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Conserved domains on  [gi|922581264|ref|NP_001300202|]
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SSD domain-containing protein [Caenorhabditis elegans]

Protein Classification

patched/dispatched family protein( domain architecture ID 1904021)

patched/dispatched family protein may be involved in hedgehog (Hh) signaling, similar to Drosophila melanogaster proteins patched and dispatched, that acts as a receptor for Hh and a regulator of Hh trafficking, respectively

Gene Ontology:  GO:0007165|GO:0016020
PubMed:  36932157|21778405

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 58-839 0e+00

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 608.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   58 YSPEKADSHFEHAVANEFFNDRGGKFWLEVTITAKD-MDNLLRRDYLDGVDSLAEYLQYNFTVPCSGVRGenklecSFSD 136
Cdd:pfam02460  18 FTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGrNSNILDISYLNDIYQLNDYISTNVEIQVDGIII------SFKD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  137 LCSGQCNDNQviPLFNLIYRNASSRLH-PNFRLTYPTMHLYNDEYYVGEHFAGVKIDPNTNVISrVKVVVLYFRTDRQTT 215
Cdd:pfam02460  92 LCSRYCDLNC--PVNKHYNGMLLSRRHnTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISY-AKAIVLWYFLKFDEE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  216 EVSQVLNNWETSLFDYVEN-FDHPFLNMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFIFAT----NSREHFVFSHN 290
Cdd:pfam02460 169 EVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlSSYTIDWVRSK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  291 VVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSIT 370
Cdd:pfam02460 249 PILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSIT 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  371 VTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLMK----LQKVGEEKKIEAamERRPKQ 446
Cdd:pfam02460 329 ITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEgrhcLFVWATSSPQRI--DSEGSE 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  447 VLSIQNSIRSTAgahpppanpNGIVSRYCRFLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDTTNLIMNDSPLNHIAW 526
Cdd:pfam02460 407 PDKSHNIEQLKS---------RFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLS 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  527 IYERFLWSEGQLVMVFVNNPPDLTKSENLHEVLELVNRFETLPYSMGKNSTSIWLR---SFLYQSSLYHNNKG----FNG 599
Cdd:pfam02460 478 LREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLReyeNFLSTLNMEEEEDEekewSYG 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  600 LLQEWLEdsEGGGARWNDMlrLKKDENGTILgiDKFMFATacAMGDDANWSTREKLQKQWRGVAHEYEHFNVTVFQSYSF 679
Cdd:pfam02460 558 NLPSFLK--APGNSHWAGD--LVWDDNTTMV--TKFRFTL--AGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  680 YIDQLDSIGATTMSTVIWAAITMDLACLLMIPGINSILTSTIAMISINIGVFGLLSMWRVNLDPITMCTTLMSIGFSVDF 759
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  760 TAHISYHYYRNpTSWTTDERLADALKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGIIFLPALL 839
Cdd:pfam02460 710 SAHIAYHFVRS-RGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIIL 788
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 58-839 0e+00

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 608.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   58 YSPEKADSHFEHAVANEFFNDRGGKFWLEVTITAKD-MDNLLRRDYLDGVDSLAEYLQYNFTVPCSGVRGenklecSFSD 136
Cdd:pfam02460  18 FTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGrNSNILDISYLNDIYQLNDYISTNVEIQVDGIII------SFKD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  137 LCSGQCNDNQviPLFNLIYRNASSRLH-PNFRLTYPTMHLYNDEYYVGEHFAGVKIDPNTNVISrVKVVVLYFRTDRQTT 215
Cdd:pfam02460  92 LCSRYCDLNC--PVNKHYNGMLLSRRHnTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISY-AKAIVLWYFLKFDEE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  216 EVSQVLNNWETSLFDYVEN-FDHPFLNMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFIFAT----NSREHFVFSHN 290
Cdd:pfam02460 169 EVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlSSYTIDWVRSK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  291 VVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSIT 370
Cdd:pfam02460 249 PILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSIT 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  371 VTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLMK----LQKVGEEKKIEAamERRPKQ 446
Cdd:pfam02460 329 ITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEgrhcLFVWATSSPQRI--DSEGSE 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  447 VLSIQNSIRSTAgahpppanpNGIVSRYCRFLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDTTNLIMNDSPLNHIAW 526
Cdd:pfam02460 407 PDKSHNIEQLKS---------RFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLS 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  527 IYERFLWSEGQLVMVFVNNPPDLTKSENLHEVLELVNRFETLPYSMGKNSTSIWLR---SFLYQSSLYHNNKG----FNG 599
Cdd:pfam02460 478 LREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLReyeNFLSTLNMEEEEDEekewSYG 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  600 LLQEWLEdsEGGGARWNDMlrLKKDENGTILgiDKFMFATacAMGDDANWSTREKLQKQWRGVAHEYEHFNVTVFQSYSF 679
Cdd:pfam02460 558 NLPSFLK--APGNSHWAGD--LVWDDNTTMV--TKFRFTL--AGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  680 YIDQLDSIGATTMSTVIWAAITMDLACLLMIPGINSILTSTIAMISINIGVFGLLSMWRVNLDPITMCTTLMSIGFSVDF 759
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  760 TAHISYHYYRNpTSWTTDERLADALKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGIIFLPALL 839
Cdd:pfam02460 710 SAHIAYHFVRS-RGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIIL 788
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 6-839 1.99e-32

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 136.19  E-value: 1.99e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264     6 AVISLYIRQFFRWTGLQVYRHPAPFFWIPVVLSLAAALGLLRFHEENRIWYLYSPEKADSHFEhavaNEFFNDRGGKFWL 85
Cdd:TIGR00917  303 STVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALE----KQYFDTHFGPFYR 378

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264    86 --EVTITAKDMDNLLRRDYLDGVDSLAEYLQYNFTVPCSGVRGENKLeCSFSDLCSGQCNdnqviPLFNLIYRNASSRLH 163
Cdd:TIGR00917  379 ieQLIIATVQTSSHEKAPEILTDDNLKLLFDIQKKVSQLFANYEGEL-ITLDSPCFKPNH-----PYNCFIYSTCKKLQN 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   164 PNFRLTYPTmhlyNDEYYVGEHFA----------------GVKIDPNT-------NVISRVKVVVLYFRTDR--QTTEVS 218
Cdd:TIGR00917  453 MYSKLKPEN----YDDYGGVDYVKycfehftspesclsafGGPVDPTTvlggfsgNNFSEASAFVVTFPVNNfvNKTNKT 528

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   219 QVLNNWETSLFDYVENFDHPFL--NMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFI-----FATNSREHFVFSHnv 291
Cdd:TIGR00917  529 EKAVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYIsltlgDSPRLKSLYVTSK-- 606

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   292 vmAILGIAGPLMATGTAFGFLFLFGFPFNSITL----VMPFLIIGVGCDDVFIIIHAMR-----------KTDKSESLED 356
Cdd:TIGR00917  607 --VLLGLSGILIVMLSVLGSVGVFSAVGLKSTLiimeVIPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLER 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   357 RIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRlmklqkvGEEKKI 436
Cdd:TIGR00917  685 RLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR-------TEDKRV 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   437 EAAmerrpKQVLSIQNSIRSTAGAHPPPAnpnGIVSRYCR-----FLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDT 511
Cdd:TIGR00917  758 DCF-----PCIKTSKSSISAEKGSGQRKA---GLLTRYFKevyapVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQ 829

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   512 TNLIMNDSPLnHIAWIYERFLWSEGQLVMVFVNNPPDLTKSENLHEVL--------ELVNRFETLPYsMGKNSTSiWLRS 583
Cdd:TIGR00917  830 QIVLPQDSYL-QIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCtmggcdkdSIVNVFNNLSY-IAKPASS-WLDD 906

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   584 FLY----QSS------------------------LYHNNKG------FNGLLQEWLEDS------EGGGARWNDMLRLKK 623
Cdd:TIGR00917  907 YLVwlspQAScccrkftngtfcngpdpqcfrcadLSSDAQGrpsttqFKEKLPWFLNALpsadcaKGGHAAYSSAVDLQG 986

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   624 deNGTILGIDKFM-FATACAMGDD---ANWSTREKLQKQWRGVAHEYEHFNVTvfqsYSFYiDQLDSIGATTMSTVIWAA 699
Cdd:TIGR00917  987 --YATIIQASSFRtYHTPLNTQVDfinAMRAAQEFAAKVSRSSKMEVYPYSVF----YVFF-EQYLTIWKTAIINLSIAL 1059

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   700 ITMDLACLLMI---PGINSILTSTIAMISINIgvFGLLSMWRVNLDPITMCTTLMSIGFSVDFTAHISyHYYRNPTSWTT 776
Cdd:TIGR00917 1060 GAIFIVCLFLLqlnALSVVNLIMSVGMAVVFC--VGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHIN-AQFSTGKHFSR 1136

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 922581264   777 DERLADALKSIGWPMIQAASSTVLC-IFPLMFNTSYMVWVF-VKTILLVTVLGLLHGIIFLPALL 839
Cdd:TIGR00917 1137 NHRAKEALGGMGSSVFSGITLTKLVgVVVLGFSRSEIFVVYyFRMYLALVLLGFLHGLVFLPVLL 1201
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
267-841 1.39e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 107.25  E-value: 1.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 267 FSVAAVVIFIFAtnsrehFVFSHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMR 346
Cdd:COG1033  224 FPLALLLILLLL------FLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 347 K-TDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLM 425
Cdd:COG1033  298 EeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKP 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 426 KLQKVGEEKKIEAAMERrpkqvlsiqnsIRSTAGAHPPPAnpngivsrycrflkdwktrLCLLLVLCGywtASYYGCKTM 505
Cdd:COG1033  378 KTRRLKKPPELGRLLAK-----------LARFVLRRPKVI-------------------LVVALVLAV---VSLYGISRL 424

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 506 EIKMDTTNLIMNDSPLN-HIAWIYERFlwsEGQLVMVFV---NNPPDLTKSENLHEVLELVNRFETLPYSmgKNSTSI-W 580
Cdd:COG1033  425 KVEYDFEDYLPEDSPIRqDLDFIEENF---GGSDPLEVVvdtGEPDGLKDPEVLKEIDRLQDYLESLPEV--GKVLSLaD 499

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 581 LRSFLYQsSLYHNNKGFNGL-------LQEWLEDSEGGGARWNDMLrlkkDENGTILGIDKFMfatacamgDDANWSTRE 653
Cdd:COG1033  500 LVKELNQ-ALNEGDPKYYALpesrellAQLLLLLSSPPGDDLSRFV----DEDYSAARVTVRL--------KDLDSEEIK 566

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 654 KLQKQWRGVAHEY---EHFNVTVF-QSYSFYiDQLDSIGATTMSTVIWAAItmdLACLLMIPGINSILTSTIAMISINIG 729
Cdd:COG1033  567 ALVEEVRAFLAENfppDGVEVTLTgSAVLFA-AINESVIESQIRSLLLALL---LIFLLLLLAFRSLRLGLISLIPNLLP 642

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 730 VFGLLSMWR---VNLDPITMCTTLMSIGFSVDFTAHISYHYYRN-PTSWTTDERLADALKSIGWPMIQAASSTVLCIFPL 805
Cdd:COG1033  643 ILLTFGLMGllgIPLNIATAVVASIALGIGVDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVL 722

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 922581264 806 MF----NTSYMVWVFVKTIL--LVTVLgllhgiIFLPALLLT 841
Cdd:COG1033  723 LFssfpPLADFGLLLALGLLvaLLAAL------LLLPALLLL 758
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 58-839 0e+00

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 608.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   58 YSPEKADSHFEHAVANEFFNDRGGKFWLEVTITAKD-MDNLLRRDYLDGVDSLAEYLQYNFTVPCSGVRGenklecSFSD 136
Cdd:pfam02460  18 FTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGrNSNILDISYLNDIYQLNDYISTNVEIQVDGIII------SFKD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  137 LCSGQCNDNQviPLFNLIYRNASSRLH-PNFRLTYPTMHLYNDEYYVGEHFAGVKIDPNTNVISrVKVVVLYFRTDRQTT 215
Cdd:pfam02460  92 LCSRYCDLNC--PVNKHYNGMLLSRRHnTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISY-AKAIVLWYFLKFDEE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  216 EVSQVLNNWETSLFDYVEN-FDHPFLNMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFIFAT----NSREHFVFSHN 290
Cdd:pfam02460 169 EVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlSSYTIDWVRSK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  291 VVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSIT 370
Cdd:pfam02460 249 PILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSIT 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  371 VTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLMK----LQKVGEEKKIEAamERRPKQ 446
Cdd:pfam02460 329 ITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEgrhcLFVWATSSPQRI--DSEGSE 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  447 VLSIQNSIRSTAgahpppanpNGIVSRYCRFLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDTTNLIMNDSPLNHIAW 526
Cdd:pfam02460 407 PDKSHNIEQLKS---------RFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLS 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  527 IYERFLWSEGQLVMVFVNNPPDLTKSENLHEVLELVNRFETLPYSMGKNSTSIWLR---SFLYQSSLYHNNKG----FNG 599
Cdd:pfam02460 478 LREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLReyeNFLSTLNMEEEEDEekewSYG 557

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  600 LLQEWLEdsEGGGARWNDMlrLKKDENGTILgiDKFMFATacAMGDDANWSTREKLQKQWRGVAHEYEHFNVTVFQSYSF 679
Cdd:pfam02460 558 NLPSFLK--APGNSHWAGD--LVWDDNTTMV--TKFRFTL--AGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  680 YIDQLDSIGATTMSTVIWAAITMDLACLLMIPGINSILTSTIAMISINIGVFGLLSMWRVNLDPITMCTTLMSIGFSVDF 759
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  760 TAHISYHYYRNpTSWTTDERLADALKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGIIFLPALL 839
Cdd:pfam02460 710 SAHIAYHFVRS-RGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIIL 788
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 322-424 7.51e-33

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 124.23  E-value: 7.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  322 ITLVMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVA 401
Cdd:pfam12349  38 ISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVA 117

                          90       100
                  ....*....|....*....|...
gi 922581264  402 VAVDFVYQLTFFVAVLVYEEKRL 424
Cdd:pfam12349 118 VLFDFLLQMTFFVAVLSLDIRRL 140
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 6-839 1.99e-32

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 136.19  E-value: 1.99e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264     6 AVISLYIRQFFRWTGLQVYRHPAPFFWIPVVLSLAAALGLLRFHEENRIWYLYSPEKADSHFEhavaNEFFNDRGGKFWL 85
Cdd:TIGR00917  303 STVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALE----KQYFDTHFGPFYR 378

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264    86 --EVTITAKDMDNLLRRDYLDGVDSLAEYLQYNFTVPCSGVRGENKLeCSFSDLCSGQCNdnqviPLFNLIYRNASSRLH 163
Cdd:TIGR00917  379 ieQLIIATVQTSSHEKAPEILTDDNLKLLFDIQKKVSQLFANYEGEL-ITLDSPCFKPNH-----PYNCFIYSTCKKLQN 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   164 PNFRLTYPTmhlyNDEYYVGEHFA----------------GVKIDPNT-------NVISRVKVVVLYFRTDR--QTTEVS 218
Cdd:TIGR00917  453 MYSKLKPEN----YDDYGGVDYVKycfehftspesclsafGGPVDPTTvlggfsgNNFSEASAFVVTFPVNNfvNKTNKT 528

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   219 QVLNNWETSLFDYVENFDHPFL--NMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFI-----FATNSREHFVFSHnv 291
Cdd:TIGR00917  529 EKAVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYIsltlgDSPRLKSLYVTSK-- 606

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   292 vmAILGIAGPLMATGTAFGFLFLFGFPFNSITL----VMPFLIIGVGCDDVFIIIHAMR-----------KTDKSESLED 356
Cdd:TIGR00917  607 --VLLGLSGILIVMLSVLGSVGVFSAVGLKSTLiimeVIPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLER 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   357 RIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRlmklqkvGEEKKI 436
Cdd:TIGR00917  685 RLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR-------TEDKRV 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   437 EAAmerrpKQVLSIQNSIRSTAGAHPPPAnpnGIVSRYCR-----FLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDT 511
Cdd:TIGR00917  758 DCF-----PCIKTSKSSISAEKGSGQRKA---GLLTRYFKevyapVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQ 829

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   512 TNLIMNDSPLnHIAWIYERFLWSEGQLVMVFVNNPPDLTKSENLHEVL--------ELVNRFETLPYsMGKNSTSiWLRS 583
Cdd:TIGR00917  830 QIVLPQDSYL-QIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCtmggcdkdSIVNVFNNLSY-IAKPASS-WLDD 906

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   584 FLY----QSS------------------------LYHNNKG------FNGLLQEWLEDS------EGGGARWNDMLRLKK 623
Cdd:TIGR00917  907 YLVwlspQAScccrkftngtfcngpdpqcfrcadLSSDAQGrpsttqFKEKLPWFLNALpsadcaKGGHAAYSSAVDLQG 986

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   624 deNGTILGIDKFM-FATACAMGDD---ANWSTREKLQKQWRGVAHEYEHFNVTvfqsYSFYiDQLDSIGATTMSTVIWAA 699
Cdd:TIGR00917  987 --YATIIQASSFRtYHTPLNTQVDfinAMRAAQEFAAKVSRSSKMEVYPYSVF----YVFF-EQYLTIWKTAIINLSIAL 1059

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   700 ITMDLACLLMI---PGINSILTSTIAMISINIgvFGLLSMWRVNLDPITMCTTLMSIGFSVDFTAHISyHYYRNPTSWTT 776
Cdd:TIGR00917 1060 GAIFIVCLFLLqlnALSVVNLIMSVGMAVVFC--VGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHIN-AQFSTGKHFSR 1136

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 922581264   777 DERLADALKSIGWPMIQAASSTVLC-IFPLMFNTSYMVWVF-VKTILLVTVLGLLHGIIFLPALL 839
Cdd:TIGR00917 1137 NHRAKEALGGMGSSVFSGITLTKLVgVVVLGFSRSEIFVVYyFRMYLALVLLGFLHGLVFLPVLL 1201
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
267-841 1.39e-23

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 107.25  E-value: 1.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 267 FSVAAVVIFIFAtnsrehFVFSHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMR 346
Cdd:COG1033  224 FPLALLLILLLL------FLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYR 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 347 K-TDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLM 425
Cdd:COG1033  298 EeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKP 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 426 KLQKVGEEKKIEAAMERrpkqvlsiqnsIRSTAGAHPPPAnpngivsrycrflkdwktrLCLLLVLCGywtASYYGCKTM 505
Cdd:COG1033  378 KTRRLKKPPELGRLLAK-----------LARFVLRRPKVI-------------------LVVALVLAV---VSLYGISRL 424

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 506 EIKMDTTNLIMNDSPLN-HIAWIYERFlwsEGQLVMVFV---NNPPDLTKSENLHEVLELVNRFETLPYSmgKNSTSI-W 580
Cdd:COG1033  425 KVEYDFEDYLPEDSPIRqDLDFIEENF---GGSDPLEVVvdtGEPDGLKDPEVLKEIDRLQDYLESLPEV--GKVLSLaD 499

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 581 LRSFLYQsSLYHNNKGFNGL-------LQEWLEDSEGGGARWNDMLrlkkDENGTILGIDKFMfatacamgDDANWSTRE 653
Cdd:COG1033  500 LVKELNQ-ALNEGDPKYYALpesrellAQLLLLLSSPPGDDLSRFV----DEDYSAARVTVRL--------KDLDSEEIK 566

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 654 KLQKQWRGVAHEY---EHFNVTVF-QSYSFYiDQLDSIGATTMSTVIWAAItmdLACLLMIPGINSILTSTIAMISINIG 729
Cdd:COG1033  567 ALVEEVRAFLAENfppDGVEVTLTgSAVLFA-AINESVIESQIRSLLLALL---LIFLLLLLAFRSLRLGLISLIPNLLP 642

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 730 VFGLLSMWR---VNLDPITMCTTLMSIGFSVDFTAHISYHYYRN-PTSWTTDERLADALKSIGWPMIQAASSTVLCIFPL 805
Cdd:COG1033  643 ILLTFGLMGllgIPLNIATAVVASIALGIGVDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVL 722

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 922581264 806 MF----NTSYMVWVFVKTIL--LVTVLgllhgiIFLPALLLT 841
Cdd:COG1033  723 LFssfpPLADFGLLLALGLLvaLLAAL------LLLPALLLL 758
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
323-865 1.22e-18

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 91.48  E-value: 1.22e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   323 TLVMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAV 402
Cdd:TIGR00918  460 TQVLPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVV 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   403 AVDFVYQLTFFVAVLVY-----EEKRL---------MKLQKVGEEKKIEAAMERRPKQVLSIQNSI--RSTAGAH----- 461
Cdd:TIGR00918  540 VFNFAAVLLVFPAILSLdlrrrEDRRLdifccffspCSARVIQIEPQAYADGSAPPVYSSHMQSTVqlRTEYDPGtqhyy 619

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   462 ----------PPPANPNGIVS-------------------------------------RYCRFLKDWKTRLCLLLVLCGY 494
Cdd:TIGR00918  620 ttneprshlsVQPSDPLSCQSpdiagstrdllsqfedskaaclslpcarwtlatfaekHYAPFLLQSWAKVVVIFLFLAL 699

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   495 WTASYYGCKTMEIKMDTTNLIMNDSplNHIAWIYERFLWSEGQLVMVFVNNPPDLTKSEnlHEVLELVNRFETLPYSMGK 574
Cdd:TIGR00918  700 LGLSLYGTTRVQDGLDLTDIVPRDT--NEHDFLDAQFRYFSFYNMYAVTQGNFDYPTQQ--QLLYDLHQSFSSVKYVLKE 775

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   575 NSTSI---WL---RSFL----------YQSS--LYHN--NKGFNGLLQEWLEDSEGGGARWNDMLRLKK----DENGTIL 630
Cdd:TIGR00918  776 DNGQLprmWLhyfRDWLqglqkafdedWRDGriTKENyrNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTqrlvNADGIIN 855

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   631 GIDKFMFATACAMGD--------------------DANWSTREKLQ-----------------------------KQWRG 661
Cdd:TIGR00918  856 PNAFYIYLSAWVSNDpvayaasqaniyphppewlhDKNDYDPENLRipaaepleyaqfpfylnglretsqfveaiEHVRA 935

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   662 VAHEYEHFNVTVFQS-YSF-YIDQ---LDSIGATTMSTVIWAAITMdLACLLMIPGINSILTSTIAMISINIgvFGLLSM 736
Cdd:TIGR00918  936 ICNNYEGFGLPSYPSgYPFlFWEQymgLRHWLLLSISVVLACTFLV-CALLLLNPWTAGLIVLVLALMTVEL--FGMMGL 1012

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264   737 WRVNLDPITMCTTLMSIGFSVDFTAHISYHYYrnPTSWTTDERLADALKSIGWPMIQAASSTVLCIFplMFNTS---YMV 813
Cdd:TIGR00918 1013 LGIKLSAIPVVILIASVGIGVEFTVHIALGFL--TAIGDRNRRAVLALEHMFAPVLDGALSTLLGVL--MLAGSefdFIV 1088

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 922581264   814 WVFVKTILLVTVLGLLHGIIFLPALLLTSG---DLSRLFGGDSIQPEKPEKLGEI 865
Cdd:TIGR00918 1089 RYFFAVLAVLTCLGVLNGLVLLPVLLSMFGpepEVSPAEGRSRLPTPSPEPPPGG 1143
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
12-418 1.92e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 58.33  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  12 IRQFFRWTGLQVYRHPAPFFWIPVVLSLAAALGLLRfheeNRIWYL---YSPEKADSHfehaVANEFFNDR-GGKFWLEV 87
Cdd:COG1033  388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISR----LKVEYDfedYLPEDSPIR----QDLDFIEENfGGSDPLEV 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  88 TITAKDMDNLLRRDYLDGVDSLAEYLQYNFTVpcSGVRgenklecSFSDlcsgqcndnqVIPLFNLIYRNASSRlhpNFR 167
Cdd:COG1033  460 VVDTGEPDGLKDPEVLKEIDRLQDYLESLPEV--GKVL-------SLAD----------LVKELNQALNEGDPK---YYA 517

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 168 LtyPTMHLYNDEYYVGEHFAGVKIDPNTNVISRVKVVVLYFRTDRQTTEVSQVLNNWETslfDYVENFDHPFLNMTVNSD 247
Cdd:COG1033  518 L--PESRELLAQLLLLLSSPPGDDLSRFVDEDYSAARVTVRLKDLDSEEIKALVEEVRA---FLAENFPPDGVEVTLTGS 592

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 248 AMIAREVR---TNGMtcvpFFSFSVAAVVIFIFATnsrehFVFsHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITL 324
Cdd:COG1033  593 AVLFAAINesvIESQ----IRSLLLALLLIFLLLL-----LAF-RSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATA 662

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 325 VMPFLIIGVGCDDVFIIIHAMRK-TDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVA 403
Cdd:COG1033  663 VVASIALGIGVDYTIHFLSRYREeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLL 742

                        410
                 ....*....|....*
gi 922581264 404 VDFVYQLTFFVAVLV 418
Cdd:COG1033  743 VALLAALLLLPALLL 757
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
485-840 2.48e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 57.95  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 485 LCLLLVLcgywtASYYGCKTMEIKMDTTNLIMNDSP----LNHIAwiyERFlwSEGQLVMVFVNNPPDLTKSENLHEVLE 560
Cdd:COG1033   21 LFLLLTL-----LLAYGAPKLEVDTDFESLLPEDDPsvqaYDEFE---EEF--GGDDTVVVAVEGKDDIFTPETLEALRE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 561 LVNRFETLPYSmgknSTSIWLRSFLYQSSlyhNNKGFNG--LLQEWLEDSEGGGARWNDMLR---------LKKDENGTI 629
Cdd:COG1033   91 LTEELEEIPGV----DSVTSLTNVRATEG---TEDGLTVepLIPDELPASPEELAELREKVLssplyvgrlVSPDGKATL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 630 LGID-KFMFATACAMGDDANWSTREKLQKqwrgvaHEYEHFNVTVFQSYSFYIDQLDSIGATTMSTVIWAAITMDLACLL 708
Cdd:COG1033  164 IVVTlDPDPLSSDLDRKEVVAEIRAIIAK------YEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264 709 M---IPGInsILTSTIAMISInIGVFGLLSMWRVNLDPITMCTTLMSIGFSVDFTAHI--SYHYYRNpTSWTTDERLADA 783
Cdd:COG1033  238 FfrsLRGV--LLPLLVVLLAV-IWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLlnRYREERR-KGLDKREALREA 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 922581264 784 LKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGIIFLPALLL 840
Cdd:COG1033  314 LRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLS 370
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 268-418 3.47e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 57.54  E-value: 3.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  268 SVAAVVIFIFAtnsrehfVFsHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIGVGCDDVFIIIHAMRK 347
Cdd:TIGR00921 576 GAILVLMILLA-------VF-RNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFE 647

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922581264  348 TDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLV 418
Cdd:TIGR00921 648 ERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLV 718
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 286-839 1.29e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 55.61  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  286 VFSHNVVMAILGIAG-PLMATGTAfgflflfgfpfnsiTLVMpflIIGVGCD-DVFIIIHAMRKTDKSESLEDRIAETME 363
Cdd:TIGR00921 228 LFGVAWVLGIMGWLGiPLYATTLL--------------AVPM---LIGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVR 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  364 EAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLV-YEEKRLMKLQKVGEEKKIEAAMER 442
Cdd:TIGR00921 291 RTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQsIDIGREKVKKEIIAIGGKSSEIEE 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  443 RPKQVLSIqnSIRstagaHPPPAnpngivsrycrflkdwktrLCLLLVLCGywtASYYGCKTMEIKMDTTNLIMNDSPLN 522
Cdd:TIGR00921 371 ELSKVLSI--TVR-----HPVPA-------------------LVAALIITG---LGLYGAAGIKPEVNIEKFIPQDLPSL 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  523 HIAWIYERFLWSEGQLVMVFVnnppdLTKSENLHEVLELVNRFetlpySMGKNSTSIWLRSFLYQS-----SLYHNNKGF 597
Cdd:TIGR00921 422 QARKVIESHMGGSHDFATILV-----KADDVRDPELVRFMDEL-----SRDIKATGVAARVFGAPSiidlvKEVEGLPAP 491

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  598 NGLLQEWLEDSEGGGARWNDMLRLKKDENGtiLGIDKFMfatacamgddanwSTREKLQkqwRGVAHEYEHFNVTVF--- 674
Cdd:TIGR00921 492 ERSALEPIPEDEEGGYISGGQIKVAVIQVQ--LKQGEPK-------------VQGRKIL---RDVQHEHPPPGVKVGvtg 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  675 QSYSFYI--DQLDSiGATTMSTVIWAAITMDLacLLMIPGINSILTSTIAMISINIGVFGLLSMWRVNLDPITMCTTLMS 752
Cdd:TIGR00921 554 LPVAFAEmhELVNE-GMRRMTIAGAILVLMIL--LAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISII 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  753 IGFSVDFTAHISYHYYRNPTSWTTDERLADALKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGI 832
Cdd:TIGR00921 631 LGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAAL 710


                  ....*..
gi 922581264  833 IFLPALL 839
Cdd:TIGR00921 711 VVFPALL 717
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 498-870 2.33e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 48.29  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  498 SYYGCKTMEIKMDTTNLIMNDSPLNHIAWIYERFLWSEGQLVMVFVNNPpDLTKSENLHEVLELVNRFETLPYSMGKNST 577
Cdd:TIGR00921  18 SAYGAQHLNVESDTEKQLPKDFESYKWYHVLQREFGTSTKTLLVVIEGD-DVTRKPVLDYMRRLEQRLREKPYVTNVRSA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  578 SIWLRSFLYQSSLYHNNKGFNGLLQEWLEDSEgggarwndmLRLKKDENGTILGIDkfmfatacaMGDDANWSTREKLQK 657
Cdd:TIGR00921  97 ADIMRQIPGNFPLPVTMPEVRPLMSEYPRSKE---------MFLSKDHTVAIIIVQ---------LKSDADYKQVVPIYN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  658 QWRGVAHEYEHFNVTVFQ-------SYSFYIDQLDSIGATTMStviwAAITMDLACLLMIPGINSILTSTIAMISINIGV 730
Cdd:TIGR00921 159 DVERSLERTNPPSGKFLDvtgspaiNYDIEREFGKDMGTTMAI----SGILVVLVLLLDFKRWWRPLLPLVIILFGVAWV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  731 FGLLSMWRVNLDPITMCTTLMSIGFSVDFTAHISYHYYRN-PTSWTTDERLADALKSIGWPMIQAASSTVLCIFPLMFNT 809
Cdd:TIGR00921 235 LGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEErDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSE 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922581264  810 SYMVWVFVKTILLVTVLGLLHGIIFLPALLLtSGDLSRLFGGDSIQPEKPEKlGEISQASS 870
Cdd:TIGR00921 315 FPMVSEFGLGLVAGLITAYLLTLLVLPALLQ-SIDIGREKVKKEIIAIGGKS-SEIEEELS 373
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 344-417 2.74e-04

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 44.85  E-value: 2.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922581264  344 AMRKTDKSEsLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVL 417
Cdd:TIGR00920 144 ALSSNSQDE-VRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTFFPACL 216
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 692-839 6.02e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 40.37  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  692 MSTV-----IWAAITMDLACLLMIPGINSILTSTIAMISINIGV-----FGLLSMWRVNLdpITMCTTLMSIGFSVDFTA 761
Cdd:TIGR03480 264 LATVsegatVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLiltaaFATLAVGHLNL--ISVAFAVLFIGLGVDFAI 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922581264  762 HISYHY----YRNPTSwttDERLADALKSIGWPMIQAASSTVLCIFPLMFnTSYmvwvfvktiLLVTVLGLLHG------ 831
Cdd:TIGR03480 342 QFSLRYreerFRGGNH---REALSVAARRMGAALLLAALATAAGFFAFLP-TDY---------KGVSELGIIAGtgmfia 408

                         170
                  ....*....|..
gi 922581264  832 ----IIFLPALL 839
Cdd:TIGR03480 409 lfvtLTVLPALL 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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