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Conserved domains on  [gi|1063709537|ref|NP_001325515|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12898758)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-323 9.38e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 9.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  34 HCAGINCLDVlkssvSNDQSYLFTGSRDGTLKRWAFDEDAtfCSATFESHVDWVND-AALAGESTLVSCSSDTTVKTWDg 112
Cdd:cd00200     8 HTGGVTCVAF-----SPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 113 LSDGVCTRTLRQHSDYVTCLAVAaKNNNVVASGGLGGEVFIWDIEaalspvtkpnDANEDSSSNGANGPVTSLRtVGSSN 192
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVA-FSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 193 NISVQSSPSH---------GYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLL 263
Cdd:cd00200   148 TFVASSSQDGtiklwdlrtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 264 DSTGRFCLSGSSDSMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYL 323
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 626-748 1.80e-37

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


:

Pssm-ID: 340561  Cd Length: 97  Bit Score: 135.10  E-value: 1.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 626 ENTKLSFFLHPCEGS--SVQVVTLGKLSAPRILRVHKVTNYVVEKMVLDNPLDslaidaasvsggqpqplfsgngllqsg 703
Cdd:cd17041     1 EFPKISFFLQPHPSSglPPKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPES--------------------------- 53

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063709537 704 lKPWQKLRPSIEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:cd17041    54 -QDASNPEEKLELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-323 9.38e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 9.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  34 HCAGINCLDVlkssvSNDQSYLFTGSRDGTLKRWAFDEDAtfCSATFESHVDWVND-AALAGESTLVSCSSDTTVKTWDg 112
Cdd:cd00200     8 HTGGVTCVAF-----SPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 113 LSDGVCTRTLRQHSDYVTCLAVAaKNNNVVASGGLGGEVFIWDIEaalspvtkpnDANEDSSSNGANGPVTSLRtVGSSN 192
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVA-FSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 193 NISVQSSPSH---------GYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLL 263
Cdd:cd00200   148 TFVASSSQDGtiklwdlrtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 264 DSTGRFCLSGSSDSMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYL 323
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
47-328 9.24e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.85  E-value: 9.24e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  47 SVSNDQSYLFTGSRDGTLKRWafDEDATFCSATFESHVDWVNDAALAGES-TLVSCSSDTTVKTWDgLSDGVCTRTLRQH 125
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWD-LATGKLLRTLTGH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 126 SDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEAALSPVTKPndanedsssnGANGPVTSLR---------TVGSSNNISV 196
Cdd:COG2319   204 TGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAfspdgrllaSGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 197 QSsPSHGYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSD 276
Cdd:COG2319   273 WD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063709537 277 SMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTDLAT 328
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 626-748 1.80e-37

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 135.10  E-value: 1.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 626 ENTKLSFFLHPCEGS--SVQVVTLGKLSAPRILRVHKVTNYVVEKMVLDNPLDslaidaasvsggqpqplfsgngllqsg 703
Cdd:cd17041     1 EFPKISFFLQPHPSSglPPKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPES--------------------------- 53

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063709537 704 lKPWQKLRPSIEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:cd17041    54 -QDASNPEEKLELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 610-748 9.74e-33

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 124.33  E-value: 9.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 610 PLWCLDAVLNNRLPPRENTKLSFFLHPCEGSSVQVVTLG-------KLSAPRILRVHKVTNYVVEKMvldnpldSLAIDA 682
Cdd:pfam11816  42 PMWLGDVLLYNKIPPKEPVKISFVLQPWPGSDLPPDKLPelpnknsRLNANRMLRVRKILAYVAEKL-------ESLTPE 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709537 683 ASVSGGQPQPLFSgngllqSGLKPWQKLrpsiEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:pfam11816 115 MKPPSPDEDENAD------KKLKPEEYL----ELLCNDQVLPPNMTLATVKTFIWKSGGDIVLHYR 170
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 94-174 4.73e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 49.30  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  94 GESTLVSCSsdttvkTWD------GLSDGVCTRTLRQHSDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEAALSPVTKPN 167
Cdd:pfam20426  92 SENFLISCG------NWEnsfqviSLNDGRMVQSIRQHKDVVSCVAVTS-DGSILATGSYDTTVMVWEVLRGRSSEKRSR 164


                  ....*..
gi 1063709537 168 DANEDSS 174
Cdd:pfam20426 165 NTQTEFP 171
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-283 8.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 8.37e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063709537  244 TGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWD 283
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-323 9.38e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 9.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  34 HCAGINCLDVlkssvSNDQSYLFTGSRDGTLKRWAFDEDAtfCSATFESHVDWVND-AALAGESTLVSCSSDTTVKTWDg 112
Cdd:cd00200     8 HTGGVTCVAF-----SPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 113 LSDGVCTRTLRQHSDYVTCLAVAaKNNNVVASGGLGGEVFIWDIEaalspvtkpnDANEDSSSNGANGPVTSLRtVGSSN 192
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVE----------TGKCLTTLRGHTDWVNSVA-FSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 193 NISVQSSPSH---------GYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLL 263
Cdd:cd00200   148 TFVASSSQDGtiklwdlrtGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 264 DSTGRFCLSGSSDSMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYL 323
Cdd:cd00200   228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
47-328 9.24e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.85  E-value: 9.24e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  47 SVSNDQSYLFTGSRDGTLKRWafDEDATFCSATFESHVDWVNDAALAGES-TLVSCSSDTTVKTWDgLSDGVCTRTLRQH 125
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWD-LATGKLLRTLTGH 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 126 SDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEAALSPVTKPndanedsssnGANGPVTSLR---------TVGSSNNISV 196
Cdd:COG2319   204 TGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAfspdgrllaSGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 197 QSsPSHGYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSD 276
Cdd:COG2319   273 WD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063709537 277 SMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTDLAT 328
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
43-366 5.22e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.85  E-value: 5.22e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  43 VLKSSVSNDQSYLFTGSRDGTLKRWafDEDATFCSATFESHVDWVNDAAL-AGESTLVSCSSDTTVKTWDgLSDGVCTRT 121
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLW--DLATGLLLRTLTGHTGAVRSVAFsPDGKTLASGSADGTVRLWD-LATGKLLRT 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 122 LRQHSDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEaalspvtkpnDANEDSSSNGANGPVTSL------RTV--GSSNN 193
Cdd:COG2319   158 LTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLA----------TGKLLRTLTGHTGAVRSVafspdgKLLasGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 194 ISVQSSPSHGYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSG 273
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 274 SSDSMIRLWDLGQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTDLATREsVLLCTKEH--PIQQLALQDNSI 351
Cdd:COG2319   307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHtgAVTSVAFSPDGR 385

                         330
                  ....*....|....*..
gi 1063709537 352 WVATT--DSSVERWPAE 366
Cdd:COG2319   386 TLASGsaDGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-363 1.57e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 1.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  76 CSATFESHVDWVNDAALAGES-TLVSCSSDTTVKTWDgLSDGVCTRTLRQHSD-YVTCLAVAakNNNVVASGGLGGEVFI 153
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWD-LETGELLRTLKGHTGpVRDVAASA--DGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 154 WDIEaalspvtkpnDANEDSSSNGANGPVTSLR---------TVGSSNNISVQSSPSHGYTPTIaKGHKESVYALAMNDT 224
Cdd:cd00200    78 WDLE----------TGECVRTLTGHTSYVSSVAfspdgrilsSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 225 GTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWDLGQQRCLHTYAVHTDSVWALA 304
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709537 305 CNPSFSHVYSGGRDQCLYLTDLATRESVLLCTK-EHPIQQLALQDNSIWVATT--DSSVERW 363
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGsaDGTIRIW 288
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 626-748 1.80e-37

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 135.10  E-value: 1.80e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 626 ENTKLSFFLHPCEGS--SVQVVTLGKLSAPRILRVHKVTNYVVEKMVLDNPLDslaidaasvsggqpqplfsgngllqsg 703
Cdd:cd17041     1 EFPKISFFLQPHPSSglPPKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPES--------------------------- 53

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063709537 704 lKPWQKLRPSIEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:cd17041    54 -QDASNPEEKLELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
WD40 COG2319
WD40 repeat [General function prediction only];
46-378 6.02e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 6.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  46 SSVSNDQSYLFTGSRDGTLKRWafDEDATFCSATFESHVDWVNDAALA-GESTLVSCSSDTTVKTWDgLSDGVCTRTLRQ 124
Cdd:COG2319    42 LAASPDGARLAAGAGDLTLLLL--DAAAGALLATLLGHTAAVLSVAFSpDGRLLASASADGTVRLWD-LATGLLLRTLTG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 125 HSDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEAAlspvtkpndanedsssngangpvTSLRTVgssnnisvqsspshgy 204
Cdd:COG2319   119 HTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-----------------------KLLRTL---------------- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 205 tptiaKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWDL 284
Cdd:COG2319   159 -----TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 285 GQQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTDLATRESV-LLCTKEHPIQQLALQDNSIWVATT--DSSVE 361
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGsdDGTVR 313

                         330
                  ....*....|....*..
gi 1063709537 362 RWpaEVQSPKTVFQRGG 378
Cdd:COG2319   314 LW--DLATGKLLRTLTG 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-283 2.15e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 2.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  41 LDVLKSSVSNDQSYLFTGSRDGTLKRWafDEDATFCSATFESHVDWVNDAALAGESTLV-SCSSDTTVKTWDgLSDGVCT 119
Cdd:cd00200    52 GPVRDVAASADGTYLASGSSDKTIRLW--DLETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWD-VETGKCL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 120 RTLRQHSDYVTCLAVAaKNNNVVASGGLGGEVFIWDIEAaLSPVTkpndanedsSSNGANGPVTSLRTVGSSNNISVQSS 199
Cdd:cd00200   129 TTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIKLWDLRT-GKCVA---------TLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 200 --------PSHGYTPTIAKGHKESVYALAMNDTGTMLVSGGTEKVLRVWDPRTGSKSMKLRGHTDNVRVLLLDSTGRFCL 271
Cdd:cd00200   198 dgtiklwdLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         250
                  ....*....|..
gi 1063709537 272 SGSSDSMIRLWD 283
Cdd:cd00200   278 SGSADGTIRIWD 289
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 610-748 9.74e-33

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 124.33  E-value: 9.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537 610 PLWCLDAVLNNRLPPRENTKLSFFLHPCEGSSVQVVTLG-------KLSAPRILRVHKVTNYVVEKMvldnpldSLAIDA 682
Cdd:pfam11816  42 PMWLGDVLLYNKIPPKEPVKISFVLQPWPGSDLPPDKLPelpnknsRLNANRMLRVRKILAYVAEKL-------ESLTPE 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709537 683 ASVSGGQPQPLFSgngllqSGLKPWQKLrpsiEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:pfam11816 115 MKPPSPDEDENAD------KKLKPEEYL----ELLCNDQVLPPNMTLATVKTFIWKSGGDIVLHYR 170
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 94-174 4.73e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 49.30  E-value: 4.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709537  94 GESTLVSCSsdttvkTWD------GLSDGVCTRTLRQHSDYVTCLAVAAkNNNVVASGGLGGEVFIWDIEAALSPVTKPN 167
Cdd:pfam20426  92 SENFLISCG------NWEnsfqviSLNDGRMVQSIRQHKDVVSCVAVTS-DGSILATGSYDTTVMVWEVLRGRSSEKRSR 164


                  ....*..
gi 1063709537 168 DANEDSS 174
Cdd:pfam20426 165 NTQTEFP 171
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 244-283 8.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 8.37e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063709537  244 TGSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWD 283
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
245-283 2.40e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063709537 245 GSKSMKLRGHTDNVRVLLLDSTGRFCLSGSSDSMIRLWD 283
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-155 8.41e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1063709537  115 DGVCTRTLRQHSDYVTCLAVaAKNNNVVASGGLGGEVFIWD 155
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 210-241 1.76e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.76e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1063709537  210 KGHKESVYALAMNDTGTMLVSGGTEKVLRVWD 241
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
RAWUL_PCGF_like cd16102
RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, ...
 714-748 2.54e-04

RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, DRIP and similar proteins; structurally similar to a beta-grasp ubiquitin-like fold; The family includes six Polycomb Group (PcG) RING finger homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR) that use epigenetic mechanisms to maintain or repress expression of their target genes. They were first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place, and are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. PCGF homologs play important roles in cell proliferation, differentiation, and tumorigenesis. They all have been found to associate with ring finger protein 2 (RNF2). The RNF2-PCGF heterodimer is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. Moreover, PCGF homologs are critical components in the assembly of distinct Polycomb Repression Complex 1 (PRC1) related complexes which are involved in the maintenance of gene repression and target different genes through distinct mechanisms. The Drosophila PRC1 core complex is formed by the Polycomb (Pc), Polyhomeotic (Ph), Posterior sex combs (Psc), and Sex combs extra (Sce, also known as Ring) subunits. In mammals, the composition of PRC1 is much more diverse and varies depending on the cellular context. All PRC1 complexes contain homologs of the Drosophila Ring protein. Ring1A/RNF1 and Ring1B/RNF2 are E3 ubiquitin ligases that mark lysine 119 of histone H2A with a single ubiquitin group (H2AK119ub). Mammalian homologs of the Drosophila Psc protein, such as PCGF2/Mel-18 or PCGF4/BMI1, regulate PRC1 enzymatic activity. PRC1 complexes can be divided into at least two classes according to the presence or absence of CBX proteins, which are homologs of Drosophila Pc. Canonical PRC1 complexes contain CBX proteins that recognize and bind H3K27me3, the mark deposited by PRC2. Therefore, canonical PRC1 complexes and PRC2 can act together to repress gene transcription and maintain this repression through cell division. Non-canonical PRC1 complexes, containing RYBP (together with additional proteins, such as L3mbtl2 or Kdm2b) rather than the CBX proteins, have recently been described in mammals. PCGF homologs contain a C3HC4-type RING-HC finger, and a RAWUL domain that might be responsible for interaction with Cbx members of the Polycomb repression complexes.


Pssm-ID: 340519  Cd Length: 87  Bit Score: 40.34  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1063709537 714 IEILCNSQVLSPDMSLATV-RAYVWKKPEDLILNYR 748
Cdd:cd16102    52 LDILCRGELLGKEHTLKFIwRTRWRKQDGPLVLQYR 87
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 286-325 2.63e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.63e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063709537  286 QQRCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTD 325
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
210-241 4.96e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.96e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1063709537 210 KGHKESVYALAMNDTGTMLVSGGTEKVLRVWD 241
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
116-155 5.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063709537 116 GVCTRTLRQHSDYVTCLAVaAKNNNVVASGGLGGEVFIWD 155
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
RAWUL pfam16207
RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the ...
 714-748 2.01e-03

RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the C-terminus of poly-comb group RING finger proteins. It is a ubiquitin-like domain. RAWUL binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health.


Pssm-ID: 465067  Cd Length: 66  Bit Score: 37.15  E-value: 2.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063709537 714 IEILCNSQVLSPDMSLATVRAYVWKKPEDLILNYR 748
Cdd:pfam16207  32 VEILYNGEPLPDSYTLDVAYIKYWKRNAPLELYYR 66
WD40 pfam00400
WD domain, G-beta repeat;
288-325 3.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063709537 288 RCLHTYAVHTDSVWALACNPSFSHVYSGGRDQCLYLTD 325
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-111 5.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 5.36e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1063709537   76 CSATFESHVDWVNDAALAGEST-LVSCSSDTTVKTWD 111
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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