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Conserved domains on  [gi|1061385304|ref|NP_001317808|]
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Ground-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

Ground-like domain-containing protein( domain architecture ID 10514438)

Ground-like domain-containing protein may bind and modulate the activity of Patched-like membrane molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 202-270 8.12e-21

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


:

Pssm-ID: 461200  Cd Length: 73  Bit Score: 83.44  E-value: 8.12e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385304 202 KCSSERLQQIMEEAM-SSNVSVSKLKISRGAKKEFGYNFDVICSQFDFSYLISSN-IFCRVELDGQICLAY 270
Cdd:pfam04155   3 KCNSEELKKIIEKNIgTCNLSESKRAIQKAAEARFGGSFEVICSEGDFSYSIFAGtLYCKVEKDGVTCLAY 73
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 48-135 2.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385304  48 PSPCGRQFQSFPSYTQPYSPVSFRPPPPTIiqqQPYYSVP-------HPIPIQ----TQQFHNSYQQTPVFTSSYNAPPF 116
Cdd:pfam03154 367 PNPQSHKHPPHLSGPSPFQMNSNLPPPPAL---KPLSSLSthhppsaHPPPLQlmpqSQQLPPPPAQPPVLTQSQSLPPP 443

                          90
                  ....*....|....*....
gi 1061385304 117 ASSSSysnAPNSFQNAPIQ 135
Cdd:pfam03154 444 AASHP---PTSGLHQVPSQ 459
 
Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 202-270 8.12e-21

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


Pssm-ID: 461200  Cd Length: 73  Bit Score: 83.44  E-value: 8.12e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385304 202 KCSSERLQQIMEEAM-SSNVSVSKLKISRGAKKEFGYNFDVICSQFDFSYLISSN-IFCRVELDGQICLAY 270
Cdd:pfam04155   3 KCNSEELKKIIEKNIgTCNLSESKRAIQKAAEARFGGSFEVICSEGDFSYSIFAGtLYCKVEKDGVTCLAY 73
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 48-135 2.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385304  48 PSPCGRQFQSFPSYTQPYSPVSFRPPPPTIiqqQPYYSVP-------HPIPIQ----TQQFHNSYQQTPVFTSSYNAPPF 116
Cdd:pfam03154 367 PNPQSHKHPPHLSGPSPFQMNSNLPPPPAL---KPLSSLSthhppsaHPPPLQlmpqSQQLPPPPAQPPVLTQSQSLPPP 443

                          90
                  ....*....|....*....
gi 1061385304 117 ASSSSysnAPNSFQNAPIQ 135
Cdd:pfam03154 444 AASHP---PTSGLHQVPSQ 459
 
Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 202-270 8.12e-21

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


Pssm-ID: 461200  Cd Length: 73  Bit Score: 83.44  E-value: 8.12e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1061385304 202 KCSSERLQQIMEEAM-SSNVSVSKLKISRGAKKEFGYNFDVICSQFDFSYLISSN-IFCRVELDGQICLAY 270
Cdd:pfam04155   3 KCNSEELKKIIEKNIgTCNLSESKRAIQKAAEARFGGSFEVICSEGDFSYSIFAGtLYCKVEKDGVTCLAY 73
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 48-135 2.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385304  48 PSPCGRQFQSFPSYTQPYSPVSFRPPPPTIiqqQPYYSVP-------HPIPIQ----TQQFHNSYQQTPVFTSSYNAPPF 116
Cdd:pfam03154 367 PNPQSHKHPPHLSGPSPFQMNSNLPPPPAL---KPLSSLSthhppsaHPPPLQlmpqSQQLPPPPAQPPVLTQSQSLPPP 443

                          90
                  ....*....|....*....
gi 1061385304 117 ASSSSysnAPNSFQNAPIQ 135
Cdd:pfam03154 444 AASHP---PTSGLHQVPSQ 459
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 29-144 3.96e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 38.48  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385304  29 RPQQCGCAAASLPVRSYCPPSPCGRQFQSFPSYTQPYSPVSFRPP-------PPTIIQ-QQPYYSVPHPIPIQTQQFHNS 100
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQqhpgqghPVTILQrPQSPQPDPAQPSIQPQAQQFH 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1061385304 101 YQQTPVFTSSY------NAPPFASSSSYSNAPNSFQNAPIQVASAKETSA 144
Cdd:pfam09770 290 QQPPPVPVQPTqilqnpNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSF 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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