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Conserved domains on  [gi|1063714350|ref|NP_001326022|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

ATP-binding protein( domain architecture ID 16031656)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase, similar to Arabidopsis thaliana BCS1-like protein

CATH:  3.40.50.300
EC:  3.6.1.-
Gene Ontology:  GO:0005524|GO:0016887
SCOP:  4003976

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
177-341 2.34e-66

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 209.13  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 177 ILNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNSELRKLLTATSSK-SIIV 255
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 256 IEDIDCSLDLTGKRKKEKNlmtsredgeqgTEEDKSFVTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRM 335
Cdd:cd19510    81 LEDIDAAFESREHNKKNPS-----------AYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIRPGRV 147

                  ....*.
gi 1063714350 336 DMHIEL 341
Cdd:cd19510   148 DMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
25-122 8.10e-16

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


:

Pssm-ID: 464152  Cd Length: 95  Bit Score: 72.58  E-value: 8.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350  25 FPNHLRIAIKEFLIstiqqlsfvqrfsdRFINFFSPYVEISFSQYEDYQFNHAFAAIETYLGAK-ATDKAKHLRASQVKE 103
Cdd:pfam14363   1 LPPELRDYLSSKLA--------------RLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTKiSPSSARRLKASKSPK 66
                          90       100
                  ....*....|....*....|
gi 1063714350 104 SKGLVLKRDE-TKVRDEYEG 122
Cdd:pfam14363  67 SKSLVLSLDDnEEVTDVFEG 86
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
177-341 2.34e-66

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 209.13  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 177 ILNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNSELRKLLTATSSK-SIIV 255
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 256 IEDIDCSLDLTGKRKKEKNlmtsredgeqgTEEDKSFVTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRM 335
Cdd:cd19510    81 LEDIDAAFESREHNKKNPS-----------AYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIRPGRV 147

                  ....*.
gi 1063714350 336 DMHIEL 341
Cdd:cd19510   148 DMKIYM 153
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
202-343 1.65e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.27  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 202 YLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNN------SELRKLLTA--TSSKSIIVIEDIDCsldltgkrkkek 273
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgeseKRLRELFEAakKLAPCVIFIDEIDA------------ 68
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 274 nLMTSREDGEQGTEEDksfvTLSGLLNFIDGIwSACGQERIIIFTTNHFEKLDPALirRGRMDMHIELSY 343
Cdd:pfam00004  69 -LAGSRGSGGDSESRR----VVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPAL--LGRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
189-360 1.52e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 94.69  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKsTMIA-AMANHLNYSIYDLELTAIRN----NSE--LRKLLTATSSK--SIIVIEDI 259
Cdd:COG1222   102 ELFRKYGIEPPKGVLLYGPPGTGK-TLLAkAVAGELGAPFIRVRGSELVSkyigEGArnVREVFELAREKapSIIFIDEI 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 260 DCsldltgkrkkeknLMTSREDGEQGTEEDKsfvTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:COG1222   181 DA-------------IAARRTDDGTSGEVQR---TVNQLLAELDGFES--RGDVLIIAATNRPDLLDPALLRPGRFDRVI 242
                         170       180       190
                  ....*....|....*....|....*....|
gi 1063714350 340 ELSYCSFEA----FKILAKNY-----LDLD 360
Cdd:COG1222   243 EVPLPDEEAreeiLKIHLRDMpladdVDLD 272
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
25-122 8.10e-16

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 72.58  E-value: 8.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350  25 FPNHLRIAIKEFLIstiqqlsfvqrfsdRFINFFSPYVEISFSQYEDYQFNHAFAAIETYLGAK-ATDKAKHLRASQVKE 103
Cdd:pfam14363   1 LPPELRDYLSSKLA--------------RLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTKiSPSSARRLKASKSPK 66
                          90       100
                  ....*....|....*....|
gi 1063714350 104 SKGLVLKRDE-TKVRDEYEG 122
Cdd:pfam14363  67 SKSLVLSLDDnEEVTDVFEG 86
ftsH CHL00176
cell division protein; Validated
137-361 5.71e-13

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 70.85  E-value: 5.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 137 FTNNPSSHWGTSKKSFWRyidfeHPASFHTLA-----------MDTKKKEeiLNDLAAFSNGKEYYKKIGKAWKRGYLLH 205
Cdd:CHL00176  150 RSSNFKGGPGQNLMNFGK-----SKARFQMEAdtgitfrdiagIEEAKEE--FEEVVSFLKKPERFTAVGAKIPKGVLLV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 206 GPPGTGKSTMIAAMANHLNYSIYDLELTAIR------NNSELRKLLTATSSKS--IIVIEDIDCsldlTGkRKKEKNLMT 277
Cdd:CHL00176  223 GPPGTGKTLLAKAIAGEAEVPFFSISGSEFVemfvgvGAARVRDLFKKAKENSpcIVFIDEIDA----VG-RQRGAGIGG 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 278 SREDGEQgteedksfvTLSGLLNFIDGIWSACGQerIIIFTTNHFEKLDPALIRRGRMDMHIELSYCSFEA----FKILA 353
Cdd:CHL00176  298 GNDEREQ---------TLNQLLTEMDGFKGNKGV--IVIAATNRVDILDAALLRPGRFDRQITVSLPDREGrldiLKVHA 366

                  ....*....
gi 1063714350 354 KNY-LDLDT 361
Cdd:CHL00176  367 RNKkLSPDV 375
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
189-341 8.19e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 64.16  E-value: 8.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLN---YSIYDLELTAI---RNNSELRKLLTAT--SSKSIIVIEDID 260
Cdd:TIGR01243 202 ELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGayfISINGPEIMSKyygESEERLREIFKEAeeNAPSIIFIDEID 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 261 CsldLTGKRKkeknlmtsredgEQGTEEDKSFVtlSGLLNFIDGIwsacgQER---IIIFTTNHFEKLDPALIRRGRMDM 337
Cdd:TIGR01243 282 A---IAPKRE------------EVTGEVEKRVV--AQLLTLMDGL-----KGRgrvIVIGATNRPDALDPALRRPGRFDR 339

                  ....
gi 1063714350 338 HIEL 341
Cdd:TIGR01243 340 EIVI 343
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
199-341 5.25e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.91  E-value: 5.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350  199 KRGYLLHGPPGTGKSTMIAAMANHLNYSIY-----DLELTAIRNNSELRKLLTATSSKSIIVIEDIDcslDLTGKRKKEK 273
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGgviyiDGEDILEEVLDQLLLIIVGGKKASGSGELRLR---LALALARKLK 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063714350  274 NL------MTSREDGEQGTEEDKSFVTLSGLLNFIDGiwsacgqERIIIFTTNHFEKLDPALIRRgRMDMHIEL 341
Cdd:smart00382  79 PDvlildeITSLLDAEQEALLLLLEELRLLLLLKSEK-------NLTVILTTNDEKDLGPALLRR-RFDRRIVL 144
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
190-251 6.93e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.09  E-value: 6.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063714350 190 YYKKIgkawkrgyLLHGPPGTGKSTMIAAMANHLNYSIYDLeltairnNSEL-RKLLTATSSK 251
Cdd:NF033453   15 YYKLI--------LLVGPPGSGKTALLRELAAKRGAPVINV-------NLELsRRLLELPEKQ 62
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
177-341 2.34e-66

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 209.13  E-value: 2.34e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 177 ILNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNSELRKLLTATSSK-SIIV 255
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 256 IEDIDCSLDLTGKRKKEKNlmtsredgeqgTEEDKSFVTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRM 335
Cdd:cd19510    81 LEDIDAAFESREHNKKNPS-----------AYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLDPALIRPGRV 147

                  ....*.
gi 1063714350 336 DMHIEL 341
Cdd:cd19510   148 DMKIYM 153
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
174-341 2.70e-23

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 95.43  E-value: 2.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 174 KEEILNDLAAFSNGKEYYKKIGKAwKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNS------ELRKLLTA 247
Cdd:cd19481     2 KASLREAVEAPRRGSRLRRYGLGL-PKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYvgesekNLRKIFER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 248 --TSSKSIIVIEDIDCsldLTGKRkkeknlmtsREDGEQGTEEDksfvTLSGLLNFIDGIwsaCGQERIIIF-TTNHFEK 324
Cdd:cd19481    81 arRLAPCILFIDEIDA---IGRKR---------DSSGESGELRR----VLNQLLTELDGV---NSRSKVLVIaATNRPDL 141
                         170
                  ....*....|....*..
gi 1063714350 325 LDPALIRRGRMDMHIEL 341
Cdd:cd19481   142 LDPALLRPGRFDEVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
202-343 1.65e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.27  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 202 YLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNN------SELRKLLTA--TSSKSIIVIEDIDCsldltgkrkkek 273
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgeseKRLRELFEAakKLAPCVIFIDEIDA------------ 68
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 274 nLMTSREDGEQGTEEDksfvTLSGLLNFIDGIwSACGQERIIIFTTNHFEKLDPALirRGRMDMHIELSY 343
Cdd:pfam00004  69 -LAGSRGSGGDSESRR----VVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPAL--LGRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
189-360 1.52e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 94.69  E-value: 1.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKsTMIA-AMANHLNYSIYDLELTAIRN----NSE--LRKLLTATSSK--SIIVIEDI 259
Cdd:COG1222   102 ELFRKYGIEPPKGVLLYGPPGTGK-TLLAkAVAGELGAPFIRVRGSELVSkyigEGArnVREVFELAREKapSIIFIDEI 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 260 DCsldltgkrkkeknLMTSREDGEQGTEEDKsfvTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:COG1222   181 DA-------------IAARRTDDGTSGEVQR---TVNQLLAELDGFES--RGDVLIIAATNRPDLLDPALLRPGRFDRVI 242
                         170       180       190
                  ....*....|....*....|....*....|
gi 1063714350 340 ELSYCSFEA----FKILAKNY-----LDLD 360
Cdd:COG1222   243 EVPLPDEEAreeiLKIHLRDMpladdVDLD 272
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
174-407 1.85e-21

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 95.75  E-value: 1.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 174 KEEILNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRN----NSE--LRKLLTA 247
Cdd:COG0464   166 KEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSkyvgETEknLREVFDK 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 248 --TSSKSIIVIEDIDcslDLTGKRKKEKNLMTSREDGEqgteedksfvtlsgLLNFIDGIWSacgqERIIIFTTNHFEKL 325
Cdd:COG0464   246 arGLAPCVLFIDEAD---ALAGKRGEVGDGVGRRVVNT--------------LLTEMEELRS----DVVVIAATNRPDLL 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 326 DPALIRrgRMDMHIELSYCSFEAFKILAKNYL-DLDTHPLFkKIESLLKETK-IAPAD---VAENLMKKNTEIDADG-SL 399
Cdd:COG0464   305 DPALLR--RFDEIIFFPLPDAEERLEIFRIHLrKRPLDEDV-DLEELAEATEgLSGADirnVVRRAALQALRLGREPvTT 381

                  ....*...
gi 1063714350 400 KDLIQALE 407
Cdd:COG0464   382 EDLLEALE 389
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
176-341 1.83e-17

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 79.26  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 176 EILNDLAAFSNGK-EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI------RNNSELRKLLTAT 248
Cdd:cd19503    10 ASLKELIELPLKYpELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvskylgESEKNLREIFEEA 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 249 SS--KSIIVIEDIDCsldLTGKRKKEKNLMTSRedgeqgteedksfvTLSGLLNFIDGIWSAcgQERIIIFTTNHFEKLD 326
Cdd:cd19503    90 RShaPSIIFIDEIDA---LAPKREEDQREVERR--------------VVAQLLTLMDGMSSR--GKVVVIAATNRPDAID 150
                         170
                  ....*....|....*
gi 1063714350 327 PALIRRGRMDMHIEL 341
Cdd:cd19503   151 PALRRPGRFDREVEI 165
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
189-340 4.78e-16

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 75.45  E-value: 4.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNysiydleLTAIR-NNSEL------------RKLLTATSSK--SI 253
Cdd:cd19502    27 ELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTD-------ATFIRvVGSELvqkyigegarlvRELFEMAREKapSI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 254 IVIEDIDCsldLTGKRKkeknlmtsrEDGEQGTEEDKSfvTLSGLLNFIDGiWSACGQERiIIFTTNHFEKLDPALIRRG 333
Cdd:cd19502   100 IFIDEIDA---IGAKRF---------DSGTGGDREVQR--TMLELLNQLDG-FDPRGNIK-VIMATNRPDILDPALLRPG 163

                  ....*..
gi 1063714350 334 RMDMHIE 340
Cdd:cd19502   164 RFDRKIE 170
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
25-122 8.10e-16

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 72.58  E-value: 8.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350  25 FPNHLRIAIKEFLIstiqqlsfvqrfsdRFINFFSPYVEISFSQYEDYQFNHAFAAIETYLGAK-ATDKAKHLRASQVKE 103
Cdd:pfam14363   1 LPPELRDYLSSKLA--------------RLFSRFSPYLTIVIDEFDGFSRNELYDAAQTYLSTKiSPSSARRLKASKSPK 66
                          90       100
                  ....*....|....*....|
gi 1063714350 104 SKGLVLKRDE-TKVRDEYEG 122
Cdd:pfam14363  67 SKSLVLSLDDnEEVTDVFEG 86
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
188-341 6.22e-15

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 72.44  E-value: 6.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 188 KEYYKKIGKAWKRGYLLHGPPGTGKsTMIA-AMANHLNYSIYDLELTAI----RNNSE--LRKLL-TATS-SKSIIVIED 258
Cdd:cd19518    23 PEYFQHLGVEPPRGVLLHGPPGCGK-TMLAnAIAGELKVPFLKISATEIvsgvSGESEekIRELFdQAISnAPCIVFIDE 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 259 IDCsldLTGKRKKEKNLMTSRedgeqgteedksfvTLSGLLNFIDGI--WSACGQERIIIFTTNHFEKLDPALIRRGRMD 336
Cdd:cd19518   102 IDA---ITPKRESAQREMERR--------------IVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRRAGRFD 164

                  ....*
gi 1063714350 337 MHIEL 341
Cdd:cd19518   165 REICL 169
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
170-411 2.96e-14

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 72.22  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 170 DTKKKeeiLNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI------RNNSELRK 243
Cdd:COG1223     9 EAKKK---LKLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLigsylgETARNLRK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 244 LLTATSSKSIIVIEDidcSLDLTGKRKKEKNLM--TSRedgeqgteedksfvTLSGLLNFIDGIwsacGQERIIIFTTNH 321
Cdd:COG1223    86 LFDFARRAPCVIFFD---EFDAIAKDRGDQNDVgeVKR--------------VVNALLQELDGL----PSGSVVIAATNH 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 322 FEKLDPALIRrgRMDMHIELSYCSFEAFKILAKNYLDLDTHPLFKKIESLLKETK-IAPADVAE---NLMKKNTEIDADG 397
Cdd:COG1223   145 PELLDSALWR--RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEgLSGADIEKvlkTALKKAILEDREK 222
                         250
                  ....*....|....*
gi 1063714350 398 SLK-DLIQALEGKKK 411
Cdd:COG1223   223 VTKeDLEEALKQRKE 237
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
189-341 7.31e-14

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 69.00  E-value: 7.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI------RNNSELRKLLTATS--SKSIIVIEDID 260
Cdd:cd19519    24 ELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEImsklagESESNLRKAFEEAEknAPAIIFIDEID 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 261 CsldLTGKRKKEKNLMTSRedgeqgteedksfvTLSGLLNFIDGIwsacgQER---IIIFTTNHFEKLDPALIRRGRMDM 337
Cdd:cd19519   104 A---IAPKREKTHGEVERR--------------IVSQLLTLMDGL-----KQRahvIVMAATNRPNSIDPALRRFGRFDR 161

                  ....
gi 1063714350 338 HIEL 341
Cdd:cd19519   162 EIDI 165
ftsH CHL00176
cell division protein; Validated
137-361 5.71e-13

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 70.85  E-value: 5.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 137 FTNNPSSHWGTSKKSFWRyidfeHPASFHTLA-----------MDTKKKEeiLNDLAAFSNGKEYYKKIGKAWKRGYLLH 205
Cdd:CHL00176  150 RSSNFKGGPGQNLMNFGK-----SKARFQMEAdtgitfrdiagIEEAKEE--FEEVVSFLKKPERFTAVGAKIPKGVLLV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 206 GPPGTGKSTMIAAMANHLNYSIYDLELTAIR------NNSELRKLLTATSSKS--IIVIEDIDCsldlTGkRKKEKNLMT 277
Cdd:CHL00176  223 GPPGTGKTLLAKAIAGEAEVPFFSISGSEFVemfvgvGAARVRDLFKKAKENSpcIVFIDEIDA----VG-RQRGAGIGG 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 278 SREDGEQgteedksfvTLSGLLNFIDGIWSACGQerIIIFTTNHFEKLDPALIRRGRMDMHIELSYCSFEA----FKILA 353
Cdd:CHL00176  298 GNDEREQ---------TLNQLLTEMDGFKGNKGV--IVIAATNRVDILDAALLRPGRFDRQITVSLPDREGrldiLKVHA 366

                  ....*....
gi 1063714350 354 KNY-LDLDT 361
Cdd:CHL00176  367 RNKkLSPDV 375
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
174-339 1.02e-12

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 66.10  E-value: 1.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 174 KEEiLNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKsTMIA-AMANHLNYSIYDL------ELTAIRNNSELRKLLT 246
Cdd:cd19501    13 KEE-LKEVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGK-TLLAkAVAGEAGVPFFSIsgsdfvEMFVGVGASRVRDLFE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 247 ATSSKS--IIVIEDIDCsldlTGkRKKEKNLMTSREDGEQgteedksfvTLSGLLNFIDGIWSACGQerIIIFTTNHFEK 324
Cdd:cd19501    91 QAKKNApcIVFIDEIDA----VG-RKRGAGLGGGHDEREQ---------TLNQLLVEMDGFESNTGV--IVIAATNRPDV 154
                         170
                  ....*....|....*
gi 1063714350 325 LDPALIRRGRMDMHI 339
Cdd:cd19501   155 LDPALLRPGRFDRQV 169
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
189-343 1.97e-12

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 68.25  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIydleltaIR-NNSEL---------RKL-----LTATSSKSI 253
Cdd:PTZ00454  169 ELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATF-------IRvVGSEFvqkylgegpRMVrdvfrLARENAPSI 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 254 IVIEDIDcsldltgkrkkekNLMTSREDGEQGTEEDKSFVTLSgLLNFIDGIWSACGQEriIIFTTNHFEKLDPALIRRG 333
Cdd:PTZ00454  242 IFIDEVD-------------SIATKRFDAQTGADREVQRILLE-LLNQMDGFDQTTNVK--VIMATNRADTLDPALLRPG 305
                         170
                  ....*....|
gi 1063714350 334 RMDMHIELSY 343
Cdd:PTZ00454  306 RLDRKIEFPL 315
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
189-339 2.87e-12

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 64.23  E-value: 2.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMAN--HLNY-SIYDLEL-TAIRNNSE--LRKLL-TATSSK-SIIVIEDID 260
Cdd:cd19511    17 DAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASeaGLNFiSVKGPELfSKYVGESEraVREIFqKARQAApCIIFFDEID 96
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063714350 261 CsldLTGKRkkeknlmtSREDGEQGTEEdksfvTLSGLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:cd19511    97 S---LAPRR--------GQSDSSGVTDR-----VVSQLLTELDGIES--LKGVVVIAATNRPDMIDPALLRPGRLDKLI 157
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
189-341 3.13e-12

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 67.87  E-value: 3.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNysiydleLTAIRN-NSEL------------RKL--LTATSSKSI 253
Cdd:PTZ00361  207 ELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETS-------ATFLRVvGSELiqkylgdgpklvRELfrVAEENAPSI 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 254 IVIEDIDCsldltgkrkkeknLMTSREDGEQGTEEDKSFVTLSgLLNFIDGiWSACGQERIIIfTTNHFEKLDPALIRRG 333
Cdd:PTZ00361  280 VFIDEIDA-------------IGTKRYDATSGGEKEIQRTMLE-LLNQLDG-FDSRGDVKVIM-ATNRIESLDPALIRPG 343

                  ....*...
gi 1063714350 334 RMDMHIEL 341
Cdd:PTZ00361  344 RIDRKIEF 351
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
189-351 3.83e-11

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 64.47  E-value: 3.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKsTMIA-AMANHLNysiydleLTAIR-NNSEL------------RKL--LTATSSKS 252
Cdd:PRK03992  155 ELFEEVGIEPPKGVLLYGPPGTGK-TLLAkAVAHETN-------ATFIRvVGSELvqkfigegarlvRELfeLAREKAPS 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 253 IIVIEDIDCsldLTGKRKKEKnlmTS--REdgeqgteedksfV--TLSGLLNFIDGiWSACGQERIIIfTTNHFEKLDPA 328
Cdd:PRK03992  227 IIFIDEIDA---IAAKRTDSG---TSgdRE------------VqrTLMQLLAEMDG-FDPRGNVKIIA-ATNRIDILDPA 286
                         170       180
                  ....*....|....*....|....*..
gi 1063714350 329 LIRRGRMDMHIELSYCSFEA----FKI 351
Cdd:PRK03992  287 ILRPGRFDRIIEVPLPDEEGrleiLKI 313
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
189-341 8.19e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 64.16  E-value: 8.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLN---YSIYDLELTAI---RNNSELRKLLTAT--SSKSIIVIEDID 260
Cdd:TIGR01243 202 ELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGayfISINGPEIMSKyygESEERLREIFKEAeeNAPSIIFIDEID 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 261 CsldLTGKRKkeknlmtsredgEQGTEEDKSFVtlSGLLNFIDGIwsacgQER---IIIFTTNHFEKLDPALIRRGRMDM 337
Cdd:TIGR01243 282 A---IAPKRE------------EVTGEVEKRVV--AQLLTLMDGL-----KGRgrvIVIGATNRPDALDPALRRPGRFDR 339

                  ....
gi 1063714350 338 HIEL 341
Cdd:TIGR01243 340 EIVI 343
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
188-339 8.46e-11

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 60.20  E-value: 8.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 188 KEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLN---YSIYDLEL---------TAIRNNseLRKllTATSSKSIIV 255
Cdd:cd19529    16 PEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNanfISVKGPELlskwvgeseKAIREI--FRK--ARQVAPCVIF 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 256 IEDIDcslDLTGKRKKeknlmtsreDGEQGTEEDksfvTLSGLLNFIDGIWSAcgQERIIIFTTNHFEKLDPALIRRGRM 335
Cdd:cd19529    92 FDEID---SIAPRRGT---------TGDSGVTER----VVNQLLTELDGLEEM--NGVVVIAATNRPDIIDPALLRAGRF 153

                  ....
gi 1063714350 336 DMHI 339
Cdd:cd19529   154 DRLI 157
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
188-339 7.70e-10

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 57.52  E-value: 7.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 188 KEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHL--NY-SIYDLELTAI---RNNSELRKLLTAT--SSKSIIVIEDI 259
Cdd:cd19528    16 PDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECqaNFiSVKGPELLTMwfgESEANVRDIFDKAraAAPCVLFFDEL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 260 DcsldltgkrkkekNLMTSReDGEQGTEEDKSFVTLSGLLNFIDGIWSAcgQERIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:cd19528    96 D-------------SIAKAR-GGNIGDAGGAADRVINQILTEMDGMNTK--KNVFIIGATNRPDIIDPAILRPGRLDQLI 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
188-426 4.20e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 58.77  E-value: 4.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 188 KEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLE----LTAIRNNSE--LRKLLTAT--SSKSIIVIEDI 259
Cdd:TIGR01243 476 PEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRgpeiLSKWVGESEkaIREIFRKArqAAPAIIFFDEI 555
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 260 DCSLDLTGKRKKEKnlMTSRedgeqgteedksfvTLSGLLNFIDGIWSACGQerIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:TIGR01243 556 DAIAPARGARFDTS--VTDR--------------IVNQLLTEMDGIQELSNV--VVIAATNRPDILDPALLRPGRFDRLI 617
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 340 EL----SYCSFEAFKILAKNYL---DLDTHPLFKK--------IESLLKETKIAPA-DVAENLMKKNTEIDADGSLKDLI 403
Cdd:TIGR01243 618 LVpppdEEARKEIFKIHTRSMPlaeDVDLEELAEMtegytgadIEAVCREAAMAALrESIGSPAKEKLEVGEEEFLKDLK 697
                         250       260
                  ....*....|....*....|....*..
gi 1063714350 404 ----QALEGKKKIHGAQVDEPKDKYTK 426
Cdd:TIGR01243 698 vemrHFLEALKKVKPSVSKEDMLRYER 724
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
163-339 6.75e-09

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 58.12  E-value: 6.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 163 SFHTLAMDTKKKEEIlNDLAAFSNGKEYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDL------ELTAIR 236
Cdd:PRK10733  150 TFADVAGCDEAKEEV-AELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTIsgsdfvEMFVGV 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 237 NNSELRKLL--TATSSKSIIVIEDIDCSldltgKRKKEKNLMTSREDGEQgteedksfvTLSGLLNFIDGIWsacGQERI 314
Cdd:PRK10733  229 GASRVRDMFeqAKKAAPCIIFIDEIDAV-----GRQRGAGLGGGHDEREQ---------TLNQMLVEMDGFE---GNEGI 291
                         170       180
                  ....*....|....*....|....*.
gi 1063714350 315 IIF-TTNHFEKLDPALIRRGRMDMHI 339
Cdd:PRK10733  292 IVIaATNRPDVLDPALLRPGRFDRQV 317
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
199-343 1.19e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 53.69  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 199 KRGYLLHGPPGTGKSTMIAAMANHL---NYSIYDLELTAIRN-----------NSELRKLLTATSSKSIIVIEDIdcslD 264
Cdd:cd00009    19 PKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEglvvaelfghfLVRLLFELAEKAKPGVLFIDEI----D 94
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063714350 265 LTGKRKKEKNLMTsredgeqgteedksfvtlsgLLNFIDGIWSacGQERIIIFTTNHFEKLDPALIRRGRMDMHIELSY 343
Cdd:cd00009    95 SLSRGAQNALLRV--------------------LETLNDLRID--RENVRVIGATNRPLLGDLDRALYDRLDIRIVIPL 151
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
162-332 1.30e-08

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 54.76  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 162 ASFH----TLAMDTKKKEEILNDLAA---FSNGKEYYKKIgkAWKRGYLLHGPPGTGKSTMIAAMANHL----NYSIYDL 230
Cdd:cd19508    10 AEFHglweSLIYDSNLKSRLLDYVTTtllFSDKNVNTNLI--TWNRLVLLHGPPGTGKTSLCKALAQKLsirlSSRYRYG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 231 ELTAIRNNSELRKLLTATSSKSIIVIEDIDCSLDLTGKR-----KKEKNLMTSREDGEQGTEEDKSFVTLSGLLNFIDGI 305
Cdd:cd19508    88 QLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDDKDALvfvliDEVESLAAARSASSSGTEPSDAIRVVNAVLTQIDRI 167
                         170       180
                  ....*....|....*....|....*..
gi 1063714350 306 WSAcgQERIIIFTTNHFEKLDPALIRR 332
Cdd:cd19508   168 KRY--HNNVILLTSNLLEKIDVAFVDR 192
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
195-332 4.38e-08

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 52.35  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 195 GKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI----RNNSE-LRKLLTATSSK---SIIVIEDIDcsldlt 266
Cdd:cd19509    28 LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLvskwVGESEkIVRALFALARElqpSIIFIDEID------ 101
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063714350 267 gkrkkekNLMTSREDGEQGTEedKSFVTlsGLLNFIDGIWSACGQERIIIFTTNHFEKLDPALIRR 332
Cdd:cd19509   102 -------SLLSERGSGEHEAS--RRVKT--EFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRR 156
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
189-336 6.09e-08

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 52.11  E-value: 6.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANH--LNY-SIYDLE-LTAIRNNSEL--RKLL--TATSSKSIIVIEDID 260
Cdd:cd19530    20 DIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANEsgANFiSVKGPElLNKYVGESERavRQVFqrARASAPCVIFFDEVD 99
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063714350 261 CsldLTGKRKKEKNLMTSRedgeqgteedksfvTLSGLLNFIDGIWSAcgQERIIIFTTNHFEKLDPALIRRGRMD 336
Cdd:cd19530   100 A---LVPKRGDGGSWASER--------------VVNQLLTEMDGLEER--SNVFVIAATNRPDIIDPAMLRPGRLD 156
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
180-336 2.10e-07

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 50.44  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 180 DLAAFSNGKEYYKKIGKAWK-----------RGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRN------NSELR 242
Cdd:cd19507     1 DVGGLDNLKDWLKKRKAAFSkqasayglptpKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGglvgesESRLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 243 KLL-TA-TSSKSIIVIEDIDcsldltgkrkkeKNLMTSREDGEQGTEED--KSFVTlsgllnfidgiWSacgQERI---- 314
Cdd:cd19507    81 QMIqTAeAIAPCVLWIDEIE------------KGFSNADSKGDSGTSSRvlGTFLT-----------WL---QEKKkpvf 134
                         170       180
                  ....*....|....*....|..
gi 1063714350 315 IIFTTNHFEKLDPALIRRGRMD 336
Cdd:cd19507   135 VVATANNVQSLPPELLRKGRFD 156
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
199-336 3.79e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 49.82  E-value: 3.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 199 KRGYLLHGPPGTGKSTMIAAMANH--LNY-SIYDLELTAI---RNNSELRKLLT-ATSSKSIIVIEDidcSLDltgkrkk 271
Cdd:cd19527    26 RSGILLYGPPGTGKTLLAKAIATEcsLNFlSVKGPELINMyigESEANVREVFQkARDAKPCVIFFD---ELD------- 95
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063714350 272 ekNLMTSR-EDGEQGTEEDKsfvTLSGLLNFIDGIwSACGQERIIIFTTNHFEKLDPALIRRGRMD 336
Cdd:cd19527    96 --SLAPSRgNSGDSGGVMDR---VVSQLLAELDGM-SSSGQDVFVIGATNRPDLLDPALLRPGRFD 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
199-341 5.25e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.91  E-value: 5.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350  199 KRGYLLHGPPGTGKSTMIAAMANHLNYSIY-----DLELTAIRNNSELRKLLTATSSKSIIVIEDIDcslDLTGKRKKEK 273
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGgviyiDGEDILEEVLDQLLLIIVGGKKASGSGELRLR---LALALARKLK 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063714350  274 NL------MTSREDGEQGTEEDKSFVTLSGLLNFIDGiwsacgqERIIIFTTNHFEKLDPALIRRgRMDMHIEL 341
Cdd:smart00382  79 PDvlildeITSLLDAEQEALLLLLEELRLLLLLKSEK-------NLTVILTTNDEKDLGPALLRR-RFDRRIVL 144
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
196-332 1.13e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 48.31  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 196 KAWKRGYLLHGPPGTGKsTMIA------AMANHLNYSIYDLELTAIRNNSELRKLLTATSSK---SIIVIEDIDcsldlt 266
Cdd:cd19524    30 RAPARGLLLFGPPGNGK-TMLAkavaaeSNATFFNISAASLTSKYVGEGEKLVRALFAVARElqpSIIFIDEVD------ 102
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063714350 267 gkrkkekNLMTSREDGEQgteeDKSFVTLSGLLNFIDGIWSACGQERIIIFTTNHFEKLDPALIRR 332
Cdd:cd19524   103 -------SLLSERSEGEH----EASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRR 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
189-341 2.75e-06

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 47.48  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTM---IAAMANH-----------LNYSIYDLElTAIRN----NSELRKLLTATSS 250
Cdd:cd19504    25 EIVEQLGCKHVKGILLYGPPGTGKTLMarqIGKMLNArepkivngpeiLNKYVGESE-ANIRKlfadAEEEQRRLGANSG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 251 KSIIVIEDIDCsldltgkrkkeknLMTSREDGEQGTEEDKSFVtlSGLLNFIDGIWSAcgQERIIIFTTNHFEKLDPALI 330
Cdd:cd19504   104 LHIIIFDEIDA-------------ICKQRGSMAGSTGVHDTVV--NQLLSKIDGVEQL--NNILVIGMTNRKDLIDEALL 166
                         170
                  ....*....|.
gi 1063714350 331 RRGRMDMHIEL 341
Cdd:cd19504   167 RPGRLEVQMEI 177
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
189-332 3.24e-06

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 47.29  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKrGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI----RNNSE-LRKLLTATS---SKSIIVIEDID 260
Cdd:cd19522    24 EFFKGIRRPWK-GVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLtskyRGESEkLVRLLFEMArfyAPTTIFIDEID 102
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063714350 261 csldltgkrkkekNLMTSREDGEqgtEEDKSFVTLSGLLNFIDGIWSACGQER-----IIIFTTNHFEKLDPALIRR 332
Cdd:cd19522   103 -------------SICSRRGTSE---EHEASRRVKSELLVQMDGVGGASENDDpskmvMVLAATNFPWDIDEALRRR 163
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
200-339 1.31e-05

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 45.75  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 200 RGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNN--SELRKLLTATSS------KSIIVIEDIDcsldltgkrkk 271
Cdd:cd19525    56 KGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKwvGEGEKMVRALFSvarckqPAVIFIDEID----------- 124
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063714350 272 ekNLMTSREDGEQgtEEDKSFVTlsGLLNFIDGIWSACGQERIIIFTTNHFEKLDPALIRRGRMDMHI 339
Cdd:cd19525   125 --SLLSQRGEGEH--ESSRRIKT--EFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
189-336 1.57e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 45.19  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 189 EYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAIRNNSELRK----------LLTATSSK---SIIV 255
Cdd:cd19517    24 EVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVSFFMRKGADCLSKwvgeaerqlrLLFEEAYRmqpSIIF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 256 IEDIDcslDLTGKRkkeknlmTSREDgeqgtEEDKSFVtlSGLLNFIDGIWSAcgQERIIIFTTNHFEKLDPALIRRGRM 335
Cdd:cd19517   104 FDEID---GLAPVR-------SSKQE-----QIHASIV--STLLALMDGLDNR--GQVVVIGATNRPDALDPALRRPGRF 164

                  .
gi 1063714350 336 D 336
Cdd:cd19517   165 D 165
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
200-332 1.91e-05

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 44.72  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 200 RGYLLHGPPGTGKsTMIA-AMANHLNYSIYDLELTAIRNN--SELRKLLTATSS------KSIIVIEDIDCSLdltGKRk 270
Cdd:cd19520    36 KGVLLYGPPGCGK-TMLAkATAKEAGARFINLQVSSLTDKwyGESQKLVAAVFSlasklqPSIIFIDEIDSFL---RQR- 110
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063714350 271 keknlmtSREDGEQGTEEDKSFVTLsgllnfIDGIwSACGQERIIIF-TTNHFEKLDPALIRR 332
Cdd:cd19520   111 -------SSTDHEATAMMKAEFMSL------WDGL-STDGNCRVIVMgATNRPQDLDEAILRR 159
PRK04195 PRK04195
replication factor C large subunit; Provisional
178-271 4.45e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 45.68  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 178 LNDLAAFSNGKEYYKKIGKAWKRGY-----LLHGPPGTGKSTMIAAMANHLNYSIydLELTA--IRNNSELRK-LLTATS 249
Cdd:PRK04195   13 LSDVVGNEKAKEQLREWIESWLKGKpkkalLLYGPPGVGKTSLAHALANDYGWEV--IELNAsdQRTADVIERvAGEAAT 90
                          90       100
                  ....*....|....*....|..
gi 1063714350 250 SKSiiviedidcsldLTGKRKK 271
Cdd:PRK04195   91 SGS------------LFGARRK 100
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
179-332 7.77e-05

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 42.93  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 179 NDLAAFSNGKEYYKKI--------------GKAWkRGYLLHGPPGTGKSTMIAAMANHLNYSIY-----DLELTAIRNNS 239
Cdd:cd19521     7 EDVAGLEGAKEALKEAvilpvkfphlftgnRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFsvsssDLVSKWMGESE 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 240 ELRKLLTATSSK---SIIVIEDIDcsldltgkrkkekNLMTSREDGEQGTE---EDKSFVTLSGLLNFIDGIwsacgqer 313
Cdd:cd19521    86 KLVKQLFAMAREnkpSIIFIDEVD-------------SLCGTRGEGESEASrriKTELLVQMNGVGNDSQGV-------- 144
                         170
                  ....*....|....*....
gi 1063714350 314 IIIFTTNHFEKLDPALIRR 332
Cdd:cd19521   145 LVLGATNIPWQLDSAIRRR 163
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
203-249 3.60e-04

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 40.30  E-value: 3.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063714350 203 LLHGPPGTGKSTMIAAMAnhlnysiydleLTAIRNNSELRKLLTATS 249
Cdd:cd17934     3 LIQGPPGTGKTTTIAAIV-----------LQLLKGLRGKRVLVTAQS 38
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
188-259 4.07e-04

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 41.88  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 188 KEYYKKIGKAWKRG-----YLLHGPPGTGKSTMIAAMANHLN---------YSIYDLELTAIRNNSELRkLLTATSSKSI 253
Cdd:COG0470     2 EEAWEQLLAAAESGrlphaLLLHGPPGIGKTTLALALARDLLcenpeggkaCGQCHSRLMAAGNHPDLL-ELNPEEKSDQ 80

                  ....*.
gi 1063714350 254 IVIEDI 259
Cdd:COG0470    81 IGIDQI 86
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
175-328 6.39e-04

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 40.18  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 175 EEILNDLAAfsngkeYYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLN-------------YSIYDLELTAIRNNSEL 241
Cdd:pfam13191   6 EEELEQLLD------ALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALErdggyflrgkcdeNLPYSPLLEALTREGLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 242 RKLLTATSSKSIiviedidcsldltgKRKKEKNLMTSREDGEQGTEEDKSFVTLsgLLNFIDgiWSACGQERIIIFtTNH 321
Cdd:pfam13191  80 RQLLDELESSLL--------------EAWRAALLEALAPVPELPGDLAERLLDL--LLRLLD--LLARGERPLVLV-LDD 140

                  ....*..
gi 1063714350 322 FEKLDPA 328
Cdd:pfam13191 141 LQWADEA 147
DEXXQc_SETX cd18042
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ...
203-223 1.15e-03

DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438712 [Multi-domain]  Cd Length: 218  Bit Score: 40.27  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|.
gi 1063714350 203 LLHGPPGTGKSTMIAAMANHL 223
Cdd:cd18042    21 LIQGPPGTGKTKTIVGILSVL 41
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
200-332 1.55e-03

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 39.10  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063714350 200 RGYLLHGPPGTGKSTMIAAMANHLNYSIYDLELTAI--RNNSELRKLLTAT------SSKSIIVIEDIDCsldltgkrkk 271
Cdd:cd19523    34 RSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLvaKWAGEGEKILQASflaarcRQPSVLFISDLDA---------- 103
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063714350 272 eknLMTSREDGEQGTEEDKsfvtlSGLLNFIDGIWSACGQERIIIFTTNHFEKLDPALIRR 332
Cdd:cd19523   104 ---LLSSQDDEASPVGRLQ-----VELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRY 156
PRK06851 PRK06851
hypothetical protein; Provisional
190-231 2.63e-03

hypothetical protein; Provisional


Pssm-ID: 235878  Cd Length: 367  Bit Score: 39.95  E-value: 2.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063714350 190 YYKKIGKAWKRGYLLHGPPGTGKSTMIAAMANHLNYSIYDLE 231
Cdd:PRK06851   21 LYDSIIDGANRIFILKGGPGTGKSTLMKKIGEEFLEKGYDVE 62
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
199-258 4.75e-03

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 38.29  E-value: 4.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063714350 199 KRGYLL-HGPPGTGKSTMIAAMANHLNysiydleltairnnselrklltATSSKSIIVIED 258
Cdd:cd01131    20 PRGLVLvTGPTGSGKSTTLAAMIDYIN----------------------ETRSKHIITIED 58
PRK08116 PRK08116
hypothetical protein; Validated
184-223 4.82e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 38.46  E-value: 4.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063714350 184 FSNGKEYYKKIGKA----WK------RGYLLHGPPGTGKSTMIAAMANHL 223
Cdd:PRK08116   89 FDKGSEKAYKIARKyvkkFEemkkenVGLLLWGSVGTGKTYLAACIANEL 138
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
199-223 5.12e-03

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 36.79  E-value: 5.12e-03
                          10        20
                  ....*....|....*....|....*
gi 1063714350 199 KRGYLLHGPPGTGKSTMIAAMANHL 223
Cdd:cd18043    14 GKNVVIQGPPGTGKSQTIANIIANA 38
AAA_11 pfam13086
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
203-225 5.64e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 404072 [Multi-domain]  Cd Length: 248  Bit Score: 38.48  E-value: 5.64e-03
                          10        20
                  ....*....|....*....|...
gi 1063714350 203 LLHGPPGTGKSTMIAAMANHLNY 225
Cdd:pfam13086  17 LIQGPPGTGKTTTIVELIRQLLS 39
AAA_28 pfam13521
AAA domain;
204-226 5.81e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 37.63  E-value: 5.81e-03
                          10        20
                  ....*....|....*....|...
gi 1063714350 204 LHGPPGTGKSTMIAAMANHLNYS 226
Cdd:pfam13521   4 ITGGPSTGKTTLAEALAARFGYP 26
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
203-245 6.67e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.53  E-value: 6.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063714350 203 LLHGPPGTGKSTMIAAMANHLNYSIYdlELTAIRNN-SELRKLL 245
Cdd:PRK13342   40 ILWGPPGTGKTTLARIIAGATDAPFE--ALSAVTSGvKDLREVI 81
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
190-251 6.93e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.09  E-value: 6.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063714350 190 YYKKIgkawkrgyLLHGPPGTGKSTMIAAMANHLNYSIYDLeltairnNSEL-RKLLTATSSK 251
Cdd:NF033453   15 YYKLI--------LLVGPPGSGKTALLRELAAKRGAPVINV-------NLELsRRLLELPEKQ 62
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
162-223 8.36e-03

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 37.92  E-value: 8.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063714350 162 ASFHTLAMDTKKKEEILNDLAAFSNGkeyYKKIGKawKRGYLLHGPPGTGKSTMIAAMANHL 223
Cdd:PRK08939  124 ASLADIDLDDRDRLDALMAALDFLEA---YPPGEK--VKGLYLYGDFGVGKSYLLAAIANEL 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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