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Conserved domains on  [gi|1063697097|ref|NP_001322926|]
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basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 385)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  20219281|15186484|1755826|8018712
SCOP:  4000913

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 61-164 3.99e-05

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd18914:

Pssm-ID: 469605 [Multi-domain]  Cd Length: 77  Bit Score: 41.13  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063697097  61 KKQDHNAKERLRRMRLHASYLTLGTLLPDHssssskvlfsllllqvryvllvvelyitflaDWQKKWSAPSIIDNVITYI 140
Cdd:cd18914     1 KKLLHNDVERQRRQEMASLFSSLRSLLPLQ-------------------------------YIKGKLSVSDHVDEAVNYI 49

                          90       100
                  ....*....|....*....|....
gi 1063697097 141 PKLQNEVGELTLRKQKLVELERRG 164
Cdd:cd18914    50 KELQEKIKELSEKRDELLKLISGV 73
 
Name Accession Description Interval E-value
bHLH_AtORG2_like cd18914
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 ...
 61-164 3.99e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins; The family includes ORG2 (also termed AtbHLH38, or EN 8) and ORG3 (also termed AtbHLH39, or EN 9), both of which act as bHLH transcription factors.


Pssm-ID: 381484 [Multi-domain]  Cd Length: 77  Bit Score: 41.13  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063697097  61 KKQDHNAKERLRRMRLHASYLTLGTLLPDHssssskvlfsllllqvryvllvvelyitflaDWQKKWSAPSIIDNVITYI 140
Cdd:cd18914     1 KKLLHNDVERQRRQEMASLFSSLRSLLPLQ-------------------------------YIKGKLSVSDHVDEAVNYI 49

                          90       100
                  ....*....|....*....|....
gi 1063697097 141 PKLQNEVGELTLRKQKLVELERRG 164
Cdd:cd18914    50 KELQEKIKELSEKRDELLKLISGV 73
 
Name Accession Description Interval E-value
bHLH_AtORG2_like cd18914
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 ...
 61-164 3.99e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins; The family includes ORG2 (also termed AtbHLH38, or EN 8) and ORG3 (also termed AtbHLH39, or EN 9), both of which act as bHLH transcription factors.


Pssm-ID: 381484 [Multi-domain]  Cd Length: 77  Bit Score: 41.13  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063697097  61 KKQDHNAKERLRRMRLHASYLTLGTLLPDHssssskvlfsllllqvryvllvvelyitflaDWQKKWSAPSIIDNVITYI 140
Cdd:cd18914     1 KKLLHNDVERQRRQEMASLFSSLRSLLPLQ-------------------------------YIKGKLSVSDHVDEAVNYI 49

                          90       100
                  ....*....|....*....|....
gi 1063697097 141 PKLQNEVGELTLRKQKLVELERRG 164
Cdd:cd18914    50 KELQEKIKELSEKRDELLKLISGV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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