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Conserved domains on  [gi|1012443738|ref|NP_001308699|]
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sulfotransferase 1C4 isoform 2 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-219 1.86e-62

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 195.25  E-value: 1.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM-----------------KIPSL-------- 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdtyfdvaegpvrlnALPSPriikthlp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  97 ------------------------------------------------------GSVCWGSWHEHVKGWWEAKDKHRILY 122
Cdd:pfam00685  81 lhllpkslwdpnakiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflnGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 123 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 202
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1012443738 203 AQNERFDEDYKKKMTDT 219
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-219 1.86e-62

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 195.25  E-value: 1.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM-----------------KIPSL-------- 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdtyfdvaegpvrlnALPSPriikthlp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  97 ------------------------------------------------------GSVCWGSWHEHVKGWWEAKDKHRILY 122
Cdd:pfam00685  81 lhllpkslwdpnakiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflnGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 123 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 202
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1012443738 203 AQNERFDEDYKKKMTDT 219
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 41-224 1.92e-15

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 73.80  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  41 FQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKS-----KRAPtHQRFPFLEMKIPSLGSV---------------- 99
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnpllKRNP-HEFVPYIEIDFPFFPSVdvlkdkgntlfsthip 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 100 ----------------------------------------------------------CWGSWHEHVKGWWEA--KDKHR 119
Cdd:PLN02164  154 ygllpdsvvksgckmvyiwrdpkdtfismwtflhkersqqgplnsleesfdmfcrglsVYGPYLDHVLGYWKAyqENPDR 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 120 ILYLFYEDMKKNPKHEIQKLAEFIGKKLDDK-----VLDKIVHYTSFDVMKqNPMANYSSIPAEIMD--HSISPFMRKGA 192
Cdd:PLN02164  234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYFRKGK 312

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1012443738 193 VGDWKKHFTVAQNERFDEDYKKKMTDTRLTFH 224
Cdd:PLN02164  313 VGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-219 1.86e-62

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 195.25  E-value: 1.86e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM-----------------KIPSL-------- 96
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdtyfdvaegpvrlnALPSPriikthlp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  97 ------------------------------------------------------GSVCWGSWHEHVKGWWEAKDKHRILY 122
Cdd:pfam00685  81 lhllpkslwdpnakiiylvrnpkdvavsyyhffrmakllkapgtpfefvedflnGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 123 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 202
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 1012443738 203 AQNERFDEDYKKKMTDT 219
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 41-224 1.92e-15

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 73.80  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738  41 FQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKS-----KRAPtHQRFPFLEMKIPSLGSV---------------- 99
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnpllKRNP-HEFVPYIEIDFPFFPSVdvlkdkgntlfsthip 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 100 ----------------------------------------------------------CWGSWHEHVKGWWEA--KDKHR 119
Cdd:PLN02164  154 ygllpdsvvksgckmvyiwrdpkdtfismwtflhkersqqgplnsleesfdmfcrglsVYGPYLDHVLGYWKAyqENPDR 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443738 120 ILYLFYEDMKKNPKHEIQKLAEFIGKKLDDK-----VLDKIVHYTSFDVMKqNPMANYSSIPAEIMD--HSISPFMRKGA 192
Cdd:PLN02164  234 ILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYFRKGK 312

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1012443738 193 VGDWKKHFTVAQNERFDEDYKKKMTDTRLTFH 224
Cdd:PLN02164  313 VGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
Sulfotransfer_3 pfam13469
Sulfotransferase family;
104-149 2.00e-03

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 37.66  E-value: 2.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1012443738 104 WHEHVKGWWEAKDKH---RILYLFYEDMKKNPKHEIQKLAEFIGKKLDD 149
Cdd:pfam13469 125 WSRAYERLMAARARVppgRFLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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