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Conserved domains on  [gi|1063699465|ref|NP_001325094|]
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phytanoyl-CoA dioxygenase (PhyH) family protein [Arabidopsis thaliana]

Protein Classification

phytanoyl-CoA dioxygenase family protein( domain architecture ID 10529740)

phytanoyl-CoA dioxygenase (PhyH) family protein similar to phytanoyl-CoA dioxygenase, which catalyzes the conversion of phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

CATH:  2.60.120.620
EC:  1.14.-.-
Gene Ontology:  GO:0051213|GO:0046872

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
15-251 4.19e-58

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


:

Pssm-ID: 399029  Cd Length: 213  Bit Score: 184.97  E-value: 4.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  15 FHSQGYLVIESFASEDEIRGLRKRMDELLNqfdcsvssifstknqkhttdnYFFESAEKISFFFEEKAFGDDGKlkqPKQ 94
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLLD---------------------RAAESGPDKDDFFDEKAAGDETG---LLE 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  95 LSINKVGHALHE--LDPLYKDFtysskfsslassLGYRRPV--VMQSMY----IFKQPGIGGEVVP-HQDNSFVYTDPQ- 164
Cdd:pfam05721  57 KSITKRDHFLHPfyLADLARAI------------LGSPVYVanVLQSMYqdlsIFKQPGTGGEVSPwHQDYTFLPTRPAe 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465 165 SCTGLWIALEDSTLVNGCLWAIPGSHK--NGLVRRFIRGDNGITFDQPSPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFE 242
Cdd:pfam05721 125 LVVNVWIALDDATEENGCLRVIPGSHKweVGPLARRLPEDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPRLLHGSGA 204

                  ....*....
gi 1063699465 243 NLSSKSRHA 251
Cdd:pfam05721 205 NRSDGSRRA 213
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
15-251 4.19e-58

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 184.97  E-value: 4.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  15 FHSQGYLVIESFASEDEIRGLRKRMDELLNqfdcsvssifstknqkhttdnYFFESAEKISFFFEEKAFGDDGKlkqPKQ 94
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLLD---------------------RAAESGPDKDDFFDEKAAGDETG---LLE 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  95 LSINKVGHALHE--LDPLYKDFtysskfsslassLGYRRPV--VMQSMY----IFKQPGIGGEVVP-HQDNSFVYTDPQ- 164
Cdd:pfam05721  57 KSITKRDHFLHPfyLADLARAI------------LGSPVYVanVLQSMYqdlsIFKQPGTGGEVSPwHQDYTFLPTRPAe 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465 165 SCTGLWIALEDSTLVNGCLWAIPGSHK--NGLVRRFIRGDNGITFDQPSPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFE 242
Cdd:pfam05721 125 LVVNVWIALDDATEENGCLRVIPGSHKweVGPLARRLPEDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPRLLHGSGA 204

                  ....*....
gi 1063699465 243 NLSSKSRHA 251
Cdd:pfam05721 205 NRSDGSRRA 213
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
7-272 3.84e-45

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 152.50  E-value: 3.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465   7 LTPDQLDFFHSQGYLVIESFASEDEIRGLRKRMDELLNQFDCSVSSIFSTKNQKHTTDNYffesaekisfffeekafgdd 86
Cdd:COG5285     2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEAPDEGDLEYSEADGGRLRRIY-------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  87 gklkqpkqlsinkvghALHELDPLYKDFTYSSKFSSLASSLGYRRPVVMQSMYIFKQPGIGGEVVPHQDNSFVYTDPQSC 166
Cdd:COG5285    62 ----------------NLHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPPGGGGATPWHQDFPYWPLEPPRA 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465 167 TGLWIALEDSTLVNGCLWAIPGSHKNGLVRRFirgDNGITFDqpsPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFENLSS 246
Cdd:COG5285   126 VTVWIALDDVTEENGCLRVVPGSHRWGLLPHR---DDDGSLD---DALDEEEAVPVELKAGDVLIFHGLTLHGSGPNRSD 199
                         250       260
                  ....*....|....*....|....*.
gi 1063699465 247 KSRHAYSLHVVeSDGCKWAKDNWIQR 272
Cdd:COG5285   200 RPRRALVLRYN-AADNRPQERQWLAV 224
 
Name Accession Description Interval E-value
PhyH pfam05721
Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA ...
15-251 4.19e-58

Phytanoyl-CoA dioxygenase (PhyH); This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.


Pssm-ID: 399029  Cd Length: 213  Bit Score: 184.97  E-value: 4.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  15 FHSQGYLVIESFASEDEIRGLRKRMDELLNqfdcsvssifstknqkhttdnYFFESAEKISFFFEEKAFGDDGKlkqPKQ 94
Cdd:pfam05721   1 FREDGYLVIEGFLSPEEVAALRAEAERLLD---------------------RAAESGPDKDDFFDEKAAGDETG---LLE 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  95 LSINKVGHALHE--LDPLYKDFtysskfsslassLGYRRPV--VMQSMY----IFKQPGIGGEVVP-HQDNSFVYTDPQ- 164
Cdd:pfam05721  57 KSITKRDHFLHPfyLADLARAI------------LGSPVYVanVLQSMYqdlsIFKQPGTGGEVSPwHQDYTFLPTRPAe 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465 165 SCTGLWIALEDSTLVNGCLWAIPGSHK--NGLVRRFIRGDNGITFDQPSPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFE 242
Cdd:pfam05721 125 LVVNVWIALDDATEENGCLRVIPGSHKweVGPLARRLPEDDYYAEDDEAPKRDEEPAVPVPMKAGDAVLFHPRLLHGSGA 204

                  ....*....
gi 1063699465 243 NLSSKSRHA 251
Cdd:pfam05721 205 NRSDGSRRA 213
PhyH COG5285
Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary ...
7-272 3.84e-45

Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 444095  Cd Length: 237  Bit Score: 152.50  E-value: 3.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465   7 LTPDQLDFFHSQGYLVIESFASEDEIRGLRKRMDELLNQFDCSVSSIFSTKNQKHTTDNYffesaekisfffeekafgdd 86
Cdd:COG5285     2 LTDEQIAFFERDGYLVLRGVLSPEEVAALRAALDRLLAEAPDEGDLEYSEADGGRLRRIY-------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465  87 gklkqpkqlsinkvghALHELDPLYKDFTYSSKFSSLASSLGYRRPVVMQSMYIFKQPGIGGEVVPHQDNSFVYTDPQSC 166
Cdd:COG5285    62 ----------------NLHRRDPAFRDLARHPRILAVAEQLLGPDVRLHHSQLFFKPPGGGGATPWHQDFPYWPLEPPRA 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699465 167 TGLWIALEDSTLVNGCLWAIPGSHKNGLVRRFirgDNGITFDqpsPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFENLSS 246
Cdd:COG5285   126 VTVWIALDDVTEENGCLRVVPGSHRWGLLPHR---DDDGSLD---DALDEEEAVPVELKAGDVLIFHGLTLHGSGPNRSD 199
                         250       260
                  ....*....|....*....|....*.
gi 1063699465 247 KSRHAYSLHVVeSDGCKWAKDNWIQR 272
Cdd:COG5285   200 RPRRALVLRYN-AADNRPQERQWLAV 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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