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Conserved domains on  [gi|1063694584|ref|NP_001321592|]
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nodulin MtN21 /EamA-like transporter family protein [Arabidopsis thaliana]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 1750314)

triose-phosphate transporter (TPT) family protein belongs to the drug/metabolite transporter (DMT) superfamily; similar to the well-characterized triose phosphate and sugar phosphate permeases of chloroplasts and its functionally uncharacterized homologs found in yeast and animals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT_S35C2 super family cl40580
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 103-225 3.61e-06

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


The actual alignment was detected with superfamily member cd21092:

Pssm-ID: 411044  Cd Length: 248  Bit Score: 46.49  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584 103 YVTSVIPIGAMFAMTLWLGNTAYLYITVAFSQMLKAimPVAVFILG--VCVGLEIMSCKMLLIMSVISFGVLVSSYGELN 180
Cdd:cd21092     4 YLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKS--SAIIFILFfsLVFKLEKPRWSLVLVVLLIAGGLFMFTYKSTQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063694584 181 INWVGVVYQMGGIVSEALRLILMEILVKRKGIKL-NPLSLMYYMSP 225
Cdd:cd21092    82 FNLEGFILVLSASFLGGLRWTLAQLLMQKAELGLqNPIDMMYHLQP 127
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 103-225 3.61e-06

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 46.49  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584 103 YVTSVIPIGAMFAMTLWLGNTAYLYITVAFSQMLKAimPVAVFILG--VCVGLEIMSCKMLLIMSVISFGVLVSSYGELN 180
Cdd:cd21092     4 YLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKS--SAIIFILFfsLVFKLEKPRWSLVLVVLLIAGGLFMFTYKSTQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063694584 181 INWVGVVYQMGGIVSEALRLILMEILVKRKGIKL-NPLSLMYYMSP 225
Cdd:cd21092    82 FNLEGFILVLSASFLGGLRWTLAQLLMQKAELGLqNPIDMMYHLQP 127
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 40-212 1.03e-05

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 45.36  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584  40 LLYITLSSGQIFFNKWVLSSkeinFPYPLGLTLLHMTFSSVLC--FLLTKVFKVMKVEEGmtleiYVTSVIPIGAMFAMT 117
Cdd:pfam03151   8 GLWYFLNIYFNIYNKKILNA----FPYPMTVSSVQLFVGSVYIlvLWGTGLRKRPKISSP-----FLKNILPLALCHTLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584 118 LWLGNTAYLYITVAFSQMLKAIMPVAVFILGVCVGLEIMSCKMLLIMSVISFGVLVSSYGELNINWVGVVYQMGGIVSEA 197
Cdd:pfam03151  79 HVLANVSLGKVAVSFTHTVKAMEPFFTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFS 158

                         170
                  ....*....|....*
gi 1063694584 198 LRLILMEILVKRKGI 212
Cdd:pfam03151 159 LRNIFSKKLMKGKDN 173
 
Name Accession Description Interval E-value
TPT_S35C2 cd21092
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
 103-225 3.61e-06

solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.


Pssm-ID: 411044  Cd Length: 248  Bit Score: 46.49  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584 103 YVTSVIPIGAMFAMTLWLGNTAYLYITVAFSQMLKAimPVAVFILG--VCVGLEIMSCKMLLIMSVISFGVLVSSYGELN 180
Cdd:cd21092     4 YLKRVAPTGLASALDIGLSNWSFLFITVSLYTMTKS--SAIIFILFfsLVFKLEKPRWSLVLVVLLIAGGLFMFTYKSTQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063694584 181 INWVGVVYQMGGIVSEALRLILMEILVKRKGIKL-NPLSLMYYMSP 225
Cdd:cd21092    82 FNLEGFILVLSASFLGGLRWTLAQLLMQKAELGLqNPIDMMYHLQP 127
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 40-212 1.03e-05

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 45.36  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584  40 LLYITLSSGQIFFNKWVLSSkeinFPYPLGLTLLHMTFSSVLC--FLLTKVFKVMKVEEGmtleiYVTSVIPIGAMFAMT 117
Cdd:pfam03151   8 GLWYFLNIYFNIYNKKILNA----FPYPMTVSSVQLFVGSVYIlvLWGTGLRKRPKISSP-----FLKNILPLALCHTLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694584 118 LWLGNTAYLYITVAFSQMLKAIMPVAVFILGVCVGLEIMSCKMLLIMSVISFGVLVSSYGELNINWVGVVYQMGGIVSEA 197
Cdd:pfam03151  79 HVLANVSLGKVAVSFTHTVKAMEPFFTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFS 158

                         170
                  ....*....|....*
gi 1063694584 198 LRLILMEILVKRKGI 212
Cdd:pfam03151 159 LRNIFSKKLMKGKDN 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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