capping protein, Arp2/3 and myosin-I linker protein 2 isoform 2 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
CARMIL_C | pfam16000 | CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
783-1076 | 7.59e-57 | |||||||
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2). : Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 199.23 E-value: 7.59e-57
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RNA1 super family | cl34950 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
250-650 | 1.17e-16 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; The actual alignment was detected with superfamily member COG5238: Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.07 E-value: 1.17e-16
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Carm_PH super family | cl39358 | Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
37-120 | 1.54e-14 | |||||||
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids. The actual alignment was detected with superfamily member pfam17888: Pssm-ID: 436119 Cd Length: 94 Bit Score: 70.39 E-value: 1.54e-14
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Name | Accession | Description | Interval | E-value | |||||||
CARMIL_C | pfam16000 | CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
783-1076 | 7.59e-57 | |||||||
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2). Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 199.23 E-value: 7.59e-57
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
250-650 | 1.17e-16 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.07 E-value: 1.17e-16
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
277-608 | 1.45e-16 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.40 E-value: 1.45e-16
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Carm_PH | pfam17888 | Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
37-120 | 1.54e-14 | |||||||
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids. Pssm-ID: 436119 Cd Length: 94 Bit Score: 70.39 E-value: 1.54e-14
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LRR_RI | smart00368 | Leucine rich repeat, ribonuclease inhibitor type; |
572-598 | 3.84e-04 | |||||||
Leucine rich repeat, ribonuclease inhibitor type; Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.93 E-value: 3.84e-04
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LRR_6 | pfam13516 | Leucine Rich repeat; |
571-594 | 1.05e-03 | |||||||
Leucine Rich repeat; Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.60 E-value: 1.05e-03
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Name | Accession | Description | Interval | E-value | |||||||
CARMIL_C | pfam16000 | CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ... |
783-1076 | 7.59e-57 | |||||||
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2). Pssm-ID: 464966 [Multi-domain] Cd Length: 299 Bit Score: 199.23 E-value: 7.59e-57
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
250-650 | 1.17e-16 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.07 E-value: 1.17e-16
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
277-608 | 1.45e-16 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.40 E-value: 1.45e-16
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
279-644 | 6.32e-15 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 77.40 E-value: 6.32e-15
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Carm_PH | pfam17888 | Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain ... |
37-120 | 1.54e-14 | |||||||
Carmil pleckstrin homology domain; This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in Swiss:Q6EDY6. Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids. Pssm-ID: 436119 Cd Length: 94 Bit Score: 70.39 E-value: 1.54e-14
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
188-479 | 1.96e-13 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.06 E-value: 1.96e-13
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
238-479 | 7.57e-11 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 65.07 E-value: 7.57e-11
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
440-652 | 1.66e-10 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 63.91 E-value: 1.66e-10
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
561-704 | 7.94e-10 | |||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 62.89 E-value: 7.94e-10
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
338-639 | 1.71e-06 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 52.24 E-value: 1.71e-06
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
201-346 | 2.32e-06 | |||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.20 E-value: 2.32e-06
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
242-463 | 3.72e-05 | |||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.01 E-value: 3.72e-05
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LRR_RI | smart00368 | Leucine rich repeat, ribonuclease inhibitor type; |
572-598 | 3.84e-04 | |||||||
Leucine rich repeat, ribonuclease inhibitor type; Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.93 E-value: 3.84e-04
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LRR_6 | pfam13516 | Leucine Rich repeat; |
571-594 | 1.05e-03 | |||||||
Leucine Rich repeat; Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.60 E-value: 1.05e-03
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Blast search parameters | ||||
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