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Conserved domains on  [gi|1063696992|ref|NP_001322738|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

folate/biopterin family MFS transporter( domain architecture ID 12041468)

folate/biopterin family major facilitator superfamily (MFS) transporter facilitates folate monoglutamate transport involved in tetrahydrofolate biosynthesis, as well as the transport of antifolates such as methotrexate and aminopterin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
61-473 1.74e-167

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


:

Pssm-ID: 308617  Cd Length: 432  Bit Score: 479.92  E-value: 1.74e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  61 QGLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMISMMV--LWL 138
Cdd:pfam03092   1 QGVALGLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLygLLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 139 HTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLL 218
Cdd:pfam03092  81 ASEASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFVT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 219 GVTAGLLVVVGMVLKESPSRsLGRKHVN-----------DKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAV-SLHIHEGM 286
Cdd:pfam03092 161 AALQLLTCVVALLIKESSLG-LPAKHEPkrpvpclfglfEMNREVISRNWKAFRYSEILTPTLFAMLSQAIlPLVIAKAN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 287 FYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYF 366
Cdd:pfam03092 240 VFFYTTNVLGPNFSYSFYGTVKVIGSIAGLIGVTLYNRFLKKHPYRLTFGVTTVLQVLSGLFDLILVKRWNRYIGISDHM 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 367 FIVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRS 446
Cdd:pfam03092 320 YILGDSIILEVLYMLKFMPVLVLLARLCPRGSESTVFALLASIANLGQSVSSSLGALLMEYLGVTRCDFSNLPLLLLIGS 399
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1063696992 447 LLRVIPIGLVFLIPN------VDSNSTILPAEM 473
Cdd:pfam03092 400 LCTLLPLPLLGLLPParicddIDEDGKAVRDAA 432
 
Name Accession Description Interval E-value
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
61-473 1.74e-167

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


Pssm-ID: 308617  Cd Length: 432  Bit Score: 479.92  E-value: 1.74e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  61 QGLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMISMMV--LWL 138
Cdd:pfam03092   1 QGVALGLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLygLLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 139 HTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLL 218
Cdd:pfam03092  81 ASEASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFVT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 219 GVTAGLLVVVGMVLKESPSRsLGRKHVN-----------DKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAV-SLHIHEGM 286
Cdd:pfam03092 161 AALQLLTCVVALLIKESSLG-LPAKHEPkrpvpclfglfEMNREVISRNWKAFRYSEILTPTLFAMLSQAIlPLVIAKAN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 287 FYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYF 366
Cdd:pfam03092 240 VFFYTTNVLGPNFSYSFYGTVKVIGSIAGLIGVTLYNRFLKKHPYRLTFGVTTVLQVLSGLFDLILVKRWNRYIGISDHM 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 367 FIVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRS 446
Cdd:pfam03092 320 YILGDSIILEVLYMLKFMPVLVLLARLCPRGSESTVFALLASIANLGQSVSSSLGALLMEYLGVTRCDFSNLPLLLLIGS 399
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1063696992 447 LLRVIPIGLVFLIPN------VDSNSTILPAEM 473
Cdd:pfam03092 400 LCTLLPLPLLGLLPParicddIDEDGKAVRDAA 432
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
52-457 6.47e-159

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 456.69  E-value: 6.47e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  52 GVIIVYGVSQGLGKGLSKVSTqYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMI 131
Cdd:cd17484     1 SVIAVVYFSQGVAGLSWLAVS-YYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 132 SMMVLWLHTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPT-LAADMQSLCGLCSSIGSLVGFSLSGVLVHLVG 210
Cdd:cd17484    80 SWLALALVSNSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQsLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 211 SKGVYGLLGVTAGLLVVVGMVLKESPSRSLGRKHVNDkflDAGSAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFYWY 290
Cdd:cd17484   160 PRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENFD---EQLKALWETVKQPSIWLPALFIFLYQATPSSGSAMFYFMT 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 291 TdskdGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFFIVV 370
Cdd:cd17484   237 N----ELGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLGLTDLILVTRWNLKLGIPDHAFVLG 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 371 DEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRSLLRV 450
Cdd:cd17484   313 DDAVVTVIGEILFMPILVLAARLCPPGIEGTVFALLMSISNLGSLTSSFLGALLTKALGVTSTNFDNLWLLILICNLSRL 392

                  ....*..
gi 1063696992 451 IPIGLVF 457
Cdd:cd17484   393 LPLLFLF 399
fbt TIGR00788
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The ...
66-460 8.42e-63

folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The only functionally characterized members of the family are from protozoa and include FT1, the major folate transporter in Leishmania, and BT1, the Leishmania biopterin/folate transporter. A related protein in Trypanosoma brucei, ESAGIO, shows weak folate/biopterin transport activity. [Cell envelope, Other]


Pssm-ID: 273268  Cd Length: 468  Bit Score: 211.95  E-value: 8.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  66 GLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGfLAMISMMVLWLHTNLH-L 144
Cdd:TIGR00788  42 GLMRLPLSPMLTDDLGLDGARYQRLVGLSSLGWALKPFAGVMSDTFPLFGYTKRWYLVLSG-LLGSAILYGLLPGKVSsA 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 145 ALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGvlvHLVGSKGVYGLLGVTAGL 224
Cdd:TIGR00788 121 KVAAAFIFLAALAKALYDVLVDSLYSERIRESPSAGPSLVSWMWGASATGGLISSLLGG---PLLDKTLTRILFLITAAL 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 225 LVVVGMV---LKESPS----RSLGRKHVNDKFLDAG---------SAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFY 288
Cdd:TIGR00788 198 LLLQLFVsnlSKERRAfvrpRIGTYLEMNMALLTLGvlanvkvqiLGLRGAIQLLEIAKPLIFIFLSYANLPGASGSVFC 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 289 WYTDSKD-GPSFSkeavGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFF 367
Cdd:TIGR00788 278 ATTQCLPgGPSFS----GMSKVVGNLGSLCGVGGYDRFLKTFPYRLLFGVTTLLYTLSSLFDLILVKRWNLAFGISDEVF 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 368 IVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRSL 447
Cdd:TIGR00788 354 VLGDSIIAEVLAQLKFMPFLVLLARLCPSGCESSVFALLASILHLGSSVSGFLGVLLMETIGITCDNSNNLWLLILGHSL 433
                         410
                  ....*....|...
gi 1063696992 448 LRVIPIGLVFLIP 460
Cdd:TIGR00788 434 APLLPLPLLHLLP 446
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-348 1.99e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.30  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  84 PSQAQIYVGLIQIPWII-KPLWGLLTDVvpvlgYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLVAGSAGVAIad 162
Cdd:COG2814    44 PAQAGLVVTAYLLGAALgAPLAGRLADR-----FGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALF-- 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 163 VTIDACVTQcsISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGL-LVVVGMVLKESPSRSLG 241
Cdd:COG2814   117 PAALALIAD--LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 242 RKhvndkfldaGSAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFYWYTDSKDgpsFSKEAVGSIMSFGAIGSLVGILL 321
Cdd:COG2814   195 RL---------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG---LSASAAGLLLALFGLGGVLGALL 262
                         250       260
                  ....*....|....*....|....*..
gi 1063696992 322 YQNFLKNFPFRNVVFWALSLSVLSGFL 348
Cdd:COG2814   263 AGRLADRFGRRRLLLIGLLLLALGLLL 289
 
Name Accession Description Interval E-value
BT1 pfam03092
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ...
61-473 1.74e-167

BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).


Pssm-ID: 308617  Cd Length: 432  Bit Score: 479.92  E-value: 1.74e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  61 QGLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMISMMV--LWL 138
Cdd:pfam03092   1 QGVALGLSRLATQFMLKDRLGLDPARYQRLSGLATLPWSIKPLYGMLSDGFALFGYRRRWYLALSGLLGGAFWLLygLLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 139 HTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLL 218
Cdd:pfam03092  81 ASEASAPVAAAFIFLSSLGVAIVDVLVDALVSERARQSPTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKPQISFFVT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 219 GVTAGLLVVVGMVLKESPSRsLGRKHVN-----------DKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAV-SLHIHEGM 286
Cdd:pfam03092 161 AALQLLTCVVALLIKESSLG-LPAKHEPkrpvpclfglfEMNREVISRNWKAFRYSEILTPTLFAMLSQAIlPLVIAKAN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 287 FYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYF 366
Cdd:pfam03092 240 VFFYTTNVLGPNFSYSFYGTVKVIGSIAGLIGVTLYNRFLKKHPYRLTFGVTTVLQVLSGLFDLILVKRWNRYIGISDHM 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 367 FIVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRS 446
Cdd:pfam03092 320 YILGDSIILEVLYMLKFMPVLVLLARLCPRGSESTVFALLASIANLGQSVSSSLGALLMEYLGVTRCDFSNLPLLLLIGS 399
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1063696992 447 LLRVIPIGLVFLIPN------VDSNSTILPAEM 473
Cdd:pfam03092 400 LCTLLPLPLLGLLPParicddIDEDGKAVRDAA 432
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
52-457 6.47e-159

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 456.69  E-value: 6.47e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  52 GVIIVYGVSQGLGKGLSKVSTqYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMI 131
Cdd:cd17484     1 SVIAVVYFSQGVAGLSWLAVS-YYYKDDLHLGPASVQALTSIASLPWAIKPLYGLLSDSVPIFGYRRKPYLILAGALGAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 132 SMMVLWLHTNLHLALALSCLVAGSAGVAIADVTIDACVTQCSISHPT-LAADMQSLCGLCSSIGSLVGFSLSGVLVHLVG 210
Cdd:cd17484    80 SWLALALVSNSSLALALLLLLLASLGVAFSDVVIDALVVEASRGAPQsLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 211 SKGVYGLLGVTAGLLVVVGMVLKESPSRSLGRKHVNDkflDAGSAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFYWY 290
Cdd:cd17484   160 PRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENFD---EQLKALWETVKQPSIWLPALFIFLYQATPSSGSAMFYFMT 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 291 TdskdGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFFIVV 370
Cdd:cd17484   237 N----ELGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLLGLTDLILVTRWNLKLGIPDHAFVLG 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 371 DEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRSLLRV 450
Cdd:cd17484   313 DDAVVTVIGEILFMPILVLAARLCPPGIEGTVFALLMSISNLGSLTSSFLGALLTKALGVTSTNFDNLWLLILICNLSRL 392

                  ....*..
gi 1063696992 451 IPIGLVF 457
Cdd:cd17484   393 LPLLFLF 399
fbt TIGR00788
folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The ...
66-460 8.42e-63

folate/biopterin transporter; The Folate-Biopterin Transporter (FBT) Family (TC 2.A.71)The only functionally characterized members of the family are from protozoa and include FT1, the major folate transporter in Leishmania, and BT1, the Leishmania biopterin/folate transporter. A related protein in Trypanosoma brucei, ESAGIO, shows weak folate/biopterin transport activity. [Cell envelope, Other]


Pssm-ID: 273268  Cd Length: 468  Bit Score: 211.95  E-value: 8.42e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  66 GLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWIIKPLWGLLTDVVPVLGYRRRPYFILAGfLAMISMMVLWLHTNLH-L 144
Cdd:TIGR00788  42 GLMRLPLSPMLTDDLGLDGARYQRLVGLSSLGWALKPFAGVMSDTFPLFGYTKRWYLVLSG-LLGSAILYGLLPGKVSsA 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 145 ALALSCLVAGSAGVAIADVTIDACVTQCSISHPTLAADMQSLCGLCSSIGSLVGFSLSGvlvHLVGSKGVYGLLGVTAGL 224
Cdd:TIGR00788 121 KVAAAFIFLAALAKALYDVLVDSLYSERIRESPSAGPSLVSWMWGASATGGLISSLLGG---PLLDKTLTRILFLITAAL 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 225 LVVVGMV---LKESPS----RSLGRKHVNDKFLDAG---------SAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFY 288
Cdd:TIGR00788 198 LLLQLFVsnlSKERRAfvrpRIGTYLEMNMALLTLGvlanvkvqiLGLRGAIQLLEIAKPLIFIFLSYANLPGASGSVFC 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 289 WYTDSKD-GPSFSkeavGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFF 367
Cdd:TIGR00788 278 ATTQCLPgGPSFS----GMSKVVGNLGSLCGVGGYDRFLKTFPYRLLFGVTTLLYTLSSLFDLILVKRWNLAFGISDEVF 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 368 IVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQFDNLWLVIVIRSL 447
Cdd:TIGR00788 354 VLGDSIIAEVLAQLKFMPFLVLLARLCPSGCESSVFALLASILHLGSSVSGFLGVLLMETIGITCDNSNNLWLLILGHSL 433
                         410
                  ....*....|...
gi 1063696992 448 LRVIPIGLVFLIP 460
Cdd:TIGR00788 434 APLLPLPLLHLLP 446
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
96-448 1.35e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.83  E-value: 1.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  96 IPWIIKPLWGLLTDVvpvlgYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLvaGSAGVAIADVTIDACVTQcsIS 175
Cdd:cd06174    43 GYALLQPLAGLLADR-----FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL--LGLGSGLIDPAVLALIAD--LF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 176 HPTLAADMQSLCGLCSSIGSLVGFSLSGVLV--HLVGSKGVYGLLGVTAGLLVVVGMVLKESPSRSLGRKHVNDKFLDAG 253
Cdd:cd06174   114 PERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 254 SAIWKTFQYGEVWRPCLFMLLSAAVSLHIhegMFYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRN 333
Cdd:cd06174   194 KLLKRVLKNPGLWLLLLAIFLVNLAYYSF---STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 334 VVFWALSLSVLSGFLdlILVLRINLKLGLPDYFFIVVDEFVSHMISrikwlplLVLSSKLCPAGMEGTFFALLMSIEHIG 413
Cdd:cd06174   271 PLLLIGLLLMALGLA--LLLLAPSLLLLLLLLLLLGFGLGGLLPLS-------FALIAELFPPEIRGTAFGLLNTFGFLG 341
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1063696992 414 HLVSSWGGGVLLhalkVTRTQFDNLWLVIVIRSLL 448
Cdd:cd06174   342 GAIGPLLAGFLL----AATFGLTGAFLVLAVLLLL 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-348 1.99e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.30  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  84 PSQAQIYVGLIQIPWII-KPLWGLLTDVvpvlgYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLVAGSAGVAIad 162
Cdd:COG2814    44 PAQAGLVVTAYLLGAALgAPLAGRLADR-----FGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALF-- 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 163 VTIDACVTQcsISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGL-LVVVGMVLKESPSRSLG 241
Cdd:COG2814   117 PAALALIAD--LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 242 RKhvndkfldaGSAIWKTFQYGEVWRPCLFMLLSAAVSLHIHEGMFYWYTDSKDgpsFSKEAVGSIMSFGAIGSLVGILL 321
Cdd:COG2814   195 RL---------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG---LSASAAGLLLALFGLGGVLGALL 262
                         250       260
                  ....*....|....*....|....*..
gi 1063696992 322 YQNFLKNFPFRNVVFWALSLSVLSGFL 348
Cdd:COG2814   263 AGRLADRFGRRRLLLIGLLLLALGLLL 289
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
74-458 4.34e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 61.84  E-value: 4.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  74 YYFKDEQKIQPSQaqiyVGLIqipWIIKPLWGLLTDvvPVLGY----------RRRPYFILAGFLAMISMMVLWLHTNLH 143
Cdd:COG2211    35 YFYTDVLGLSAAL----VGLI---LLVARLWDAITD--PLIGAlsdrtrtrwgRRRPWILIGAIPLALSFVLLFTAPDLS 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 144 LALALsclvagsAGVAIADVTIDACVTQCSISHPTLAADM----------QSLCGLCSSIGSLVGFSLSGVLVHLVGSKG 213
Cdd:COG2211   106 PTGKL-------IYALVTYLLLGLAYTLVNIPYSALGAELtpdyeertrlSSWRFAFAGLGGLLASVLPPPLVAAFGGDA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 214 VYG--LLGVTAGLLVVVGMVL-----KESPSRSLGRKhvndKFLDAGSAIWKTFQygevWRPCLFMLLSAAVSLHIHEGM 286
Cdd:COG2211   179 ALGyrLTALIFAVLGLLAFLLtffgtKERPVPEEEKV----SLKESLKALLKNRP----FLLLLLAYLLFFLALALVAAL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 287 FYWYTdsKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLsGFLDLILVLRINLKLGlpdyf 366
Cdd:COG2211   251 LLYYF--KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL-GLLLLFFLGPGNLWLL----- 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 367 fivvdeFVSHMISRIKWLPLLVLS----SKLCPAG-------MEGTFFALLMSIEHIGHLVSSWGGGVLLHALKVTRTQF 435
Cdd:COG2211   323 ------LVLAALAGIGLGAILVLPwamlADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA 396
                         410       420
                  ....*....|....*....|...
gi 1063696992 436 DNLWLVIVIRSLLRVIPIGLVFL 458
Cdd:COG2211   397 QSPSALTGIRLLFFLLPAVLLLL 419
MFS_1 pfam07690
Major Facilitator Superfamily;
62-418 4.93e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  62 GLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWII-KPLWGLLTDVvpvlgYRRRPYFILAGFLAMISMMVLWLHT 140
Cdd:pfam07690   9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALaQPLAGRLSDR-----FGRRRVLLIGLLLFALGLLLLLFAS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 141 NLHLALALSclVAGSAGVAIADVTIDACVTQcsISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLLGV 220
Cdd:pfam07690  84 SLWLLLVLR--VLQGLGAGALFPAALALIAD--WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 221 tAGLLVVVGMVLKESPSRSLGRKHVNDKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAVSlhiheGMFYWYTDSKDGPSFS 300
Cdd:pfam07690 160 -LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF-----GLLTYLPLYQEVLGLS 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 301 KEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFFIVVDEFVShmisr 380
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV----- 308
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1063696992 381 ikWLPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSS 418
Cdd:pfam07690 309 --FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_AmpG_like cd17486
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...
54-321 1.17e-06

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341039 [Multi-domain]  Cd Length: 387  Bit Score: 50.68  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  54 IIVYGVSQGLGKGLSKVSTQYYFKDEQkiqpSQAQI--YVGLIQIPWIIKPLWGLLTD--VVPVLGyRRRPYFILAGFLA 129
Cdd:cd17486     1 ILLLGFASGLPYLLTGTTLQAWLKEAG----VDLDTigLFSLVGLPYSLKFLWAPLVDrySTPFLG-RRRGWILLTQILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 130 MISMMVLWLH---TNLHLALALSCLVAGSAgvAIADVTIDACVTQcsISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLV 206
Cdd:cd17486    76 MAALIALAFLdpfTNLVLSALLFLLVAFFS--ATQDIAIDAYRIE--ALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 207 HLVGSKGVYGLLGVTAGLLVVVGMVLKESPsrslGRKHVNDKFLDAGSAIWKTFQYGEVWRPCLFMLLSAAvslhihegm 286
Cdd:cd17486   152 DSLSWSAVYLIMAALMGPGILATLFAPEPP----RTDPPANSLSETVVAFFAPFKDFFGQPGALLILAFIL--------- 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1063696992 287 FYWYTDSKDG---------PSFSKEAVGSIMS-FGAIGSLVGILL 321
Cdd:cd17486   219 LYKLGDAMLGamatpflldLGFTKTEIGAVYKtVGLIATIVGGLL 263
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
116-428 3.78e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.15  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 116 YRRRPYFILAGFLAMISMMVLWLHT---NLHLALALSCLVAGSAGVAIADVTIDACVTQcsISHPTLAADMQSLCGLCSS 192
Cdd:cd06173    61 FDRRRLLILADLLRALLAAVLALLAllgSLSLWLLLVLAFLLGIASAFFGPARQALLPE--LVPKEQLVRANALNSLATQ 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 193 IGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGLLVVVGMVLKeSPSRSLGRKHVNDKFLDAGSAIWKTFQYGEVWRPCLFM 272
Cdd:cd06173   139 LARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR-RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLAL 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 273 LLSAAVSLHIHEGMFYWytdSKDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALslsVLSGFLDLIL 352
Cdd:cd06173   218 ALFALLGGALTVLLPLL---AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA---LLLGLALLVL 291
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063696992 353 VLRINLKLGLPDYFFIvvdeFVSHMISRIkwlPLLVLSSKLCPAGMEGTFFALLMSIEHIGHLVSSWGGGVLLHAL 428
Cdd:cd06173   292 GLSPSLWLLLAALFLL----GLAGGLFNV---PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
91-428 7.50e-06

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 47.99  E-value: 7.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  91 VGLIQIPWIIKPLWGLLTD--VVPVLGYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLVAGSAGVAIADVTIDAC 168
Cdd:cd17485    37 LKLLYLPWVLKFLWAPLVDryGLPRLGRRRSWLLPTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 169 VTQcsishpTLAADMQSLCGLCSSIGSLVGFSL-SGVLVHLVGSKGVYGLLGVTAGLLVVVGMVLKESPSRSLGRK-HVN 246
Cdd:cd17485   117 AVE------LLTPEERGLGNAAQVVGYKLGSLLgGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQpPAS 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 247 DKFLDAGSAIWKTFQYGEVwRPCLFMLLSAAVSLHIHEGMF-YWYTDSkdgpSFSKEAVGSIMS-FGAIGSLVGILLYQN 324
Cdd:cd17485   191 ERGAALKASLRAFLRRPGT-RWLLLFLLLYKLGEQGALAMLpPFLVDR----GFSLSQIGLLSGvGGSLVSIAGSLLGGY 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 325 FLKNFPFRNVVFWALSLSVLSGFLDLILVLRINLKLGLPDYFFIVVDEFVSHMISrikwLPLLVLSSKLCPAGMEGTFFA 404
Cdd:cd17485   266 LLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMIT----TALFTLMMDCSQQAQAGTDYT 341
                         330       340
                  ....*....|....*....|....
gi 1063696992 405 LLMSIEHIGHLVSSWGGGVLLHAL 428
Cdd:cd17485   342 LLATVEVLGKLLFGSLAGFLADHL 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-238 7.00e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 7.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  45 LHWSFFFGVIIVYGVSQGLGKglskvstqyYFKDEQKIQPSQAQIYVGLIQIPWII-KPLWGLLTDVVPvlgyRRRPYFI 123
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPT---------YLVEVRGLSLAQAGLLLSLPFLAGIVgSLLGGWLSDRLG----RRRKLVL 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 124 LAGFLAMISMMVLWLHTNlHLALALSCLVAGSAGVAIADVTIDACVTQcsISHPTLAADMQSLCGLCSSIGSLVGFSLSG 203
Cdd:COG2271   252 AIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAE--LFPKKARGTASGLVNTFGFLGGALGPLLVG 328
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063696992 204 VLVHLVGSKGVYGLLGVTAGLLVVVGMVLKESPSR 238
Cdd:COG2271   329 YLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
110-348 8.86e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 8.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 110 VVPVLGYRRrpyFILAGFLAMISMMVLWLHTNLHLALALSCLVAGsAGVAIADVTIDACVTQCsisHPTLAADMQSLCGL 189
Cdd:COG0738    66 LIDRFGYKR---GLLLGLLLMALGLLLFALAPSYPLLLLALFLLG-LGLGLLDVAANPYVAAL---GPETAASRLNLLHA 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 190 CSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGLLVVVGMVLkeSPSRSLGRKHVNDKFLDAGSAIWKTFQYGEVWRPC 269
Cdd:COG0738   139 FFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLF--LRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGG 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 270 LFMLLSAAVslhihEGMFYWYTDS--KDGPSFSKEAVGSIMSFGAIGSLVGILLYQNFLKNFPFRNVVFWALSLSVLSGF 347
Cdd:COG0738   217 LAIFLYVGA-----EGAIGDWLPLylKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291

                  .
gi 1063696992 348 L 348
Cdd:COG0738   292 L 292
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
99-424 1.58e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.10  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  99 IIKPLWGLLTDVvpvLGYRRrpyFILAGFLAMI--SMMVLWLHTNLHLALALSCLVAGSAGVA------IADvtidacvt 170
Cdd:cd17325    46 LFSPPAGRLSDR---FGRKR---LLLLGLLLLAvsTLLFAFATSYWQLLLARFLQGLASAAVWpaamalIAD-------- 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 171 qcsISHPTLAADMQSLCGLCSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGL-LVVVGMVLKESPSRSLGRKHVNDKF 249
Cdd:cd17325   112 ---IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLaLVLALLLLPEPRPPPNKRAVSAARL 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 250 LdagSAIWKTFQYGEVWRPCLFMLLSAaVSLHIHEGMFYWYTDSKDGpsFSKEAVGSIMSFGAIGSLVGILLYQNFLKNF 329
Cdd:cd17325   189 R---SGLRLLLRDRRLLALFLAIFVLA-FAFGALEPFLPLYAAELGG--LSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 330 PFRNVVFWALSLSVLSGFLdLILVlrinlklglPDYFFIVVDEFVSHMISRIKWLPLLVLSSKLCPAGMEGTFFALLMSI 409
Cdd:cd17325   263 GRKPLILIGLLLSAVALLL-LPLA---------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
                         330
                  ....*....|....*
gi 1063696992 410 EHIGHLVSSWGGGVL 424
Cdd:cd17325   333 FSLGMVLGPLLGGFL 347
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
102-348 3.76e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.57  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 102 PLWGLLTDVvpvlgYRRRPYFILAGFLAMISMMVLWLHTNLHLALALSCLV-AGSAGVAIADVTIDACVTQCSIshptlA 180
Cdd:cd17330    52 PLWGRLSDR-----YGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDgLTGGNVSVAQAYIADITDEEER-----A 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 181 ADMqSLCGLCSSIGSLVGFSLSGVLVHLVGskgvYGLLGVTAGLLVVVGMVLkespsrslgrkhvndkfldagsaIWktF 260
Cdd:cd17330   122 KAF-GIISAAFGLGFILGPALGGFLSTPYG----YALPFLVAAALALLNLVL-----------------------VL--F 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 261 QYGEVWRPCLFMLLSAAVSLHIHEGMFYWytdSKDGPSFSKEAVGSIMS-FGAIGSLVGILLYQNFLKNFPFRNVVFWAL 339
Cdd:cd17330   172 FLPPLRRLLLVYFLIALAFAGLESVFSLF---LKDRFGFSPSQIGLLLAlVGIAGILAQLLLIPRLAKRLGERKLLRLGL 248

                  ....*....
gi 1063696992 340 SLSVLSGFL 348
Cdd:cd17330   249 LLAIIGLLL 257
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
99-370 6.69e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.21  E-value: 6.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  99 IIKPLWGLLTDVVPVLGYRRRPYFILAGFLAMISMMVLWLH----TNLHLALALSCLVAGSAGVAIADVTIdacvtqCSI 174
Cdd:cd17332    50 INDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALLFVLLFTTpdgsGTGKLIYALITYILLDLLYTLVNIPY------TAL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 175 ShPTLAADMQ---SLCGL---CSSIGSLVGFSLSGVLVHLVGSKGVYGLLGVTAGLLVVVGMVL--------KESPsRSL 240
Cdd:cd17332   124 I-PELTDDPEertSLTSWrmfFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILllicffgtRERV-VPP 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 241 GRKHVNDKFLDAGSAIWKTFQYgevWRPCLFMLLSAAVSLHIHEGMFYWYTDSKDGPSFSKEAVGSIMSFGAIGSLVGIL 320
Cdd:cd17332   202 EEEKSKLPLLKSLKALLKNRPF---LILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPP 278
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063696992 321 lyqnFLKNFPFRNVVFWALSLSVLsGFLDLILVLRINLKLGLPDYFFIVV 370
Cdd:cd17332   279 ----LKKRFGKKKAFFIGLLLAIL-GLLLLFFLPPGNLVLILVLAVLAGI 323
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
51-232 7.32e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 7.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992  51 FGVIIVYGVSQGLGKGLSKVSTQYYFKDEQKIQPSQAQIYVGLIQIPWII-KPLWGLLTDVvpvlgYRRRPYFILAGFLA 129
Cdd:COG2211   230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLgAPLWPRLAKR-----FGKKKAFIIGLLLA 304
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063696992 130 MISMMVLWLHTNLHLALALSCLVAGSAGVAIADVTIDACVTQCS-----ISHPTLAADMQSLCGLCSSIGSLVGFSLSGV 204
Cdd:COG2211   305 ALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGL 384
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1063696992 205 LVHLVG-----------SKGVYGLLGVTAGLLVVVGMVL 232
Cdd:COG2211   385 LLALFGyvagaaqspsaLTGIRLLFFLLPAVLLLLAALL 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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