|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
90-604 |
8.26e-84 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 267.41 E-value: 8.26e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 90 VGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEDEQLVAG 169
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 170 nsnteeaepisldvknsqpslelifvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltpspr 249
Cdd:COG0471 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 250 kqklnrkyrshhdqmickcLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVVSW 329
Cdd:COG0471 81 -------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLLLW 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 330 FWMHWLFlgcnfketcslskKKKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPgwdsffekk 409
Cdd:COG0471 140 LVLYRLL-------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP--------- 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 410 gyrtDATVSVFLGFLLFLIPakkpcfgkkndgenqehslgtepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTW 489
Cdd:COG0471 198 ----IAVVALLGAVLLLLTG-----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAW 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 490 IGNQMLS-LSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPN 568
Cdd:COG0471 251 LADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPN 330
|
490 500 510
....*....|....*....|....*....|....*.
gi 970598236 569 AIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTW 604
Cdd:COG0471 331 AIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
38-605 |
2.87e-60 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 205.90 E-value: 2.87e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 38 AYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAG 117
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 118 AKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLqelvsaedeqlvagnsnteeaepisldvknsqpslelifvne 197
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLA------------------------------------------ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 198 drsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltpspRKQKLNrkyrshhdqmiCKCLSLSISYSA 277
Cdd:cd01115 119 ---------------------------------------------------AKLDIS-----------PSRLLMPLAFAA 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 278 TIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskkkktkreq 357
Cdd:cd01115 137 SIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV--------------------- 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 358 lsekriqeeyeklgdisypemvtgFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIpakkpcFGK 437
Cdd:cd01115 194 ------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVF------GGV 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 438 kndgenqehslgtepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLS-LSSLPPWAVTLLACILVSIV 516
Cdd:cd01115 230 ----------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVL 293
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 517 TEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVI 596
Cdd:cd01115 294 TNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVV 373
|
....*....
gi 970598236 597 VMVAINTWG 605
Cdd:cd01115 374 SVTMIPLIW 382
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
32-609 |
5.25e-60 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 207.61 E-value: 5.25e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 32 SSEASCAYVLIVTAVYWVSEAVPLGAAALVP----AFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKR 107
Cdd:pfam00939 28 SKAWHLFAIFIATIVGWILEPLPMAVIALFAislsAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 108 IALRMVLMAGAKPgmLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAedeqlvagnsnteeaepisldvknsq 187
Cdd:pfam00939 108 IALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA-------------------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 188 pslelifvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvLTPSPRKQKLNRkyrshhdqmICK 267
Cdd:pfam00939 160 --------------------------------------------------------FGSDPEKGSERR---------IGA 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 268 CLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGcnfketcsl 347
Cdd:pfam00939 175 YLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPP--------- 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 348 skkkKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPgfvPGWDsffekkgyrtDATVSVFLGFLLFL 427
Cdd:pfam00939 244 ----EIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGS---LNID----------ATTVAIIGLALMLL 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 428 IPakkpcfgkkndgenqehslgtepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVT 506
Cdd:pfam00939 307 LR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMA 363
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 507 LLACILVSIVT--EFVSNPATITIFLPILCSLSETLH-INPLYTLIPVTMCISFA-VMLPVGNPPNAIVFSYGHCQIKDM 582
Cdd:pfam00939 364 FIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDW 443
|
570 580
....*....|....*....|....*..
gi 970598236 583 VKAGLGVNVIGLVIVMVAINTWGVSLF 609
Cdd:pfam00939 444 WRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
40-604 |
4.53e-46 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 169.06 E-value: 4.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 40 VLIVTAVYWVSEAVPLGAAALVP-AFLYPFFGVLRSNEVAAE--YFKNTTLLLV-GVICVAAAVEKWNLHKRIALRMV-L 114
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNAlsGFADPTIWLFfGAFILATALVKTGLGKRIAYKLVgK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 115 MAGAKPGMLLLCFMCCTTLLSMWLSNTS-TTAMVMPIVEAVLQELVSAEDeqlvagnsnteeaepisldvknsqpsleli 193
Cdd:TIGR00785 96 MGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPE------------------------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 194 fvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltPSPRKqklnrkyrshhdqmICKCLSLSI 273
Cdd:TIGR00785 146 ----------------------------------------------------KSPRK--------------IGKYLMLGI 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 274 SYSATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKKKT 353
Cdd:TIGR00785 160 AYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELK 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 354 KREQLSeKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLipakkp 433
Cdd:TIGR00785 226 LKDEVD-LWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF------ 285
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 434 cFGkkndgenqehslgtepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACIL 512
Cdd:TIGR00785 286 -LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVV 348
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 513 VSIV--TEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGV 589
Cdd:TIGR00785 349 LFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAII 428
|
570
....*....|....*
gi 970598236 590 NVIGLVIVMVAINTW 604
Cdd:TIGR00785 429 GIVGLIVLLLVGTLW 443
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
90-604 |
8.26e-84 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 267.41 E-value: 8.26e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 90 VGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAEDEQLVAG 169
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 170 nsnteeaepisldvknsqpslelifvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltpspr 249
Cdd:COG0471 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 250 kqklnrkyrshhdqmickcLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYpaAEVVNFGTWFLFSFPISLIMLVVSW 329
Cdd:COG0471 81 -------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT--GIPISFFEWMLVGLPVALVGLLLLW 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 330 FWMHWLFlgcnfketcslskKKKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPgwdsffekk 409
Cdd:COG0471 140 LVLYRLL-------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIP--------- 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 410 gyrtDATVSVFLGFLLFLIPakkpcfgkkndgenqehslgtepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTW 489
Cdd:COG0471 198 ----IAVVALLGAVLLLLTG-----------------------VLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAW 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 490 IGNQMLS-LSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPN 568
Cdd:COG0471 251 LADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPN 330
|
490 500 510
....*....|....*....|....*....|....*.
gi 970598236 569 AIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTW 604
Cdd:COG0471 331 AIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
38-605 |
2.87e-60 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 205.90 E-value: 2.87e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 38 AYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAG 117
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 118 AKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLqelvsaedeqlvagnsnteeaepisldvknsqpslelifvne 197
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLA------------------------------------------ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 198 drsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltpspRKQKLNrkyrshhdqmiCKCLSLSISYSA 277
Cdd:cd01115 119 ---------------------------------------------------AKLDIS-----------PSRLLMPLAFAA 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 278 TIGGLTTIIGTSTSLIFLEHFNnqYPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslskkkktkreq 357
Cdd:cd01115 137 SIGGMLTLIGTPPNLVASGYLE--SLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAV--------------------- 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 358 lsekriqeeyeklgdisypemvtgFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIpakkpcFGK 437
Cdd:cd01115 194 ------------------------LIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVF------GGV 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 438 kndgenqehslgtepiITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLS-LSSLPPWAVTLLACILVSIV 516
Cdd:cd01115 230 ----------------LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVL 293
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 517 TEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVI 596
Cdd:cd01115 294 TNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVV 373
|
....*....
gi 970598236 597 VMVAINTWG 605
Cdd:cd01115 374 SVTMIPLIW 382
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
32-609 |
5.25e-60 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 207.61 E-value: 5.25e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 32 SSEASCAYVLIVTAVYWVSEAVPLGAAALVP----AFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKR 107
Cdd:pfam00939 28 SKAWHLFAIFIATIVGWILEPLPMAVIALFAislsAILIGTLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 108 IALRMVLMAGAKPgmLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELVSAedeqlvagnsnteeaepisldvknsq 187
Cdd:pfam00939 108 IALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA-------------------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 188 pslelifvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvLTPSPRKQKLNRkyrshhdqmICK 267
Cdd:pfam00939 160 --------------------------------------------------------FGSDPEKGSERR---------IGA 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 268 CLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGcnfketcsl 347
Cdd:pfam00939 175 YLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSI--LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPP--------- 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 348 skkkKTKREQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPgfvPGWDsffekkgyrtDATVSVFLGFLLFL 427
Cdd:pfam00939 244 ----EIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGS---LNID----------ATTVAIIGLALMLL 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 428 IPakkpcfgkkndgenqehslgtepIITWKD-FQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVT 506
Cdd:pfam00939 307 LR-----------------------ILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMA 363
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 507 LLACILVSIVT--EFVSNPATITIFLPILCSLSETLH-INPLYTLIPVTMCISFA-VMLPVGNPPNAIVFSYGHCQIKDM 582
Cdd:pfam00939 364 FIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDW 443
|
570 580
....*....|....*....|....*..
gi 970598236 583 VKAGLGVNVIGLVIVMVAINTWGVSLF 609
Cdd:pfam00939 444 WRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
40-604 |
4.53e-46 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 169.06 E-value: 4.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 40 VLIVTAVYWVSEAVPLGAAALVP-AFLYPFFGVLRSNEVAAE--YFKNTTLLLV-GVICVAAAVEKWNLHKRIALRMV-L 114
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNAlsGFADPTIWLFfGAFILATALVKTGLGKRIAYKLVgK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 115 MAGAKPGMLLLCFMCCTTLLSMWLSNTS-TTAMVMPIVEAVLQELVSAEDeqlvagnsnteeaepisldvknsqpsleli 193
Cdd:TIGR00785 96 MGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPE------------------------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 194 fvnedrsnadlttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqvltPSPRKqklnrkyrshhdqmICKCLSLSI 273
Cdd:TIGR00785 146 ----------------------------------------------------KSPRK--------------IGKYLMLGI 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 274 SYSATIGGLTTIIGTSTSLIFLEHFNNQypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKKKT 353
Cdd:TIGR00785 160 AYSASIGSSGFLTGSAPNALAAGILSKI--LGIQISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELK 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 354 KREQLSeKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFtrepgfvpgwdsfFEKKGYRTDATVSVFLGFLLFLipakkp 433
Cdd:TIGR00785 226 LKDEVD-LWAKEELEEMGPMSFREKALLGIFLLALLLWI-------------FGGSLGINASVVALLAVVLMLF------ 285
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 434 cFGkkndgenqehslgtepIITWKDFQK-TMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACIL 512
Cdd:TIGR00785 286 -LG----------------IVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVV 348
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 513 VSIV--TEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGV 589
Cdd:TIGR00785 349 LFYIilYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAII 428
|
570
....*....|....*
gi 970598236 590 NVIGLVIVMVAINTW 604
Cdd:TIGR00785 429 GIVGLIVLLLVGTLW 443
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
45-601 |
4.29e-37 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 142.77 E-value: 4.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 45 AVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLL 124
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 125 LcFMCCTTLLSMWLSNTSTTAMVMPIVEAVLqelvsaedeqlvagnsnteeaepisldvknsqpslelifvnedrsnadl 204
Cdd:cd00625 81 L-LMLLTAALSAFFSNDATAVLLTPIVLALL------------------------------------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 205 ttlmhnenlngvpsitnpiktanqhqgkkqHPSQEKPQVLtpsprkqklnrkyrshhdqmickcLSLSISYSATIGGLTT 284
Cdd:cd00625 111 ------------------------------RKLGLSPPVP------------------------LLLALAFAANIGGAAT 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 285 IIGTSTSLIFLehfnnqypAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKKKTKREQLSEKRIQ 364
Cdd:cd00625 137 PIGNPPNLIIA--------SLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLF------------RKKLLLPDEDKLTVLA 196
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 365 EEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPgwdsffekkgyrtdATVSVFLGFLLFLIpakkpcfgkkndgenq 444
Cdd:cd00625 197 EPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLI--------------ALLGALLLLLLLVR---------------- 246
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 445 ehslgtepIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPA 524
Cdd:cd00625 247 --------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVP 318
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 525 TITIFLPILCSLSET-----LHINPLYTLIPVTMCISFAVMLPVGNPPNAIV-FSYGhcqikDMVKAGLGVNVIGLVIVM 598
Cdd:cd00625 319 TVALLLPIAASLAPPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGVgISFG-----EFLKVGLPLTLLSLVVSL 393
|
...
gi 970598236 599 VAI 601
Cdd:cd00625 394 LYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
45-549 |
6.75e-24 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 103.16 E-value: 6.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 45 AVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLL 124
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 125 LCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELvsaedeqlvagnsnteeaepisldvknsqpslelifvnedrsnadl 204
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL---------------------------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 205 ttlmhnenlngvpsitnpiktanqhqgkkqhpsqekpqVLTPSPrkqklnrkyrshhdqmickcLSLSISYSATIGGLTT 284
Cdd:pfam03600 115 --------------------------------------GLPPSP--------------------LLIALAFAANIGGTAT 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 285 IIGTSTSLIFLEHFnnqypaaeVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLgcnfketcslskkkktKREQLSEKRIQ 364
Cdd:pfam03600 137 PIGDPPNIIIASAL--------GLSFGDFGFFMFPPVGVALLLVGLLPLLLIF----------------RKLLPVRKEEE 192
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 365 EEYEKLGDISYPEMVTGFFFILMTVLWFtrepgfvpgwdsffekkgyrtdatVSVFLGFLLFLIPAKkpcfgkkndgenq 444
Cdd:pfam03600 193 AELEELRKRAIKDKLLLAISALVLALVI------------------------LGFLLLSVLALAGAL------------- 235
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 445 ehSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSslPPWAVTLLACILVSIVTEFVSNPA 524
Cdd:pfam03600 236 --LLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSALLSAFISNVP 311
|
490 500
....*....|....*....|....*
gi 970598236 525 TITIFLPILCSLSETLHINPLYTLI 549
Cdd:pfam03600 312 TAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
452-601 |
1.47e-13 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 72.34 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 452 PIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLP 531
Cdd:pfam03600 26 GVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIP 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 970598236 532 ILCSLSETLHINPLYTLIPVTMCISFA-VMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAI 601
Cdd:pfam03600 106 IVLALARRLGLPPSPLLIALAFAANIGgTATPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
38-601 |
1.17e-09 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 60.53 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 38 AYVLIVTAVYWVSEAVP--LGAAALVpaflypFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLM 115
Cdd:COG1055 12 TYLLIILEPRGLNRAVAalLGAALLL------LLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 116 AGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQELvsaedeqlvagnsnteeaepisldvknsqpslelifv 195
Cdd:COG1055 86 AKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL------------------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 196 nedrsnadlttlmhneNLNGVPsitnpiktanqhqgkkqhpsqekpqvltpsprkqklnrkyrshhdqmickcLSLSISY 275
Cdd:COG1055 129 ----------------GLNPVP---------------------------------------------------FLIAIVF 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 276 SATIGGLTTIIGTSTSLIFLEHFNnqypaaevVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslsKKKKTKR 355
Cdd:COG1055 142 AANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLF------------RKELPAA 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 356 EQLSekriQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWdsffekkgyrtdatVSVFLGFLLFLIPAKKPcf 435
Cdd:COG1055 202 PDLE----DDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPAL--------------IALLGAAVLLLLARVDV-- 261
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 436 gkkndgenqehslgtEPIItwkdfqKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSI 515
Cdd:COG1055 262 ---------------REVL------KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAI 320
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 516 VTEFVSNPATITIFLPILCSLSETLHINPLYTLipVTMCISFA-VMLPVGNPPNAIVFS----YGHcQI--KDMVKAGLG 588
Cdd:COG1055 321 LSAVVDNVPLVAALLPLIPDLGATGNPEPLWLA--LALGATLGgNLTPIGSAANVIVLGiaekKGI-KIsfGEFLKVGLP 397
|
570
....*....|...
gi 970598236 589 VNVIGLVIVMVAI 601
Cdd:COG1055 398 LTLLTLLIALLYL 410
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
40-158 |
6.82e-08 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 54.78 E-value: 6.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 40 VLIVTAVYWVSEA---VPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMV-LM 115
Cdd:COG0471 180 IFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLpLL 259
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 970598236 116 AGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL 158
Cdd:COG0471 260 GGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
451-599 |
1.75e-06 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 50.71 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 451 EPIITWKDfqktmpWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFL 530
Cdd:cd01116 39 ETIVSWVD------WETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMV 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 531 PILCSLSETLHINPLYTLIPVTMCISFAVML-PVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMV 599
Cdd:cd01116 113 PVTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFNDFLLHMLPSVVLALVVTFI 182
|
|
| DctM |
pfam06808 |
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ... |
466-600 |
3.41e-05 |
|
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.
Pssm-ID: 284275 [Multi-domain] Cd Length: 413 Bit Score: 46.48 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 466 EIVILVGGGYALASGSKSSGLSTWIGNQMLSLSsLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPl 545
Cdd:pfam06808 274 AVLFILAAAGIFAGLLTITGVPFKLSDWLLSLG-GGNLLFLILVNLLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDP- 351
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 970598236 546 ytlIPVTMCISFAVMLPVGNPPNAIVFsYGHCQIKDMVKAGLGVNVIGLVIVMVA 600
Cdd:pfam06808 352 ---IHFGVVIVYNGSIGLITPPVGLAL-FVAAGIAKVSFEEVVKGVVPFLFVLVP 402
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
271-599 |
1.61e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 44.55 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 271 LSISYSATIGGLTTIIGTSTSLIFlehfnnqyPAAEVVNFGTWFLFSFPISLIMLVVSWFWMHWLFlgcnfketcslSKK 350
Cdd:cd01116 131 ISEVIAANIGGAATLIGDPPNIMI--------GSAAGLTFNDFLLHMLPSVVLALVVTFILLYFLY-----------RNI 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 351 KKTKREQLSEKRIQEEYEKLGDISYPeMVTGFFFILMTVLWFTRE-PGFVPGWDSFfekkgyrtdatvsvfLGFLLFLIp 429
Cdd:cd01116 192 LKAREEDVLALAELEPKYPIKDKVLL-LKSLTILTLVIIGFVLHSpLGVSLGWIAL---------------LGALLLLL- 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 430 akkpcFGKKNDGENQEHSLGtepiitwkdfqktmpWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLA 509
Cdd:cd01116 255 -----LADKLDFEDVLSRVE---------------WDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILI 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 510 CILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFA-VMLPVGNPPNAIV--FSYGH-CQI--KDMV 583
Cdd:cd01116 315 LWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGgNGTLIGASANVVAagIAEQHgYKIsfWEFL 394
|
330
....*....|....*.
gi 970598236 584 KAGLGVNVIGLVIVMV 599
Cdd:cd01116 395 KVGFPIMLVSLILATV 410
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
38-156 |
9.41e-04 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 41.91 E-value: 9.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 38 AYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALrmVLMAG 117
Cdd:pfam03600 209 LAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALAD--ALGGL 286
|
90 100 110
....*....|....*....|....*....|....*....
gi 970598236 118 AKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQ 156
Cdd:pfam03600 287 SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAP 325
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
38-158 |
2.67e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 40.70 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970598236 38 AYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRsnEVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAG 117
Cdd:cd01116 4 TYALIIFEKVHRTVAALAGALWLVILGLATLSPDLE--TIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISK 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 970598236 118 AKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL 158
Cdd:cd01116 82 GRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVL 122
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
271-337 |
6.60e-03 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 39.34 E-value: 6.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 970598236 271 LSISYSATIGGLTTIIGTSTSLIFLEhfnnqypAAE----VVNFGTWFLFSFPISLIMLVVSWFWMHWLFL 337
Cdd:COG1055 352 LALALGATLGGNLTPIGSAANVIVLG-------IAEkkgiKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| |
