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Conserved domains on  [gi|1063686700|ref|NP_001321074|]
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ROP-interactive CRIB motif-containing protein 2 [Arabidopsis thaliana]

Protein Classification

Wiskott-Aldrich syndrome protein; serine/threonine-protein kinase PAK 3( domain architecture ID 10645184)

Wiskott-Aldrich syndrome protein (WASp) acts as an effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex| serine/threonine-protein kinase PAK 3 (p21-activated kinase 3) catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 127-162 8.21e-08

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


:

Pssm-ID: 197628  Cd Length: 36  Bit Score: 46.05  E-value: 8.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1063686700  127 IGFPTDVKHLSHIGVDGTMTTFDNTSSSFPFSGFHL 162
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 127-162 8.21e-08

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 46.05  E-value: 8.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1063686700  127 IGFPTDVKHLSHIGVDGTMTTFDNTSSSFPFSGFHL 162
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 125-143 4.90e-04

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 36.26  E-value: 4.90e-04
                          10
                  ....*....|....*....
gi 1063686700 125 MEIGFPTDVKHLSHIGVDG 143
Cdd:cd00132     1 MEISTPTDFKHISHVGWDG 19
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 127-162 8.21e-08

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 46.05  E-value: 8.21e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1063686700  127 IGFPTDVKHLSHIGVDGTMTTFDNTSSSFPFSGFHL 162
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 125-143 4.90e-04

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 36.26  E-value: 4.90e-04
                          10
                  ....*....|....*....
gi 1063686700 125 MEIGFPTDVKHLSHIGVDG 143
Cdd:cd00132     1 MEISTPTDFKHISHVGWDG 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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