NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1063705224|ref|NP_001325344|]
View 

phosphate transporter 4;1 [Arabidopsis thaliana]

Protein Classification

ACS family MFS transporter( domain architecture ID 13024350)

anion:cation symporter (ACS) family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes in a sodium dependent manner of specific anions such as inorganic phosphate and ascorbate, among others

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options Â»

Show site features     Horizontal zoom: Ã—

List of domain hits

Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
1-383 1.03e-163

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 463.18  E-value: 1.03e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRA 80
Cdd:cd17380    18 MPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRI 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAe 160
Cdd:cd17380    98 LLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLkFNLMESGLL 240
Cdd:cd17380   177 --------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVF 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:cd17380   218 NVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLV 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063705224 321 NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQ-HGSWDDVFTISVGLYLVGTVIWNLFS 383
Cdd:cd17380   298 NHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEaTGSWSLVFVLAAVVNLVGAVVFLLFG 361
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
1-383 1.03e-163

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 463.18  E-value: 1.03e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRA 80
Cdd:cd17380    18 MPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRI 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAe 160
Cdd:cd17380    98 LLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLkFNLMESGLL 240
Cdd:cd17380   177 --------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVF 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:cd17380   218 NVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLV 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063705224 321 NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQ-HGSWDDVFTISVGLYLVGTVIWNLFS 383
Cdd:cd17380   298 NHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEaTGSWSLVFVLAAVVNLVGAVVFLLFG 361
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
11-386 3.53e-69

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 225.01  E-value: 3.53e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  11 EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAM 90
Cdd:TIGR00894  70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVS 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  91 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI-HQFGWPSVFYSFGSLGTVWLTLWLTkaesSPLEDPTL 169
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFV----FPADDPSI 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 170 LPEERKLIADNCASK------EPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVF 243
Cdd:TIGR00894 226 HPCISKFEKKYINSSlqgqkgSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSL 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 244 PWMTMAISANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLTQLKHIDSP---TMAVLCMAcsQGTDAFSQSGLY 319
Cdd:TIGR00894 306 PYLFAWLCSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAfylTIIILTLA--NAVSSGPLAGVL 383
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 320 SNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGS---WDDVFTISVGLYLVGTVIWNLFSTGE 386
Cdd:TIGR00894 384 INSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSknvWLIVFLIMAFVNILCVIFYLIFGSAE 453
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-379 1.06e-55

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 187.00  E-value: 1.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:COG2271    29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLwltkae 160
Cdd:COG2271   107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------ 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipwrlilskpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLL 240
Cdd:COG2271   181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 321 NHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 379
Cdd:COG2271   295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS_1 pfam07690
Major Facilitator Superfamily;
1-349 4.21e-40

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 145.25  E-value: 4.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAE 160
Cdd:pfam07690  94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 SSPLEDPTLLPEERKLIAdncaskepvksIPWRLILSKPPVWALISChFCHNWGTFILLTWMPTyYHQVLKFNLMESGLL 240
Cdd:pfam07690 174 PPESKRPKPAEEARLSLI-----------VAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPL-YQEVLGLSALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 1063705224 321 NHQDIAP-RYSGVLLGLSNTAGVLAGVLGT 349
Cdd:pfam07690 315 LVSDLAPkEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
8-142 1.43e-11

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 65.37  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEG 87
Cdd:PRK11551   41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAW--DFPSLLVARLLTGVGLG 118
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY 142
Cdd:PRK11551  119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY 173
 
Name Accession Description Interval E-value
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
1-383 1.03e-163

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 463.18  E-value: 1.03e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRA 80
Cdd:cd17380    18 MPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRI 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAe 160
Cdd:cd17380    98 LLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLkFNLMESGLL 240
Cdd:cd17380   177 --------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVF 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:cd17380   218 NVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLV 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063705224 321 NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQ-HGSWDDVFTISVGLYLVGTVIWNLFS 383
Cdd:cd17380   298 NHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEaTGSWSLVFVLAAVVNLVGAVVFLLFG 361
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
11-382 1.77e-114

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 339.21  E-value: 1.77e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  11 EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAM 90
Cdd:cd17318    50 EFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTF 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  91 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWltkaesspledptll 170
Cdd:cd17318   130 PAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW--------------- 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 171 peerkliadncaskepvksipWRLIlskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAI 250
Cdd:cd17318   195 ---------------------FFLV---LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWI 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 251 SANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLTQLKHI-DSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPR 328
Cdd:cd17318   251 CSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGPGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPN 330
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224 329 YSGVLLGLSNTAGVLAGVLGTAATGHILQH----GSWDDVFTISVGLYLVGTVIWNLF 382
Cdd:cd17318   331 YAGTLMGITNTAATIAGIISPLIVGAIVKNdqtiGQWRIVFFISAAIYILGAIFYLIF 388
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
9-382 1.22e-81

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 254.57  E-value: 1.22e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   9 SAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGV 88
Cdd:cd17382    41 KAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGV 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  89 AMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWltkaesspledpt 168
Cdd:cd17382   121 TYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW------------- 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 169 llpeerkliadncaskepvksipwrlILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTM 248
Cdd:cd17382   188 --------------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVM 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 249 AISANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAP 327
Cdd:cd17382   242 TIIVPIGGQLADYLRSRGiLSTTAVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAP 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224 328 RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGS---WDDVFTISVGLYLVGTVIWNLF 382
Cdd:cd17382   322 RYASILMGISNGIGTLSGMVCPVIVGALTKHKTreeWQYVFLIASLVHFFGVIFYAIF 379
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
12-382 2.45e-78

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 246.62  E-value: 2.45e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  12 YGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAMP 91
Cdd:cd17381    60 YDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFP 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  92 AMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTkaesspledptllp 171
Cdd:cd17381   140 AMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIW-------------- 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 172 eerkliadncaskepvksipwrLILskpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAIS 251
Cdd:cd17381   206 ----------------------LVM---PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLF 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 252 ANAGGWIADTLVSR-GFSVTNVRKIMQTIGFLGPAFFLTQLKHID-SPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRY 329
Cdd:cd17381   261 MILSGQIADNLREKqNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSY 340
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705224 330 SGVLLGLSNTAGVLAGVLGTAATGHILQH---GSWDDVFTISVGLYLVGTVIWNLF 382
Cdd:cd17381   341 AGILLGITNTFATIPGMVGPVIAKSLTHNntvEEWQTVFYISAAINVFGAIFFTIF 396
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
11-386 3.53e-69

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 225.01  E-value: 3.53e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  11 EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEGVAM 90
Cdd:TIGR00894  70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVS 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  91 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI-HQFGWPSVFYSFGSLGTVWLTLWLTkaesSPLEDPTL 169
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFV----FPADDPSI 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 170 LPEERKLIADNCASK------EPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVF 243
Cdd:TIGR00894 226 HPCISKFEKKYINSSlqgqkgSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSL 305
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 244 PWMTMAISANAGGWIADTLVSRG-FSVTNVRKIMQTIGFLGPAFFLTQLKHIDSP---TMAVLCMAcsQGTDAFSQSGLY 319
Cdd:TIGR00894 306 PYLFAWLCSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPYLSAAfylTIIILTLA--NAVSSGPLAGVL 383
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 320 SNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGS---WDDVFTISVGLYLVGTVIWNLFSTGE 386
Cdd:TIGR00894 384 INSLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSQDSknvWLIVFLIMAFVNILCVIFYLIFGSAE 453
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
1-379 3.93e-57

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 190.47  E-value: 3.93e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:cd17319    22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRF 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWltkae 160
Cdd:cd17319   100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLW----- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipWRLIlskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLL 240
Cdd:cd17319   175 -------------------------------WFYL---RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLvsrgfsVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:cd17319   221 AAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 321 NHQDIAPR-YSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTVIW 379
Cdd:cd17319   295 LPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLV 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-379 1.06e-55

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 187.00  E-value: 1.06e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:COG2271    29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLwltkae 160
Cdd:COG2271   107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------ 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 sspledptllpeerkliadncaskepvksipwrlilskpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLL 240
Cdd:COG2271   181 ---------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:COG2271   222 LSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 321 NHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 379
Cdd:COG2271   295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS_1 pfam07690
Major Facilitator Superfamily;
1-349 4.21e-40

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 145.25  E-value: 4.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAE 160
Cdd:pfam07690  94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 SSPLEDPTLLPEERKLIAdncaskepvksIPWRLILSKPPVWALISChFCHNWGTFILLTWMPTyYHQVLKFNLMESGLL 240
Cdd:pfam07690 174 PPESKRPKPAEEARLSLI-----------VAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPL-YQEVLGLSALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYS 320
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 1063705224 321 NHQDIAP-RYSGVLLGLSNTAGVLAGVLGT 349
Cdd:pfam07690 315 LVSDLAPkEERGTASGLYNTAGSLGGALGP 344
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
2-378 4.72e-40

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 146.71  E-value: 4.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTpvAAKLGLPYLLVVRAF 81
Cdd:TIGR00893  14 SFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQ--AFAGAYVSLYILRVL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAES 161
Cdd:TIGR00893  92 LGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKFIPD 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 162 SPLEDPTLLPEERKLIAD----NCASKEPVKSIPWRL--ILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLM 235
Cdd:TIGR00893 172 PPQKAKWLTEEEKYIVVGgllaEQQGKGPSTPKKYQIkeLLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSIL 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 236 ESGLLSVFPWMTMAISANAGGWIADTLVSRGFSVtNVRKIMQTIGFLGpAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQ 315
Cdd:TIGR00893 252 EAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSL-VFARKTAIIAGLV-LSLLMFATNYVNIPYAALALVALGFFGLGAG 329
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705224 316 SGLYSNHQDIAPRYS-GVLLGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGLYLVGTVI 378
Cdd:TIGR00893 330 AIGWALISDNAPGNIaGLTGGLINSLGNLGGIVGPIVIGAIAaTTGSFAGALMVVAALALIGALS 394
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-379 1.33e-30

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 120.76  E-value: 1.33e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRA 80
Cdd:COG2223    24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAE 160
Cdd:COG2223   102 LLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 SSPLEDPTllpeerkliadncASKEPVKSipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLL 240
Cdd:COG2223   182 DPPAGAAA-------------AAKASLRD--QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 -SVFPWMTMAISAnAGGWIADTLvsRGFSVTNVRKIMQTIGFLGPAFFLTqlkhidSPTMAVLCMACSQGTDAFSQSGLY 319
Cdd:COG2223   247 aALFALLGALGRP-LGGWLSDRI--GGRRVLLIVFALMALGLLLLALALG------SLWLFLVLFLLLGLALGGGNGAVF 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063705224 320 SNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTVIW 379
Cdd:COG2223   318 ALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAVLALVALVLT 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-347 2.31e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.61  E-value: 2.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:COG2814    29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARF 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTV-WLTLWLTKA 159
Cdd:COG2814   107 LQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLP 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 160 ESSPLEDPTLLPEerkliadncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGL 239
Cdd:COG2814   187 ESRPAARARLRGS-------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 240 LSVFPWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLY 319
Cdd:COG2814   248 LLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318
                         330       340
                  ....*....|....*....|....*....
gi 1063705224 320 SNHQDIAP-RYSGVLLGLSNTAGVLAGVL 347
Cdd:COG2814   319 ALVAELAPpEARGRASGLYNSAFFLGGPL 347
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-378 5.45e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 110.59  E-value: 5.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:cd06174    15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRF 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLI--HQFGWPSVFYSFGSLGTVWLTLWLTK 158
Cdd:cd06174    93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 159 AESSPLEDPtllpeerkliADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESG 238
Cdd:cd06174   173 VPDPPESAR----------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAG 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 239 LLSVFPWMTMAISANAGGWIADTLVSrgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGL 318
Cdd:cd06174   243 LLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063705224 319 YS-NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGLYLVGTVI 378
Cdd:cd06174   315 FAlIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
5-383 6.04e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 101.88  E-value: 6.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   5 ILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLglPYLLVVRAFMG 83
Cdd:cd17325    18 ILPlYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--WQLLLARFLQG 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  84 VGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTvwLTLWLTkaessp 163
Cdd:cd17325    96 LASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL--LALVLA------ 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 164 ledpTLLPEERKLIADNCASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVF 243
Cdd:cd17325   168 ----LLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 244 PWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQ 323
Cdd:cd17325   244 QGLASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 324 DIAPRYS-GVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIWNLFS 383
Cdd:cd17325   315 DIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
1-379 2.16e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 88.76  E-value: 2.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVR 79
Cdd:cd17324    17 VIQGLLPdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLAR 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  80 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKA 159
Cdd:cd17324    95 ALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 160 ESSPLEDPTLLPEERkliadncaskepvksiPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKF-NLMESG 238
Cdd:cd17324   175 PSLPPKKPGSLGLLS----------------SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFsSSAIIG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 239 LLSVFpWMTMAISANAGGWIADTLVsrgfsvtnVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFsQSGL 318
Cdd:cd17324   239 LLLLF-GVAGVVGSPLAGRLADRGG--------RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA-HSAL 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 319 YSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 379
Cdd:cd17324   309 QTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
2-365 3.72e-17

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 82.04  E-value: 3.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILtpVAAKLGLPYLLVVRAF 81
Cdd:TIGR00881  15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWAL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQF-GWPSVFYSFGSLGTVWLTLWLTKAE 160
Cdd:TIGR00881  93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLLR 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 SSPL--------EDPTLLPEERKLIADNCASKepvKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKF 232
Cdd:TIGR00881 173 DSPQscglppaeEMPNEEPDGDAEKKEEELTK---KQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGF 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 233 NLMESGLLSVFPWMTMAISANAGGWIADTLV-SRGFSVTNVRKIMQTIGFLGPAFFLTQlkhidSPTMAVLCMACSQGTD 311
Cdd:TIGR00881 250 SKEKASWAFTLYELGGLVGTLLAGWLSDKLFnGRRGPLAVFFMALIIVSLLVYWLNPAA-----NPLMDLICLFALGFLV 324
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063705224 312 AFSQSGLYSNHQDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVF 365
Cdd:TIGR00881 325 YGPQMLIGVIASELAPkKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
1-265 2.21e-16

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 80.09  E-value: 2.21e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:TIGR00895  36 MGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT--NVTQLLILRF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYsFGSLGTVWLTLWLTKAE 160
Cdd:TIGR00895 114 LAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY-VGGIAPLLLLLLLMRFL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 161 SSPLE-----------------DPTLLPEERKLIADNcASKEPVKSIPWRLILSK------PPVWAlisCHFCHNWGTFI 217
Cdd:TIGR00895 193 PESIDflvskrpetvrrivnaiAPQMQAEAQSALPEQ-KSTQGTKRSVFKALFQGktaritVLLWL---LYFMLLVGVYF 268
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1063705224 218 LLTWMPTYYHQvLKFNLMESGLLSVFPWMTMAISANAGGWIADTLVSR 265
Cdd:TIGR00895 269 LTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR 315
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-378 3.00e-16

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 79.53  E-value: 3.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   7 PMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGE 86
Cdd:COG2807    43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  87 GVAMPAMNNILSKWVPvQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTkaesspled 166
Cdd:COG2807   121 AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP--------- 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 167 ptLLPEERKliadncASKEPVKSIPWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQvLKFNLMESG-LLSVFPW 245
Cdd:COG2807   191 --LLRRRPA------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGlLLSLFQL 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 246 MTMAISAnAGGWIADTLVSRGFSVTnVRKIMQTIGFLGPAFFLTQLkhidsPTMAVLCMACSQGTdAFSQSGLYSNHQDI 325
Cdd:COG2807   262 AGIPGSL-LVPLLADRLGDRRPLLL-LLGLLGLAGLLGLLLAPGSL-----PWLWAVLLGLGQGG-LFPLALTLIGLRAR 333
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063705224 326 APRYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTVI 378
Cdd:COG2807   334 TPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLVA 387
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
1-157 2.39e-15

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 76.47  E-value: 2.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRA 80
Cdd:cd17365    18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQ--SVLQLALLRF 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVW-------LT 153
Cdd:cd17365    96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILlpllrgtLL 175

                  ....
gi 1063705224 154 LWLT 157
Cdd:cd17365   176 LWVT 179
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
1-161 6.03e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 74.85  E-value: 6.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAakLGLPYLLVVRA 80
Cdd:COG0477    33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAE 160
Cdd:COG0477   111 LQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPE 190

                  .
gi 1063705224 161 S 161
Cdd:COG0477   191 S 191
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-374 7.38e-15

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 75.28  E-value: 7.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   3 IAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFM 82
Cdd:COG0738    29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP--SYPLLLLALFLL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  83 GVGEGVAMPAMNNILSKWVPVQERSRsLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAess 162
Cdd:COG0738   107 GLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL--- 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 163 pledPTLLPEERKLIADNCASKEPVKSipwrlILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSV 242
Cdd:COG0738   183 ----RSKLPEIEEEEEEAAGSAASLKS-----LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 243 FPWMTMAIsanaGGWIADTLVSRgFSVTNVRKIMQTIGFLGPAFFLTqlkhIDSPTMAVLCMACSQGTDAFSQSGLYSNH 322
Cdd:COG0738   254 LFWGGMTI----GRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALL----APGPWLALIGLALVGLGLSLMFPTIFSLA 324
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063705224 323 QDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLV 374
Cdd:COG0738   325 LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
4-147 1.46e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.53  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   4 AILP--MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAF 81
Cdd:cd17325   220 PFLPlyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLAL 297
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSL 147
Cdd:cd17325   298 LGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
7-308 3.96e-14

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 73.42  E-value: 3.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   7 PMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAFMGVGE 86
Cdd:cd17328    24 DIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGE 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  87 GVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQF-GWPSVFYSFGSLGTVWLTL-WLTkaesspL 164
Cdd:cd17328   102 ASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILlLLF------V 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 165 EDPTLLPEERKLIADNCASKEPVKsipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFP 244
Cdd:cd17328   176 REPPRGAAEGGVMAKSTATSFLAD---LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIF 252
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224 245 WMTMAISANAGGWIADTLvSRGFSVTNVR--KIMQTIGFLG--PAFFLTQLKHIDSPTMAVLCMACSQ 308
Cdd:cd17328   253 GAITCIAGVLGVLLGGIL-ADRLRRKTPRadPLVCAVGLLAaaPFLFLALVLALSNLLLAWVLLFLGE 319
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
8-378 6.01e-14

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 72.66  E-value: 6.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGViwWSIATILTPVAAKLGLPYLLVVRAFMGVGEG 87
Cdd:cd17475    22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGL--LLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGS---LGTVWLTLWLTKAESSPL 164
Cdd:cd17475   100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLvsiLAAVLFWLFYREPPAASA 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 165 EDPTLLPEERKLiadncaskepvksipwRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFP 244
Cdd:cd17475   180 ATESASTLLRSL----------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 245 WMTMAISANAGGWIADTLVSRgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLC-MACSQGTDAFSQSGLYSNH- 322
Cdd:cd17475   244 QLGGALGRIGLGRVSDRVFGG-----RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLGLFAIGWNGLYLTLv 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224 323 QDIAP-RYSGVLLGLSNTAGVLAGVLGTAATGHILQH-GSWDDVFTISVGLYLVGTVI 378
Cdd:cd17475   319 AESAGpEQAGTALGLANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALL 376
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
15-379 2.62e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 67.64  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  15 NPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLG---LPYLLVVRAFMGVGEGVAMP 91
Cdd:cd06173    32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslsLWLLLVLAFLLGIASAFFGP 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  92 AMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY--SFGSLGTVWLTLWLTKAESSPLEDPTL 169
Cdd:cd06173   112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinALSFLLSALLLLFIRRPPPAAPGESSS 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 170 LPEERKLIAdncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLsvfpwmtMA 249
Cdd:cd06173   192 LLLRDLREG-------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL-------LA 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 250 ISAnAGGWIADTLVSRGFSVTNVRKIMqTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSN-HQDIAPR 328
Cdd:cd06173   252 AFG-VGALLGALLLGRLSKRRRRGRLL-LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlQLRVPDE 329
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 329 YSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 379
Cdd:cd06173   330 LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
1-379 6.70e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 66.09  E-value: 6.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWN--PATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVV 78
Cdd:cd17316    18 IGFVAPVLAAEFSLGlsLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  79 RAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLG----SVTGLAFSPFLIHQFGWPSVFYsFGSLGTVwLTL 154
Cdd:cd17316    96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGallaALVASLLIPLLSGDWGWRILFL-IGALPAL-LAL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 155 WLTKAesspledptllpeerkliadncaskepvksipwrlilskppVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNL 234
Cdd:cd17316   174 LLRRR-----------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 235 MESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtnVRKIMQTIGFL--GPAFFLTQLKHIDSPTMAVLCMACSQGTDA 312
Cdd:cd17316   213 ATSSLYLLLISLGALVGALIAGLLSDRI---------GRKKTLVIGLIlsGILALPLFYLLSGSPTLLLLLLFILSFFVG 283
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 313 FSQSGLYSNHQDIAP---RYSGVllGLSNTAGVLAGVLGTAATGHIL-QHGSWDDVFTISVGLYLVGTVIW 379
Cdd:cd17316   284 GVWGALYAYLAELFPtevRATGV--GLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALLAIVALIVA 352
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
2-359 9.77e-12

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 65.66  E-value: 9.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAF 81
Cdd:cd17321    16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP--SLAFLIAARAL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGtvwltlwltkaes 161
Cdd:cd17321    94 QGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG------------- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 162 spledptllpeerkLIAdncaskepvksipwrLILSKPPVWALIsCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLS 241
Cdd:cd17321   161 --------------LVA---------------LLLARTFSGAVL-AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 242 VFPWMTMAISANAGGWIADTLVSRGFSVTNVrkIMQTIGFLGPAFFLTqlkHIDSPTMAVLCMACSQGTDAFSQSGLYSN 321
Cdd:cd17321   211 LPLALAMLVAAPLAGRLADRFGPRLVLVAGL--LLTAVGLLLLALLGA---DSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1063705224 322 HQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHG 359
Cdd:cd17321   286 LSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
8-142 1.43e-11

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 65.37  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEG 87
Cdd:PRK11551   41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAW--DFPSLLVARLLTGVGLG 118
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY 142
Cdd:PRK11551  119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY 173
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
2-262 2.48e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 64.63  E-value: 2.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAF 81
Cdd:cd17371    19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRAL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLG-----SVTGLAFsPFLIHQFGWPSVFYS--FGSLGTVWLTL 154
Cdd:cd17371    97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllatLLAALLF-PLLPPEIAWRVLFLLgaLPALLVLFIRR 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 155 WLTKAESspledptllpeerklIADNCASKEPVKSIPWRLILSKPP------VWALISChfCHNWGTFILLTWMPTYYHQ 228
Cdd:cd17371   176 FVKEPPQ---------------WQAARAARRHFADRPSLRELFSPPllrttlLASLLAT--GALGGYYGITTWLPSYLTG 238
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1063705224 229 VLKFNLMESGLLSVFPWMTMAISANAGGWIADTL 262
Cdd:cd17371   239 ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI 272
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
1-172 5.65e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.38  E-value: 5.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSA-EYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVR 79
Cdd:cd17489    14 LLLPVLPLYAhDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL--LLVLR 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  80 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFY-SFGSLGTVWLTLWLTK 158
Cdd:cd17489    92 LIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIvAAVLALLALLLVFLVK 171
                         170
                  ....*....|....
gi 1063705224 159 AESSPLEDPTLLPE 172
Cdd:cd17489   172 DPPPVAAEEAEAGT 185
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
2-377 8.68e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 59.59  E-value: 8.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILtpVAAKLGLPYLLVVRAF 81
Cdd:cd17312    23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVwltlwltkaes 161
Cdd:cd17312   101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLV----------- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 162 spledptllpeerkliadncaskepVKSIPWRLILSKPP-VWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLL 240
Cdd:cd17312   170 -------------------------VAIILFFFLRDSPPyVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWF 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 241 SVFPWMTMAISANAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAvLCMACSQGTDAFSqSGLYS 320
Cdd:cd17312   225 SSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLF-LIGFFVGGPINLI-GGAAA 302
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224 321 nhQDIAPRY-SGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTV 377
Cdd:cd17312   303 --QDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
1-361 1.09e-09

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 59.51  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSffwgYLLTQIAG----GIWADTVGGKRVLGFGVIWWSIATILTPVAAKLglPYLL 76
Cdd:cd17503    15 VNVALPTIMGDLGASLDTVQWVITS----YLLALAIMiplsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL--ASLI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  77 VVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLwl 156
Cdd:cd17503    89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL-- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 157 tkaesSPLEDPTLLpeerkliadncasKEPVKSIpwrlilskppvwALISChFCHNWGTFILLTWMPTYYHQVLKFNLME 236
Cdd:cd17503   167 -----APLLDLRLF-------------KDRNFTL------------GLLLS-FLLGLGLFGAMFLLPLYLQNVLGYSAFE 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 237 SGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIMqTIGFLGPAFFLTQLKHIdSPTMAVLCMACSQGTDAFSQS 316
Cdd:cd17503   216 SGLVLAPGGLASAILSPLVGRLLDKF--------GPRLLL-LAGLLLLALGTLLLAFL-TPDTSLWLIILPLFIRGLGMG 285
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063705224 317 GLYSN-----HQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSW 361
Cdd:cd17503   286 LVFMPlntlaLNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQ 335
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
1-382 1.89e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVR 79
Cdd:cd17474    17 IVDPILPaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD--SFALLLAGR 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  80 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGsvtgLAFSPFL---IHQFGWPSVFYSFGSLGTVWLTLWL 156
Cdd:cd17474    95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG----IAVGPLLgglLAAISWRYPFFLLAALIPVAFLAIL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 157 TKAESSPLEDPTLLPEERKLiadncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLME 236
Cdd:cd17474   171 FLLPEPKEKAKSSSATKLRD---------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 237 SGLLSVFPWMTMAISANAGGWIadtlVSRGFSvtnVRKIMqTIGFLGPAFFLTQLKHIDSPTMAVLCMACS---QGTDAF 313
Cdd:cd17474   236 IGLLFAGWSVLLALGSLFVGRL----LKKRFG---ARRIL-VIGLLLYALSLLLLGFVPSLALLLIAIVLFglgLGLNLP 307
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063705224 314 SQSGLYSNHQDIAPRysGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIWNLF 382
Cdd:cd17474   308 LLTTLVTELAPEEER--GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
21-267 2.61e-09

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 58.41  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  21 LIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTpvAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKW 100
Cdd:cd17327    45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 101 VPVQERSRSLALVYSGMYLGSVTG--LAFSPFLIHQF----GWPSVFYSFG---SLGTVWLTLWLTKaesSPLEDPTLLP 171
Cdd:cd17327   123 YKREEQAKRIAFFYAAAGLGSIFGglLAYGVFKILGVgglaGWRWLFIIEGlitIIIGLVIFFWLPD---NPSKAWFLTE 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 172 EERKL----IADNCASKEPVKSIP--WRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQvLKFNLMESGLLSVFPW 245
Cdd:cd17327   200 EEKELaverLRANQTGKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIG 278
                         250       260
                  ....*....|....*....|..
gi 1063705224 246 MTMAISANAGGWIADTLVSRGF 267
Cdd:cd17327   279 ALGAVSLLIAALLSDRFKKRGL 300
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
12-379 1.19e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 56.18  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  12 YGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKlgLPYLLVVRAFMGVGEGVAMP 91
Cdd:cd17333    26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS--IYLFVVLMFLAGLGAGILDT 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  92 AMNNIL-SKWVPVQERSRSLALVYSGMylGSVTGLAFSPFLIHQFGWPSVFYSfGSLGTVWLTLWLTKAESSPLEDPTLL 170
Cdd:cd17333   104 GANTFVgALFEESSATRLNVLHGFFGL--GALIGPLIATSLLTSELSWSWAYL-IIGLIYLLLAILILLTLFPELPSARN 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 171 PEERKLIADNCASKEpvksipwrliLSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAI 250
Cdd:cd17333   181 PQQSVGAFSASASRL----------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITI 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 251 SANAGGWIADTLVSRGFSVtnvrkimqTIGFLGPAFFLTQLKHIDSPTMAVLCMACSqgtdaFSQSGLY----SNHQDIA 326
Cdd:cd17333   251 GRLLGGPISRRIKPHTLLV--------LSGSGALLGLLILLLAPTLVVGLVATALLG-----LFMAALFptilSLGISNL 317
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063705224 327 PRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVIW 379
Cdd:cd17333   318 PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLA 370
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
2-367 1.82e-08

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 55.71  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVA--AKLGLPYLLVVR 79
Cdd:cd17345    23 SLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  80 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYS-----GMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTL 154
Cdd:cd17345   103 FLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVL 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 155 WLTK--AES---SPLEdpTLLPEERKLIADNCASKE-PVKSIPWRLILSKPPVWALISChfchnwGTFI------LLTWM 222
Cdd:cd17345   183 FLGKdtPESeglPPIE--EYKGDYPEEADGEEEEQElSAWEIFVKYVLKNKLLWYIAIA------NVFVylvrygILDWA 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 223 PTYYHQVLKFNLMES-GLLSVFPWMTMAISANAgGWIADTLVSrgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAV 301
Cdd:cd17345   255 PTYLSEVKGFSKAQAmWAFSLFEWAAIPGTLLA-GWLSDKLFK------GRRAPTGIIFMILVIVALIVYWLAPNVLVDL 327
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224 302 LCMACSqGTDAFSQS---GLYSNhqDIAPRYS-GVLLGLSNTAGVLAG-VLGTAATGHILQHGSWDDVFTI 367
Cdd:cd17345   328 IALIAL-GFLIYGPVmliGLQAL--ELVPKKAaGTAAGLTGLFGYLGGsVLATALIGIIVDHFGWNGGFIV 395
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
4-361 4.52e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 54.50  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   4 AILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMG 83
Cdd:cd17320    21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS--SIEQLLIARFLQG 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  84 VGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTV-WLTLWLTKAESS 162
Cdd:cd17320    99 LGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLlLLLVLLFLPETL 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 163 PLEDPTLLPeeRKLIADncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSV 242
Cdd:cd17320   179 PEEKRKPLL--SSLLRA------------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 243 FPWMTMAISANAGGWIAdtlvsRGFSVTNVRKIMQTIGFLGPAFFL--TQLKHIDSPTMAVLCMACsqgtdAFSQSGLYS 320
Cdd:cd17320   245 LNAIALILGSLLNGRLV-----RRFGPRRLLRLGLLLLLAAALVLLlaALLGGLSLWPLVAPLFLI-----FFGFGLIFP 314
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1063705224 321 NHQDIA----PRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSW 361
Cdd:cd17320   315 NATSLAlepfPHVAGTASALLGFLQFLIGALAGALVGLLPNGTAL 359
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
1-150 7.64e-08

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 53.81  E-value: 7.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVrA 80
Cdd:cd17355    22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG-L 100
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTV 150
Cdd:cd17355   101 LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALL 170
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
13-158 9.01e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 50.31  E-value: 9.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  13 GWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAFMGVGEGVAMPA 92
Cdd:cd06173   240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL--LLAALFLLGLAGGLFNVP 317
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705224  93 MNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTK 158
Cdd:cd06173   318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
4-378 1.53e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.86  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   4 AILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVVRAFM 82
Cdd:cd17478    17 ALLPlLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--LLLLVALA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  83 GVGEGVAMPAMNNILSKWVPVQeRSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAESS 162
Cdd:cd17478    95 GIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 163 PLEDPTllpeerkliADNCASKEPVKSIPWRLILskpPVWALIschFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSV 242
Cdd:cd17478   174 KPEAKK---------AAAKSSARSTLKGVWRALL---LLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 243 FpWMTMAISANAGGWIADTLvsrgfsvtNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSnh 322
Cdd:cd17478   239 F-LFAGAIGTLIGGPLSDRF--------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA-- 307
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705224 323 QDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVI 378
Cdd:cd17478   308 QELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-157 1.54e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.48  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVG--GKRVLGFGVIWWSIATILTPVAAKLGLPYLLVvrAFMGVG 85
Cdd:COG2271   207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALL--FLAGFG 284
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063705224  86 EGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLT 157
Cdd:COG2271   285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-359 3.33e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  11 EYGWNPATVGLIQS-SFFWGyLLTQIAGGIWAD---TVGGKR--VLGFGVIWWSIATILTPVAAKLG----LPYLLVVRA 80
Cdd:COG2211    40 VLGLSAALVGLILLvARLWD-AITDPLIGALSDrtrTRWGRRrpWILIGAIPLALSFVLLFTAPDLSptgkLIYALVTYL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  81 FMGVGEGVAMPAMNNILSKWVP-VQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFG--------WPSVFYSFGSLGTVW 151
Cdd:COG2211   119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyrLTALIFAVLGLLAFL 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 152 LTLWLTKaessplEDPTLLPEERKLIADncaskepvksipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLK 231
Cdd:COG2211   199 LTFFGTK------ERPVPEEEKVSLKES------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLG 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 232 FNLMESGLLSVFPWMTMAISANAGGWIADTL-VSRGFSVTNvrkIMQTIGFLGPAFFltqlkHIDSPTMAVLCMACSQGT 310
Cdd:COG2211   261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKKAFIIGL---LLAALGLLLLFFL-----GPGNLWLLLVLAALAGIG 332
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063705224 311 DAFSQSGLYSNHQDIAP--------RYSGVLLGLSNTAGVLAGVLGTAATGHILQHG 359
Cdd:COG2211   333 LGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
2-378 3.41e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 48.76  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   2 SIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYlLVVRAF 81
Cdd:cd17353    23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-LGYGVL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  82 MGVGEGVAMPAMNNILSKWVPvqERsRSLA--LVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKA 159
Cdd:cd17353   102 GGIGAGIGYITPVSTAVKWFP--DK-RGLAtgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 160 ESSPledPTLLPEERKLIADNCASKEPVKSipWRLILSKPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLME--- 236
Cdd:cd17353   179 RDPP---KGWVPPGVDPLANNAENSPRDYT--PREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIaal 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 237 -SGLLSVFpwmtmaisaNAG-----GWIADTLvSRgfsvtnvRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMACSqgt 310
Cdd:cd17353   254 aVSILSIF---------NGGgrpfwGWLSDKI-GR-------KNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALI--- 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063705224 311 dAFSQSGLYS-----NHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVI 378
Cdd:cd17353   314 -GFCYGGGFAlfpalTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
38-147 3.62e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.41  E-value: 3.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  38 GIWADTVGGKRVLGFGVIWWSIatILTPVAAKLGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGM 117
Cdd:cd17391   261 GKLGDRIGHHRILLGALLASAL--LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQ 338
                          90       100       110
                  ....*....|....*....|....*....|
gi 1063705224 118 YLGSVTGLAFSPFLIHQFGWPSVFYSFGSL 147
Cdd:cd17391   339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
38-262 3.63e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 3.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  38 GIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGM 117
Cdd:cd17473    56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLD--SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 118 YLGSVTGLAFSPFLIhQFGWPSVFYSFGSLGTVWLTLWLtkaesspledptLLPE-ERKLIADNCASKEPVKSIPWRlil 196
Cdd:cd17473   134 SLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLL------------FLPEpARKSKSAASPGAATAAALPWK--- 197
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705224 197 skpPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTL 262
Cdd:cd17473   198 ---RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
5-163 5.18e-06

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 48.07  E-value: 5.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   5 ILP-MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGViwWSIATILTPVAAKLGLPYLLVVRAFMG 83
Cdd:cd06180    21 LLPlMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGL--LLTVLLLAAMALTSGFAALLALRFLAG 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  84 VGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGS-VTGLAFSPFLIHQFGWPSVFYSFG---SLGTVWLTLWLTKA 159
Cdd:cd06180    99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIaLSGLLVPAGLGGGLSWRAGWLALAllsAVLLLLSFLLLRRG 178

                  ....
gi 1063705224 160 ESSP 163
Cdd:cd06180   179 PSAP 182
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
13-154 9.39e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 47.26  E-value: 9.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  13 GWNPATVGLIQSSFFwgylltqIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPA 92
Cdd:cd17476    36 SWLAASYSLTVGTFI-------LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP--NFIFFIICRALQGLGPAFLLPN 106
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063705224  93 MNNILSK-WVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTL 154
Cdd:cd17476   107 AMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
1-147 1.15e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.80  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILPMSAEYGWNPATVGLIQSSFFWGYLLTQIA-GGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVvr 79
Cdd:cd17330   194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA-- 271
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224  80 AFMGVGEGVAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLiHQFGWPSVFYSFGSL 147
Cdd:cd17330   272 AILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL-YSFLGPGVPFLLAAG 338
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
29-379 1.43e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 43.32  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  29 GYLLTQIAG----GIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEGVAMPAMNNILSKWVPVQ 104
Cdd:cd17502    38 AYLLTSTAFqpiyGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP--NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 105 ERSRSLALVySGMY-LGSVTGLAFSPFLIHQFGWPSVFY---SFGSLGTVWLtlwltkaesspledptllpeerkliadn 180
Cdd:cd17502   116 ERGKYQGYI-GAVFgIASVAGPLIGGAFTDHLSWRWCFYinlPIGGLALALL---------------------------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 181 caskepvksipwrlilskPPVWALISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIAD 260
Cdd:cd17502   167 ------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIS 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 261 TLVsrgfsvtNVRKIMQTIGFLGP--AFFLTQLKHIDSPTMAVLCMA-CSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLS 337
Cdd:cd17502   229 KTG-------RYKPLIVIGTILMSvgAGLLTTLTLDTSKWLLIGYLIlLGLGLGIGFQQPLVAVQNAVPPADVGVATATN 301
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1063705224 338 NTAGVLAGVLGTAATghilqhgswdDVFTISVGLYLVGTVIW 379
Cdd:cd17502   302 TFFRSLGGTLGVAIT----------DVFLVALALAALAFLLS 333
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
8-138 2.29e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.98  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEG 87
Cdd:cd17329    26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--SPWLFAIALVLTGFGGG 103
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSVTG-LAFSPFLIHQFGWP 138
Cdd:cd17329   104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGpLLGGLLLLYSFRLL 155
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
20-378 3.79e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 42.20  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  20 GLIQSSFfwgylltQIAGGIWADTVGGKRVLGFGVIWWSIATILtpvAAKLGLPYLLVV-RAFMGVG--EGVAMpAMnni 96
Cdd:cd17472    42 GLTQAIF-------QIPFGLLSDRIGRKPVILFGLLLFIAGSLL---AAYATSIYGLILgRALQGSGaiSSVVM-AL--- 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  97 LSKWVPVQERSRSLALVysGMYLGS--VTGLAFSPFLIHQFGWPSVFYSFGSLGTV-WLTLWLtkaesspledptLLPEE 173
Cdd:cd17472   108 LADLTREENRTKAMALI--GASIGIafAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLF------------FVPDP 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 174 RKLIADNCASKEPVKSipwrlILSKPPVWALischfchNWGTFIL-LTWMPTYYhqVLKFNLMESGLLSVFPWMTMaISA 252
Cdd:cd17472   174 PKIVQISEKEKKKLKK-----LLKNKRLLRL-------DFSIFILhFVLMAFFY--ILPLLLTQLGGGKGQLWKVY-LPA 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 253 NAGGWIADTLVSRGFSVTNVRKIMQTIGFLGPAF-FLTQLKHIDSPTMAVLCMACsqgtdAFSQSGLYSN------HQDI 325
Cdd:cd17472   239 ILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVgFLLLLFAATSLWLLIIGLII-----FFIGFNLLEAllpslvSKIA 313
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063705224 326 APRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDDVFTISVGLYLVGTVI 378
Cdd:cd17472   314 PKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
1-142 4.03e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILP-MSAEYGWNPATVGLIQSSFFW-GYLLTQIAGGiWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLpyLLVV 78
Cdd:cd17504    14 MLSPALPtIQREFGTSAAAVSWVLTAYLLvGAVSTPILGR-LGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--LIAG 90
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705224  79 RAFMGVGEGV---AMPAMNNILSKwvpvqERSRSLALVYSGMY-LGSVTGLAFSPFLIHQFGWPSVFY 142
Cdd:cd17504    91 RALQGIGGAVfplAFALVREEFPP-----ERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGWRWIFW 153
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
8-144 5.48e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 5.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAklGLPYLLVVRAFMGVGEG 87
Cdd:cd17473   224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS--GLWVVLLGAILAGLGFG 301
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYSGMYLGSvtglAFSPFLIHQFGWPSVFYSF 144
Cdd:cd17473   302 LLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ----FLSPLVLGPLVNLTGGLSG 354
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
12-163 5.67e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 41.57  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  12 YGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAakLGLPYLLVVRAFMGVGEGVAMP 91
Cdd:cd17362    34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLA--PSYPVLLVGRLIYGVGIGLAMH 111
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063705224  92 AMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWLTKAESSP 163
Cdd:cd17362   112 AAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSP 183
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
8-156 8.26e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   8 MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKLGLPYLLVVRAFMGVGEG 87
Cdd:cd17316   204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVG 283
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  88 VAMPAMNNILSKWVPVQERSRSLALVYS-GMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVWLTLWL 156
Cdd:cd17316   284 GVWGALYAYLAELFPTEVRATGVGLSYNlGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
1-89 1.25e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 40.64  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   1 MSIAILP--MSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAA------KLGL 72
Cdd:PRK05122   33 LPLAVLPgyVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGllaawpVLSL 112
                          90
                  ....*....|....*..
gi 1063705224  73 PYLLVVRAFMGVGEGVA 89
Cdd:PRK05122  113 LLLLLGRLLLGIGESLA 129
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
6-378 2.93e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 39.32  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224   6 LPMSAEYGWNPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVAAKlGLPYLLVVRAFMGVG 85
Cdd:cd17314    27 QPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFN-SFPLSYACFVFIGAG 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  86 EGVAMPAMNNILSKWVPvQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVfysFGSLGTVWLTLWLTKAESSPLE 165
Cdd:cd17314   106 TGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV---YTILGILAAIVLSVVSLLGFKE 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 166 DPtllpeerkliaDNCASKEPVK-SIPWRLILSKPPV-WALISCHFCHNWGTFILLTWMPTYyhqVLKFNLMESG----L 239
Cdd:cd17314   182 PP-----------DNQARLHVQKkKTQTMGEIFRDKVfWILFIAIFLVLIGGFLFIANMASL---VRSLQLDAPSfvtkL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 240 LSVFPWMTmAISANAGGWIADTLVSRgfsvTNVRKIMQTIGFLGPAFFLTQLKHIDSPTMAVLCMAcsqgtdAFSQSGLY 319
Cdd:cd17314   248 MSIYGLFN-AFGRLLWGIVADFFGGR----LSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLL------GFSYGGLF 316
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063705224 320 SNHQDIAP-----RYSGVLLGLSNTAGVLAGVLGTAATGHI-LQHGSWDDVFTISVGLYLVGTVI 378
Cdd:cd17314   317 TVYPATVStvfgtESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAVIVFLASAI 381
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
15-151 5.38e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 38.80  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224  15 NPATVGLIQSSFFWGYLLTQIAGGIWADTVGGKRVLGFGVIWWSIATILTPVA----AKLGLPYLLVVRAFMGVGEGVAM 90
Cdd:cd17364    37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstPLGVMGWLIFFRFLLGIGIGGDY 116
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063705224  91 PAMNNILSKWVPVQERSRSLALVYSGMYLGSVTGLAFSPFLIHQFGWPSVFYSFGSLGTVW 151
Cdd:cd17364   117 PLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHHADLVW 177
MFS_1 pfam07690
Major Facilitator Superfamily;
204-382 7.93e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 7.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 204 LISCHFCHNWGTFILLTWMPTYYHQVLKFNLMESGLLSVFPWMTMAISANAGGWIADTLvsrgfsvtNVRKIMQTIGFLG 283
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--------GRRRVLLIGLLLF 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705224 284 PAFFLTQLKHIDSPTMAVLCMACSQGTDAFSQSGLYSNHQDIAPRYSGVLLGLSNTAGVLAGVLGTAATGHILQHGSWDD 363
Cdd:pfam07690  73 ALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
                         170
                  ....*....|....*....
gi 1063705224 364 VFTISVGLYLVGTVIWNLF 382
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLP 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure