTSGIPPFGRLlskmptW 160
Cdd:cd17478   141 ALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE-------------AKKAAAKSSARSTLKGVWRALLLL------L 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 161 AVIVansMHSWGFFVILSWMPIYFNSVYhvnlkQAAWFSAVPWSMMAFTG----YIAGFWSDlliRRGtsitltRKIMQS 236
Cdd:cd17478   202 IIVF---LRSWVLSSLTTFLPFYLVQRG-----YSLVFAGLLLSLFLFAGaigtLIGGPLSD---RFG------RRRVII 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 237 IGFIGPGIALIGLTTAkqPLVASAWLSLAVGLKSFSHLGFLINL-QEIAPEYSGVLHGMCL-----TAGTLAAIVGTVGA 310
Cdd:cd17478   265 ASLLLAAPFLLLFLLT--PGIWSYILLVLAGFLLFASFPVTVVLaQELLPGNVGLASGLMMglsfgLGGIGAPVLGALAD 342

                         330       340
                  ....*....|....*....|
gi 1063715379 311 GFFVELLGSFQGFILLTAIL 330
Cdd:cd17478   343 AFGLESVLLILALLPLLGAL 362
MFS_SpdSyn NF037959
fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major ...
 293-346 4.96e-03

fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major Facilitator Superfamily) transporter domain and a C-terminal spermidine synthase (SpdSyn)-like domain. The encoding genes usually near the genes encoding S-adenosylmethionine decarboxylase (AdoMetDC) on many bacterial genomes. It has been shown in Shewanella oneidensis that the fused protein aminopropylates a substrate other than putrescine, and has a role outside of polyamine biosynthesis.


Pssm-ID: 468290 [Multi-domain]  Cd Length: 480  Bit Score: 38.67  E-value: 4.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063715379 293 GMCLTAGTLAAIVGTVGAGF-FVELLGSfQGFILLTAILYLLSALFYNIYATGER 346
Cdd:NF037959  133 GAMFAAGAIGAIAGTLLAGFlFISWLGS-AGTLLVVAAVYALLALLFLWLAGGRR 186
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 1-337 7.17e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 38.05  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379   1 MAWGVALWSLATFLTPWAadSSLWALLAARAMVGVAEGVALPCMNNMVARWFPPTERSRAVGIAMAGFQLGNVV-GLMLS 79
Cdd:cd06180    67 IRGGLLLTVLLLAAMALT--SGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVP 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379  80 PILMSQGGIYGPFVIFGLSGFLWLLVWLSATSSAPDRHPQITkseleyikqkkqistmenkristsgiPPFGRLLSKMPT 159
Cdd:cd06180   145 AGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS--------------------------AAESAPGLNRPL 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 160 WAVIVANSMHSWGFFVILSWMPIYFNSvyhvnLKQAAWFSAVPWSMMAFTGYIAGF-WSDLLIRRGTSITLTRKI-MQSI 237
Cdd:cd06180   199 WRLALAYGLFGFGYIITATFLPLIARE-----TGAGSLLAGLLWSLFGLAAVPSCFlWGALSDRWGTRRALAANLlVQAV 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063715379 238 GFIGPGIAliglttakqPLVASAWLS-LAVGLKSFSHLGFLINL-QEIAPEYSGVLHGMCLTAGTLAAIVGTVGAGFFVE 315
Cdd:cd06180   274 GVLLPLLS---------PGPAGLVLSaVLFGGTFMAITALVMALaRELAPPAAPRALALMTASFGVGQILGPLLAGWLAD 344

                         330       340
                  ....*....|....*....|..
gi 1063715379 316 LLGSFQGFILLTAILYLLSALF 337
Cdd:cd06180   345 ATGGFAPALILAAAALVVAALL 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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