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Conserved domains on  [gi|922581720|ref|NP_001300369|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-431 9.07e-34

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17317:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 331  Bit Score: 129.24  E-value: 9.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  24 WKLNPNNEFYSLSVERGFACQKNSNQTTAmmSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLS 103
Cdd:cd17317    2 WEFDYSVSESTIVTEWDLVCDRDWLVALV--QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 104 WMTInaTLAAMGFFCGGYMVTNFVILTEaFELPKSRLLVVSLNG--WSVSMAVTALAASYTLNWYAYHtiFAIVGACIAI 181
Cdd:cd17317   80 LFLV--LRFLVGVTSAGIFTVGFVLGME-IVGPKYRSFVGILFGlfWALGYMLLALLAYLIRDWRWLQ--LAISLPGLLF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 182 ISLatcsesCRWLsanglqndakkialqitllnnnrdieeddisilswheilgfsaPTHTdekktwktlfkstrflkptA 261
Cdd:cd17317  155 LLL------LWWL-------------------------------------------PRRT-------------------I 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 262 VMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISS---VGLCCLAALMILPiqy 338
Cdd:cd17317  167 IVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSlllAGLACLVTALLPD--- 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 339 ydiqCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVL 418
Cdd:cd17317  244 ----DENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVL 319

                        410
                 ....*....|...
gi 922581720 419 LFIQLVViVIFLP 431
Cdd:cd17317  320 ALLGGLL-TLLLP 331
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 24-431 9.07e-34

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 129.24  E-value: 9.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  24 WKLNPNNEFYSLSVERGFACQKNSNQTTAmmSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLS 103
Cdd:cd17317    2 WEFDYSVSESTIVTEWDLVCDRDWLVALV--QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 104 WMTInaTLAAMGFFCGGYMVTNFVILTEaFELPKSRLLVVSLNG--WSVSMAVTALAASYTLNWYAYHtiFAIVGACIAI 181
Cdd:cd17317   80 LFLV--LRFLVGVTSAGIFTVGFVLGME-IVGPKYRSFVGILFGlfWALGYMLLALLAYLIRDWRWLQ--LAISLPGLLF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 182 ISLatcsesCRWLsanglqndakkialqitllnnnrdieeddisilswheilgfsaPTHTdekktwktlfkstrflkptA 261
Cdd:cd17317  155 LLL------LWWL-------------------------------------------PRRT-------------------I 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 262 VMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISS---VGLCCLAALMILPiqy 338
Cdd:cd17317  167 IVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSlllAGLACLVTALLPD--- 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 339 ydiqCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVL 418
Cdd:cd17317  244 ----DENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVL 319

                        410
                 ....*....|...
gi 922581720 419 LFIQLVViVIFLP 431
Cdd:cd17317  320 ALLGGLL-TLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 5-431 4.01e-33

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 130.52  E-value: 4.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720    5 AFMEPSPEWCDTVRETEQSwklnpnnefySLSVERGFACQKNSNQttAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLG 84
Cdd:TIGR00898  95 AATEPCLDGWEYSYDTFSS----------TIVTEWDLVCEDAWKV--DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   85 CLLMITIGHILLTFSMYLSWMTINATLAamGFFCGGYMVTNFVILTEAfeLPKS-RLLVVSLNG--WSVSMAVTALAASY 161
Cdd:TIGR00898 163 STLVTAVSGVLTAFSPNYTVFLVFRLLV--GMGIGGIWVQAVVLNTEF--LPKKqRAIVGTLIQvfFSLGLVLLPLVAYF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  162 TLNWYAYHTIFAIVGACIAIISLATCsESCRWLSANGLQNDAKKIALQITLLNNNRdiEEDDISILSWHEILGFSAPTHT 241
Cdd:TIGR00898 239 IPDWRWLQLAVSLPTFLFFLLSWFVP-ESPRWLISQGRIEEALKILQRIAKINGKK--LPAEVLSLSLEKDLSSSKKQYS 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  242 DekktwKTLFKSTRFLKPTAVMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKR-AIAI 320
Cdd:TIGR00898 316 F-----LDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRyTMAA 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  321 SSV--GLCCLAALMILPIQYydiqcmrWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAP 398
Cdd:TIGR00898 391 SLLlaGVALLLLLFVPVDLY-------FLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISP 463

                         410       420       430
                  ....*....|....*....|....*....|...
gi 922581720  399 MIVYLRTFGFFIPNAIFAVLLFIQLVViVIFLP 431
Cdd:TIGR00898 464 FLVYLGEKWLFLPLVLFGGLALLAGIL-TLFLP 495
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
47-397 6.31e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.78  E-value: 6.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTinATLAAMGFFCGGYMVTNF 126
Cdd:COG2814   43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLL--AARFLQGLGAGALFPAAL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIvGACIAIISLatcsescrwlsanglqndak 204
Cdd:COG2814  121 ALIADLVP-PERRGRALGLLgaGLGLGPALGPLLGGLLADLFGWRWVFLV-NAVLALLAL-------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 205 kialqitllnnnrdieeddisILSWHEILGFSAPTHTDEKKTWKTLFKSTRFLKPTAVM-CYSFMASSIVSFGFYFSIDV 283
Cdd:COG2814  179 ---------------------LLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAfLLGFGFFALFTYLPLYLQEV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 284 L---PGNRYYNMTIMGILKFILGF-TPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYydiqcmrWVIIMLSLMIAAGI 359
Cdd:COG2814  238 LglsASAAGLLLALFGLGGVLGALlAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-------WLLLLALFLLGFGF 310

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 922581720 360 DPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMA 397
Cdd:COG2814  311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
Sugar_tr pfam00083
Sugar (and other) transporter;
29-431 9.58e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 9.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   29 NNEFYSLSVERGFACQKNSNQTTA-------MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFS-M 100
Cdd:pfam00083  19 IGAFLTLIDFFKNFGLSKSVSSLAalsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  101 YLSWMTINATLAAMGFFCGGYMVTNFVILTEaFELPKSRLLVVSLNGWSVSM-----AVTALAASYTLNWYAYHTIFA-- 173
Cdd:pfam00083  99 KWSVYQLIVGRVLVGIGVGGASVLAPMYISE-IAPKKLRGALGSLYQLAITFgillaYIFGLGLNKTSNSDGWRIPLGlq 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  174 IVGACIAIISLATCSESCRWLSANGLQNDAKKIalqitlLNNNRDIEEDDISILSWHEILGFSAPThtdEKKTWKTLFKS 253
Cdd:pfam00083 178 LVPALLLIIGLLFLPESPRWLVEKGRLEEAREV------LAKLRGVPDVDRELDEIKDSLEAGQEA---EKASWKELFST 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  254 TRFLKP--TAVMCYSFMASSIVSFGFYFSI----DVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRA--IAISSVGL 325
Cdd:pfam00083 249 KTRRQRllIGVMLQIFQQLTGINAIFYYSTtifeNLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPllLLGAAGMA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  326 CCLAALMILPIQYYDIQ-CMRWVIIMLSLMIAAGIDPTW-KINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIV-- 401
Cdd:pfam00083 329 ICFVILGIVALLGVSKSdWAGIVAIVFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFpi 408

                         410       420       430
                  ....*....|....*....|....*....|...
gi 922581720  402 ---YLRTFGFFIPNAIFAVLLFIqlvVIVIFLP 431
Cdd:pfam00083 409 itdAIGLGYTFFIFAGLLVLFII---FVFFFVP 438
emrD PRK11652
multidrug transporter EmrD;
53-122 5.50e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.20  E-value: 5.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGalIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYM 122
Cdd:PRK11652  49 MAAYLLTYG--LSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVM 116
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 24-431 9.07e-34

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 129.24  E-value: 9.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  24 WKLNPNNEFYSLSVERGFACQKNSNQTTAmmSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLS 103
Cdd:cd17317    2 WEFDYSVSESTIVTEWDLVCDRDWLVALV--QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 104 WMTInaTLAAMGFFCGGYMVTNFVILTEaFELPKSRLLVVSLNG--WSVSMAVTALAASYTLNWYAYHtiFAIVGACIAI 181
Cdd:cd17317   80 LFLV--LRFLVGVTSAGIFTVGFVLGME-IVGPKYRSFVGILFGlfWALGYMLLALLAYLIRDWRWLQ--LAISLPGLLF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 182 ISLatcsesCRWLsanglqndakkialqitllnnnrdieeddisilswheilgfsaPTHTdekktwktlfkstrflkptA 261
Cdd:cd17317  155 LLL------LWWL-------------------------------------------PRRT-------------------I 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 262 VMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISS---VGLCCLAALMILPiqy 338
Cdd:cd17317  167 IVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSlllAGLACLVTALLPD--- 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 339 ydiqCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVL 418
Cdd:cd17317  244 ----DENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVL 319

                        410
                 ....*....|...
gi 922581720 419 LFIQLVViVIFLP 431
Cdd:cd17317  320 ALLGGLL-TLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 5-431 4.01e-33

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 130.52  E-value: 4.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720    5 AFMEPSPEWCDTVRETEQSwklnpnnefySLSVERGFACQKNSNQttAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLG 84
Cdd:TIGR00898  95 AATEPCLDGWEYSYDTFSS----------TIVTEWDLVCEDAWKV--DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   85 CLLMITIGHILLTFSMYLSWMTINATLAamGFFCGGYMVTNFVILTEAfeLPKS-RLLVVSLNG--WSVSMAVTALAASY 161
Cdd:TIGR00898 163 STLVTAVSGVLTAFSPNYTVFLVFRLLV--GMGIGGIWVQAVVLNTEF--LPKKqRAIVGTLIQvfFSLGLVLLPLVAYF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  162 TLNWYAYHTIFAIVGACIAIISLATCsESCRWLSANGLQNDAKKIALQITLLNNNRdiEEDDISILSWHEILGFSAPTHT 241
Cdd:TIGR00898 239 IPDWRWLQLAVSLPTFLFFLLSWFVP-ESPRWLISQGRIEEALKILQRIAKINGKK--LPAEVLSLSLEKDLSSSKKQYS 315

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  242 DekktwKTLFKSTRFLKPTAVMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKR-AIAI 320
Cdd:TIGR00898 316 F-----LDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRyTMAA 390

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  321 SSV--GLCCLAALMILPIQYydiqcmrWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAP 398
Cdd:TIGR00898 391 SLLlaGVALLLLLFVPVDLY-------FLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISP 463

                         410       420       430
                  ....*....|....*....|....*....|...
gi 922581720  399 MIVYLRTFGFFIPNAIFAVLLFIQLVViVIFLP 431
Cdd:TIGR00898 464 FLVYLGEKWLFLPLVLFGGLALLAGIL-TLFLP 495
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 53-431 1.04e-18

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 86.96  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILL----TFSMYLSWMTInatlaaMGFFCGGYMVTNFVI 128
Cdd:cd17374   39 VAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAafapTFPVYCVLRFL------AGFAVSGISINTLIL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 129 LTEaFELPKSRLLVVSLNG--WSVSMAVTALAASYTLNWyayHTIFAIVGACIAIISLATCsescrWLSanglqndakki 206
Cdd:cd17374  113 GTE-WTTPRHRALAITLTScfFSIGQMLLAGLAYAIRDW---RLLQLVVSVPFFLFFLYSW-----WLP----------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 207 alqitllnnnrdieeddisilswheilgfsapthtdekktwktlfkstrflKPTAVMCYSFMASSIVSFGFYFSIDVLPG 286
Cdd:cd17374  173 ---------------------------------------------------KRTLILSFVWFANSFSYYGLSLDLQHLGL 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 287 NRYYNMTIMGILKFILGFTPFFLNRFLTKR---AIAISSVGLCCLAaLMILPiqyYDIQCMRWVIIMLSLMIAAGidpTW 363
Cdd:cd17374  202 NVFLLQFLFGAVEVPARCLALFLLNHMGRRisqAVLLLLAGLCILA-NIFVP---QEMQTLRTVLAVLGKGSSAA---AF 274

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922581720 364 KINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQlVVIVIFLP 431
Cdd:cd17374  275 TISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILA-GLLALLLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 53-431 1.20e-15

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 77.89  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMylSWMTINATLAAMGFFCGGYMVTNFVILTEA 132
Cdd:cd17376   39 LTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSP--SWEMFTVLFVIVGMGQISNYVVAFVLGTEI 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 133 FElPKSRLLVVSLN---GWSVSMAVTALAASYTLNWyayhtifaivgaciaiislatcsescRWLSanglqndakkIALQ 209
Cdd:cd17376  117 LG-KSVRILFSTLGvciFYAIGYMLLPLFAYFIRDW--------------------------RMLL----------LALT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 210 ITLLnnnrdieeddISILSWheilgfsapthtdekktWktlfkstrFLKPTAVMC-YSFMASSIVSFGFYFSIDVLPGNR 288
Cdd:cd17376  160 LPGV----------LCVPLW-----------------W--------FIPITTIMSlLLWMAISVGYFGLSLNTPNLHGDP 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 289 YYNMTIMGILKFILGFTPFFLNRFLTKRaIAISSVGLCCLAALMILPIQYYDIQCMRWVIIMLSLMiaaGIDPTWKINHL 368
Cdd:cd17376  205 YLNCFLSAVIEVPAYIIAWLLLRSLPRR-YSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKF---GITAAFSMVYV 280

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922581720 369 YSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLfIQLVVIVIFLP 431
Cdd:cd17376  281 YTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLT-VLIGILTLFLP 342
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
47-397 6.31e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.78  E-value: 6.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTinATLAAMGFFCGGYMVTNF 126
Cdd:COG2814   43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLL--AARFLQGLGAGALFPAAL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIvGACIAIISLatcsescrwlsanglqndak 204
Cdd:COG2814  121 ALIADLVP-PERRGRALGLLgaGLGLGPALGPLLGGLLADLFGWRWVFLV-NAVLALLAL-------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 205 kialqitllnnnrdieeddisILSWHEILGFSAPTHTDEKKTWKTLFKSTRFLKPTAVM-CYSFMASSIVSFGFYFSIDV 283
Cdd:COG2814  179 ---------------------LLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAfLLGFGFFALFTYLPLYLQEV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 284 L---PGNRYYNMTIMGILKFILGF-TPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYydiqcmrWVIIMLSLMIAAGI 359
Cdd:COG2814  238 LglsASAAGLLLALFGLGGVLGALlAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-------WLLLLALFLLGFGF 310

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 922581720 360 DPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMA 397
Cdd:COG2814  311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
Sugar_tr pfam00083
Sugar (and other) transporter;
29-431 9.58e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 9.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   29 NNEFYSLSVERGFACQKNSNQTTA-------MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFS-M 100
Cdd:pfam00083  19 IGAFLTLIDFFKNFGLSKSVSSLAalsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  101 YLSWMTINATLAAMGFFCGGYMVTNFVILTEaFELPKSRLLVVSLNGWSVSM-----AVTALAASYTLNWYAYHTIFA-- 173
Cdd:pfam00083  99 KWSVYQLIVGRVLVGIGVGGASVLAPMYISE-IAPKKLRGALGSLYQLAITFgillaYIFGLGLNKTSNSDGWRIPLGlq 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  174 IVGACIAIISLATCSESCRWLSANGLQNDAKKIalqitlLNNNRDIEEDDISILSWHEILGFSAPThtdEKKTWKTLFKS 253
Cdd:pfam00083 178 LVPALLLIIGLLFLPESPRWLVEKGRLEEAREV------LAKLRGVPDVDRELDEIKDSLEAGQEA---EKASWKELFST 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  254 TRFLKP--TAVMCYSFMASSIVSFGFYFSI----DVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRA--IAISSVGL 325
Cdd:pfam00083 249 KTRRQRllIGVMLQIFQQLTGINAIFYYSTtifeNLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPllLLGAAGMA 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  326 CCLAALMILPIQYYDIQ-CMRWVIIMLSLMIAAGIDPTW-KINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIV-- 401
Cdd:pfam00083 329 ICFVILGIVALLGVSKSdWAGIVAIVFIALFIAFFAMGWgPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFpi 408

                         410       420       430
                  ....*....|....*....|....*....|...
gi 922581720  402 ---YLRTFGFFIPNAIFAVLLFIqlvVIVIFLP 431
Cdd:pfam00083 409 itdAIGLGYTFFIFAGLLVLFII---FVFFFVP 438
MFS_1 pfam07690
Major Facilitator Superfamily;
47-398 8.65e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.07  E-value: 8.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTInaTLAAMGFFCGGYMVTNF 126
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGLGAGALFPAAL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  127 VILTEAFElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIvgacIAIISLATCSESCRWLSANGLQNDAK 204
Cdd:pfam07690 108 ALIADWFP-PEERGRALGLVsaGFGLGAALGPLLGGLLASLFGWRAAFLI----LAILSLLAAVLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  205 KIALQITLLnnnrdieeddisilswheilgfsapthtdekKTWKTLFKStRFLKPTAVMCYSFMASSIVSFGFYFSIDVL 284
Cdd:pfam07690 183 AEEARLSLI-------------------------------VAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  285 PGNRYYNMTIMGILKFILGFTPFFLNRFLTK---RAIAISSVGLCCLAALMILPIQYYDIQCMRWVIIMLSLMIAAGIDP 361
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 922581720  362 TWkinHLYSAELFPTSVRSMARGVCNAGGRLGSVMAP 398
Cdd:pfam07690 311 AL---NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 53-431 3.34e-13

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 70.46  E-value: 3.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLaaMGFFCGGYMVTNFVILTEA 132
Cdd:cd17379   37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFL--QGLFGKGGWMTGYVLVTEF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 133 FELPKSRLL-VVSLNGWSVSMAVTALAASYTLNWyayhtifaivgaciaiislatcsescRWLSanglqndakkiaLQIT 211
Cdd:cd17379  115 VGSKYRRTVgIVYQMFFTLGLLILPGIAYFIPHW--------------------------RWLQ------------LAVT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 212 LLNnnrdieeddISILSWHEILgfsaPTHTdekktwktlfkstrflkptAVMCYSFMASSIVSFGFYFSIDVLPGNRYYN 291
Cdd:cd17379  157 LPN---------FLFLLYYWFI----PKHT-------------------FILMYAWFTSAVVYQGLIMRLGITGGNLYLD 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 292 MTIMGILKFILGFTPFF-LNRFLTKRAIAISSV--GLCCLAALMILPiqyydiqCMRWVIIMLSLMIAAGIDPTWKINHL 368
Cdd:cd17379  205 FFISALVELPAAFIILLtIDRIGRRLPFAASNIvaGAACLITAFIPP-------DLHWLKTTIACVGRLGITMAFEIVCL 277

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581720 369 YSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVY-LRTFGFFIPNAIFAVLLFIQlVVIVIFLP 431
Cdd:cd17379  278 VNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGVLALVA-GGLVLLLP 340
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
47-432 3.81e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.28  E-value: 3.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMylSWMTINATLAAMGFFCGGYMVTNF 126
Cdd:COG2271   43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAAL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLATcsescRWLsanglqndak 204
Cdd:COG2271  121 KLIAEWFP-PKERGRALGIFnaGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR-----FWL---------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 205 kIALQITLLNnnrdieeddisiLSWHEILGFSAPthtdekktwktlfkstrFLKptavmcySFMASSIVSFGFYFSIdvl 284
Cdd:COG2271  185 -LALAYFLVY------------FALYGFLTWLPT-----------------YLV-------EVRGLSLAQAGLLLSL--- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 285 pgnryynMTIMGILKFILGftPFFLNRFLTKRAIAIsSVGLCCLAALMILPIQYYDIqcmrWVIIMLSLMIAAGIDPTWK 364
Cdd:COG2271  225 -------PFLAGIVGSLLG--GWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSP----ALAIALLFLAGFGLGGAFG 290

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 365 INHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIV--YLRTFGFFIPNAIFAVLLFIQLVVIVIFLPD 432
Cdd:COG2271  291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAALALLAALLALLLLRE 360
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 12-415 7.64e-13

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 69.42  E-value: 7.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  12 EWCDTVRETEQSWKLNPNNEFYSLSVErgFACQKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITI 91
Cdd:cd17377    4 EWLLTANDSEVHKHVHFSSSFTSIVSE--WFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDIL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  92 GHILLTFSMYLSWMTINATLaaMGFFCGGYMVTNFVILTEAFELpKSRLLVVSLNG--WSVSMAVTALAASYTLNWYAYH 169
Cdd:cd17377   82 FAYFNALAPSYEFFAVSRFL--VGVMNGGMSLVAFVLLNECVGK-SYWALAGSLGGlfFAVGIAQYALLGYFIRSWRTLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 170 TIFAIVGACIAIISLatcsescrwlsanglqndakkialqitllnnnrdieeddisILSWHeilgfsapthtdekktwkt 249
Cdd:cd17377  159 VVVNLQGTLVFLLSL-----------------------------------------FIPGR------------------- 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 250 lfkstrflkpTAVMCYSFMASSIVSFGFYFSIDVLPGNRYYNMTIMGILKF-ILGFTPFFLN--RFLTKRAIA--ISSVG 324
Cdd:cd17377  179 ----------TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELpAYPLCIYLINqkWSGRRRTLAgfLFLGG 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 325 LCCLAaLMILPIQYYDIQCMRWVIIMLSLMIAAGIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLR 404
Cdd:cd17377  249 IACLL-VMFVPEKKDSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLK 327

                        410
                 ....*....|.
gi 922581720 405 TFGFFIPNAIF 415
Cdd:cd17377  328 SVQWSLPFIVF 338
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 47-428 6.30e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 66.47  E-value: 6.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLaaMGFFCGGYMVTNF 126
Cdd:cd17316   34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFL--QGIGIGGEYPGAS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEaFELPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHT---IFAIVGACIAIISLAtcsescrwlsanglqn 201
Cdd:cd17316  112 TYVAE-FAPSKRRGFALGLLqsGWALGALLAALVASLLIPLLSGDWgwrILFLIGALPALLALL---------------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 202 dAKKIALQITLLNnnrdieeddisilswheilgfsapthtdekktwktlfkstrflkptavMCYSFMASSIVSFG--FYF 279
Cdd:cd17316  175 -LRRRTLLLILLW------------------------------------------------FFISFGYYGLTTFLptYLQ 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 280 SIDVLPGNRYYNMTIMGILKFILG--FTPFFLNRFLTKRAIAISSVGLCCLAALMilpiqYYDIQCMRWVIIMLSLMIAA 357
Cdd:cd17316  206 TVLGLSPATSSLYLLLISLGALVGalIAGLLSDRIGRKKTLVIGLILSGILALPL-----FYLLSGSPTLLLLLLFILSF 280

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922581720 358 GIDPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIV--YLRTFGFFIPNAIFAVLLFIQLVVIVI 428
Cdd:cd17316  281 FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGGTGVPALILALLAIVALIVAL 353
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 61-401 5.06e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 63.91  E-value: 5.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   61 GALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFfcgGYMVTNFVILTEAFELPKSRL 140
Cdd:TIGR00895  64 GMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGL---GGLMPNLNALVSEYAPKRFRG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  141 LVVSL--NGWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLATCS---ESCRWLSANGLQNDAK---KIALQItl 212
Cdd:TIGR00895 141 TAVGLmfCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRflpESIDFLVSKRPETVRRivnAIAPQM-- 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  213 lnnnrdieeddisilswHEILGFSAPTHTDEKKTWKTLFK---STRFLKPTAVM--CYSFMassivSFGFYFSIDVLP-- 285
Cdd:TIGR00895 219 -----------------QAEAQSALPEQKSTQGTKRSVFKalfQGKTARITVLLwlLYFML-----LVGVYFLTNWLPkl 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  286 -----GNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYYDIqcmrwVIIMLSLMIAAGID 360
Cdd:TIGR00895 277 mvelgFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFS-----PTLLLLLGAIAGFF 351

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 922581720  361 PTWKINHLY--SAELFPTSVRSMARGVCNAGGRLGSVMAPMIV 401
Cdd:TIGR00895 352 VNGGQSGLYalMALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 52-431 1.00e-10

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 63.36  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  52 AMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAamGFFCGGYMVTNFVILTE 131
Cdd:cd17358   44 SWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLA--GFGGGAASVVVPVYIAE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 132 AFElPKSRLLVVSLNGWSVsmaVTALAASYTLNWYAYHTIFAIVGAC---IAIISLATCSESCRWLSANGLQNDAKKiAL 208
Cdd:cd17358  122 IAP-KNVRGALGSLNQLLV---NIGILLGYVLGSFLPWRTLALIGAIppvVFLILLFFIPESPRWLAKKGREEEAEK-SL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 209 QItlLNNNRDIEEDDISilswhEILGFSAPTHTDEKKTWKTLFKSTRFLKPTAVM-------------CYSFMASSI-VS 274
Cdd:cd17358  197 QF--LRGKDADISKEAA-----EIQEELAELEKEAKESSFSDLFQRKYLKPLVIGlglmlfqqlsginAVIFYASSIfDE 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 275 FGFYFSIDVlpgnryyNMTIMGILKFILGFTPFFL-NRFLTKRAIAISSVGLC-CLAALMI---LPIQYYDIQCMRWV-I 348
Cdd:cd17358  270 AGSGLDPNT-------ATIIIGVVQVVGTLVATLLvDRLGRRPLLLVSAIGMGiGLLALGLyfyLQEHGALLSSVSWLpL 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 349 IMLSLMI---AAGIDP-TWKINhlysAELFPTSVRSMARGVCNAGGRLGS-VMA----PMIVYLRTFGFFIpnaIFAVLL 419
Cdd:cd17358  343 VGLVIYIisfSIGLGPlPWVIM----SEIFPAKIKGLAGSLVTLVNWLFAfIVTktfpFLTLAWGASGTFW---IFAGIC 415

                        410
                 ....*....|..
gi 922581720 420 FIQLVVIVIFLP 431
Cdd:cd17358  416 GLALVFVLLFVP 427
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 47-427 1.97e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.06  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTInaTLAAMGFFCGGYMVTNF 126
Cdd:cd06174   29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL--GRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFELPKSRLLVVSLNGW-SVSMAVTALAASYTLNWYAYHTIFAIVGACIAIIslatcsescrwlsanglqndakk 205
Cdd:cd06174  107 ALIADLFPERERGRALGLLQAFgSVGGILGPLLGGILASSLGFGWRAVFLIAAALAL----------------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 206 ialqITLLNNNRDIEEDDISILSWHEilgfsAPTHTDEKKTWKTLFKSTRFLKPT-AVMCYSFMASSIVSFGFYFSIDVL 284
Cdd:cd06174  164 ----LAAILLLLVVPDPPESARAKNE-----EASSKSVLKLLKRVLKNPGLWLLLlAIFLVNLAYYSFSTLLPLFLLDLG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 285 pGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYYDIQCMRWVIIMLsLMIAAGIDPTWK 364
Cdd:cd06174  235 -GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL-LLLGFGLGGLLP 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922581720 365 INHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMI---VYLRTFGFFIPNAIFAVLLFIQLVVIV 427
Cdd:cd06174  313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLagfLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 53-421 3.62e-10

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 61.30  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSM-YLSWMTINATLAAMGffcGGYMVTNFVILTE 131
Cdd:cd17375   39 LIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFdYYSFVIVRFLLAMVS---SGYLVVVFVYVTE 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 132 AFELPKSRLLVVSLNG-WSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIislatcsesCRWLsanglqndakkialqi 210
Cdd:cd17375  116 FTGIKARTWASMHVHAfFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFIL---------CCWM---------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 211 tllnnnrdieeddisilswheilgFSAPTHTdekkTWKTLFkstrflkpTAVMCYSFMASSIVSFGfyfsidvlpGNRYY 290
Cdd:cd17375  171 ------------------------LPKRTIT----VWLIWF--------TGSLGYYVFSLGSVNLG---------GNEYL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 291 NMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQyydiQCMRWVIIMLSLMIAAGIDPTWKINHLYS 370
Cdd:cd17375  206 NLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIP----QDYEVLTIVLSMTGKFAIAIAFGLIYLYT 281

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922581720 371 AELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFI 421
Cdd:cd17375  282 AELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFL 332
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 45-436 1.97e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 59.20  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  45 KNSNQTTAMMSSLLMwGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFS--MYLSWMTINATLaAMGFFCGGYM 122
Cdd:cd17357   46 ELDLLWSLIVSIFFI-GGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksAKSPELLIFGRF-LVGIACGLST 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 123 VTNFVILTEAfeLPKS-RLLVVSLNGWSVSMA--VTALAA------SYTLNWYAYHTIFAIVGACIAIisLATCSESCRW 193
Cdd:cd17357  124 GFVPMYLQEI--SPSElRGALGSLTQIGVTLGilLGQVFGlpsvlgTETLWPYLLFFPGIPALLQLAA--LPFFPESPKF 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 194 L-SANGLQNDAKKiALQiTLLNNNRDIEEDDISILSWHEilgfsAPTHTDEKKTWKtLFKSTRFLKPTAVMCySFMASSI 272
Cdd:cd17357  200 LlISKGDEEEAEK-SLK-FLRGIEDDVDQELEEIKKESE-----QMGDQKQVSLMQ-LLRDPSLRLPLLLVL-VVSASQQ 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 273 VSfG----FYFSIDVL------PGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLC--CLAALMILPIQYYD 340
Cdd:cd17357  271 FS-GinaiFFYSTFIFenagfsPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCavALLLMSVFLFLSEQ 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 341 IQCMRWVIIMLSLM----IAAGIDPtwkINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVY-LRTFGFFIPNAIF 415
Cdd:cd17357  350 NSWMSYGCIVAIFLfiffFAIGLGP---IPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPpLQSIGGGFVFIIF 426

                        410       420
                 ....*....|....*....|.
gi 922581720 416 AVLLFIQLVVIVIFLPDDSDK 436
Cdd:cd17357  427 AIPCALFLLYLYRYLPETKGR 447
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 46-431 3.05e-09

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 58.20  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  46 NSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFfcgGYMVTN 125
Cdd:cd17446   30 NHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMAL---SGIVLN 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 126 FVILTEAFELPKSRLLVVSLNGWSVSMAVTALAAsytlnwyayhtifaivgaciaiisLATCSESCRWLSanglqndakk 205
Cdd:cd17446  107 SVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAG------------------------VAYAIRDWRWLQ---------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 206 ialqitllnnnrdieeddisilswheiLGFSAPTHTDEKKTWktlfkstRFLKPTAVMCYSFMASSIVSFGFYFSIDVLP 285
Cdd:cd17446  153 ---------------------------LAVSLPFFIFFLYSW-------WFPRITFCLSLVWFSTSFAYYGLAMDLQKFG 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 286 GNRYYNMTIMGIL----KFILGFTPFFLNRFLTKrAIAISSVGLCCLAaLMILPiqyYDIQCMRWVIIMLSLMIAAGidp 361
Cdd:cd17446  199 VSIYLIQIIFGAVdipaKFISTLTMSYLGRRPTQ-AAALILAGIMILA-NIFVP---QDLQTVRTALAVFGKGCLAA--- 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 362 TWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQLVViVIFLP 431
Cdd:cd17446  271 SFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIA-ACFLP 339
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 47-185 9.27e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.79  E-value: 9.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMylSWMTINATLAAMGFFCGGYMVTNF 126
Cdd:cd17324   32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWAIAA 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922581720 127 VILTEAFElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLA 185
Cdd:cd17324  110 AYAADLVP-PEKRGRAIGLVfsGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALL 169
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 51-417 3.32e-08

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 55.06  E-value: 3.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  51 TAMMSSLLMWGALIGSFVCGFLSD-RLGRKPVYLGCLLMITIGHILLTFS------MYLSWMTinatlaamGFFCGGYMV 123
Cdd:cd17378   35 VGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSpnywvyAFLRFLT--------GFGRSGIGT 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 124 TNFVILTEAFElPKSRLLV--VSLNGWSVSMAVTALAAsytlnwYAYHTIFAIVGACIAIISLATCsescrwlsanglqn 201
Cdd:cd17378  107 CALVLATEPVG-PKWRGQVgmSTFFFFVLGFMSLPGIA------YLNGSSWRVLYFWTSIPALIYC-------------- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 202 dakkialqiTLLnnnrdieeddisilswheilgfsapthtdekktwktLFKSTRFLKPTAVMCysfmASSIVSFGFYFSI 281
Cdd:cd17378  166 ---------ILV------------------------------------YLFARRLLAVMVIGF----GIGMVYYGIPLAV 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 282 DVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQYYDIQCMRWVIIMLSLMIAAGidp 361
Cdd:cd17378  197 GNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAG--- 273

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 922581720 362 TWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAV 417
Cdd:cd17378  274 AFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGV 329
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 47-432 3.40e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.39  E-value: 3.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFfcGGYMVTNF 126
Cdd:cd17371   32 DEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGF--GGEWAAGA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFElPKSRLLVVSL--NGWSVSMAVTALAASYTLNWYAYHT------IFAIVGACIAIISLATCSESCRWLSANG 198
Cdd:cd17371  110 ALMAEYVP-ARHRGKALGYvqSGWAVGWLLATLLAALLFPLLPPEIawrvlfLLGALPALLVLFIRRFVKEPPQWQAARA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 199 lqndakkialqitllnnnrdieeddisilswheilgfsAPTHTDEKKTWKTLFkSTRFLKPTAVmcySFMASSIVSFGFY 278
Cdd:cd17371  189 --------------------------------------ARRHFADRPSLRELF-SPPLLRTTLL---ASLLATGALGGYY 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 279 FSIDVLP------------GNRYYNMTImgILKFILGF--TPFFLNRFLTKRAIAISSvglCCLAALMILPIQYYDIQCM 344
Cdd:cd17371  227 GITTWLPsyltgerglsfeGSAGYLVVT--ILGGFLGYlaGGFLADRIGRRNNFALFA---LGSAISILLYFFLPLSPTL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 345 RWVIIMLSLMIAAGIDPTWKInhlYSAELFPTSVRSMARGVCNAGGRLGSVMAPMIV-YLRTFGFF-IPNAIFAVLLFIQ 422
Cdd:cd17371  302 ILILGFPLGFFASGPFSGMGA---YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVgFLATSGSLgTAIAVFAAVYYIA 378

                        410
                 ....*....|
gi 922581720 423 LVVIVIFLPD 432
Cdd:cd17371  379 GLVLALLLPE 388
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 47-184 5.46e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.05  E-value: 5.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSmyLSWMTINATLAAMGFFCGGYMVTNF 126
Cdd:COG0477   47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFElPKSRLLVVSLNG--WSVSMAVTALAASYTLNWYAYHTIFaIVGACIAIISL 184
Cdd:COG0477  125 ALIAELFP-ARERGRALGLWGaaIGLGLALGPLLGGLLVAALGWRWIF-LINAPLGLLAL 182
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
47-429 5.88e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.50  E-value: 5.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLswmtinATLAAMGFFCGGYMVTNF 126
Cdd:COG2223   38 SAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY------WLLLLLGLLLGIGGGGSF 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VI---LTEAFELPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLatcsescrwLSANGLQN 201
Cdd:COG2223  112 AVgiaLVSKWFPPDRRGLALGLAagGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV---------LAWLFLRD 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 202 DAKkialqitllnnnrdieeddisilswheilgFSAPTHTDEKKTWKTLFKSTRFLKptAVMCYSFMASSIVSFGFYFSI 281
Cdd:COG2223  183 PPA------------------------------GAAAAAKASLRDQLEALRDPRFWL--LSLLYFGTFGSFIGFSSWLPP 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 282 ------DVLPGNRYYNMTIMGILKFILG-FTPFFLNRFLTKRAIAISSVGLCCLAALMILPIQyyDIQCMRWVIIMLSLM 354
Cdd:COG2223  231 ylvdqfGLSAATAGLLAALFALLGALGRpLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG--SLWLFLVLFLLLGLA 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922581720 355 IAAGIDPTWKinhlYSAELFPTSVRSMARGVCNAGGRLGSVMAPMI---VYLRTFGFFIPNAIFAVLLFIQLVVIVIF 429
Cdd:COG2223  309 LGGGNGAVFA----LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfgaLLDATGSYTAAFLVFAVLALVALVLTLLL 382
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
46-185 3.34e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.21  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  46 NSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMVTN 125
Cdd:COG2211  261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 126 FVILTEAFELPKSRL------LVVSLNGWS--VSMAVTALAASYTLNWYAYHT--------------IFAIVGACIAIIS 183
Cdd:COG2211  341 WAMLADVVDYDEWKTgrrregLYFGIFTFAikLGQALAGALAGLLLALFGYVAgaaqspsaltgirlLFFLLPAVLLLLA 420


                 ..
gi 922581720 184 LA 185
Cdd:COG2211  421 AL 422
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 47-119 3.65e-07

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 51.89  E-value: 3.65e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCG 119
Cdd:cd17364   37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLG 109
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 50-358 7.21e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.04  E-value: 7.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  50 TTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINAtlAAMGFFCGGYMVTNFVIL 129
Cdd:cd17320   35 AVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIAR--FLQGLGAAAGSVVARAIV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 130 TEAFELPKSRLLVVSLNGW-SVSMAVTALAASYTLNWYAYHTIFAIVgACIAIISLATCSescrwlsanglqndakkIAL 208
Cdd:cd17320  113 RDLYSGAELAKIFSLLMMIlAIAPALAPLLGGLLLLFFGWRAIFVFL-ALLGLLLLLLVL-----------------LFL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 209 QITLLNNNRdieeddisILSWHEILgfsapthtdekKTWKTLFKSTRFLkpTAVMCYSFMASSIVSF-----GFYFSIDV 283
Cdd:cd17320  175 PETLPEEKR--------KPLLSSLL-----------RAYKRVLKNRRFL--GYALALGLSFAGLFAYlaaapFIYIEQLG 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922581720 284 LPGNRYYNMTIMGILKFILG--FTPFFLNRFLTKRAIAISSVGLCCLAALMILpiqYYDIQCMRWVIIMLSLMIAAG 358
Cdd:cd17320  234 LSPAQFGLLFALNAIALILGslLNGRLVRRFGPRRLLRLGLLLLLAAALVLLL---AALLGGLSLWPLVAPLFLIFF 307
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 47-400 1.24e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 50.23  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLaaMGFFCGGymVTNF 126
Cdd:cd17372   32 SAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCL--VGLGLGG--GPQL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 127 VILTEAFELPKSR--LLVVSLNGWSVSMAVTALAASY---TLNWYAYHTIFAIVGACIAIIslatcsesCRWLSANGLQn 201
Cdd:cd17372  108 ASWYLEFLPAKSRgtWMVLFSVFWTVGTIFEASLAWLvmpRLGWRWLLAFSSVPSSLLLVF--------YRWTPKTTLL- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 202 dakkiaLQITLLNNNrdieeddisiLSWHEILGFSAPthtdekktwktlfkstrfLKPTAVMCYSFMASSIVSFGFYFSI 281
Cdd:cd17372  179 ------LWVIWFGNA----------FAYYGVVLLTTE------------------LNNSHNVCGSKSDSDSGESPTEKQC 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 282 DVLPGNRYYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVGLCCLAALMILpiqyydIQCMRWVIIMLSLMIAAGIDP 361
Cdd:cd17372  225 RNSNDVDYRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLL------ICQSPFILTVLLFGGRACISA 298

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 922581720 362 TWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMI 400
Cdd:cd17372  299 AFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFI 337
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 61-432 6.12e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 48.04  E-value: 6.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  61 GALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLaaMGFFCGGYMVTNFVILTEAFElPKSRL 140
Cdd:cd17360   47 GAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVL--VGLGVGIASMTVPLYIAEAAP-PRIRG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 141 LVVSLN-----GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLATCSESCRW-------LSANGLQndakkIAL 208
Cdd:cd17360  124 RLVTINvlfitGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWpstrralIVGCGLQ-----AFQ 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 209 QITLLNnnrdieeddisilswheilgfsapthtdekktwktlfkstrflkptAVMCYSfmASSIVSFGFYFSIDVLpgnr 288
Cdd:cd17360  199 QFSGIN----------------------------------------------TVMYYS--ATILQMAGFKDNQNAI---- 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 289 yYNMTIMGILKFILGFTPFFLNRFLTKRAIAISSVgLCCLAALMILPIqyydiqcmrWVIIM-LSLMIAA---GIDPT-W 363
Cdd:cd17360  227 -WLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISL-FGVIVALVVLAV---------WLALVgLILYLAFfapGMGPVpW 295

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581720 364 KINhlysAELFPTSVRSMARGVCNAGGRLGSVMAP-----MIVYLRTFGFFipnAIFAVLLFIQLVVIVIFLPD 432
Cdd:cd17360  296 TVN----SEIYPLWARGTGGGCAAAVNWVFNLLVSqtfltLTQAIGPYGTF---LLFAGLAVLGLIFIYFCVPE 362
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 47-176 8.28e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.58  E-value: 8.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLswmtinATLAAMGFFCG---GYMV 123
Cdd:cd17365   32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV------LQLALLRFLTGlglGAAM 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 922581720 124 TNFVILTEAFELPKSRLLVVSL--NGWSVSMAVTALAASYTLNWYAYHTIFAIVG 176
Cdd:cd17365  106 PNAITLVSEYAPARRRSLAVTLmfCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 61-185 8.63e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 8.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  61 GALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLsWMTInATLAAMGFFCGGYMVTNFVILTEAFElPKSRL 140
Cdd:cd06173  256 GALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL-WLLL-AALFLLGLAGGLFNVPLNTLLQLRVP-DELRG 332

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 922581720 141 LVVSLNGW--SVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLA 185
Cdd:cd06173  333 RVFSVYNAlnSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 47-186 9.70e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 47.55  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMtinatLAAMGFFCGGYMVTNF 126
Cdd:cd17477  221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLA-----LLVLLFLWGGAAGPLY 295

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922581720 127 -VILTEAFE-LPKSRLlvVSLNG-----WSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLAT 186
Cdd:cd17477  296 tLALALAGDrLPGDEL--VAANAallllYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 291-440 1.68e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.65  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 291 NMTIMGILKFILGFtpfFLNRFLTKRAIAISSVGLCCLAALMILPIQYydiqcmrWVIIMLSLMIAAGIDPTWKINHLYS 370
Cdd:cd06174   40 FSLGYALLQPLAGL---LADRFGRRPVLLLGLLLFALGALLFAFAPSF-------WLLLLGRFLLGLGSGLIDPAVLALI 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581720 371 AELFPTSVRSMARGVCNA----GGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQLVVIVIFLPDDSDKDANE 440
Cdd:cd06174  110 ADLFPERERGRALGLLQAfgsvGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 61-444 1.82e-05

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 47.03  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   61 GALIGSFVCGFLSDRLGRKPVYlGCLLMITI-GHILLTFSMYLSWMTINATLA----AMGFFCGGYMVTNFVILTEaFEL 135
Cdd:TIGR00887  68 GTLAGQLFFGWLADKLGRKRVY-GMELIIMIiATVASGLSPGSSPKSVMATLCfwrfWLGVGIGGDYPLSAIITSE-FAT 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  136 PKSR----LLVVSLNGWS------VSMAVTAL------AASYTLNW---------YAYHTI--FAIVGACIAIISLATCS 188
Cdd:TIGR00887 146 KKWRgammAAVFAMQGFGilagaiVALIVLAGfkhsleAAADEASCtgscvpavdYMWRILigFGAVPALLALYFRLTIP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  189 ESCRWLSANGlqNDAKKIALQIT-LLNNNRDIEEDDISILSWH-EILGFSAP---THTDEKKTWKTLF--KSTRFLKPTA 261
Cdd:TIGR00887 226 ETPRYTADVA--KDVEQAASDMSaVLQVKIEAEPDEVEKASTAvEVPKASWSdffTHFFKWRHGKHLLgtAGSWFLLDIA 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  262 VMCYSFMASSIVSfGFYFSIDVLPGNRY---YNMTIMGILKFILG------FTPFFLNRFLTKraiAISSVGLCCLAALM 332
Cdd:TIGR00887 304 FYGVNLNQKVILS-AIGYSPPAATNNAYeelYKTAVGNLIIALAGtvpgywVTVFLVDIIGRK---PIQLMGFFILTVLF 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  333 I-LPIQYYDIQCMRWVIIMLSLMIAAGIDPTwKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPM-IVYLRTFG--- 407
Cdd:TIGR00887 380 FvLGFAYNHLSTHGFLAIYVLAQFFANFGPN-ATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFgFLYLAQHGdpt 458

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 922581720  408 ------FFIPNA--IFAVLLFIQlVVIVIFLPDDSDKDANEMNDE 444
Cdd:TIGR00887 459 kgyptgIWMGHVleIFALFMFLG-ILFTLLIPETKGKSLEELSGE 502
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
47-185 1.95e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.77  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGhiLLTFSMYLSWMTINATLAAMGFFCGGYMVTNF 126
Cdd:COG0738   41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG--LLLFALAPSYPLLLLALFLLGLGLGLLDVAAN 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922581720 127 VILTEAFELPKSRLLVVSLNGWSVSMAVTALAASYTLNW---YAYHTIFAIVGACIAIISLA 185
Cdd:COG0738  119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALL 180
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 50-186 2.71e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 46.13  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  50 TTAMMSSLLMwgALIGSFVCGFLSDRLGRKPVylgcLLMITIGHILLTFSMYL------SWMTINATLAAMGFFCGGYMV 123
Cdd:cd17367  262 TWITTAALLV--FMLLQPLGGRLSDRIGRRPL----LLFFGIGGTLATVPLLSaldhtdSPYTAFALVLVGLVFLSGYTS 335

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 922581720 124 TNFVILTEAFElPKSRLLVVSLnGWSVSMAVTALAASYTLNWYAYH----TIFAIVGACIAIISLAT 186
Cdd:cd17367  336 INAVVKAELFP-THVRALGVGL-PYALAVAIFGGTAPYVALWLKSIghewVFFWYVAGLIAISLVVY 400
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 53-430 3.45e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAamGFFCGGYMVTNFVILTEA 132
Cdd:cd17325   35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ--GLASAAVWPAAMALIADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 133 FElPKSRLLVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIIslatcsescrwlsanglqndakkIALQI 210
Cdd:cd17325  113 AP-PEERGRAMGIFssAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLA-----------------------LVLAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 211 TLLNNNRDIEEDDisilswheilgfsAPTHTDEKKTWKTLFKSTRFLkptavmcYSFMASSIVSFGFYFSIDVLP--GNR 288
Cdd:cd17325  169 LLLPEPRPPPNKR-------------AVSAARLRSGLRLLLRDRRLL-------ALFLAIFVLAFAFGALEPFLPlyAAE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 289 YYNMTIMGI-LKFILGFTPFFLNRFLT--------KRAIAISSVGLCCLAALMILPIQYYdiqcmrWVIIMLSLMIAAGI 359
Cdd:cd17325  229 LGGLSPAQIgLLFGAQGLASALSQPPAgklsdrigRKPLILIGLLLSAVALLLLPLATSF------WLLLLLLALLGLGL 302

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922581720 360 DPTWKINHLYSAELFPTSVRSMARGVCNAGGRLGSVMAPMI--VYLRTFGFFIPNAIFAVLLFIQLVVIVIFL 430
Cdd:cd17325  303 GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLggFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 33-119 6.72e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.87  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  33 YSLSVERGFACQKNSNQTTAMMSSLLMwGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLA 112
Cdd:cd17315   19 ALLYIAKDLGFGLSTSLQGLVVSSLLL-GAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97


                 ....*..
gi 922581720 113 amGFFCG 119
Cdd:cd17315   98 --GLGVG 102
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 50-185 7.16e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 44.68  E-value: 7.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   50 TTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGhilltfSMYLSWMTINATLAAM----GFFCGGYMVTN 125
Cdd:TIGR00710  41 IVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS------SLGLALSNNIETLLVLrfvqAFGASAGSVIS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922581720  126 FVILTEAFELPKSRLLVVSLNGW-SVSMAVTALAASYTLNWYAYHTIFAIVGAcIAIISLA 185
Cdd:TIGR00710 115 QALVRDIYPGEELSRIYSILMPVlALAPAVAPLLGGYILVWLSWHAIFAFLSL-AGILLSA 174
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 43-210 1.01e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 44.58  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   43 CQKNSNQttAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAamGFFCGGYM 122
Cdd:TIGR01299 198 CIPDSGK--GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLS--GFGIGGAI 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  123 VTNFVILTEAFELPK-----SRLLVVSLNGwSVSMAVTALAASYTLNW-------YAYHT--IFAIVGA--CI-AIISLA 185
Cdd:TIGR01299 274 PIVFSYFAEFLAQEKrgehlSWLCMFWMIG-GIYAAAMAWAIIPHYGWsfqmgsaYQFHSwrVFVIVCAfpCVfAIGALT 352

                         170       180
                  ....*....|....*....|....*
gi 922581720  186 TCSESCRWLSANGLQNDAKKIALQI 210
Cdd:TIGR01299 353 FMPESPRFFLENGKHDEAWMILKLI 377
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 44-181 1.01e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  44 QKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLmITIGHILLTFSMYLSWMTInaTLAAMGFFCGGYMV 123
Cdd:cd17478  225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLL-LAAPFLLLFLLTPGIWSYI--LLVLAGFLLFASFP 301

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 922581720 124 TNFVILTEAfeLPKSRLLVVSLN---GWSV----SMAVTALAASYTLNW-YAYHTIFAIVGACIAI 181
Cdd:cd17478  302 VTVVLAQEL--LPGNVGLASGLMmglSFGLggigAPVLGALADAFGLESvLLILALLPLLGALLAF 365
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 61-178 1.55e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  61 GALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMylSWMTINATLAAMGFFCGGYMVTNFVILTEAFElPKSRL 140
Cdd:cd17329   47 AGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--SPWLFAIALVLTGFGGGLFEPASEAMIADVTT-PENRT 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 922581720 141 LVVSLNGW--SVSMAVTALAASYTLNwYAYHTIFAIVGAC 178
Cdd:cd17329  124 RAFSLLYWaiNLGVAIGPLLGGLLLL-YSFRLLFLAAAVL 162
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 45-443 1.72e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.78  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  45 KNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAmGFFCGGYMVT 124
Cdd:cd17356   41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVGRIIA-GLGVGFASVL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 125 NFVILTEaFELPKSRLLVVSLNGWSVS-----MAVTALAASYTLNWYAYHTIFAI--VGACIAIISLATCSESCRWLsan 197
Cdd:cd17356  120 VPVYQSE-VAPKHIRGTLVSLYQLAITigilvAYCINYGTHKLDGSAQWRIPLGLqiVWGLLLLIGMFFLPESPRWL--- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 198 glqndakkialQITLLNnnrdieeddISILSWHEILGFSApthtdekktwkTLFKSTRFLKPTAVMCYSFMASSIvsfgf 277
Cdd:cd17356  196 -----------YRTILG---------IMLQLFQQLTGINY-----------FFYYGTTIFQSTGLTGSSPLLTSI----- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 278 yfsidvlpgnryynmtIMGILKFILGF-TPFFLNRFLTKRAIAISSVGLCCL----AALMILPIQYYDIQCM------RW 346
Cdd:cd17356  240 ----------------ILYIVNFVSTIpGLFFVDKFGRRTCLLIGAAGMSIClfiyAAVGVRYLIPNPQSGTsnksagNG 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 347 VIIMLSLMIAaGIDPTW-KINHLYSAELFPTSVRSMARGVCNAGGRLG----SVMAPMIVYLRTFGFFIpnaIFAVLLFI 421
Cdd:cd17356  304 MIVFICLFIF-SFATTWgPIAWVYVAEVFPLRVRSKGMALATAFNWLWnfliSFFTPFIIGSIGFKYYY---IFAGCNLL 379

                        410       420
                 ....*....|....*....|..
gi 922581720 422 QLVVIVIFLPDDSDKDANEMND 443
Cdd:cd17356  380 AFIVVFFFVPETKGLTLEEIDE 401
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 50-198 3.35e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.55  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  50 TTAMMSSLLMWGALIGSFVCGFLSDRLGRKPvylgcllMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMVTNFVIL 129
Cdd:cd17359   37 LEGLVVSSALLGAAIGALFAGRLADRFGRRK-------TLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASAL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 130 TEAF--EL--PKSRLLVVSLNGWsvsMAVTALAASYTLNWYAYHTI---------------FAIVGACIAIISLATCSES 190
Cdd:cd17359  110 VPMYiaEVapAEIRGRLVSLNQL---MIVFGQLLAYIVNYLIANAGgadwlgaegwrwmlgLEAIPAILFLLGMLFIPES 186


                 ....*...
gi 922581720 191 CRWLSANG 198
Cdd:cd17359  187 PRWLVSKG 194
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 17-184 3.84e-04

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 42.41  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  17 VRETEQSWKLNpNNEFYS-LSVERGFAC-QKNSNQTTAmmsSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHI 94
Cdd:cd17447    5 VVPCQNGWVYD-HSTFSStIATEWDLVCdRKGLNQATA---TFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  95 LLTFSMYLSWMTINATLAamGFFCGGYMVTNFVILTEAFELPKSRLL-VVSLNGWSVSMAVTALAASYTLNWyaYHTIFA 173
Cdd:cd17447   81 ASAFSVSYVMFAITRTLT--GFALTGFSIISMVLCVEWVDIEHRTVAgVLISLFWTVGNMLLALVAYLIRDW--RWLILA 156

                        170
                 ....*....|..
gi 922581720 174 IVGAC-IAIISL 184
Cdd:cd17447  157 VTLPCaPGIITW 168
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 57-186 4.02e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.51  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  57 LLMWGALIGSFVC---GFLSDRLGRKPVYL-GCLLMitighILLTFSMYL------SWMTINATLAAMGFFCGGYMVTNF 126
Cdd:cd17369  269 AVLIASVVAAITIplfGWLSDRVGRRPVYLaGALLA-----ALFAFPFFWlldtgsTWLIVLAAVVVLGVLHGMMYGPQA 343

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 922581720 127 VILTEAFElPKSRLLVVSLnGWSVS---------MAVTALAASYTLNWYAyhTIFAIVGACIAIISLAT 186
Cdd:cd17369  344 AFLAELFP-TRVRYTGASL-GYQLGailgggfapLIATALVAATGSWWPV--ALYLAALAVISLVAALF 408
emrD PRK11652
multidrug transporter EmrD;
53-122 5.50e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.20  E-value: 5.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  53 MMSSLLMWGalIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYM 122
Cdd:PRK11652  49 MAAYLLTYG--LSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVM 116
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 49-185 5.81e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 5.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  49 QTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTInATLAAMGFFCGGYMVTNFVI 128
Cdd:cd17353  249 GIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFV-LGVALIGFCYGGGFALFPAL 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 922581720 129 LTEAFELP-KSRLLVVSLNGWSVSMAVTALAASYTLNWYAYHTIFaIVGACIAIISLA 185
Cdd:cd17353  328 TADFFGTKnAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAF-IIAAALSLVALA 384
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
47-182 6.42e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 6.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGhiLLTFSMYLSWMTINATLAAMGFFCGGYMVTNF 126
Cdd:COG0738  244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG--LLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 922581720 127 VILTEAFELPKSRLLVVSLNGWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAII 182
Cdd:COG0738  322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 52-184 1.04e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.11  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  52 AMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFS-----MYLSWMtINATLAAMGFFCGGYMVTNF 126
Cdd:cd17312   41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFStslwfFAVLWG-LNGLFQSMGWPPCVKLLGNW 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922581720 127 vilteaFElPKSRLLVVSLngWSVSM----AVTALAASYTLNWYAYHTIFAIVGACIAIISL 184
Cdd:cd17312  120 ------FS-KKERGTVYGI--WSTSHnfggILAPILAASLASYYGWRAAFLVPGIVGLVVAI 172
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 61-186 1.09e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  61 GALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMVTNFVILTeafeLPKSRL 140
Cdd:cd17324  246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL----APEARG 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 922581720 141 LVVSLN--GWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLAT 186
Cdd:cd17324  322 LASSLYlaAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 54-185 1.20e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  54 MSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMVTNFVILteaf 133
Cdd:cd17489   36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVAD---- 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 922581720 134 ELPKSRLL-VVSLNGWS--VSMAVTALAASYTLNWYAYHTIFAIVGACIAIISLA 185
Cdd:cd17489  112 IIPPSRRGeGIGYYGLAttLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL 166
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 47-117 1.51e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 40.69  E-value: 1.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRL--GRK-PVYLGCLLMITIGHILLTFSMYLSWMTInaTLAAMGFF 117
Cdd:cd17345  265 SKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRaPTGIIFMILVIVALIVYWLAPNVLVDLI--ALIALGFL 336
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 54-120 2.25e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 40.05  E-value: 2.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720   54 MSSLLMWGALIGSFVCGFLSDRL---GRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGG 120
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYG 326
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 63-134 3.24e-03

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 39.52  E-value: 3.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 922581720  63 LIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYL----SWM---TINATLAAMGFFCGGYMVTNFVILTEAFE 134
Cdd:cd17432  307 VLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLqntvSWMpylSIVCIFAYIASFGIGPAGVPFILTTEIFD 385
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
37-120 3.93e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.47  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  37 VERGFacqknSNQTTAMMSSLLMWGALIGSFVCGFLSDRLG-RKPVYLGCLLMITIGHILLTFsMYLSWMTINATLaaMG 115
Cdd:COG2807  243 RDAGL-----SAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLL-APGSLPWLWAVL--LG 314


                 ....*
gi 922581720 116 FFCGG 120
Cdd:COG2807  315 LGQGG 319
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 63-122 5.59e-03

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 38.76  E-value: 5.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922581720  63 LIGSFVCGFLSDRLGR-KPVYLGCLLMITIGHILLTFSMYLSWMTIN-ATLAAMGFFCGGYM 122
Cdd:cd17398  276 LVGSVVAGIWLDKTKKyKETTIIVYILSFIGMVAFTFTLDLGSIWVVfLTAGALGFFMTGYL 337
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 51-182 5.80e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.93  E-value: 5.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  51 TAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFsMYLSWMTINATLAAMGFFCGGYMVTNFVILT 130
Cdd:cd17314   40 IATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY-VFNSFPLSYACFVFIGAGTGILYGSAVLVTT 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 922581720 131 EAFELPKSRLLVVSLNGWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAII 182
Cdd:cd17314  119 QYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIV 170
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 311-428 7.03e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 38.27  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720 311 RFLTKRAIAISSVGLCCLAALMILPI--------QYYDIQCMR----WVIIMLSLMIAAGIDPTWKINHLYSAELFPTSV 378
Cdd:cd17373  217 DFLGRRGGLLLFMILTGLASLLLLGLlnligkysQHPDSGMSDsvkdKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVI 296

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 922581720 379 RSMARGVCNAGGRLGSVMAPMIVYLRTFGFFIPNAIFAVLLFIQLVVIVI 428
Cdd:cd17373  297 RGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVFACCALLCILCILL 346
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 47-185 8.95e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 8.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  47 SNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFS-MYLSWMTINatlAAMGFFCGGYMVTN 125
Cdd:cd17477   29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTdSPWVWFLLR---FVMGIGLAGLFVVS 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581720 126 FVILTEAFElPKSRLLVVSLNGWSVSMAVTA----LAASYTLNWYAYHTIFAIVGACIAIISLA 185
Cdd:cd17477  106 ESWLNALAT-NENRGRVLGLYSTVLGLGFALgpllLALVGTAGALPFLIAAVLLLLALVPLLLT 168
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 62-182 9.81e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 37.96  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  62 ALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFfcgGYMVTNFVILTeAFELPKSRLL 141
Cdd:cd17489  240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF---GLLFPALQALA-VDLVPPHRRG 315

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 922581720 142 VVS---LNGWSVSMAVTALAASYTLNWYAYHTIFAIVGACIAII 182
Cdd:cd17489  316 AANgtfFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLA 359
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 44-137 9.83e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 37.92  E-value: 9.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  44 QKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAAMGFFCGGYMV 123
Cdd:cd17352  213 LGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSS 292

                         90
                 ....*....|....
gi 922581720 124 TNFVILTEAFELPK 137
Cdd:cd17352  293 LTPVILADLVGLEK 306
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 39-120 9.97e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 37.94  E-value: 9.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581720  39 RGFACQKNSNQTTAMMSSLLMWGALIGSFVCGFLSDRLGRKPVYLGCLLMITIGHILLTFSMYLSWMTINATLAamGFFC 118
Cdd:cd17330   24 REFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD--GLTG 101


                 ..
gi 922581720 119 GG 120
Cdd:cd17330  102 GN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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