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Conserved domains on  [gi|1063729058|ref|NP_001318751|]
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Bax inhibitor-1 family protein [Arabidopsis thaliana]

Protein Classification

Bax inhibitor 1 family protein( domain architecture ID 1847)

Bax inhibitor 1 family protein similar to Saccharomyces cerevisiae Bax inhibitor 1 that links the unfolded protein response and programmed cell death, and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like super family cl00473
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 2-193 4.57e-57

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


The actual alignment was detected with superfamily member cd10430:

Pssm-ID: 469783  Cd Length: 213  Bit Score: 179.34  E-value: 4.57e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRLNIGGTITKLGWV-LSLLEHVVSCPPYKHKIRFSLLLLFGVLHGASVGPCIKSTIDID 80
Cdd:cd10430    14 KVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLgLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGASLGPLLDLVIAIN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  81 SSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLLTWLKNSDQFA--SATVEIQMYLGLLLFVGCIVVNTQ 158
Cdd:cd10430    94 PSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGgsKFLFQAELYLGLLVFCGFVLFDTQ 173

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063729058 159 EIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:cd10430   174 MIIEKAENGDRDYIWHALDLFVDFVALFRRLLIIL 208
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 2-193 4.57e-57

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 179.34  E-value: 4.57e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRLNIGGTITKLGWV-LSLLEHVVSCPPYKHKIRFSLLLLFGVLHGASVGPCIKSTIDID 80
Cdd:cd10430    14 KVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLgLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGASLGPLLDLVIAIN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  81 SSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLLTWLKNSDQFA--SATVEIQMYLGLLLFVGCIVVNTQ 158
Cdd:cd10430    94 PSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGgsKFLFQAELYLGLLVFCGFVLFDTQ 173

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063729058 159 EIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:cd10430   174 MIIEKAENGDRDYIWHALDLFVDFVALFRRLLIIL 208
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 2-193 1.71e-19

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 82.22  E-value: 1.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYL------------HMRLNIGGTITKLGWVLSLLEHVVScPPYKHKIRFSLLLLFGVLHGASV 69
Cdd:pfam01027   6 KVYGLLALGLLLTAAVAYLvlsspallfpslHPPLFWVLIIAPLGLLFGALLLARK-RKYSSNVALLLLLAFTLLMGLTL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  70 GPCIKSTidiDSSILITAFLGTAVIFFCFSAVAMLARRREYiYLGGLLSSGFSLLTW--LKNSDQFASATVEIQMYLGLL 147
Cdd:pfam01027  85 GPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKRDLS-FLGGFLFAGLIGLIVasLVNIFLPSSALSLAISYLGVL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063729058 148 LFVGCIVVNTQEIIEKA-HCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:pfam01027 161 LFSGFILYDTQRIIKRYgEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 2-193 1.65e-06

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 47.10  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRL----NIGGTITKLGWVLSLLE----HVVSCPPYKHKIRFSLLLLFG--VLHGASVGP 71
Cdd:COG0670    25 NTYGLLALGLLLTALVAYLGMALpglaALLFGSPGLFWVLLIAPlglvFLLSKLANRANSAAALALLFAytALMGLTLSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  72 CIKS-TIDIDSSILITAFLGTAVIFFCFSAVAMLArRREYIYLGGLLSSGF------SLLTWLknsdqFASATVEIQM-Y 143
Cdd:COG0670   105 ILLVyTGLSGPASIAQAFGGTAATFGGLSLYGYTT-KRDLSFLGSFLFMGLigliiaSLVNIF-----LQSPALSLAIsV 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063729058 144 LGLLLFVGCIVVNTQEIIEKAHCGDMdYAVHSLILYIGFVRVFLQILSIM 193
Cdd:COG0670   179 AGVLLFSGLTLYDTQRIKHGYETNKQ-YIMAALSLYLDFINLFLSLLRLL 227
PRK10447 PRK10447
FtsH protease modulator YccA;
66-199 9.40e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.05  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  66 GASVGPCIKSTIDIDSSILIT-AFLGTAVIFFCFSAVaMLARRREYIYLGGLLSSGFSLLTWLKNSDQFAS--ATVEIQM 142
Cdd:PRK10447   87 GYILGPILNTYLSAGMGDVIAlALGGTALVFFCCSAY-VLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQlpALHLAIS 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063729058 143 YLGLLLFVGCIVVNTQEIIekaHCGDMDYAVHSLILYIGFVRVFLQILSIMWNTSAD 199
Cdd:PRK10447  166 AVFILISSGAILFETSNII---HGGETNYIRATVSLYVSLYNIFVSLLSILGFASRD 219
 
Name Accession Description Interval E-value
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 2-193 4.57e-57

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 179.34  E-value: 4.57e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRLNIGGTITKLGWV-LSLLEHVVSCPPYKHKIRFSLLLLFGVLHGASVGPCIKSTIDID 80
Cdd:cd10430    14 KVYLTLAVALLAAAVGAYVHMVINIGGLLTGLLSLgLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGASLGPLLDLVIAIN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  81 SSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLLTWLKNSDQFA--SATVEIQMYLGLLLFVGCIVVNTQ 158
Cdd:cd10430    94 PSIIVTAFLGTAVIFACFSLAALLAKRREYLYLGGLLSSALSILLLVSLANIFGgsKFLFQAELYLGLLVFCGFVLFDTQ 173

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1063729058 159 EIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:cd10430   174 MIIEKAENGDRDYIWHALDLFVDFVALFRRLLIIL 208
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 2-193 1.71e-19

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 82.22  E-value: 1.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYL------------HMRLNIGGTITKLGWVLSLLEHVVScPPYKHKIRFSLLLLFGVLHGASV 69
Cdd:pfam01027   6 KVYGLLALGLLLTAAVAYLvlsspallfpslHPPLFWVLIIAPLGLLFGALLLARK-RKYSSNVALLLLLAFTLLMGLTL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  70 GPCIKSTidiDSSILITAFLGTAVIFFCFSAVAMLARRREYiYLGGLLSSGFSLLTW--LKNSDQFASATVEIQMYLGLL 147
Cdd:pfam01027  85 GPLLLVY---TGAIIATAFLGTAAIFGGLSLYALTTKRDLS-FLGGFLFAGLIGLIVasLVNIFLPSSALSLAISYLGVL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063729058 148 LFVGCIVVNTQEIIEKA-HCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:pfam01027 161 LFSGFILYDTQRIIKRYgEYGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 2-193 1.35e-16

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 74.76  E-value: 1.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRLNIG--GTITKLGWVLSLLEHVVSCPPYKHKIRFSLLLLFG--VLHGASVGPCIKSTi 77
Cdd:cd06181     8 KVYMILALQLLLTAATATAFTVCDPGwyWSPALMGLLTSMLALMATAAMIRAKMPVNLILLFGftGLMGYVVGPLLFFY- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  78 diDSSILITAFLGTAVIFFCFSAVAMLArRREYIYLGGLLSSGFS--LLTWLKNSDQFASATVEIQMYLGLLLFVGCIVV 155
Cdd:cd06181    87 --GPTILLRALGGTALVFFGLTVYALQA-RKDFLFLGGPLMAGLGflLLSFLLNTFFYSPWLHLVAAAVGLVLFCGFLLY 163

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063729058 156 NTQEIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIM 193
Cdd:cd06181   164 DTQLIIHKAEVGPEDYINACISLYLDIINIFIRLLTIL 201
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 59-193 6.60e-08

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 51.23  E-value: 6.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  59 LLFGVLHGASVGP-CIkstidIDSSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLL-------TWLKNS 130
Cdd:cd10431   114 LGHSGVQGAVLAPlCF-----LGGPLLIRAALYTAGIVGGLSTVAACAPSEKFLYMGGPLAIGLGVVfasslgsMFLPPT 188

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058 131 DQFASATVEIQMYLGLLLFVGCIVVNTQEIIEKAHCGDMdYAVH-------SLILYIGFVRVFLQILSIM 193
Cdd:cd10431   189 TALGAGLYSVSLYGGLVLFGGFLLYDTQKIIKRAETHPL-YGVRkydpinaSMSIYMDTINIFIRLVTIL 257
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 2-193 1.65e-06

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 47.10  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMRL----NIGGTITKLGWVLSLLE----HVVSCPPYKHKIRFSLLLLFG--VLHGASVGP 71
Cdd:COG0670    25 NTYGLLALGLLLTALVAYLGMALpglaALLFGSPGLFWVLLIAPlglvFLLSKLANRANSAAALALLFAytALMGLTLSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  72 CIKS-TIDIDSSILITAFLGTAVIFFCFSAVAMLArRREYIYLGGLLSSGF------SLLTWLknsdqFASATVEIQM-Y 143
Cdd:COG0670   105 ILLVyTGLSGPASIAQAFGGTAATFGGLSLYGYTT-KRDLSFLGSFLFMGLigliiaSLVNIF-----LQSPALSLAIsV 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063729058 144 LGLLLFVGCIVVNTQEIIEKAHCGDMdYAVHSLILYIGFVRVFLQILSIM 193
Cdd:COG0670   179 AGVLLFSGLTLYDTQRIKHGYETNKQ-YIMAALSLYLDFINLFLSLLRLL 227
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 4-192 1.31e-04

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 41.42  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   4 YFSLFCILAASAFGAYLHMRLNIG--GTITKLGWVLSLLEHVvscppykHKIRFS-----LLLLFGVLHGASVGPCIKST 76
Cdd:cd10433    11 YMLLSMTLAFSALGAGVSMAGGSPimGLLLTLVGAYGLLFLI-------EKTRNSawgivLVFAFTGFMGYTLGPILNMY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  77 IDID--SSILITAFLGTAVIFFCFSAVAmLARRREYIYLGGLLSSGF--SLLTWLKN------SDQFASATVEIqmylgl 146
Cdd:cd10433    84 LALPngGQIIMTALGGTAAIFFGLSAYA-LTTKKDFSFLGGFLFVGAivLLLAAVANiflqipALSLAISAAFV------ 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1063729058 147 LLFVGCIVVNTQEIIekaHCGDMDYAVHSLILYIGFVRVFLQILSI 192
Cdd:cd10433   157 LFSSGFILYDTSRII---HGGETNYIMATVSLYVSIYNLFVSLLNL 199
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 2-193 3.16e-04

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 40.24  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058   2 RVYFSLFCILAASAFGAYLHMR----LNIGGTITKLGWVLSLLEHVVSCPPYKHKIRFS----LLLLFGVLHGASVGPCI 73
Cdd:cd10432     8 KVYGLMAAGLLLTAVGAYVGAStpalLLIAGSPLMWVLLIAELALVFGLSFRINKMSVAtalpLFFAFAALTGLTLSPIL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  74 KSTIdidSSILITAFLGTAVIFFCFSAVAMLaRRREYIYLGGLLSSG-FSLLTWLKNSDQFASATVEIQM-YLGLLLFVG 151
Cdd:cd10432    88 LVYT---GASIAQAFFTTAATFGGLSLYGYT-TKKDLSFLGSFLFMGlIGLIIASLVNIFLQSSALQFAIsAIGVLIFSG 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063729058 152 CIVVNTQEIIEKAHCGDMDYAVHS-----LILYIGFVRVFLQILSIM 193
Cdd:cd10432   164 LIAYDTQRIKRMYEAGGGESGYKDaimgaLSLYLDFINLFLFLLRLF 210
PRK10447 PRK10447
FtsH protease modulator YccA;
66-199 9.40e-04

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 39.05  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063729058  66 GASVGPCIKSTIDIDSSILIT-AFLGTAVIFFCFSAVaMLARRREYIYLGGLLSSGFSLLTWLKNSDQFAS--ATVEIQM 142
Cdd:PRK10447   87 GYILGPILNTYLSAGMGDVIAlALGGTALVFFCCSAY-VLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQlpALHLAIS 165

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063729058 143 YLGLLLFVGCIVVNTQEIIekaHCGDMDYAVHSLILYIGFVRVFLQILSIMWNTSAD 199
Cdd:PRK10447  166 AVFILISSGAILFETSNII---HGGETNYIRATVSLYVSLYNIFVSLLSILGFASRD 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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