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Conserved domains on  [gi|1063731687|ref|NP_001318556|]
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zinc induced facilitator-like 1 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 13023689)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 41-411 7.07e-60

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 198.19  E-value: 7.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330    78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330   149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330   181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVTRPKRSS 411
Cdd:cd17330   256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGK 300
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 41-411 7.07e-60

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 198.19  E-value: 7.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330    78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330   149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330   181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVTRPKRSS 411
Cdd:cd17330   256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGK 300
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
38-384 3.73e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 3.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqyp 196
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 197 sLFSQDSIFgkfpfflpcLAISVFAFLVTIVSSR-IPETLHNHKFNDDESYdalkdlsddpesnkvaerngkSSLLNNWP 275
Cdd:COG2814   160 -LFGWRWVF---------LVNAVLALLALLLLLRlLPESRPAARARLRGSL---------------------RELLRRPR 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSL 355
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEV-----LGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLL 282

                         330       340
                  ....*....|....*....|....*....
gi 1063731687 356 AMVVLSCYPLIAKLSGLALTVTVTSASVA 384
Cdd:COG2814   283 LALGLLLLALAGSLWLLLLALFLLGFGFG 311
MFS_1 pfam07690
Major Facilitator Superfamily;
41-378 2.77e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.16  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVV 119
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISP------TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 120 FNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypSL 198
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-------SL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 199 FSQDSIFgkfpfflpclAISVFAFLVTIVSSRIPETLHNHKFNDDEsydalkdlsddpESNKVAERNGKSSLLNNWPLIS 278
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPESKRPKPA------------EEARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 279 SIIVYCVFSLhdmayteIFSLWANSPRKYGGLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMV 358
Cdd:pfam07690 206 LLALLLFGFA-------FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLIL 277

                         330       340
                  ....*....|....*....|
gi 1063731687 359 VLSCYPLIAKLSGLALTVTV 378
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLA 297
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-234 5.35e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 63.05  E-value: 5.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEER 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpFFLPCLAISVFAFLVTIvssrIPET 234
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILALAAFILLAFL----LPET 141
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
38-230 5.88e-10

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 60.70  E-value: 5.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK09874   16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAY-AMEIFRDEyQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqyp 196
Cdd:PRK09874   95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNK-SGWALGTLSTGGVSGALLGPLAGGLLADS----- 168

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1063731687 197 slfsqdsiFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:PRK09874  169 --------YGLRPVFFITASVLFLCFLVTLFCIR 194
 
Name Accession Description Interval E-value
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 41-411 7.07e-60

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 198.19  E-value: 7.07e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNiakKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFN---KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqypslfs 200
Cdd:cd17330    78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP--------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 201 qdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddpesnkvaerngkssllnnWPLISSI 280
Cdd:cd17330   149 -------YGYALPFLVAAALALLNLVLVLFFL-----------------------------------------PPLRRLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 281 IVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVL 360
Cdd:cd17330   181 LVYFLIALAFAGLESVFSLFLKDR-----FGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 361 SCYPLIAKLSGLALTVTVTSASVAksvlgtSAITGLFILQNKAVTRPKRSS 411
Cdd:cd17330   256 LLLPFASSVPLLVLAAAILAFGTG------IVFPALSALLSKSVPSKEQGK 300
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
38-384 3.73e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 3.73e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGAS------PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqyp 196
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 197 sLFSQDSIFgkfpfflpcLAISVFAFLVTIVSSR-IPETLHNHKFNDDESYdalkdlsddpesnkvaerngkSSLLNNWP 275
Cdd:COG2814   160 -LFGWRWVF---------LVNAVLALLALLLLLRlLPESRPAARARLRGSL---------------------RELLRRPR 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSL 355
Cdd:COG2814   209 LLLLLLLAFLLGFGFFALFTYLPLYLQEV-----LGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLL 282

                         330       340
                  ....*....|....*....|....*....
gi 1063731687 356 AMVVLSCYPLIAKLSGLALTVTVTSASVA 384
Cdd:COG2814   283 LALGLLLLALAGSLWLLLLALFLLGFGFG 311
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 41-384 1.15e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 98.42  E-value: 1.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGAS------VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslf 199
Cdd:cd17325    75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA---------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 200 sqDSIFGKFPFFLpCLAISVFAFLVTIVSSRIPETLHNHKFNDDESydalkdlsddpesnkvaERNGKSSLLNNWPLISS 279
Cdd:cd17325   145 --DALGYRAPFLV-CAALALLALVLALLLLPEPRPPPNKRAVSAAR-----------------LRSGLRLLLRDRRLLAL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 280 IIVYCVFSLHDMAYTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMVV 359
Cdd:cd17325   205 FLAIFVLAFAFGALEPFLPLYAAEL-----GGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVA 278

                         330       340
                  ....*....|....*....|....*
gi 1063731687 360 LSCYPLIAKLSGLALTVTVTSASVA 384
Cdd:cd17325   279 LLLLPLATSFWLLLLLLALLGLGLG 303
MFS_1 pfam07690
Major Facilitator Superfamily;
41-378 2.77e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.16  E-value: 2.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVV 119
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISP------TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 120 FNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypSL 198
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPaALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-------SL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 199 FSQDSIFgkfpfflpclAISVFAFLVTIVSSRIPETLHNHKFNDDEsydalkdlsddpESNKVAERNGKSSLLNNWPLIS 278
Cdd:pfam07690 148 FGWRAAF----------LILAILSLLAAVLLLLPRPPPESKRPKPA------------EEARLSLIVAWKALLRDPVLWL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 279 SIIVYCVFSLhdmayteIFSLWANSPRKYGGLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISGSLAMV 358
Cdd:pfam07690 206 LLALLLFGFA-------FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLIL 277

                         330       340
                  ....*....|....*....|
gi 1063731687 359 VLSCYPLIAKLSGLALTVTV 378
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLA 297
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
27-190 2.40e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 82.61  E-value: 2.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGR 106
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ------LGLLASAFFLGYALGQIPAGLLADRFGR 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIG 185
Cdd:COG2271    75 RRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIaEWFPPKERGRALGIFNAGGPLGGALAPPLL 154


                  ....*
gi 1063731687 186 GFLAQ 190
Cdd:COG2271   155 GWLLA 159
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-231 4.51e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 82.24  E-value: 4.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIakKEEDIGFYAGFVGCSFMLGRAFTsvawGLVADRYG 105
Cdd:cd17325   190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLpLYAAELGGL--SPAQIGLLFGAQGLASALSQPPA----GKLSDRIG 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 106 RKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAI 184
Cdd:cd17325   264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063731687 185 GGFLAQpakqypslfsqdsifgKFPFFLPCLAISVFAFLVTIVSSRI 231
Cdd:cd17325   344 GGFLYD----------------AFGFATPFLAAAALLLLAAVLFLLL 374
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 26-190 3.72e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 78.31  E-value: 3.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  26 MKRLRRGFPFWELFTVWIIVLCTALP---ISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVAD 102
Cdd:COG0477     1 MSSTDAAPTRRRRRALLALALGTFLEgldFTIVNVALPSIAADLGAS------SAQLGWIVSAYLLGRAIGLLLFGRLGD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 103 RYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIG 181
Cdd:COG0477    75 RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGaLALIAELFPARERGRALGLWGAAIGLGLALG 154


                  ....*....
gi 1063731687 182 PAIGGFLAQ 190
Cdd:COG0477   155 PLLGGLLVA 163
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 41-384 3.07e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 73.61  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSA------SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslf 199
Cdd:cd06174    75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAvLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS--------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 200 sqdsiFGKFPFFLPCLAISVFAFLVTIVSSRIPETLHNHKFNDDESYDALKDLSDdpesnkvaerngKSSLLNNWPLISS 279
Cdd:cd06174   146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL------------LKRVLKNPGLWLL 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 280 IIVYcvfSLHDMAYTEIFSLWANSPRKYGGLGYSTAdvGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVV 359
Cdd:cd06174   209 LLAI---FLVNLAYYSFSTLLPLFLLDLGGLSVAVA--GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALG 283

                         330       340
                  ....*....|....*....|....*
gi 1063731687 360 LSCYPLIAKLSGLALTVTVTSASVA 384
Cdd:cd06174   284 LALLLLAPSLLLLLLLLLLLGFGLG 308
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
26-398 1.94e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 71.42  E-value: 1.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  26 MKRLRRGFPFWELFTVWIIvlcTALPISSLFPFLYFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYG 105
Cdd:COG0738     1 MSKKNYRRALIAIYLLFFL---WGFATALWGPLIPALKDAFGLSD------AQAGLLLFAFFLGYLLASLPAGRLIDRFG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 106 RKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRdEYQGLALSAVSTAWGIGLIIGPAI 184
Cdd:COG0738    72 YKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVaANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 185 GGFLaqpakqypsLFSQDSIFGKFPFFLpcLAISVFAFLVTIVSSRIPETlhnhkfnddesydalkdlsDDPESNKVAER 264
Cdd:COG0738   151 GGLL---------ILLGLSLSWHLPYLI--LAVLLLLLALLFLRSKLPEI-------------------EEEEEEAAGSA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 265 NGKSSLLNNWPLISSIIvyCVFSlhdMAYTEIfSLWANSPRkYG--GLGYSTADVGSVLAFSGFGLLIFqlslysyaeRL 342
Cdd:COG0738   201 ASLKSLLKNPRLLLGGL--AIFL---YVGAEG-AIGDWLPL-YLkdVLGLSEATAALGLSLFWGGMTIG---------RF 264

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063731687 343 LGPIIVTRISGSLAMVVLSCypliakLSGLALTVTVTSASVAKSVLGTsAITGLFI 398
Cdd:COG0738   265 LGGFLLKRFGPVRLLRLSAL------LAAVGLLLALLAPGPWLALIGL-ALVGLGL 313
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 41-226 4.13e-12

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 67.29  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFV-GCSFmLGRAFTSVAWGLVADRYGRKPVILigTASVVV 119
Cdd:cd17391     1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGL-VELWSGLAfSSTF-LVSAIFSPIWGRLADRYGRKPMLL--RASLGM 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 120 FNTLFGLSL--NFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqyps 197
Cdd:cd17391    77 AIVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAD------- 149

                         170       180
                  ....*....|....*....|....*....
gi 1063731687 198 lfsqdsIFGKFPFFLPCLAISVFAFLVTI 226
Cdd:cd17391   150 ------LFGIRNVFFITGGLLFLAFLLTL 172
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-234 5.35e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 63.05  E-value: 5.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPPEER 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpFFLPCLAISVFAFLVTIvssrIPET 234
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPF----------LFLAILALAAFILLAFL----LPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 79-190 9.79e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 66.03  E-value: 9.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEI 157
Cdd:cd17324    36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAaAYAADL 115

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17324   116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ 148
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-177 7.23e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.07  E-value: 7.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIAkkEEDIGFYAGFVGCSFMLGraftSVAWGLVADRYG 105
Cdd:COG2814   198 GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLpLYLQEVLGLS--ASAAGLLLALFGLGGVLG----ALLAGRLADRFG 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063731687 106 RKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIG 177
Cdd:COG2814   272 RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPlLQALVAELAPPEARGRASGLYNSAFFLG 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-234 2.76e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.44  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  35 FWELFTVWIIVLCTALPISSLFPFlyFMIDDFNIAKKeeDIGFYAGFVGCSFMLGRAFtsvaWGLVADRYGRKPVILIGT 114
Cdd:COG2223   207 FWLLSLLYFGTFGSFIGFSSWLPP--YLVDQFGLSAA--TAGLLAALFALLGALGRPL----GGWLSDRIGGRRVLLIVF 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 115 ASVVVFNTLFGLSL-NFWMAIITRFCLGSFNGL-LGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPA 192
Cdd:COG2223   279 ALMALGLLLLALALgSLWLFLVLFLLLGLALGGgNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1063731687 193 KQYPslfsqdsifgkfPFFLPCLAISVFAFLVTIVSSRIPET 234
Cdd:COG2223   359 GSYT------------AAFLVFAVLALVALVLTLLLYRRPRR 388
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 85-190 3.52e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 61.03  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIK-AYAMEIFRDEYQ 163
Cdd:cd17321    39 AYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASlALIAATFPGERR 118

                          90       100
                  ....*....|....*....|....*..
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17321   119 GRALGLWGAVVGIGAALGPLLGGLLLE 145
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
38-230 5.88e-10

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 60.70  E-value: 5.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEdIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK09874   16 LTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSA-LNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAY-AMEIFRDEyQGLALSAVSTAWGIGLIIGPAIGGFLAQPakqyp 196
Cdd:PRK09874   95 GIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALiATQVPRNK-SGWALGTLSTGGVSGALLGPLAGGLLADS----- 168

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1063731687 197 slfsqdsiFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:PRK09874  169 --------YGLRPVFFITASVLFLCFLVTLFCIR 194
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 85-227 6.02e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 60.28  E-value: 6.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkAYAM--EIFRDEY 162
Cdd:cd17474    42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL-ALTLigDLFEGGE 120

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063731687 163 QGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYpslfsqdsifgkfPFFLPCLAIsVFAFLVTIV 227
Cdd:cd17474   121 RAKAMGLYEAALGLGIAVGPLLGGLLAAISWRY-------------PFFLLAALI-PVAFLAILF 171
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 77-200 6.69e-10

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 60.32  E-value: 6.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  77 FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAME 156
Cdd:cd17390    31 TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSD 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1063731687 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAK--QYPSLFS 200
Cdd:cd17390   111 LVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGgfYYVALLC 156
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 77-185 9.68e-10

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 59.52  E-value: 9.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  77 FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAM 155
Cdd:cd17317    25 WLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGvTSAGIFTVGFVLGM 104

                          90       100       110
                  ....*....|....*....|....*....|
gi 1063731687 156 EIFRDEYQGLALSAVSTAWGIGLIIGPAIG 185
Cdd:cd17317   105 EIVGPKYRSFVGILFGLFWALGYMLLALLA 134
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 38-378 1.39e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 59.16  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLY-FMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTAS 116
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLS------ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 117 VVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqy 195
Cdd:cd17329    75 RALGFALLGFAHSPWLFAIALVLTGFGGGLFEPaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 196 pslfsqdsifgkFPFFLPCLAISVFAFLVTIVSSRIPetlhnhkfnddesydalkdlsddPESNKVAERNGKSSLLNNWP 275
Cdd:cd17329   150 ------------YSFRLLFLAAAVLFLLAALVLLFLL-----------------------PETRPKRRAAEKTEILRGYK 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 276 LISSIIVYCVFSLHDMAYTEIFSLWANSPRKYGG--LGYSTADVGSVLAFSGFGLLIFQLSLYSYAERlLGPIIVTRISG 353
Cdd:cd17329   195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeiLGLGESLLGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGI 273

                         330       340
                  ....*....|....*....|....*
gi 1063731687 354 SLAMVVLSCYPLIAKLSGLALTVTV 378
Cdd:cd17329   274 LLFAIGFAVLAFANTLAVLILAMIV 298
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 38-224 1.48e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 59.13  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEEDIGFyagfvgCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGV------SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYP 196
Cdd:cd17323    75 VIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIaDLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ-SLGWR 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1063731687 197 SLFSQDSIFGKFPFFL------PCLAISVFAFLV 224
Cdd:cd17323   154 WIFWFLAIISGFCLILiflflpIVLLLGLYVGLV 187
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 79-188 1.56e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.15  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEI 157
Cdd:cd17316    38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGiGIGGEYPGASTYVAEF 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17316   118 APSKRRGFALGLLQSGWALGALLAALVASLL 148
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 65-188 1.59e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 59.29  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  65 DFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SF 143
Cdd:TIGR00895  46 EWGLDPVQ------LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGlGL 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063731687 144 NGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 86-240 1.92e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 58.74  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGsFNGLLGPIKAYAM--EIFRDEYQ 163
Cdd:cd17320    43 YLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQG-LGAAAGSVVARAIvrDLYSGAEL 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIFgkfpfflpcLAISVFAFLVTIVSS-RIPETLHNHKF 240
Cdd:cd17320   122 AKIFSLLMMILAIAPALAPLLGGLLLL-------FFGWRAIF---------VFLALLGLLLLLLVLlFLPETLPEEKR 183
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-230 2.46e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 58.34  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLY----FMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGR--KPVIL 111
Cdd:COG2271   179 LLRFWLLALAYFLVYFALYGFLTwlptYLVEVRGLSLAQ------AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 112 IGTASVVVFNTLFGLSLNFWMAIITRFCLGSF-NGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:COG2271   253 IGLLLAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD 332

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1063731687 191 pakqypslfsqdsIFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:COG2271   333 -------------ATGYQAAFLLLAALALLAALLALLLLR 359
PRK12307 PRK12307
MFS transporter;
38-330 3.44e-09

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 58.40  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:PRK12307   20 LFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDME------GAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGpaiggflAQPAKQYP 196
Cdd:PRK12307   94 SVGTGLSGLASGVIMLTLSRFIVGmGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIA-------AYFMPSFA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 197 SLFSQDSIFgkFPFFLPCLaisvfafLVTIVSSRIPETlhnhkfnDDESYDALKDLSDDPESNKVAERNGKSSLLNNWPL 276
Cdd:PRK12307  167 EAYGWRAAF--FVGLLPVL-------LVIYIRARAPES-------KEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQF 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063731687 277 ISSIIVYCV-FSLHDmAYTEIFSLWansPRKYGGLGYSTADVGSVLAFSGFGLLI 330
Cdd:PRK12307  231 PLTLCVFIVlFSIFG-ANWPIFGLL---PTYLAGEGFDTGVVSNLMTAAAFGTVL 281
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 43-361 4.13e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 58.03  E-value: 4.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  43 IIVLCTALPISSLFPFLYFMIDDFniAKKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNT 122
Cdd:cd17388     6 VTVLLDAMGIGLIMPVLPTLLREF--VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 123 LFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPslfsqd 202
Cdd:cd17388    84 LMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAP------ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 203 sifgkfpfFLPCLAISVFAFLVtiVSSRIPETLHNHKFNDdesydalkdlSDDPESNKVaernGKSSLLNNWPLISSIIV 282
Cdd:cd17388   158 --------FLVAAGLNGLNFLL--GLFVLPESLPPERRRA----------FRWRRANPF----GSLRWLTGFPGLLGLLA 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 283 ycVFSLHDMAYTEIFSLWAnsprKYGG--LGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLG---PIIVTRISGSLAM 357
Cdd:cd17388   214 --VFFLIQLIGQVPATTWV----LFTEdrFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGekrAILLGLAADALGF 287


                  ....
gi 1063731687 358 VVLS 361
Cdd:cd17388   288 LLLA 291
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 25-226 9.99e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 56.67  E-value: 9.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  25 QMKRLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADR 103
Cdd:cd06174   192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLpLFLLDLGGLSVAV------AGLLLSLFGLAGALGSLLLGLLSDR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 104 Y-GRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIG 181
Cdd:cd06174   266 LiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLsFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1063731687 182 PAIGGFLaqpakqypslfsQDSIFGKFPFFLPCLAISVFAFLVTI 226
Cdd:cd06174   346 PLLAGFL------------LAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 78-236 2.17e-08

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 55.74  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  78 YAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEI 157
Cdd:cd17389    65 FGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslfSQDSIFGKFPFFLPCLAISVFAFLVTI-VSSRIPETLH 236
Cdd:cd17389   145 TSPKKRSKGMALIGVAFSLGFIIGPMIGAYFA----------SFTRSLGEVFFSMPALFALVLALADLLfIFFFLPETLP 214
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 85-188 2.55e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 55.27  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDEYQ 163
Cdd:cd17503    39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLaQTILLRIYPPEKR 118

                          90       100
                  ....*....|....*....|....*
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17503   119 GAAMGLVGLVILLAPAIGPTLGGWL 143
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 76-398 5.38e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.54  E-value: 5.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  76 GFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPV-----ILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPI 150
Cdd:cd06173    33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 151 K-AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslfsqdSIFGkfpfFLPCLAISVFAFLVTIVS- 228
Cdd:cd06173   113 RqALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-------------ALLG----PGGAFAINALSFLLSALLl 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 229 SRIPETLHNHKfnddesydalkdlSDDPESNKVAERNGKSSLLNNWPLISSIIVYCVFSLHDMAYTEIFSLWANSPrkyg 308
Cdd:cd06173   176 LFIRRPPPAAP-------------GESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV---- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 309 gLGYSTADVGSVLAFSGFGLLIfqlslysyaerllGPIIVTRISGSLAMVVLScyPLIAKLSGLALTVTVTSASVAKSVL 388
Cdd:cd06173   239 -LGGGAAGYGLLLAAFGVGALL-------------GALLLGRLSKRRRRGRLL--LIGALLLGLALLVLGLSPSLWLLLA 302

                         330
                  ....*....|
gi 1063731687 389 GTsAITGLFI 398
Cdd:cd06173   303 AL-FLLGLAG 311
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
38-190 8.77e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkEEDIGFYAGFvgcsFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:COG2223     7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLS--AAQLGLLFAI----PVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063731687 118 VVFNTLFGLSLNFWMAIITRFCLGSFNGLL--GPIkAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSfaVGI-ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 59-190 2.47e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.24  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  59 LYFMiDDFNIA------KKEEDIG-FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFW 131
Cdd:cd17328    10 LNYM-DRFTIAgvlpdiQSDFLIDdSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063731687 132 MAIITRFCLG----SFNGLLGPIKAyamEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17328    89 QLLLFRALVGigeaSYSPIAPTIIA---DLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ 148
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 61-189 2.82e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 52.19  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  61 FMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCL 140
Cdd:cd17319    28 TIMKDLGLSPTQ------YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063731687 141 GSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17319   102 GVAEAGFFPGAIKALaEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL 151
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 86-190 2.99e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.16  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGL-LGPIKAYAMEIFRDEYQG 164
Cdd:cd17370   243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqESIERAAVADLVPAELRG 322

                          90       100
                  ....*....|....*....|....*.
gi 1063731687 165 LALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17370   323 TAYGLFNTVVGIGWLLASLIAGYLWD 348
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 79-239 3.63e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEI 157
Cdd:cd17489    33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTaAATLVADI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFsqdsifgkfpfflpcLAISVFAFLVTIVSSRIPETLHN 237
Cdd:cd17489   113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLF---------------IVAAVLALLALLLVFLVKDPPPV 176


                  ..
gi 1063731687 238 HK 239
Cdd:cd17489   177 AA 178
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 74-199 4.70e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  74 DIGFYAGFVGCSFMLGRAFTsvawGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKA 152
Cdd:cd17489   228 NAGLFFTVYAIALLLSRPFS----GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaLQA 303

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063731687 153 YAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLF 199
Cdd:cd17489   304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE-LFGYRAMF 349
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 75-179 8.52e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 50.76  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  75 IGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYA 154
Cdd:cd17371    32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111

                          90       100
                  ....*....|....*....|....*.
gi 1063731687 155 M-EIFRDEYQGLALSAVSTAWGIGLI 179
Cdd:cd17371   112 MaEYVPARHRGKALGYVQSGWAVGWL 137
MFS_1 pfam07690
Major Facilitator Superfamily;
38-182 1.00e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASV 117
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA------LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLL 275

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063731687 118 VVFN---TLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGP 182
Cdd:pfam07690 276 ILAAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPaLNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-190 1.01e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.62  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  61 FMIDDFNIAkkEEDIGFYAGFVGCSFMLGRAFTsvawGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCL 140
Cdd:COG0738   236 YLKDVLGLS--EATAALGLSLFWGGMTIGRFLG----GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV 309

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 141 GSFNGLLGP-IKAYAMEIFrDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:COG0738   310 GLGLSLMFPtIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-188 1.47e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  24 DQMKRLRRGFPFWELFtvwIIVLCTALPISSLFP-FLYFMIDDFNIAKKeedigfYAGFVGCSFMLGRAFTSVAWGLVAD 102
Cdd:COG2211   219 ESLKALLKNRPFLLLL---LAYLLFFLALALVAAlLLYYFKYVLGLSAA------LVGLLLALYFLAALLGAPLWPRLAK 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 103 RYGRKPVILIGTASVVVFNTLFGLSL--NFWMAIITRFCLGSFNGLLGPIkAYAMEIFRDEYQ---------GLALSAVS 171
Cdd:COG2211   290 RFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVL-PWAMLADVVDYDewktgrrreGLYFGIFT 368

                         170
                  ....*....|....*..
gi 1063731687 172 TAWGIGLIIGPAIGGFL 188
Cdd:COG2211   369 FAIKLGQALAGALAGLL 385
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
85-236 1.93e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 49.53  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFclgsFNGLLGP-----IKAYAMEIFR 159
Cdd:PRK11102   34 AYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF----LHGLAAAaasvvINALMRDMFP 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063731687 160 DEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypsLFSQDSIFgkfpfflpcLAISVFAFLVTI-VSSRIPETLH 236
Cdd:PRK11102  110 KEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-------WFSWHAIF---------WVLALAAILAAAlVFFFIPETLP 171
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 42-189 2.67e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.16  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  42 WIIVLCTALPISSLFPFLYFMIDDFNIAKKEedIGFYAGFVGcsfmLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFN 121
Cdd:cd17475     2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQ--VGLLLSALN----LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAA 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063731687 122 TLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYA-MEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17475    76 LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAiMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA 144
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 67-399 3.45e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 49.54  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687   67 NIAKK---EEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSL---NFWMAIITRFCL 140
Cdd:PRK08633    34 NTLIKaydGSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYylgWFWLAFAVTFLL 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  141 GSFNGLLGPIKA-YAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQpaKQYPslfSQDSIFGKFPFFLPCLAIsV 219
Cdd:PRK08633   114 GAQSAIYSPAKYgIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFE--SVNG---NTPSEILGRIAPAGLVLL-A 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  220 FAFLVTIVSSRIPETLHnhkfnddesydALKDLSDDPESNKVAE--RNGKsSLLNNWPLISSIIVYCVFSLHDMAYTEIF 297
Cdd:PRK08633   188 VAVLGLIFAYRLPKVPA-----------AAPEVFDKKKYLFPKLlwRNLK-LLRSDRVLWLAIIGLSYFWFISQLAQANF 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  298 SLWAnspRKYGGLGySTADVGSVLAFSGFGLLIfqlslysyaerllGPIIVTRISGS---LAMVVLSCYPLIAKLSGLAL 374
Cdd:PRK08633   256 PAYA---KEVLGLD-NTFQVQYLLAASAIGIGI-------------GSLLAGRLSGRhieLGLVPLGALGLALSLFLLPT 318

                          330       340
                   ....*....|....*....|....*
gi 1063731687  375 TVTVTSASVAKSVLGTSAitGLFIL 399
Cdd:PRK08633   319 APSLASVLVLFFLFGFSA--GLFIV 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 85-188 4.86e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 48.47  E-value: 4.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQ 163
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNtEFLPKKQR 214

                          90       100
                  ....*....|....*....|....*
gi 1063731687 164 GLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00898 215 AIVGTLIQVFFSLGLVLLPLVAYFI 239
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 79-190 5.96e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 47.94  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkAYAM--E 156
Cdd:cd17502    32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSL-AFIIiaD 110

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063731687 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17502   111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 38-187 6.82e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 47.94  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFPFL-YFMIDDFNIakkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTAS 116
Cdd:cd17478   197 LLLLLIIVFLRSWVLSSLTTFLpFYLVQRGYS-------LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLL 269

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063731687 117 VVVFNTLFgLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRdEYQGLAlSAVST--AWGIGLIIGPAIGGF 187
Cdd:cd17478   270 AAPFLLLF-LLTPGIWSYILLVLAGFLLFASFPvTVVLAQELLP-GNVGLA-SGLMMglSFGLGGIGAPVLGAL 340
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 79-189 7.43e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.58  E-value: 7.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFclgsFNGL-LGPIKAYAMEI 157
Cdd:cd17365    36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF----LTGLgLGAAMPNAITL 111

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063731687 158 FRdEY--QGLALSAVSTAWgIGLIIGPAIGGFLA 189
Cdd:cd17365   112 VS-EYapARRRSLAVTLMF-CGYPLGAALGGFLA 143
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 41-189 8.22e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.60  E-value: 8.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALP---ISSLFPFLYFMIDDFNIAKkeedIGFYAGFVGCSFMLGraftSVAWGLVADRYGRKPVILIGTASV 117
Cdd:cd17316   182 LILLWFFISFGyygLTTFLPTYLQTVLGLSPAT----SSLYLLLISLGALVG----ALIAGLLSDRIGRKKTLVIGLILS 253

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063731687 118 VVFNTLFGLSL--NFWMAIITRFCLGSFNGLL-GPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17316   254 GILALPLFYLLsgSPTLLLLLLFILSFFVGGVwGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 86-180 1.41e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 46.90  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17374    44 FMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGfAVSGISINTLILGTEWTTPRHRA 123

                          90
                  ....*....|....*.
gi 1063731687 165 LALSAVSTAWGIGLII 180
Cdd:cd17374   124 LAITLTSCFFSIGQML 139
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 78-178 2.18e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.37  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  78 YAGFVGCSFMlgrAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSL---NFWMAIITRFCLGSF--NGLLGPIKA 152
Cdd:cd17369   268 LAVLIASVVA---AITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLdtgSTWLIVLAAVVVLGVlhGMMYGPQAA 344

                          90       100
                  ....*....|....*....|....*....
gi 1063731687 153 YAMEIF--RDEYQGLALSA-VSTAWGIGL 178
Cdd:cd17369   345 FLAELFptRVRYTGASLGYqLGAILGGGF 373
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 87-361 3.17e-05

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 45.77  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  87 MLGRAFTSVAWGLVADRYGRKPVILI-----GTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRD 160
Cdd:TIGR00900  44 MLPYVVLSPIAGALADRYDRKKVMIGadlirAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTPaYQAMLPDLVPE 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 161 EYQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslfsqdSIFGKFPFFLPclAISVFAFLVTIVSSRIPE--TLHNH 238
Cdd:TIGR00900 124 EQLTQANSLSQAVRSLFYIVGPGIGGLMYA------------TLGIKWAIWVD--AVGFAISALLIVSVRIPElaASEIQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 239 KFnddeSYDALKDLsddpesnkvaeRNGKSSLLNNWPLISSIIVYCVFSLHDMAYteIFSLWANSPRKYggLGYSTADVG 318
Cdd:TIGR00900 190 AL----SNAVLRDT-----------REGIKFVLKNPLLRTLLLLALLFNLVFAPA--IVALFPYVQSKY--LGRGSTHYG 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1063731687 319 SVLAFSGFGLLIFQLsLYSYAERLLGPIIVTRIS---GSLAMVVLS 361
Cdd:TIGR00900 251 WVLAAFGLGALLGAL-LLGLLGRYFKRMALMTGAifvIGLAILVVG 295
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
27-190 3.24e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.63  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  27 KRLRRGFPFWELFTVWIIVLCTALPISSLFPFLYFMIDDFNIAkkeediGFYAGFVGCSFMLGRAFTSVAWGLVADRYGR 106
Cdd:COG2807     9 RRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLS------ATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-----IKAYAmeifrDEYQGLALSAVSTAWGIGLIIG 181
Cdd:COG2807    83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVllpglIKRWF-----PDRVGLMTGLYTAAMGLGAALA 157


                  ....*....
gi 1063731687 182 PAIGGFLAQ 190
Cdd:COG2807   158 AGLTVPLAA 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
58-230 3.73e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  58 FLYFMIDDFNIAkkeedigfyAGFVGCSFMLGR---AFTSVAWGLVADRYG-----RKPVILIGTASVVVFNTL------ 123
Cdd:COG2211    33 LLYFYTDVLGLS---------AALVGLILLVARlwdAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapd 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 124 FGLSLNFWMAIITRFCLGSFNGLLG-PIKAYAMEIFRDEYQGLALSAVSTAWG-IGLIIGPAIGGFLAqpakqypSLFSQ 201
Cdd:COG2211   104 LSPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEERTRLSSWRFAFAgLGGLLASVLPPPLV-------AAFGG 176

                         170       180
                  ....*....|....*....|....*....
gi 1063731687 202 DSIFGKFPFFLPCLAISVFAFLVTIVSSR 230
Cdd:COG2211   177 DAALGYRLTALIFAVLGLLAFLLTFFGTK 205
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 86-185 4.15e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 45.11  E-value: 4.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGS-FNGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17447    44 FFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFaLTGFSIISMVLCVEWVDIEHRT 123

                          90       100
                  ....*....|....*....|.
gi 1063731687 165 LALSAVSTAWGIGLIIGPAIG 185
Cdd:cd17447   124 VAGVLISLFWTVGNMLLALVA 144
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 86-226 4.26e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 45.28  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSfngllGPIKAYAM----EIFRDE 161
Cdd:cd17472    41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-----GAISSVVMallaDLTREE 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063731687 162 YQGLALSAVSTAWGIGLIIGPAIGGFLAQpakqypslfsqdsIFGKFPFFLPCLAISVFAFLVTI 226
Cdd:cd17472   116 NRTKAMALIGASIGIAFAISMVLGPLLAA-------------HLGVSGLFLITAILSLVSLLILL 167
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 43-190 4.61e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 45.26  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  43 IIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFML-GRAFTSVAwGLVADRYGRKPVILIGTASVVVFN 121
Cdd:cd17504     3 LAALAVMLVETMLSPALPTIQREFGTSAAA------VSWVLTAYLLvGAVSTPIL-GRLGDLYGRKKVLLIVLAIYTAGS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 122 TLFGLSLNFWMAIITRFCLGSFNGLLgPIkAYAM--EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17504    76 LLAAFAPNLPVLIAGRALQGIGGAVF-PL-AFALvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ 144
Sugar_tr pfam00083
Sugar (and other) transporter;
73-234 5.19e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 45.34  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  73 EDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLS---LNFWMAIITRFCLGSFNGLLGP 149
Cdd:pfam00083  42 AALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 150 I-KAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAqpakqypslFSQDSIFGKFPFFLpclaISVFAFLVTIVS 228
Cdd:pfam00083 122 LaPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLN---------KTSNSDGWRIPLGL----QLVPALLLIIGL 188


                  ....*.
gi 1063731687 229 SRIPET 234
Cdd:pfam00083 189 LFLPES 194
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 85-188 5.50e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 45.07  E-value: 5.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  85 SFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFcLGSFNGLLGPIKAYAMeiFRDEYQG 164
Cdd:TIGR00710  48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRF-VQAFGASAGSVISQAL--VRDIYPG 124

                          90       100
                  ....*....|....*....|....
gi 1063731687 165 LALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:TIGR00710 125 EELSRIYSILMPVLALAPAVAPLL 148
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 78-146 5.64e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.87  E-value: 5.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063731687  78 YAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGL 146
Cdd:cd17315    35 LQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGL 103
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 86-190 6.50e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIItrFCLGSFNGLLGPIKAYAMEIFRDEYQGL 165
Cdd:cd17477   232 FVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL--VLLFLWGGAAGPLYTLALALAGDRLPGD 309

                          90       100
                  ....*....|....*....|....*....
gi 1063731687 166 ALSAVSTA----WGIGLIIGPAIGGFLAQ 190
Cdd:cd17477   310 ELVAANAAllllYGLGSVIGPLLAGALMD 338
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 97-190 8.41e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.54  E-value: 8.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGI 176
Cdd:cd06179    52 VGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASP 131

                          90
                  ....*....|....
gi 1063731687 177 GLIIGPAIGGFLAQ 190
Cdd:cd06179   132 GSALGPLIAGALVE 145
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 79-199 9.22e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.11  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLN-FWMAIITRFCLGSF-NGLLGPIKAYAME 156
Cdd:cd17365   208 ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPAsLVLLYVLVFLAGACvNGAQVGLYALAAR 287

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1063731687 157 IFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPSLF 199
Cdd:cd17365   288 FYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVF 330
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 86-214 1.72e-04

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 43.20  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  86 FMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSF-NGLLGPIKAYAMEIFRDEYQG 164
Cdd:cd17375    44 FMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVsSGYLVVVFVYVTEFTGIKART 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063731687 165 LALSAVSTAWGIGLIIgPAIGGFLAQPAKQYPSLFSQDSIfgkfPFFLPC 214
Cdd:cd17375   124 WASMHVHAFFAVGIMV-VALVGYLVRTWWIYQIILSLVTI----PFILCC 168
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 28-190 1.72e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 43.40  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  28 RLRRGFPFWELFTVWIIVLCTALPISSLFPFL-YFMIDDFNIAKKEEDIGfYAGFVGCSFMlGRAFTsvawGLVADRYGR 106
Cdd:cd17393   191 KPGFLLPNRLLLLLGLLALAAALAEGAAADWSaLYLRDVLGASAALAALG-YAVFSLAMTV-GRLFG----DRLVDRFGD 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 107 KPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-----------SFNGLLGPIKAyameifrdeyqGLALSAVSTAWG 175
Cdd:cd17393   265 VAVLRAGALLAALGLLLALLAPSVWVALAGFALMGlglsvvvplafSAAGALPGLAA-----------GIAVARVATLGY 333

                         170
                  ....*....|....*
gi 1063731687 176 IGLIIGPAIGGFLAQ 190
Cdd:cd17393   334 LGFLVGPPLIGFLAD 348
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 96-223 1.77e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 43.30  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  96 AWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkayAMEIFRD---EYQGLALSAVST 172
Cdd:cd17471   254 LAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGL---GISYFQDlmpGQPGLATTLYSN 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687 173 AWGIGLIIGPAIGGFLAQpakqypslfsqdsIFGKFPFFLPCLAISVFAFL 223
Cdd:cd17471   331 ASRIGSLLGGLLAGVIAQ-------------YFGYRAVFLVCAVLALLALV 368
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 79-189 1.80e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.50  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPV----ILIGTASVVVFNTLFglslNFWMAIITRFCLGSF-NGLLGPIKAY 153
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRLGPRVTalllLLGAVFAVLVGSTLF----SPTLLLLLGAIAGFFvNGGQSGLYAL 362

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063731687 154 AMEIFRDEYQGlalSAVSTAWGIG---LIIGPAIGGFLA 189
Cdd:TIGR00895 363 MALFYPTAIRA---TGVGWAIGIGrlgAIIGPILAGYLL 398
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 91-226 1.86e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 43.42  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  91 AFTSVAWGLVADRYGRKPVILIG------TASVVVFNTLFGLSLNFWMAIITRF---CLGSFNGLLGPIKAYAMEIFRDE 161
Cdd:cd17386    44 LFSSLFLGSWSDRYGRKPPLLMSlvglllSSLILVLIVYFTTVPSVWWFYLSAIplaLFGGFTAFLSASFAYISDISSEK 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 162 YQGLALSAVSTAWGIGLIIGPAIGGFLAQpAKQYPSLFSQDSIFGKFP-----FFLPCLAISVFAFLVTI 226
Cdd:cd17386   124 KRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWSFSISAALLLIAllyilFFLTLLILLLLAAFLTI 192
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 43-190 2.25e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  43 IIVLCTALPISSLFPFL-YFMIDDFNIAKkeedigFYAGFVGCSFMLGRAFTSVAWGLVADR-YGRKPVILIGTASVVVF 120
Cdd:cd17471     3 LATLLTGLAGAFVLPYLsLFLTEELGASP------LQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALG 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIF---RDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17471    77 YLLFAFLRNYWVLLLVGVVLLSLGAAAFPqLFALAREYAdrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLD 150
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 88-196 2.91e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  88 LGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIkayAMEIFRDEYQGLA- 166
Cdd:cd17473    46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTL---ATALIGDYFEGEEr 122

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1063731687 167 ---LSAVSTAWGIGLIIGPAIGGFLAQPAKQYP 196
Cdd:cd17473   123 akmLGLQSAAMSLGGVVFLLLGGALAEIGWRAP 155
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 92-234 3.83e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 42.63  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  92 FTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNF-----WMAI--ITRFCL--GSFNGLLGPIKAYAM-EIFRDE 161
Cdd:cd17357   308 LSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLseqnsWMSYgcIVAIFLfiFFFAIGLGPIPWFIGaELFPQA 387

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063731687 162 YQGLALS-AVSTAWGIGLIIGPAiggflaqpakqYPSLFSQDSIFgkfpFFLPCLAISVFAFLVTIVssRIPET 234
Cdd:cd17357   388 PRSAAQSlGSSVNWTSNFIVGMA-----------FPPLQSIGGGF----VFIIFAIPCALFLLYLYR--YLPET 444
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 33-189 4.19e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.25  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  33 FPFWELFTVWIIVLCTALPISslfPFLYFMIDDfnIAKKEEDIGFYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILI 112
Cdd:cd17391   201 SLLISLFVTTFIIQLANQSIE---PILTLYIRQ--LMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLG 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063731687 113 GTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17391   276 ALLASALLYIPQAFVQTPWQLGILRFLLGlATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA 353
PRK10489 PRK10489
enterobactin transporter EntS;
98-188 1.22e-03

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 40.73  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  98 GLVADRYGRKPVILIGTASVVVFntLFGLSLNFWM---AIITRFCLGSFNGLLGPIKAYAME------IFRDEY-QGLAL 167
Cdd:PRK10489   73 GVLADRYDRKKLILLARGTCGLG--FIGLALNAFLpepSLLAIYLLGLWDGFFGSLGVTALLaatpalVGRENLmQAGAI 150

                          90       100
                  ....*....|....*....|.
gi 1063731687 168 SAVSTAwgIGLIIGPAIGGFL 188
Cdd:PRK10489  151 TMLTVR--LGSVISPALGGLL 169
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 60-234 1.73e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 40.44  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  60 YFMIDDFNIAKKE--EDIGFYA---GFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAI 134
Cdd:TIGR00881   8 YLVRKNFALAMPYlvEEIGLSKtdlGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 135 ITRFCLGSFNGLLGPIKAYAMEIFRDEYQ-GLALSAVSTAWGIGLIIGPAIGGFLAQpakqypSLFSQDSIFgkfpFFLP 213
Cdd:TIGR00881  88 ALWALNGIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFGIA------ELYSWHWVF----IVPG 157

                         170       180
                  ....*....|....*....|.
gi 1063731687 214 CLAIsVFAFLVTIVSSRIPET 234
Cdd:TIGR00881 158 IIAI-IVSLICFLLLRDSPQS 177
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 79-224 1.76e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  79 AGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEI 157
Cdd:cd17473   235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPtLNSWAMSL 314

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPSLFsqdSIFGKFpfflpCLAISVFAFLV 224
Cdd:cd17473   315 VPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF---LILGVL-----ALVLAIVLLLL 373
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 35-188 2.03e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 39.89  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  35 FWELFT---VWIIVLC---TALPISSLFPFLYFMIDDFNiakkeedigFYAGFVGCSFMLG---RAFTSVAWGLVADRYG 105
Cdd:cd17385   194 MLKLLKipsVLLLCLSivsGSVSLGFLDPTLSPHLRQFK---------LSPGQVGLMFLILagsYAISAPLWGWLSDKKK 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 106 -RKPVILIGTASVVVFNTLFG------LSLNFWMAIITRFCLG---------SFNGLLGPIKAYAMEifrDEY--QGLAL 167
Cdd:cd17385   265 iPKWLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLLGlslgaalvpTFPELLNCAREYGFP---DNLstYGLVS 341

                         170       180
                  ....*....|....*....|.
gi 1063731687 168 SAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17385   342 GLFNAAFSLGAFIGPTLGGFL 362
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 88-188 2.21e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 40.03  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  88 LGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFnGLLGPIKAYAM--EIFRDEYQGL 165
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLF-GKGGWMTGYVLvtEFVGSKYRRT 122

                          90       100
                  ....*....|....*....|...
gi 1063731687 166 ALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17379   123 VGIVYQMFFTLGLLILPGIAYFI 145
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 41-188 2.37e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.00  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  41 VWIIVLCTALPISSLFPFLYFMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVF 120
Cdd:cd17333     1 LYISFFSNGLTDALLGILGPSLEEAFNLNVAD------VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063731687 121 NTLFGLSLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFrDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17333    75 LALIFATPSIYLFVVLMFLAGLGAGILDTGaNTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSL 142
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 80-189 2.44e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  80 GFVGCSFMLGRAFTSVAWG-LVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEI 157
Cdd:cd17474   237 GLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPlLTTLVTEL 316

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1063731687 158 FRDEYQGLALSAVSTAWGIGLIIGPAIGGFLA 189
Cdd:cd17474   317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 98-190 2.44e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  98 GLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLG-PIKAYAMEIFRDEYQGLALSAVSTAWGI 176
Cdd:cd06173   265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNvPLNTLLQLRVPDELRGRVFSVYNALNSG 344

                          90
                  ....*....|....
gi 1063731687 177 GLIIGPAIGGFLAQ 190
Cdd:cd06173   345 AMPLGALLAGLLAD 358
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 95-145 2.51e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 39.76  E-value: 2.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063731687  95 VAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNG 145
Cdd:cd17377    57 VSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNG 107
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 76-333 2.62e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  76 GFYAGFVGCSFMLGRaftsvawglVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG-SFNGLLGPIKAYA 154
Cdd:cd17477    39 AYYLGILLGSPLVPR---------LIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGiGLAGLFVVSESWL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 155 MEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLaqpakqypslfsqdSIFGKFPFFLPCLAISVFAFLVTIVSSRIPET 234
Cdd:cd17477   110 NALATNENRGRVLGLYSTVLGLGFALGPLLLALV--------------GTAGALPFLIAAVLLLLALVPLLLTRRAAPEI 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 235 lhnhkfnddesydalkdlsddpesnkvaERNGKSSLLNNWPLISSIIVYC-VFSLHDMAYTEIFSLWANSprkyggLGYS 313
Cdd:cd17477   176 ----------------------------EEAESISLRRLLRIAPLALLGAfVAGFLEGAFYSLLPLYGLR------LGLS 221

                         250       260
                  ....*....|....*....|
gi 1063731687 314 TADVGSVLAFSGFGLLIFQL 333
Cdd:cd17477   222 VAQAALLLAAFVLGGLLLQW 241
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 98-396 2.68e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.51  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  98 GLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEyQGLALSAVSTAWGIG 177
Cdd:cd17331    56 GRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGE-RAAALGRLGLSYGIG 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 178 LIIGPAIGGFLAqpakqypslfsqdsifGKFPFFLPCLAISVFAFLVTIVSSRIPEtlhnhkfndDESYDALKDLSDDPE 257
Cdd:cd17331   135 MVVGSFLGGLLT----------------KKFGEQAAALVAAVGSLLSIVLVILLIP---------SNTKSKREKEAKESA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 258 SNKVAERNGKSSLLNNWPLISSIIVYCVFSLHDMA-YTEIFSLWANSPrkyggLGYSTADVGSVLAFSGFGLLIFQLSLY 336
Cdd:cd17331   190 SPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGmFQSMFSLVAMDF-----FGLTPEENGYLMSYAGVLGMVVQGLLV 264

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063731687 337 SYAERLLGPIIVTRISgSLAMVVlsCYPLIAKLS----GLALTVTVTSASVAKSVLGTSAITGL 396
Cdd:cd17331   265 GPLTKRFGERSLLKLS-VALLAI--GYLLLAFVTtvwqLLVLLLPLVIGGSVLYTVITSLLTKA 325
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 61-141 3.08e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 39.47  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  61 FMIDDFNIAKKEEdigfyaGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIgtASVVVFNTLFG--LSLNFWMAIITRF 138
Cdd:cd17359    26 FLQTDFNLTPFLE------GLVVSSALLGAAIGALFAGRLADRFGRRKTLLI--SAVLFFISALGsaFSPNFTIFIIARI 97


                  ...
gi 1063731687 139 CLG 141
Cdd:cd17359    98 IGG 100
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 84-234 3.51e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 39.48  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  84 CSFMLG--RAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWM--------AIITRFCL----GSFNGLLGP 149
Cdd:cd17358   279 ATIIIGvvQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYFYLQEhgallssvSWLPLVGLviyiISFSIGLGP 358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 150 IKAYAM-EIFRDEYQGLALS-AVSTAWGIGLIIgpaiggflaqpAKQYPSLFSQDSIFGKFPFFlpcLAISVFAFLVTIV 227
Cdd:cd17358   359 LPWVIMsEIFPAKIKGLAGSlVTLVNWLFAFIV-----------TKTFPFLTLAWGASGTFWIF---AGICGLALVFVLL 424


                  ....*..
gi 1063731687 228 SsrIPET 234
Cdd:cd17358   425 F--VPET 429
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 97-192 3.98e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.17  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGPikaYAMEIFRDEYQG-----LALSAVS 171
Cdd:cd17476    53 FGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLP---NAMALLGRTYPPgprknIVFSLFG 129

                          90       100
                  ....*....|....*....|.
gi 1063731687 172 TAWGIGLIIGPAIGGFLAQPA 192
Cdd:cd17476   130 ATAPLGFALGGVFGGLFAQLA 150
emrD PRK11652
multidrug transporter EmrD;
97-235 3.98e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.12  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  97 WGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGpikAYAMEIFRDEYQGLAL----SAVST 172
Cdd:PRK11652   63 YGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGG---VMARTLPRDLYEGTQLrhanSLLNM 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063731687 173 AWGIGLIIGPAIGGFLAqpakqypSLFSQDSIFgkfpFFLPCLAISVFAFLVTivssRIPETL 235
Cdd:PRK11652  140 GILVSPLLAPLIGGLLT-------TLFGWRACY----LFLLLLGAGVTFSMAR----WMPETR 187
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 53-224 4.18e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  53 SSLFPFLYFMIDDFNIAKKEedigfyagfVGCSFMLGRAFTSVA---WGLVADRYGRKPVILIGTASVVVFNTLFGLSLN 129
Cdd:cd17478    13 GFLPALLPLLIAKLGLSYAQ---------AGLLVSVFSITSSLLqplFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 130 FWMAIITRFCLGSFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFlaqpakqypsLFSQDSIFGKFP 209
Cdd:cd17478    84 YWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA----------LVALFGGLGLLI 153

                         170
                  ....*....|....*
gi 1063731687 210 FFLPCLAISVFAFLV 224
Cdd:cd17478   154 LLIIPGLAVALLLLR 168
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 75-190 4.92e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  75 IGFYAGFVGCsfmlgraftsVAWGLVADRYG---RKPVILIGTASVVVFNTLFGLSLNFWMAIITrFCLGSF--NGLLGP 149
Cdd:cd17319   223 IPFLAGAIGM----------ILGGRLSDRLLrgaRRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL-LSLAGFgiGAASPV 291

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063731687 150 IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17319   292 FWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD 332
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 48-149 5.00e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  48 TALPISSLFpflyfMIDDFNIAKKEedigfyAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTA--SVVVFNTLFG 125
Cdd:cd17380    16 VNMPIAIVP-----MAKEFGWSKTD------QGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVAlwSLATLLTPLL 84

                          90       100
                  ....*....|....*....|....
gi 1063731687 126 LSLNFWMAIITRFCLGSFNGLLGP 149
Cdd:cd17380    85 AYSSLPLLILSRILLGLGEGVHFP 108
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 52-232 6.19e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 38.33  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  52 ISSLFPFL--YFmiddfniakkeEDIGFYA---GFVGCSFMLGRAFTSVAWGLVADRYG-RKPVILIGTASVVVFNTLFG 125
Cdd:cd17335    13 LGSLLPFLsvYL-----------KQLGLSPtqiGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687 126 L-SLNFWMAIITRFCLGSFNGLLGPI-KAYAMEIFRDE---YQGLALsavstaWG-IGLIIGPAIGGFLAQPAKQYPSlf 199
Cdd:cd17335    82 FvAQIFWLLLLLVILGAFFSAPVVPLvDSITLQYLGEErerYGKQRL------WGsIGFGIAALLVGILIDRSSTYKN-- 153

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1063731687 200 sqdsifgkfpfFLPCLAI-SVFAFLVTIVSSRIP 232
Cdd:cd17335   154 -----------YTIAFYVfAVLMLLALLLALKFP 176
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 62-192 7.85e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 38.40  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  62 MIDDFNIAKKEEDIGFYAGFVGcsFMLGRAFTsvawGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLG 141
Cdd:PRK11551   41 MAQEFGLDVAQMGWAFSAGILG--LLPGALLG----GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTG 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063731687 142 -SFNGLLGPIKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPA 192
Cdd:PRK11551  115 vGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDA 166
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 58-190 9.45e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 38.02  E-value: 9.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  58 FLYFMIDDFNIAKKE--EDIGFYA---GFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWM 132
Cdd:cd17312    14 AYYVCRKNFSVAKPPivEEIGLSKddlGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063731687 133 AIITRFCLGSFNGLLGPIKAYAM-EIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17312    94 FAVLWGLNGLFQSMGWPPCVKLLgNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS 152
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 87-190 9.61e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 37.97  E-value: 9.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  87 MLGRAFtsvaWGLVADRYGRKPVILI--GTASVVVFNTLFGLSLNFW---MAIITRFCLGsfnGLLGPIKAYAMEIFRDE 161
Cdd:cd17353   263 GGGRPF----WGWLSDKIGRKNTLSIafLIQGVAMFLLPFIGSVAVLfvlGVALIGFCYG---GGFALFPALTADFFGTK 335

                          90       100
                  ....*....|....*....|....*....
gi 1063731687 162 YQGLALSAVSTAWGIGLIIGPAIGGFLAQ 190
Cdd:cd17353   336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLY 364
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 38-191 9.75e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 37.94  E-value: 9.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  38 LFTVWIIVLCTALPISSLFP-FLYFMIDDFNIAKKeeDIGFYAGFVGCSFMLGRAFtsvAWGLVADRYGRKPVILIGTAS 116
Cdd:cd17330   176 LRRLLLVYFLIALAFAGLESvFSLFLKDRFGFSPS--QIGLLLALVGIAGILAQLL---LIPRLAKRLGERKLLRLGLLL 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063731687 117 VVVFNTLFGLSLNFWMAIITRFCLGSFNGLLGP-IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQP 191
Cdd:cd17330   251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPaLSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF 326
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 77-188 9.79e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 9.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063731687  77 FYAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVV---FNTLFGLSLNFWMAIITRFCLGSFNGLL-GPIKA 152
Cdd:cd17321   204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVgllLLALLGADSSVWLLLPGLVLLGLGLGLFaTPLTN 283

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063731687 153 YAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFL 188
Cdd:cd17321   284 AALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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