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Conserved domains on  [gi|1022943271|ref|NP_001311054|]
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cytoplasmic FMR1-interacting protein 1 isoform f [Homo sapiens]

Protein Classification

FragX_IP domain-containing protein( domain architecture ID 10532330)

FragX_IP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 267-1100 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


:

Pssm-ID: 461799  Cd Length: 842  Bit Score: 1438.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  267 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 346
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  347 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 426
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  427 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 504
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  505 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 584
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  585 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 663
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  664 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 741
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  742 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 821
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  822 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 901
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  902 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 974
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  975 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1054
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 1022943271 1055 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1100
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 267-1100 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1438.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  267 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 346
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  347 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 426
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  427 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 504
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  505 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 584
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  585 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 663
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  664 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 741
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  742 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 821
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  822 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 901
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  902 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 974
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  975 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1054
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 1022943271 1055 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1100
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 6-1118 3.40e-177

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 553.41  E-value: 3.40e-177
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271    6 FQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQE 84
Cdd:PLN03099   123 WQSSAASKLAADMQRFSRPERRINGPTVTHMWSMLKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMRE 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271   85 S-QNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLd 163
Cdd:PLN03099   203 ElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQVLIVFCLESLESDFVLLYSERHILLRVLPVLVVLATSSEKEGESL- 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  164 aKKRINLSKIDKYFKQlqvvplfgdmqielaryiktsahyeenksrwtctssgsspQYNICEQMIQIREDH----MRFIS 239
Cdd:PLN03099   282 -FKRIKINRLINIFQR----------------------------------------EYLIVNHMGAIRAEHddfcIRFAS 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  240 ELARYSNSEVVTGSGRQEAQKTDAEyrkLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT-DKYSNKDCPDSAEEYERATR 318
Cdd:PLN03099   321 AMNQLQLLKSADGVDTAWSREIKEN---MYDVVVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVR 397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  319 YNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNvIQSVLQAIRKTVCD 398
Cdd:PLN03099   398 CNYTAEERKALVELIGYIKGVGSMLERCDTLVADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAAD 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  399 WETGHEPFNDPALRG-EKDPKSGFDIKVprRAVGPSSTQLYMVRTMLESLIADKSGSKKTL---RSSLEGPT--ILDIEK 472
Cdd:PLN03099   477 WMANTRPEEKMPSRQrENDESRPNFFYP--RPVAPTAAQLHCLQFLIHELVSGGSPKKPGGffgNNGSEIPVndLKQLET 554

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  473 FHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDS 552
Cdd:PLN03099   555 FFNKLAFFPHILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDS 632

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  553 AHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNqGATIHLPPSnRYETLLKQRH 632
Cdd:PLN03099   633 AQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDN-GEKFSVQPK-RYDALFKMRR 710

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  633 VQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS- 711
Cdd:PLN03099   711 VKILGRTIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISl 790

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  712 -APYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPP 790
Cdd:PLN03099   791 vSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLP 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  791 HFQVICRLLGYQGIAVVMEELLKVVKSLLQGtILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYaELKTV 870
Cdd:PLN03099   871 HMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSE 948

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  871 CFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRvhvKEGE--RLDAKMKRLES--KYAPLHLVPLIERLGT 946
Cdd:PLN03099   949 VLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQlqQADDNESPLVSlfKEATSAVVSSPGCLNP 1025

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  947 PQQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSFLDDPiwrgplPSNGVMHVDECVEFHRLWSAMQFVYC 1017
Cdd:PLN03099  1026 SAFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSKWSAP------PKTGFIDITTSKDFYRIYSGLQYVYL 1099

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271 1018 IPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQK-------HDGKDEIIKN----VPLKKMVERI 1086
Cdd:PLN03099  1100 EEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSEvesasasHTHRNERLKSpsyhQGWEGFLENA 1179

                         1130      1140      1150
                   ....*....|....*....|....*....|....*....
gi 1022943271 1087 RKFQILNDEIITIL-------DKYLKSGDGEGTPVEHVR 1118
Cdd:PLN03099  1180 RKARRLNNHVFSLLrarcpleDKLASMIKQSGAPVHRVK 1218
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 267-1100 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1438.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  267 KLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRM 346
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  347 ESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKsGFDIKVP 426
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPK-GFDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  427 RRAVGPSSTQLYMVRTMLESLIADKSG--SKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREF 504
Cdd:pfam05994  160 RRAVGPSSTQLYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFFFPYLLNLSETLQECCDLSQLWFREF 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  505 FLEltMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKL 584
Cdd:pfam05994  240 YLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTKLKSQFLYDEIEAEVNLCFDQFVYKL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  585 ADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHL-PPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIG 663
Cdd:pfam05994  318 SEQIFTYYKTLAASILLDKRFRAELKNAGILIPPyPPANRYETLLQQRHVQLLGRSIDLNRLIAQRLNAAFRKSLDIAIG 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  664 RFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS--APYGRITLHVFWELNYDFLPNYCYNGSTNR 741
Cdd:pfam05994  398 RFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGRITLHVFSELNYDFLPNYCYNSTTQR 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  742 FVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQG 821
Cdd:pfam05994  478 FVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIVRLLGYGGIAVLIEELLKIVSNKIQG 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  822 TILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLL 901
Cdd:pfam05994  558 FLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFRELGNIILFCLLLDQALSQEEVTDLL 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  902 HAAPFQNILPRVHvKEGERLDAK------MKRLESKYAPLH-LVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVI 974
Cdd:pfam05994  638 QAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQSAIAEEADLLTKERLCCGLSLFEVV 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  975 LTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAV 1054
Cdd:pfam05994  717 LARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEELFGDGLMWAGCAIIALLGQQRRFEA 796

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 1022943271 1055 LDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITIL 1100
Cdd:pfam05994  797 LDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 6-1118 3.40e-177

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 553.41  E-value: 3.40e-177
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271    6 FQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQE 84
Cdd:PLN03099   123 WQSSAASKLAADMQRFSRPERRINGPTVTHMWSMLKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMRE 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271   85 S-QNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLd 163
Cdd:PLN03099   203 ElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQVLIVFCLESLESDFVLLYSERHILLRVLPVLVVLATSSEKEGESL- 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  164 aKKRINLSKIDKYFKQlqvvplfgdmqielaryiktsahyeenksrwtctssgsspQYNICEQMIQIREDH----MRFIS 239
Cdd:PLN03099   282 -FKRIKINRLINIFQR----------------------------------------EYLIVNHMGAIRAEHddfcIRFAS 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  240 ELARYSNSEVVTGSGRQEAQKTDAEyrkLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT-DKYSNKDCPDSAEEYERATR 318
Cdd:PLN03099   321 AMNQLQLLKSADGVDTAWSREIKEN---MYDVVVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVR 397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  319 YNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNvIQSVLQAIRKTVCD 398
Cdd:PLN03099   398 CNYTAEERKALVELIGYIKGVGSMLERCDTLVADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAAD 476

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  399 WETGHEPFNDPALRG-EKDPKSGFDIKVprRAVGPSSTQLYMVRTMLESLIADKSGSKKTL---RSSLEGPT--ILDIEK 472
Cdd:PLN03099   477 WMANTRPEEKMPSRQrENDESRPNFFYP--RPVAPTAAQLHCLQFLIHELVSGGSPKKPGGffgNNGSEIPVndLKQLET 554

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  473 FHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDS 552
Cdd:PLN03099   555 FFNKLAFFPHILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDS 632

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  553 AHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNqGATIHLPPSnRYETLLKQRH 632
Cdd:PLN03099   633 AQHALRVLKQRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDN-GEKFSVQPK-RYDALFKMRR 710

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  633 VQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVS- 711
Cdd:PLN03099   711 VKILGRTIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISl 790

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  712 -APYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPP 790
Cdd:PLN03099   791 vSFSSRLASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLP 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  791 HFQVICRLLGYQGIAVVMEELLKVVKSLLQGtILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYaELKTV 870
Cdd:PLN03099   871 HMFAIVKLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSE 948

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  871 CFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRvhvKEGE--RLDAKMKRLES--KYAPLHLVPLIERLGT 946
Cdd:PLN03099   949 VLRGLKEIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQlqQADDNESPLVSlfKEATSAVVSSPGCLNP 1025

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271  947 PQQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSFLDDPiwrgplPSNGVMHVDECVEFHRLWSAMQFVYC 1017
Cdd:PLN03099  1026 SAFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSKWSAP------PKTGFIDITTSKDFYRIYSGLQYVYL 1099

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943271 1018 IPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQK-------HDGKDEIIKN----VPLKKMVERI 1086
Cdd:PLN03099  1100 EEISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSEvesasasHTHRNERLKSpsyhQGWEGFLENA 1179

                         1130      1140      1150
                   ....*....|....*....|....*....|....*....
gi 1022943271 1087 RKFQILNDEIITIL-------DKYLKSGDGEGTPVEHVR 1118
Cdd:PLN03099  1180 RKARRLNNHVFSLLrarcpleDKLASMIKQSGAPVHRVK 1218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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