triose-phosphate transporter (TPT) family protein belongs to the drug/metabolite transporter (DMT) superfamily; similar to the well-characterized triose phosphate and sugar phosphate permeases of chloroplasts and its functionally uncharacterized homologs found in yeast and animals
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
141-371
2.09e-60
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
The actual alignment was detected with superfamily member cd21092:
Pssm-ID: 411044 Cd Length: 248 Bit Score: 196.34 E-value: 2.09e-60
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
141-371
2.09e-60
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
Pssm-ID: 411044 Cd Length: 248 Bit Score: 196.34 E-value: 2.09e-60
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
107-374
9.33e-14
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 71.41 E-value: 9.33e-14
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
73-372
1.35e-10
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]
Pssm-ID: 129898 [Multi-domain] Cd Length: 302 Bit Score: 62.05 E-value: 1.35e-10
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute ...
141-371
2.09e-60
solute carrier family 35 member C2, member of the triose-phosphate transporter family; Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
Pssm-ID: 411044 Cd Length: 248 Bit Score: 196.34 E-value: 2.09e-60
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
107-374
9.33e-14
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 71.41 E-value: 9.33e-14
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
73-372
1.35e-10
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]
Pssm-ID: 129898 [Multi-domain] Cd Length: 302 Bit Score: 62.05 E-value: 1.35e-10
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
107-216
1.78e-04
EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.
Pssm-ID: 307170 Cd Length: 136 Bit Score: 41.41 E-value: 1.78e-04
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
225-374
1.38e-03
EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.
Pssm-ID: 307170 Cd Length: 136 Bit Score: 38.72 E-value: 1.38e-03
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal ...
166-370
2.23e-03
Purine nucleobase transmembrane transport; PUNUT is a family of largely plant and fungal purine transporters. Most members are 10-pass transmembrane proteins, and they belong to the drug/metabolite transporter (dmt) superfamily. The plant vascular system transports nucloebases and their derivatives such as cytokinins and caffeine by a common H+-coupled high-affinity purine transport system; the PUNUT family members carry out this transport.
Pssm-ID: 293518 [Multi-domain] Cd Length: 321 Bit Score: 39.96 E-value: 2.23e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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