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Conserved domains on  [gi|1060099273|ref|NP_001317328|]
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spindle and kinetochore-associated protein 2 isoform 3 [Homo sapiens]

Protein Classification

SKA2 domain-containing protein( domain architecture ID 10191736)

SKA2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SKA2 cd12955
Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the ...
 5-100 4.05e-45

Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, annd SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA2 has also been identified as a glucocorticoid receptor-interacting protein and may be involved in regulating cancer cell proliferation.


:

Pssm-ID: 214020  Cd Length: 116  Bit Score: 141.82  E-value: 4.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099273   5 VDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKK 84
Cdd:cd12955     1 VDKLEAMFQKAESDLDYIQRRLESEFKENSPESAGEKNPVELLERLSAIKSRYSTLCAQAEEIKKAQKESVSSIRAQLHK 80

                          90
                  ....*....|....*.
gi 1060099273  85 TMNMIQKLQKQTDLEV 100
Cdd:cd12955    81 AMQLLQELQQTTDTEL 96
 
Name Accession Description Interval E-value
SKA2 cd12955
Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the ...
 5-100 4.05e-45

Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, annd SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA2 has also been identified as a glucocorticoid receptor-interacting protein and may be involved in regulating cancer cell proliferation.


Pssm-ID: 214020  Cd Length: 116  Bit Score: 141.82  E-value: 4.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099273   5 VDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKK 84
Cdd:cd12955     1 VDKLEAMFQKAESDLDYIQRRLESEFKENSPESAGEKNPVELLERLSAIKSRYSTLCAQAEEIKKAQKESVSSIRAQLHK 80

                          90
                  ....*....|....*.
gi 1060099273  85 TMNMIQKLQKQTDLEV 100
Cdd:cd12955    81 AMQLLQELQQTTDTEL 96
SKA2 pfam16740
Spindle and kinetochore-associated protein 2; Spindle and kinetochore-associated protein 2 ...
 2-101 1.11e-36

Spindle and kinetochore-associated protein 2; Spindle and kinetochore-associated protein 2 (SKA2) interacts with the N-termini of SKA1 and SKA3 and forms the Ska complex. This is a microtubule binding complex required for chromosome segregation.


Pssm-ID: 465252  Cd Length: 110  Bit Score: 120.03  E-value: 1.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099273   2 EAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSAseKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICAT 81
Cdd:pfam16740   1 EQAVDGLEAMFQKAESDLDYVQHRLDYEFQQSYPDNA--ENPVKLLERLKKVKSEYQALKEQCQELLAEKQELVDSIRTQ 78

                          90       100
                  ....*....|....*....|
gi 1060099273  82 VKKTMNMIQKLQKQTDLEVM 101
Cdd:pfam16740  79 LVANRNLLQRLQASAGLPPL 98
 
Name Accession Description Interval E-value
SKA2 cd12955
Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the ...
 5-100 4.05e-45

Spindle and kinetochore-associated protein 2; SKA2, also called FAM33A, is a component of the SKA complex, which is formed by the association of three subunits (SKA1, SKA2, annd SKA3). The SKA complex is essential for accurate cell division. It functions with the Ndc80 network to establish stable kinetochore-microtubule interactions, which are crucial for the highly orchestrated chromosome movements during mitosis. The biological unit is a W-shaped homodimer of the three-subunit complex. SKA2 has also been identified as a glucocorticoid receptor-interacting protein and may be involved in regulating cancer cell proliferation.


Pssm-ID: 214020  Cd Length: 116  Bit Score: 141.82  E-value: 4.05e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099273   5 VDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSASEKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICATVKK 84
Cdd:cd12955     1 VDKLEAMFQKAESDLDYIQRRLESEFKENSPESAGEKNPVELLERLSAIKSRYSTLCAQAEEIKKAQKESVSSIRAQLHK 80

                          90
                  ....*....|....*.
gi 1060099273  85 TMNMIQKLQKQTDLEV 100
Cdd:cd12955    81 AMQLLQELQQTTDTEL 96
SKA2 pfam16740
Spindle and kinetochore-associated protein 2; Spindle and kinetochore-associated protein 2 ...
 2-101 1.11e-36

Spindle and kinetochore-associated protein 2; Spindle and kinetochore-associated protein 2 (SKA2) interacts with the N-termini of SKA1 and SKA3 and forms the Ska complex. This is a microtubule binding complex required for chromosome segregation.


Pssm-ID: 465252  Cd Length: 110  Bit Score: 120.03  E-value: 1.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099273   2 EAEVDKLELMFQKAESDLDYIQYRLEYEIKTNHPDSAseKNPVTLLKELSVIKSRYQTLYARFKPVAVEQKESKSRICAT 81
Cdd:pfam16740   1 EQAVDGLEAMFQKAESDLDYVQHRLDYEFQQSYPDNA--ENPVKLLERLKKVKSEYQALKEQCQELLAEKQELVDSIRTQ 78

                          90       100
                  ....*....|....*....|
gi 1060099273  82 VKKTMNMIQKLQKQTDLEVM 101
Cdd:pfam16740  79 LVANRNLLQRLQASAGLPPL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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