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Conserved domains on  [gi|1019033668|ref|NP_001309956|]
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dynein regulatory complex protein 9 isoform a [Homo sapiens]

Protein Classification

IQ calmodulin-binding motif-containing protein( domain architecture ID 10635649)

IQ calmodulin-binding motif-containing protein may be involved in cooperative interactions with calmodulins or calmodulin-like proteins

Gene Ontology:  GO:0005516
PubMed:  9141499

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 384-422 3.29e-10

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


:

Pssm-ID: 467744  Cd Length: 40  Bit Score: 54.86  E-value: 3.29e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1019033668 384 KKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDK 422
Cdd:cd23766     1 RREKEQEELELRAAIKIQAWWRGIMVRKGLGPFKKKKKK 39
SCP-1 super family cl30946
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 199-395 1.29e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


The actual alignment was detected with superfamily member pfam05483:

Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 199 LSKERENKMHFYDIIAREEKgrkQIISLQKQLINVKKEwqfeVQSQNEYIANLKDQLQEMKAKSNLENRYMKT------N 272
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEK---QMKILENKCNNLKKQ----IENKNKNIEELHQENKALKKKGSAENKQLNAyeikvnK 640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 273 TELQIAQTQKKCNR--------------TEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDT 338
Cdd:pfam05483 641 LELELASAKQKFEEiidnyqkeiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII 720

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1019033668 339 EMKQNELNALK-------ATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELK 395
Cdd:pfam05483 721 EERDSELGLYKnkeqeqsSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILK 784
 
Name Accession Description Interval E-value
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 384-422 3.29e-10

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 54.86  E-value: 3.29e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1019033668 384 KKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDK 422
Cdd:cd23766     1 RREKEQEELELRAAIKIQAWWRGIMVRKGLGPFKKKKKK 39
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 199-395 1.29e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 199 LSKERENKMHFYDIIAREEKgrkQIISLQKQLINVKKEwqfeVQSQNEYIANLKDQLQEMKAKSNLENRYMKT------N 272
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEK---QMKILENKCNNLKKQ----IENKNKNIEELHQENKALKKKGSAENKQLNAyeikvnK 640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 273 TELQIAQTQKKCNR--------------TEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDT 338
Cdd:pfam05483 641 LELELASAKQKFEEiidnyqkeiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII 720

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1019033668 339 EMKQNELNALK-------ATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELK 395
Cdd:pfam05483 721 EERDSELGLYKnkeqeqsSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILK 784
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 393-412 8.23e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 33.84  E-value: 8.23e-03
                           10        20
                   ....*....|....*....|
gi 1019033668  393 ELKSVIKLQAWWRGTMIRRE 412
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKR 21
 
Name Accession Description Interval E-value
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 384-422 3.29e-10

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 54.86  E-value: 3.29e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1019033668 384 KKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDK 422
Cdd:cd23766     1 RREKEQEELELRAAIKIQAWWRGIMVRKGLGPFKKKKKK 39
IQCG-IQCD cd21098
IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to ...
 389-411 6.64e-06

IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to the IQ motif-containing protein family which contain a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQCG protein (also known as DRC9 and CFAP122) is essential for sperm flagellum formation in mice. The IQCD protein (also known as DRC10) is involved in sperm fertilization and the acrosome reaction. Both proteins are components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility. IQCG and IQCD proteins contain a central coiled-coil domain and a C-terminal IQ (isoleucine-glutamine) motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, that interacts with calmodulin (CaM) in a calcium-independent manner. IQ motif-containing proteins that are known to bind calmodulin (CaM) have a wide diversity of biological functions, and they include neuronal growth proteins, myosins, voltage-operated channels, phosphatases, Ras exchange proteins, sperm surface proteins, Ras Gap-like proteins, spindle-associated proteins, and several proteins in plants.


Pssm-ID: 467743  Cd Length: 25  Bit Score: 42.36  E-value: 6.64e-06
                          10        20
                  ....*....|....*....|...
gi 1019033668 389 QDLLELKSVIKLQAWWRGTMIRR 411
Cdd:cd21098     3 EDERELWAATKIQALWRGYMVRR 25
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 199-395 1.29e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 199 LSKERENKMHFYDIIAREEKgrkQIISLQKQLINVKKEwqfeVQSQNEYIANLKDQLQEMKAKSNLENRYMKT------N 272
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEK---QMKILENKCNNLKKQ----IENKNKNIEELHQENKALKKKGSAENKQLNAyeikvnK 640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1019033668 273 TELQIAQTQKKCNR--------------TEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDT 338
Cdd:pfam05483 641 LELELASAKQKFEEiidnyqkeiedkkiSEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII 720

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1019033668 339 EMKQNELNALK-------ATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELK 395
Cdd:pfam05483 721 EERDSELGLYKnkeqeqsSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILK 784
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 393-412 8.23e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 33.84  E-value: 8.23e-03
                           10        20
                   ....*....|....*....|
gi 1019033668  393 ELKSVIKLQAWWRGTMIRRE 412
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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